Indian Journal of Ophthalmology最新文献

{"title":"Indications for exchange of posterior chamber phakic intraocular lens in high myopia.","authors":"Priyanka Sudanaboina, Somasheila I Murthy","doi":"10.4103/IJO.IJO_1190_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1190_24","url":null,"abstract":"<p><strong>Purpose: </strong>To enumerate and analyze the indications for the exchange of phakic intraocular lens (pIOL) in patients with high myopia.</p><p><strong>Design: </strong>Retrospective observational case series.</p><p><strong>Methods: </strong>We retrospectively analyzed the medical reports of patients who underwent an exchange of posterior chamber pIOL at our institution between 2015 and 2022. Preoperative refractive and biometric measurements, pIOL parameters, cause for exchange, and outcomes were assessed.</p><p><strong>Results: </strong>During the study period, 1715 posterior chamber pIOL implantations were performed. Spherical pIOLs were implanted in 328 (19.1%), and toric pIOLs were implanted in 1387 (80.8%) eyes during primary surgery. Nineteen eyes from 18 patients (1.107%) required exchange. Indications for pIOL exchange included high vault in nine eyes, low vault in two, and rotation of the pIOL in five. The mean follow-up period after the pIOL exchange was 3.3 months (range: 1-6.04 months). Repeat surgery was not required for any case. None of the patients had any residual refractive error, and their best-corrected visual acuity was preserved.</p><p><strong>Conclusion: </strong>Overall, the rate of pIOL exchange in our study was low, and it is associated with good outcomes. The most common cause for exchange was high vault, followed by toric pIOL misalignment.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the efficacy and safety of iontophoresis-assisted corneal cross-linking compared to standard CXL in the treatment of keratoconus.","authors":"Noor Alqudah, Asem Alqudah, Sarah Alshamarti, Zaki Shannak","doi":"10.4103/IJO.IJO_1836_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1836_24","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the outcomes of standard corneal cross-linking (S-CXL) and iontophoresis-assisted CXL (I-CXL) in Jordanian keratoconus patients over a 12-month follow-up period.</p><p><strong>Design: </strong>This retrospective, observational cohort study included 107 keratoconus patients who underwent either S-CXL (n = 53) or I-CXL (n = 54) between January 2015 and December 2019.</p><p><strong>Methods: </strong>Data collected included demographic information, clinical history, and ophthalmic examinations. The primary outcome was the change in best-corrected visual acuity (BCVA) from baseline to 12 months post-procedure. Secondary outcomes included changes in spherical equivalent, cylindrical values, corneal curvature (K1, K2, Kmean, Kmax), and thinnest corneal location. Postoperative complications, such as corneal haze, keratitis, and the need for penetrating keratoplasty, were also assessed. Statistical analysis was performed using R statistical software.</p><p><strong>Results: </strong>The mean age of patients was 25.0 years, with a male predominance (60%). Decreased vision was the most common symptom (63%). BCVA improvement was similar in both groups at all intervals. At 12 months, the mean BCVA change was 0.05 in the S-CXL group and 0.04 in the I-CXL group. No significant differences were observed in spherical equivalent values. Corneal curvature values (K1, K2, Kmean, Kmax) were significantly higher in the I-CXL group. Postoperative complications were minimal, with 40% of S-CXL patients and 93% of I-CXL patients experiencing no complications. Mild haze was more common in the S-CXL group (54%).</p><p><strong>Conclusions: </strong>S-CXL demonstrated superiority in improving corneal curvature at 6 and 12 months. Postoperative complications were minimal, with higher incidence of mild haze in the S-CXL group. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these results.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of simultaneous photorefractive keratectomy and corneal cross-linking in managing suspected keratoconus.","authors":"Ali Dal, Mehmet Canleblebici, Murat Erdağ","doi":"10.4103/IJO.IJO_1941_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1941_24","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety and efficacy of combining photorefractive keratectomy (PRK) and corneal cross-linking (CXL) in patients with suspected keratoconus.</p><p><strong>Methods: </strong>This retrospective, non-randomized study included patients who underwent simultaneous PRK and CXL between March 2020 and March 2023. Patients were divided into two groups: group 1 (PRK only without keratoconus) and group 2 (PRK + CXL with suspected keratoconus). Eligibility criteria included stable refractive error for at least 1 year, spherical equivalent refractive error not exceeding -4.0 D, and central corneal thickness between 470 and 500 μm. Exclusion criteria included corneal ectasia, previous ocular surgeries, systemic diseases, and pregnancy. Preoperative and postoperative assessments included uncorrected distance visual acuity (UCVA), best-corrected visual acuity (BCVA), spherical equivalent, corneal topography, and endothelial cell count.</p><p><strong>Results: </strong>The study included 98 eyes from 98 patients, with 47 eyes in group 1 and 51 eyes in group 2. Significant improvements in UCVA and BCVA were observed in both groups 12 months postoperatively (P < 0.001). Similar reductions in cycloplegic spherical and cylindrical refraction values were observed in both groups (P < 0.01). No cases of corneal ectasia were reported. Grade 1 corneal haze was observed in 8.5% of eyes in group 1 and 9.8% of eyes in group 2, all of which resolved within the 12-month follow-up period.</p><p><strong>Conclusion: </strong>The combination of PRK and CXL is a safe and effective treatment option for patients with suspected keratoconus, providing significant improvements in visual acuity and refractive stability without increasing the risk of corneal ectasia.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical outcomes of phacoemulsification with implantation of two new aspheric intraocular lenses: Real-world data.","authors":"Shikha Talwar Bassi","doi":"10.4103/IJO.IJO_2395_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2395_24","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to compare the visual and refractive outcomes of two new aspheric intraocular lenses (IOLs), that is, Clareon (Model CNA0T0) and Tecnis Eyhance (Model ICB00), in patients undergoing phacoemulsification cataract surgery.</p><p><strong>Methods: </strong>A retrospective comparative analysis was conducted at a tertiary referral institute in South India. A total of 132 eyes (91 patients) were included, with 66 eyes implanted with Clareon IOL (group 1) and 66 eyes with Tecnis Eyhance IOL (group 2). Preoperative and postoperative data were collected from January 2022 to April 2024. Primary outcomes included uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), spherical equivalent, and refractive cylinder, measured at 3 weeks postoperatively. Statistical analysis was performed using an independent sample t-test and Statistical Package for the Social Sciences software, with P values <0.05 considered significant.</p><p><strong>Results: </strong>The mean log of minimum angle of resolution (logMAR) UDVA in group 1 was 0.14 (95% confidence interval [CI] [0.11, 0.17]) and in group 2 was 0.16 (95% CI [0.13, 0.19]) (P value 0.16). The mean logMAR UNVA in group 1 was M = 0.55 (95% CI [0.53, 0.58]) and in group 2 was M = 0.5 (95% CI [0.48, 0.52]) (P value 0.0006). The mean add required for group 1 was + 1.76 (95% CI [1.66, 1.86]) and for group 2 was M = 1.56 (95% CI [1.49, 1.62]) (P value 0.0005).</p><p><strong>Conclusion: </strong>At 3 weeks postoperatively, both IOLs provided excellent visual outcomes. Tecnis Eyhance IOL offered enhanced near-vision performance.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management and outcome of microsporidia-induced stromal inflammatory keratitis - A long-term follow-up study.","authors":"Amrita Mohanty, Himansu Sekhar Behera, Sujata Das, Merle Fernandes, Priyadarshini Parida, Srikant Kumar Sahu","doi":"10.4103/IJO.IJO_1141_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1141_24","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the course of disease, management, and outcome of immune stromal keratitis (ISK)/interstitial keratitis (IK) associated with microsporidial epithelial keratitis with a long-term follow-up.</p><p><strong>Methods: </strong>We reviewed the medical records of 20 patients with microsporidia-associated IK between October 2020-2022. Microsporidia involvement was confirmed microbiologically (smear/molecular diagnosis) using corneal epithelium scrapings and clinically characterized by the presence of disciform keratitis, immune ring, and sub-epithelial infiltrates. Patients with over three months of follow-up were included. The course of the disease and management was analyzed.</p><p><strong>Results: </strong>We found 11 out of 20 (55%) microsporidia-associated IK during the study period followed beyond three months. The mean duration of follow-up was 342.1 ± 178.3 days (100 days-23 months). Topical steroids and topical tacrolimus ointment 0.03% were discontinued in nine out of 11 patients after the resolution of initial episode. Among the five out of nine (45%) had six episodes of recurrences 4 ± 3.9 months after discontinuing medications. Re-scraping was performed in four episodes, and microsporidia spores were detected again on two occasions. Among five patients with recurrence, topical steroids were used in the initial treatment for 6 ± 2.1 weeks, and topical tacrolimus was prescribed to only one patient for eight weeks. For the recurrent attacks, topical tacrolimus was added for over 10 weeks, with topical steroids. The patients were followed up for at least six months, with no new episodes of recurrence.</p><p><strong>Conclusion: </strong>Microsporidia-associated ISK/IK is a novel condition having a chronic course with recurrences. It requires close follow-up for recurrences at least six months after discontinuing medications, and topical 0.03% tacrolimus ointment is an effective corticosteroid-sparing agent.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical profile and treatment outcomes in acute retinal necrosis in a South Indian patient population.","authors":"Vidya S Mooss, Krishna R Murthy, Kalpana Babu, Aniruddha A Tirumalai","doi":"10.4103/IJO.IJO_1585_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1585_24","url":null,"abstract":"<p><strong>Purpose: </strong>To look at the clinical profile, treatment methods, and outcomes in cases of acute retinal necrosis (ARN) from a tertiary eye care center.</p><p><strong>Methods: </strong>Hospital-based retrospective observational study wherein cases of ARN presented between January 2016 and December 2023 were reviewed. Demographic details, clinical presentation, complications, management, and visual outcome were evaluated.</p><p><strong>Results: </strong>Twenty eyes of 18 cases were included in the study. Mean age was 40.77 ± 16.38 years, male to female ratio was 2:1, and 11.11% had bilaterality at presentation. Mean duration of uveitis was 3.312 ± 0.95 months. The most commonly found organism was VZV (50%), followed by HSV (45%). All cases were given intravitreal ganciclovir in addition to systemic antivirals and oral steroids. The mean number of intravitreal injections was 5.53 ± 3.87. Maintenance dose of oral valacyclovir (500 mg twice daily) was continued in all cases for an average duration of 5.61 ± 3.79 months. The most common complications noted were retinal detachment (50%) followed by optic atrophy (44.44%). No significant association was noted between the extent of retinitis and the development of complications ( P = 0.215). However, there was a significant difference seen in the rate of complications between the HSV and VZV groups, with more complication rates seen with the VZV group ( P = 0.04). The mean visual acuity was 0.87 ± 0.85 logMAR at presentation and 0.65 ± 0.67 logMAR at the end of the study.</p><p><strong>Conclusion: </strong>Timely diagnosis, aggressive initial treatment with intravitreal ganciclovir along with systemic antivirals and long-term maintenance therapy with systemic antivirals are crucial in ARN to obtain the best visual prognosis achievable and prevent lifelong disabilities.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current perspectives on infections following refractive kerato-lenticule extraction (KLex) surgery.","authors":"Venugopal Anitha, Josephine S Christy, Murugesan Vanathi, Divya Manohar, Radhika Tandon, Meenakshi Ravindran","doi":"10.4103/IJO.IJO_2280_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2280_24","url":null,"abstract":"<p><strong>Abstract: </strong>Refractive kerato-lenticule extraction surgery (KLex), also known as \"small incision lenticule extraction (SMILE),\" or \"smooth incision keratomileusis\" (SILK), represents a significant advancement in refractive surgery with its minimally invasive approach and impressive success rates. Despite these advancements, postoperative infectious keratitis, though rare, poses a critical challenge and profoundly impacts visual outcomes. Unlike infections following surface ablation procedures, which benefit from direct drug penetration into the site of infection, KLex and LASIK face hurdles due to the depth of infection location. In laser-assisted in situ keratomileusis (LASIK), infections begin at the interface between the flap and the stromal bed, whereas in KLex, they occur within the stromal bed. This position of the infiltrate poses the challenge of inadequate drug penetration, making management more complex. This review explores the nuances of post-KLex infectious keratitis, delving into the incidence, predisposing factors, and pathophysiology. It also covers the common organisms causing the infection, clinical manifestations, and management strategies. By offering a comprehensive guide, this paper aims to furnish clinicians with the knowledge necessary for vigilant monitoring and timely intervention, thereby enhancing patient outcomes following KLex procedures.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical results of management of aphakia with Soemmering ring in microcornea.","authors":"Jayapratha R Selvaraj, Dhivya Ashok Kumar, Priya Narang, Ashvin Agarwal, Rhea Narang, Soosan Jacob, Amar Agarwal","doi":"10.4103/IJO.IJO_1084_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1084_24","url":null,"abstract":"<p><strong>Purpose: </strong>To present clinical outcomes of glued IOL scaffold for management of aphakia with Soemmering ring in eyes with microcornea.</p><p><strong>Design: </strong>Prospective, Interventional series.</p><p><strong>Setting: </strong>Private practice.</p><p><strong>Methods: </strong>11 eyes of 6 patients (3 males, 3 females) with microcornea underwent glued IOL scaffold procedure for aphakia associated with Soemmering ring. All patients had undergone initial cataract surgery at age less than 10 years and were rendered aphakic.</p><p><strong>Main outcome measures: </strong>Uncorrected and best-corrected visual acuity (UCVA; BCVA), Specular count and IOL centration.</p><p><strong>Results: </strong>The mean age group of the cases was 22.9±11years, the mean corneal diameter was 7.8±0.25mm, the mean axial length was 21.7±1.2mm and the mean extent of Soemmering ring was 5.2±2.4 (range 3-10) clock hours. The mean follow-up period was 31.6±16.8 months. The mean preoperative and postoperative UCVA was 1.64±0.15 LogMAR and 0.68±0.18 LogMAR respectively (p=0.003). The preoperative and postoperative specular count was 2463.4±451.3 cells/sq mm and 2264.5±459.4 cells/sq mm respectively. The mean percentage of endothelial cell loss was 8.3±4.8%. The mean haptic length trimmed was 1.3±0.17mm and all the haptics were well-placed in subscleral position. Negative correlation was observed between the corneal diameter and the extent of haptic length trim. The IOL was well-centred in all the cases and there was no incidence of slippage of soemmering material into the vitreous cavity.</p><p><strong>Conclusions: </strong>Satisfactory visual outcomes can be achieved in eyes with microcornea and aphakia with associated soemmering ring.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of intraocular lens decentration and tilt on higher-order aberrations in patients with high and super-high myopia following cataract surgery.","authors":"Yu Wang, Bo Zang, Qianlong Bi, Jing Huang, Wei Xu, Chunmeng Dai, Xiaoxia Ding, Dong Li, Zixi Zhou","doi":"10.4103/IJO.IJO_2244_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2244_24","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate how intraocular lens (IOL) positioning affects visual quality in patients with high myopia after cataract surgery.</p><p><strong>Methods: </strong>This prospective, randomized study was conducted on 50 eyes from 50 patients with high myopia (axial length [AL] >26 mm) or super-high myopia (AL >30 mm) who underwent cataract surgery between October 2022 and October 2023. We assessed the IOL position using optical coherence tomography and measured higher-order aberrations (HOAs) with the iTrace system. Correlations between IOL positioning and visual quality markers were then examined.</p><p><strong>Results: </strong>Follow-up rates were 100% (50 eyes) at 1 month and 84% (42 eyes) at 3 months post-surgery. At 1 month, IOL tilt showed a positive correlation with total HOAs in both the high and super-high myopia groups (rs = 0.449, P = 0.010 and rs = 0.570, P = 0.017). IOL decentration was associated with specific aberrations: coma in the high myopia group (rs = 0.492, P = 0.004) and trefoil in the super-high myopia group (rs = 0.539, P = 0.026). At 3 months, IOL decentration negatively correlated with overall visual quality, measured by the modulation transfer function, in the high myopia group (rs = -0.558, P = 0.001), but no significant correlation was observed in the super-high myopia group.</p><p><strong>Conclusion: </strong>IOL positioning significantly affects visual quality in patients with high myopia after cataract surgery. The effects vary based on the degree of myopia and type of IOL misalignment. These findings emphasize the importance of precise IOL placement to optimize visual outcomes in this patient population.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To study the anatomic and intraoperative factors responsible for gas bubble migration in the anterior chamber during femtosecond laser-assisted in situ keratomileusis (FS-LASIK) flap creation.","authors":"Suman Lata, Sohini Mandal, Rajesh Sinha, Jeewan S Titiyal","doi":"10.4103/IJO.IJO_3098_23","DOIUrl":"https://doi.org/10.4103/IJO.IJO_3098_23","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the factors responsible for gas bubble migration into the anterior chamber during femtosecond-assisted laser-assisted in situ keratomileusis (FS-LASIK) flap creation.</p><p><strong>Methods: </strong>A retrospective data analysis was conducted on 20 eyes of 12 patients undergoing bilateral laser-assisted in situ keratomileusis surgery, where intraoperative gas bubble migration was observed. Data from age-matched controls without gas bubble migration were also analyzed. Various preoperative and intraoperative parameters were compared between the groups, including refractive error, keratometry, white-to-white (WTW) distance, angle parameters, anterior chamber depth (ACD), central corneal thickness, flap diameter, pulse energy, suction time, anterior chamber width (ACW), angle opening distance (AOD) 500 and AOD 750, trabecular iris space area (TISA) 500, TISA 750, trabecular iris area (TIA) 500, TIA 750, and anterior chamber width (ACW) using CASIA anterior segment optical coherence tomography (ASOCT), to find the correlation between angle anatomy and migration of gas bubble in AC.</p><p><strong>Results: </strong>The study found no significant differences in median age and spherical error between the groups. However, significant differences were observed in WTW (study: 11.5 ± 0.377 mm, control: 11.78 ± 0.181 mm; P = 0.04), ACD (study: 3.39 ± 0.372 mm, control: 3.86 ± 0.284 mm; P = 0.005), angle (study: 35.22° ±4.28°, control: 41.79° ± 3.95°; P = 0.002), ACW (study: 11.37 ± 0.435 mm, control: 11.83 ± 0.264 mm; P = 0.01), flap diameter (study: 8.82 mm, control: 8.68 mm; P = 0.04), and suction time (study: 62 ± 12.89 sec, control: 85.3 ± 13.35 sec; P = 0.0009). The laser energy parameters were similar between the groups.</p><p><strong>Conclusion: </strong>Smaller WTW, larger flap diameter, lower ACD, and ACW are significant predisposing factors for gas bubble migration into the anterior chamber during FS-LASIK. Preoperative evaluations using Pentacam and CASIA ASOCT can help identify eyes at risk.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}