Indian Journal of Ophthalmology最新文献

Quantitative and qualitative assessment of evaporative dry eye post intense pulsed light therapy, a prospective study. 强脉冲光治疗后蒸发性干眼的定量和定性评价，一项前瞻性研究。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2024-12-27 DOI: 10.4103/IJO.IJO_1136_24

Sourabh D Patwardhan, Ankita Sangle, Nidhi S Patwardhan, Seema Mane

{"title":"Quantitative and qualitative assessment of evaporative dry eye post intense pulsed light therapy, a prospective study.","authors":"Sourabh D Patwardhan, Ankita Sangle, Nidhi S Patwardhan, Seema Mane","doi":"10.4103/IJO.IJO_1136_24","DOIUrl":"10.4103/IJO.IJO_1136_24","url":null,"abstract":"Purpose: This study aimed to determine the effect of intense pulsed light (IPL) treatment on meibomian gland disease.Settings and design: This is a prospective interventional study.Methods: Seventy eyes of patients with dry eye disease undergoing three sessions of IPL therapy, 15 days apart, were included. Each patient completed the dry eye questionnaire (SPEED) for symptomatic assessment. Dry eye evaluation tests were performed, including Schirmer's 1 test, meiboscopy, noninvasive tear break-up time (NIBUT) and interferometry. These tests were repeated before each IPL session.Statistical analysis used: Data analysis was performed using IBM SPSS Statistics software (Version 20, Inc., Chicago, Illinois, USA). To Kolmogorov-Smirnov test was used to assess the normality of the variables. The Chi-square test was applied for statistical analysis. Level of significance was set at p ≤ 0.05.Results: The mean symptom score from the dry eye questionnaire (SPEED) showed a significant reduction of 24.5% ( p < 0.001) in symptoms. Schirmer's 1 test showed an improvement of 16.43% on day 15 and 40.13% on day 45. Meiboscopy grade improved by 13.54% on day 45. NIBUT improved from 53.29% on day 15 to 135.53% on day 45. Interferometry showed an improvement of 58.91% on day 45.Conclusions: The various investigative tests demonstrated both qualitative and quantitative improvements in dry eye disease, and patients reported symptomatic relief. The effects of IPL therapy, in terms of symptomatic relief, continued to improve with each session. The quality of the tear film also improved progressively. IPL therapy is a potential therapeutic option for MGD.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"590-593"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vernal keratoconjunctivitis in human immunodeficiency positives: A case series.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI: 10.4103/IJO.IJO_2314_24

Shweta Agarwal, Bhaskar Srinivasan, Geetha Iyer, Nilay Patel, Rama Rajagopal, Srividya Gurumurthy, Sridharan Sudharshan

{"title":"Vernal keratoconjunctivitis in human immunodeficiency positives: A case series.","authors":"Shweta Agarwal, Bhaskar Srinivasan, Geetha Iyer, Nilay Patel, Rama Rajagopal, Srividya Gurumurthy, Sridharan Sudharshan","doi":"10.4103/IJO.IJO_2314_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2314_24","url":null,"abstract":"Purpose: To analyze the clinical profile of vernal keratoconjunctivitis (VKC) and its response to treatment in human immunodeficiency virus (HIV) patients and its relation with CD4 counts.Methods: This study is a retrospective observational case series of patients with HIV and VKC.Results: Thirteen patients presented with HIV and VKC, with 69.2% having a severe-grade VKC. Median age of onset of VKC was 5 years in children and 31.5 years in adults. Seventy percent had a drop in CD4 counts at the onset of VKC. The duration between diagnosis of HIV and onset of VKC was statistically less in adults than in children. Eleven were on highly active antiretroviral therapy at presentation, and three patients were changed to second line of therapy, two of whom showed worsening of VKC just before shifting.Conclusion: The study thus highlights the correlation between worsening of VKC and decrease in CD4 counts, and thus there is a need for aggressive management of HIV to prevent VKC-related complications.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 4","pages":"599-602"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current perspectives on topical antiallergics. 当前对局部抗过敏药物的看法。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2024-12-27 DOI: 10.4103/IJO.IJO_1608_24

Nikhil S Gokhale

引用次数: 0

Outcome of tenonplasty in scleral ischemia secondary to acute ocular surface burn. 急性眼表烧伤继发巩膜缺血的腱膜成形术效果。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2024-09-10 DOI: 10.4103/IJO.IJO_204_24

Nidhi Gupta, Shweta Singh, Virender Sangwan, Umang Mathur

{"title":"Outcome of tenonplasty in scleral ischemia secondary to acute ocular surface burn.","authors":"Nidhi Gupta, Shweta Singh, Virender Sangwan, Umang Mathur","doi":"10.4103/IJO.IJO_204_24","DOIUrl":"10.4103/IJO.IJO_204_24","url":null,"abstract":"Purpose: To study the outcome of tenonplasty in eyes with perilimbal ischemia in acute ocular surface burns.Methods: This was a single-center retrospective study that included all patients presenting between May 2012 and December 2022 with acute ocular surface burn (within 6 weeks from injury) with perilimbal scleral ischemia, without perforation or previous surgical intervention for the same. All these patients underwent single-stage tenonplasty with amniotic membrane transplantation and medical management. Successful outcome was defined as globe preservation at 6 months.Results: Twenty-three eyes of 20 patients were included in our study. Out of these, alkali was the most common offending agent (10 eyes of 8 patients). The extent of scleral ischemia was <90° in seven eyes, 90°-180° in six eyes, and >180° in 10 eyes. The mean interval between the injury and tenonplasty was 16.5 days. Globe integrity in 20 of the 23 eyes was maintained 6 months post injury. Three eyes that developed hypotony at the end of 6 months had more than 180° of perilimbal scleral ischemia at presentation. The extent of scleral ischemia correlated with the development of phthisis bulbi, but the values were not statistically significant ( P = 0.081).Conclusion: Tenonplasty in the acute stage acts as a globe-salvaging procedure in acute chemical burns with perilimbal scleral ischemia. Extensive scleral ischemia in an acute chemical burn remains a poor prognostic factor for globe integrity in the long term.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"582-585"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous Tenon's patch graft: Techniques, clinical outcome, and complications in cases of immune corneal melt.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI: 10.4103/IJO.IJO_1890_24

Nisha Rani, Srikant K Sahu, Sonali Sahoo

{"title":"Autologous Tenon's patch graft: Techniques, clinical outcome, and complications in cases of immune corneal melt.","authors":"Nisha Rani, Srikant K Sahu, Sonali Sahoo","doi":"10.4103/IJO.IJO_1890_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1890_24","url":null,"abstract":"Purpose: To study the techniques, clinical outcomes, and complications of autologous Tenon's patch grafting in patients with non-infectious corneal melt.Methods: This retrospective analysis included 15 eyes from 15 patients with non-infective corneal melt who underwent autologous Tenon's patch grafting between January 2021 and December 2023 at our tertiary care institute. The age of the patients ranged from 16 to 79 years (mean: 46.64 ± 17.20 years), and there were eight males and seven females. Tenon's tissue was harvested from the same eye in all patients, placed on the perforation site, and tucked in and secured with 10-0 nylon sutures in 14 eyes and with additional cyanoacrylate glue in one eye. The follow-ups ranged from 1 month to 2 years (mean: 9.17 ± 6.83 months).Results: The graft healed with scarring and vascularization in 10 eyes (66.67%), and loss of Tenon's patch graft was seen in two eyes (13%). Three (20%) patients were lost to follow-up, and five (33%) achieved a vision of >20/200.Conclusion: In active immune corneal melt, Tenon's patch graft restores cornea and globe integrity, delaying the need for keratoplasty in an inflammatory condition.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 4","pages":"563-566"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From expertise to mentorship: Advancing keratoprosthesis surgery worldwide.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI: 10.4103/IJO.IJO_85_25

Christopher Liu, Mehran Zarei-Ghanavati, Venkata S Avadhanam

引用次数: 0

Understanding the immunology of the ocular surface and its relevance to clinical practice.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI: 10.4103/IJO.IJO_1721_24

Sharon D'Souza, Rohit Shetty, Swaminathan Sethu

{"title":"Understanding the immunology of the ocular surface and its relevance to clinical practice.","authors":"Sharon D'Souza, Rohit Shetty, Swaminathan Sethu","doi":"10.4103/IJO.IJO_1721_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1721_24","url":null,"abstract":"The immunology of the ocular surface has an important role in maintaining homeostasis and in the etiopathogenesis of a number of diseases when dysregulated. This can result in damage to the cornea and ocular surface and loss of clarity and vision. As the entire ocular surface is linked via its epithelium, vascular supply, and innervation, changes across one aspect have tangible effects on the other. Immune cells residing on the ocular surface and those that traffic across the ocular surface interact with the structural tissues to release molecular factors and result in tissue response and disease. Studies in animal models and in vitro experiments along with in vivo studies on the human ocular surface have given newer insights with closer representation of actual health and disease. Some of the diseases which have been found to have a strong immunological basis include dry eye disease (DED) and Sjogren's syndrome, keratoconus, corneal graft rejection, autoimmune conditions such as peripheral ulcerative keratitis, and Stevens-Johnson syndrome. The ocular surface immunology has unique patterns and signatures across different diseases. These give us an opportunity to understand the diseases better find newer targets for therapy and an opportunity to reduce visual morbidity. Clinically, we envisage a shift from steroids and broad action immunomodulators toward target specific drugs making personalized medicine and customized therapy the way forward.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 4","pages":"516-520"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OSSN in South India: Clinical presentation, treatment outcomes, and histopathologic correlations. 南印度的 OSSN：临床表现、治疗效果和组织病理学相关性。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2024-10-25 DOI: 10.4103/IJO.IJO_909_24

P V Tejaswi Prasad, Shanti Radha Krishnan, Naveen Radhakrishnan, Sahithya Bhaskaran, N Venkatesh Prajna

{"title":"OSSN in South India: Clinical presentation, treatment outcomes, and histopathologic correlations.","authors":"P V Tejaswi Prasad, Shanti Radha Krishnan, Naveen Radhakrishnan, Sahithya Bhaskaran, N Venkatesh Prajna","doi":"10.4103/IJO.IJO_909_24","DOIUrl":"10.4103/IJO.IJO_909_24","url":null,"abstract":"Purpose: This study aimed to analyze the clinical presentation, treatment outcomes, and histopathology features of ocular surface squamous neoplasia (OSSN) in a South Indian population and correlate the area of lesions to the histopathological grade/severity of carcinoma in situ (CIN) and squamous cell carcinoma (SqCC) invasive and noninvasive tumors.Methods: The study was a retrospective cross-sectional study. The study reviewed electronic medical records (EMRs) of 99 eyes of 99 South Indian patients who underwent en bloc excision and biopsy for tumors in the corneal and conjunctival epithelium with suspicion of OSSN over 1 year from January 2019 to December 2019. Postoperatively, patients were treated with three cycles of topical 0.04% mitomycin C eye drops. Sixty-three had requisite EMR data with a follow-up period of 1 year.Results: Patients had equal gender distribution with an age range of 28-83 years. The most common clinical variant was leukoplakic lesion, and the area of the lesion was the only predicting factor for SqCC and CIN.Conclusion: Bigger (T2) lesions should be strongly suspected for OSSN and promptly excised. Histopathologic analysis should be performed, and post-op topical mitomycin C or interferon alpha 2b is administered to avoid recurrence. In this study, by correlating the area of the lesion, we introduce a new variable that may aid in clinical prognostication alongside the AJCC classification.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"586-589"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amniotic membrane grafting for acute ocular involvement in Stevens-Johnson syndrome: Review of perioperative considerations, surgical techniques, and outcomes.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI: 10.4103/IJO.IJO_1238_24

Prabhakar Singh, Aparna Palit, Abhishek Gupta, Subhrashis G Niyogi, Sekar Loganathan, Mahuya Chattopadhyay, Sheel Meshram, Abhishek Verma, Peeyush K Tripathy

{"title":"Amniotic membrane grafting for acute ocular involvement in Stevens-Johnson syndrome: Review of perioperative considerations, surgical techniques, and outcomes.","authors":"Prabhakar Singh, Aparna Palit, Abhishek Gupta, Subhrashis G Niyogi, Sekar Loganathan, Mahuya Chattopadhyay, Sheel Meshram, Abhishek Verma, Peeyush K Tripathy","doi":"10.4103/IJO.IJO_1238_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1238_24","url":null,"abstract":"To review the perioperative considerations, surgical techniques, and outcomes of amniotic membrane grafting for acute ocular manifestations in Stevens-Johnson syndrome (SJS) and discuss a novel amniotic membrane grafting method. An online literature search of published articles on amniotic membrane grafting in acute SJS was performed using appropriate keywords on March 1, 2024. The relevant articles were included and analyzed. The review summarizes the relevance of amniotic membrane grafting in the current scenario. It also compares different techniques of amniotic membrane grafting and the ocular surface coverage each procedure provides. A novel technique of amniotic membrane grafting has been discussed with a schematic explanation. It also summarizes the complications of amniotic membrane grafting and their management, and the long-term outcomes of amniotic membrane grafting in preventing chronic sequelae. One should have a lower threshold for doing amniotic membrane grafting in cases with ocular involvement. This prevents the development of long-term sequelae and subsequent corneal blindness.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 4","pages":"553-562"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotrophic keratopathy: Update in diagnosis and management.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI: 10.4103/IJO.IJO_2963_24

Carlos Segundo Font, Maria Soledad Cortina

引用次数: 0