Indian Journal of Ophthalmology最新文献

The Retilight, a portable LED endo-illuminator. 这是一款便携式LED内照灯。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.4103/IJO.IJO_2234_24

Prithvi Chandrakanth, Shishir Verghese, Aishwarya Naik, K Chandrakanth

引用次数: 0

Bacterial 16S rRNA gene alterations in the conjunctival sac and lacrimal sac in chronic dacryocystitis. 慢性泪囊炎患者结膜囊和泪囊细菌16S rRNA基因的改变。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.4103/IJO.IJO_1314_24

Jie Chen, Fangzheng Shi, Siya Chen, Yulu Liu, Yuxin Xu

{"title":"Bacterial 16S rRNA gene alterations in the conjunctival sac and lacrimal sac in chronic dacryocystitis.","authors":"Jie Chen, Fangzheng Shi, Siya Chen, Yulu Liu, Yuxin Xu","doi":"10.4103/IJO.IJO_1314_24","DOIUrl":"10.4103/IJO.IJO_1314_24","url":null,"abstract":"Purpose: Dysbiosis of the microbial community in the lacrimal sac has been associated with the occurrence and development of chronic dacryocystitis. The aim of this study was to investigate the microbial characteristics of the conjunctival sac and lacrimal sac in patients with chronic dacryocystitis using 16S rRNA sequencing and explore their relevance to this condition.Methods: This was achieved through the application of Illumina MiSeq technology for the comprehensive sequencing of 16S rRNA genes in bacterial DNA samples isolated from the conjunctival and lacrimal sacs of 20 patients with chronic dacryocystitis.Results: The conjunctival sac microbiota showed slightly higher diversity compared to the lacrimal sac. However, their microbial communities were similar. In the cohort representing the lacrimal sac, there was a notable reduction in the relative abundance of Proteobacteria. Conversely, an increase in the relative richness of phyla such as Firmicutes, Actinobacteria, and Bacteroidetes was observed. Linear discriminant analysis and effect size analysis elucidated a significant enrichment of the Methylobacterium and Cetobacterium genera within the conjunctival sac cohort, in contrast to the lacrimal sac cohort. The dominant pathway in both sites was biosynthesis according to Kyoto Encyclopedia of Genes and Genomes analysis.Conclusion: In individuals suffering from chronic dacryocystitis, the microbiota of the lacrimal sac exhibits a reduced α-diversity and a comparable β-diversity, alongside exhibiting distinct taxonomic profiles when contrasted with the microbiota of the conjunctival sac.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S410-S417"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular surface squamous neoplasia masquerades: Clinical profile and outcome. 假面具眼表鳞状瘤变：临床概况和结果。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.4103/IJO.IJO_3391_23

Shirali Gokharu, Deepanjali Arya, Deepender Chauhan, Sima Das

{"title":"Ocular surface squamous neoplasia masquerades: Clinical profile and outcome.","authors":"Shirali Gokharu, Deepanjali Arya, Deepender Chauhan, Sima Das","doi":"10.4103/IJO.IJO_3391_23","DOIUrl":"10.4103/IJO.IJO_3391_23","url":null,"abstract":"Purpose: The diagnosis of ocular surface squamous neoplasia (OSSN) is primarily clinical, confirmed through histopathology, cytology, or imaging. This study describes a series of OSSN patients with atypical clinical presentation masquerading non-neoplastic etiologies, identifies clinical features distinguishing OSSN from benign lesions, and thus aids clinicians in early diagnosis and prompt management.Methods: A retrospective review was conducted on medical records of OSSN patients, and patients initially diagnosed with anterior segment infection or inflammation were identified. Data collected included clinical presentation, initial diagnosis and treatment, response to treatment, final diagnosis, treatment type and outcome, and clinical clues to the diagnosis.Results: In the study period, 153 OSSN patients were identified from medical records of which 11 patients (7.2%) were initially diagnosed as anterior segment infection or inflammation. One patient presented with limbal stem cell deficiency, two with nodular episcleritis and necrotizing scleritis, and eight with various corneal involvement such as dendritic ulcer, corneal degeneration/dystrophy, corneal dermoid, exposure keratopathy, peripheral ulcerative keratitis, and perforated corneal ulcer. Three underwent extended enucleation due to intraocular spread, two required excision biopsies with adjuvant topical therapy, and the remaining patients were treated with topical therapy (Interferon α -2b 1% and/or mitomycin-C 0.04%). One patient was lost to follow up, one had a recurrence, and nine achieved complete resolution at mean follow-up of 18 months.Conclusion: OSSN can mimic ocular surface infection, inflammation, or degeneration. A meticulous anterior segment evaluation can provide clinical clues to diagnosis which can be confirmed on histopathology.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S405-S409"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of peripapillary nerve fiber layer thickness, optic nerve head, and macular parameters using spectral domain optical coherence tomography in patients with migraine. 利用光谱域光学相干断层扫描评估偏头痛患者的乳头周围神经纤维层厚度、视神经头和黄斑参数。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_2300_24

Tanya Yadav, Pradeep Kumar Panigrahi, Lolly Pattnaik, Lulup Kumar Sahoo

{"title":"Assessment of peripapillary nerve fiber layer thickness, optic nerve head, and macular parameters using spectral domain optical coherence tomography in patients with migraine.","authors":"Tanya Yadav, Pradeep Kumar Panigrahi, Lolly Pattnaik, Lulup Kumar Sahoo","doi":"10.4103/IJO.IJO_2300_24","DOIUrl":"10.4103/IJO.IJO_2300_24","url":null,"abstract":"Purpose: Assessment of peripapillary retinal nerve fiber layer (pRNFL) thickness, optic nerve head (ONH), and macular parameters using spectral domain optical coherence tomography (OCT) in migraine patients and comparison with age- and gender-matched healthy comparable patients.Methods: Patients diagnosed with migraines who fulfilled the inclusion criteria were included in the study. Healthy subjects without any ocular and systemic disorders constituted the control group. pRNFL thickness, ONH, and macular parameters were assessed using spectral domain OCT in all patients. The various study parameters were analyzed and compared between the two groups at the end of the study period. The migraine patients were also analyzed based on type, duration, and severity of migraine.Results: The study included 100 migraine patients and 100 age- and sex-matched healthy subjects. The mean age in migraine and control groups was 31.01 ± 8.56 and 30.80 ± 8.65 years, respectively. Females comprised 84% of the study subjects. Migraine patients had statistically significant (P < 0.05) thinner pRNFL and macular parameters compared to healthy subjects. Chronic migraine, severe migraine, and duration of more than 5 years were associated with statistically significant thinner pRNFL and macular parameters.Conclusion: Migraine patients have significantly thinner pRNFL and macular parameters than healthy patients, and this is especially so for patients with greater severity of migraine.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 6","pages":"900-905"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Brolucizumab-associated intraocular inflammation in Indian patients by VRSI study group". 对“VRSI研究组印度患者的brolucizumab相关眼内炎症”的评论。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_2590_24

Sabyasachi Sengupta, Aditya Kelkar, Harsh H Jain

引用次数: 0

Evaluation of anterior scleral thickness in eyes with central serous chorioretinopathy. 中枢性浆液性脉络膜视网膜病变眼前巩膜厚度的评价。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_3116_24

Parvathy Prabhakaran, B C Pradeep, Akanksha D Pandit, Pradeep Sagar, A Varsha, Shubhra Sweta, Suchitra Biswal, H N Ravishankar

{"title":"Evaluation of anterior scleral thickness in eyes with central serous chorioretinopathy.","authors":"Parvathy Prabhakaran, B C Pradeep, Akanksha D Pandit, Pradeep Sagar, A Varsha, Shubhra Sweta, Suchitra Biswal, H N Ravishankar","doi":"10.4103/IJO.IJO_3116_24","DOIUrl":"10.4103/IJO.IJO_3116_24","url":null,"abstract":"Purpose: To compare the anterior scleral thickness in eyes with central serous chorioretinopathy (CSC) and healthy eyes.Design: Cross-sectional observational study.Methods: The study included patients with CSC and age and gender-matched healthy individuals. The subfoveal choroidal thickness (SFCT) and scleral thickness at 3 mm, 4 mm, and 8 mm posterior to the scleral spur were measured using swept source optical coherence tomography (Topcon DRI-OCT Triton plus).Results: The study included 35 eyes with CSC and 35 control eyes. In CSC group, 82.86% were simple and 17.14% were complex. There was no statistically significant difference in the scleral thickness in CSC and control groups. Though the sclera was thicker in the complex CSC group compared to simple CSC at 3 mm (nasal: 724.33 ± 180.53 vs 658.48 ± 57.63, temporal: 696.17 ± 212.91 vs 628.83 ± 107.7) and 4 mm (nasal: 656.67 ± 109.34 vs 621.62 ± 79.31, temporal: 640.17 ± 191.31 vs 616.48 ± 86.30), the difference was not statistically significant. A moderate negative correlation was noted between SFCT and scleral thickness at 8 mm (r -0.349) and 3 mm on the nasal side (r -0.388) in the control group. A moderate negative correlation was noted between SFCT and scleral thickness at 4 mm (r -0.377) and 3 mm (r -0.403) on the temporal side in CSC group.Conclusion: The anterior scleral thickness was similar in CSC and healthy eyes. As the study sample predominantly included simple CSC, the findings indicate that the anterior scleral thickness may not be involved in the pathogenesis of simple CSC.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 6","pages":"833-836"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OCT angiography in polycythemia vera. 真性红细胞增多症的OCT血管造影。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_2562_24

Pradeep K Panigrahi

引用次数: 0

Visual loss and blurred optic discs. 视力丧失和视盘模糊。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-30 DOI: 10.4103/IJO.IJO_2526_24

Ana Bárbara Dias Lopes Urzedo, Bruna Predabon, Kenzo Hokazono

引用次数: 0

Comments on: Clinicopathologic study of caruncular lesions. 点评：环形病变的临床病理研究。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-30 DOI: 10.4103/IJO.IJO_2419_24

Soham S Pal, Md Shahid Alam

引用次数: 0

Clinical profile and visual outcomes in ethambutol-induced toxic optic neuropathy. 乙胺丁醇引起的中毒性视神经病变的临床特点和视力结果。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-30 DOI: 10.4103/IJO.IJO_1807_24

Jenil Sheth, Virender Sachdeva, Ashima Goyal, Aditi Parikh, Rohan Nalawade, Hardik Nanavati, Ramesh Kekunnaya

{"title":"Clinical profile and visual outcomes in ethambutol-induced toxic optic neuropathy.","authors":"Jenil Sheth, Virender Sachdeva, Ashima Goyal, Aditi Parikh, Rohan Nalawade, Hardik Nanavati, Ramesh Kekunnaya","doi":"10.4103/IJO.IJO_1807_24","DOIUrl":"10.4103/IJO.IJO_1807_24","url":null,"abstract":"Purpose: To characterize the severity of vision loss, dose-related adverse effects, and visual outcomes in ethambutol-induced toxic optic neuropathy (ETON) patients.Methods: A prospective observational study was conducted in a tertiary eye center in South India between July 2019 and December 2021. Consecutive adults (age >18 years) taking revised antitubercular regimens and diagnosed with ETON were included. Data collected regarding patient demographics, presentation, dose-related severity of vision loss, and visual outcomes after drug discontinuation were analyzed.Results: We analyzed 214 eyes from 107 patients (mean age: 51.1 ± 13 years; male: female ratio = 2:1). The median follow-up time was 11 months (interquartile range: 4-14 months). Mean visual acuity improved from 1.2 ± 0.6 log of minimum angle of resolution (logMAR) at presentation to 0.8 ± 0.6 logMAR at the final follow-up. Patients above 60 years old had the worst visual acuity at presentation and had the least improvement at the last follow-up compared to those in younger age groups (1.3-1.2 logMAR, P = 0.2). The mean exposure time to ethambutol was 6.8 ± 3.3 months, and the mean dose was 1042 ± 247 mg/day, that is, 16.7 ± 4 mg/kg/day. Mean presenting best corrected visual acuity (BCVA; 1.3 ± 0.6 logMAR) was worse in patients taking a higher dose of ethambutol (≥16 mg/kg) compared to those taking <16 mg/kg (mean BCVA: 1 ± 0.5 logMAR).Conclusion: Higher age and higher doses of ethambutol were associated with an increased risk of vision loss and worse vision at presentation. Prolonged exposure to high-dose ethambutol, as in fixed drug dose combinations, leads to severe visual impairment which might be partially reversible.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 Suppl 3","pages":"S484-S491"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0