Indian Journal of Ophthalmology最新文献

{"title":"A case study of pars plana vitrectomy with scleral flaps covering a two-point sutured scleral-fixated intraocular lens in a tertiary care eye hospital.","authors":"Talabhaktula Krishna, Ajay Sharma, Manali Gajmal, Donkada R Teja","doi":"10.4103/IJO.IJO_1572_25","DOIUrl":"10.4103/IJO.IJO_1572_25","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the functional outcomes and complications of pars plana vitrectomy with scleral flaps covered with a two-point sutured scleral-fixated intraocular lens (SFIOL).</p><p><strong>Methods: </strong>A retrospective, single-center, single-surgeon case study, including 97 cases. About 25 G pars plana vitrectomy with a two-point sutured scleral-fixated IOL was used as a surgical modality.</p><p><strong>Results: </strong>This study included 97 patients and eyes with scleral IOL fixation, with a mean follow-up of 6 months. The indications for SFIOL were divided into cases of surgical aphakia (63, 64.94%), hyper-mature cataract not suitable for routine procedure (5,5.15%), traumatic cataracts not suitable for routine procedures (18,18.5%), and other categories (11,64.94%). In this study, the median ± standard deviation of best-corrected visual acuity (BCVA) values in logarithm of the minimum angle of resolution (LogMAR) pre, post 1 month, 3 months, 6 months showed statistically significant improvement in VA with P value <0.001. The most common complications as number of cases seen in our study were cystoid macular edema (four cases), Descemet membrane folds (three cases), epiretinal membrane (five cases), exposed suture knots (one case), iatrogenic retinal break (two cases), iatrogenic retinal touch (two cases), IOL edge glare (one case), IOL tilt (one case), secondary glaucoma (three cases), post-op uveitis (one case), retinal detachment (one case), no complications 73 cases out of total cases.</p><p><strong>Conclusion: </strong>The mean BCVA improved from preoperative to postoperative 1 day, 1 month, 3 months, and 6 months ( P < 0.001) using this technique. This technique, which is more time-consuming, offers advantages over other available options, including improved stability, reduced risk of complications, and enhanced visual outcome.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S92-S96"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pupillary dilatation on optical biometry parameters and intraocular lens power calculation.","authors":"Uma Shroff, Uday Gajiwala, Kavin Shroff","doi":"10.4103/IJO.IJO_2494_25","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2494_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"74 Suppl 1","pages":"S158-S160"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of osteo-odonto-keratoprosthesis surgery: Results for the United Kingdom national cohort.","authors":"Christopher Liu, Venkata S Avadhanam, Jordan V Chervenkoff, Mehran Zarei-Ghanavati","doi":"10.4103/IJO.IJO_2696_25","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2696_25","url":null,"abstract":"<p><strong>Introduction: </strong>The osteo-odonto-keratoprosthesis (OOKP) is the most durable device among all keratoprostheses (KPros) to date. The aim of this study was to present a brief overview of the long-term outcomes and key lessons learned from this cohort.</p><p><strong>Methods: </strong>A retrospective review of OOKP patient records who completed at least one year of follow-up was conducted. Visual outcomes, complications, and laminar survival were analyzed. Kaplan-Meier survival curves with the log-rank test were used to assess for statistically significant differences between groups.</p><p><strong>Results: </strong>A total of 64 patients were included in this study; 65 eyes had complete OOKP procedures. In total, 60 tooth autografts, 11 tooth allografts, and 3 tibial grafts were implanted in this cohort. Stevens-Johnson syndrome (SJS) was the most common indication for OOKP (43%, n = 27), while glaucoma was the most frequent complication (86%, n = 57). The probability of retaining a functioning OOKP lamina for autografts was 91% over 18 years ( P = 0.001) and over 15 years. After 10 years of follow-up, 59% ( n = 13/22) of eyes with surviving laminae had a visual acuity (VA) of 6/12 or better, and 82% ( n = 18/22) had vision better than 6/60. Eyes with autografts showed a 34% probability of retention of 6/12 or better VA and a 71% probability of retaining VA between 6/12 and 6/60 ( P = 0.332).</p><p><strong>Conclusion: </strong>SJS was the most common diagnosis. Endophthalmitis was the common cause of visual loss, and glaucoma was the common cause of lack of visual improvement after OOKP. Overall, OOKP offers excellent long-term anatomical retention of the lamina and visual restoration.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"74 Suppl 1","pages":"S118-S124"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective visual quality after bilateral implantation of three diffractive trifocal intraocular lenses: A prospective randomized clinical trial.","authors":"Ivan C Teixeira, Bernardo Kaplan Moscovici, Wilson T Hida, Mauro Silveira de Queiroz Campos","doi":"10.4103/IJO.IJO_2566_25","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2566_25","url":null,"abstract":"<p><strong>Purpose: </strong>To compare subjective visual quality and patient-reported outcomes after bilateral implantation of three diffractive trifocal intraocular lenses (IOLs): AT LISA tri 839MP, AcrySof IQ PanOptix, and Tecnis Synergy.</p><p><strong>Design: </strong>Prospective, randomized, comparative clinical trial.</p><p><strong>Methods: </strong>Forty-three patients with bilateral cataract were randomized to one of the three trifocal IOL models. A single surgeon used standardized techniques, and assessments were performed 3 months after second-eye surgery. Subjective visual quality was evaluated using three validated patient-reported outcome measures: Cataract TyPE Spec (TyPE), Near Activity Visual Questionnaire (NAVQ), and Catquest-9SF (Rasch-modeled). Outcomes included global and item-level scores, satisfaction, and photic phenomena. Nonparametric tests (Kruskal-Wallis; Mann-Whitney U with Bonferroni) were applied at the patient level.</p><p><strong>Results: </strong>All IOLs yielded high visual function and satisfaction, with ceiling effects across questionnaires. The median TyPE global scores were 56 (AT LISA tri), 54 (PanOptix), and 59 (Synergy) ( P = 0.322). NAVQ indicated minimal difficulty with near/intermediate tasks ( P = 0.127). The Catquest-9SF Rasch person measures were -3.52 ± 0.77, -3.64 ± 0.35, and -3.79 ± 0.29, respectively ( P = 0.221). One TyPE intermediate-vision item favored Synergy over PanOptix ( P = 0.015). Photic phenomena were infrequent and comparable among groups.</p><p><strong>Conclusions: </strong>All three diffractive trifocal IOLs provided excellent subjective visual performance, satisfaction, and spectacle independence. Although Synergy showed a slight advantage for intermediate tasks, overall differences were minimal, supporting consistently high patient-reported outcomes with current trifocal optics.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"74 Suppl 1","pages":"S40-S45"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of a large limbal dermoid with excision and ipsilateral limbal epithelial translocation.","authors":"Sunita Chaurasia, Muralidhar Ramappa","doi":"10.4103/IJO.IJO_146_26","DOIUrl":"https://doi.org/10.4103/IJO.IJO_146_26","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"74 Suppl 1","pages":"S164-S166"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular lens-sling 2.0: A safer modification for implanting foldable intraocular lens following complicated cataract surgery.","authors":"Manas Nath, Annamalai Odayappan, Koushik Tripathy, Josephine Christy, Sivagami Nachiappan","doi":"10.4103/IJO.IJO_2097_25","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2097_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"74 Suppl 1","pages":"S156-S157"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From bench to bed: The evolution of anti-vascular endothelial growth factor therapies.","authors":"Alok Sen, Gaurav Kohli, Aditi Agarwal, Ritika Chauhan","doi":"10.4103/IJO.IJO_869_26","DOIUrl":"https://doi.org/10.4103/IJO.IJO_869_26","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"74 5","pages":"630-632"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal biomechanics with CORVIS-ST in post-keratoplasty corneas.","authors":"Tapashree Ghosh, Murugesan Vanathi, Noopur Gupta, Radhika Tandon, Maroof Khan","doi":"10.4103/IJO.IJO_1029_25","DOIUrl":"10.4103/IJO.IJO_1029_25","url":null,"abstract":"<p><strong>Purpose: </strong>Comparative evaluation of the corneal biomechanical parameters by the dynamic corneal response imaging with CORVIS-ST ST in normal and post-keratoplasty eyes.</p><p><strong>Methods: </strong>Cross-sectional observational study of CORVIS-ST imaging of 150 normal corneas and 150 post-keratoplasty corneas was done to evaluate corneal biomechanics of normal Asian-Indian corneas and post-keratoplasty corneas. Data on demographic details, postoperative period, visual acuity (UCVA, BCVA) (logmar units), refraction, axial length (D), corneal topography Scheimpflug's imaging with Pentacam [Anterior-K1(AK1), Anterior-K2 (AK2), Posterior-K1(PK1), PosteriorK2(PK2), Mean keratometry (Kmean), Keratometry maximum (Kmax), Q-value, D-value, Thinnest pachymetry (TP), Corneal elevation [anterior (CE ant) and posterior (CE post)], CORVIS-ST imaging (bIOP, 1 st and 2 nd Appl time HCT, 1 st Appl length, DA, TBI, CBI, HC rad, Vel in and out, DA ratio, IR, Inv CR, SSI, SPA1, ARTh) were recorded.</p><p><strong>Results: </strong>Comparative evaluation of CORVIS-ST in 150 normal corneas [mean age 32.54 ± 10 (9-68) years] and 150 post-keratoplasty corneas [mean age 35.14 ± 16.96 (8-72) years; PK (58), DSAEK (29), DALK (58), HALK (8), and SALK (3)] noted 18 parameters (bIOP, 1 st and 2 nd Appl time HCT, 1 st Appl length, DA, TBI, CBI, HC rad, Vel in and out, DA ratio, IR, Inv CR, SSI, SPA1, ARTh) and showed that 12 of these were statistically different in post-keratoplasty corneas. Parameters of DA, TBI, CBI, IR, and Inv CR were higher, whereas HC rad, SSI, SPA1, and ARTh showed significantly lesser values in post-keratoplasty corneas as compared to normal corneas. Subgroup analysis (PK, DSAEK, DALK, HALK) showed eyes that underwent DSAEK had biomechanical values closest to that of normal corneas. Post-DALK in comparison to post-PK corneas showed significantly higher values in CBI and IR, and lower values in HC rad, SSI, and ARTh (0.87 ± 0.17, 9.9 ± 3.5, 0.85 ± 0.25, 190.92 ± 119.06 and 0.71 ± 0.25, 8.19 ± 1.92, 1.02 ± 0.38, and 340.90 ± 178.37, respectively). Correlational analysis showed significant mild positive correlation of CBI with corneal curvature in normal and post-PK corneas ( P = 0.004 and 0.040, respectively).</p><p><strong>Conclusion: </strong>Post-keratoplasty corneas were seen to have lesser biomechanical strength as compared to normal corneas. Post-DSAEK corneas had a better biomechanical strength than other groups and closest biomechanics to normal corneas. Post-DALK in comparison to post-PK corneas showed a lower biomechanical strength in our study.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S103-S113"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of a mobile imaging device for anterior segment (MIDAS) with a commercially available portable and conventional slit-lamp imaging for cataract photography.","authors":"Dayna W W Yong, Liang Sheng, Rubin Hs Yong, David Z Chen","doi":"10.4103/IJO.IJO_3037_24","DOIUrl":"10.4103/IJO.IJO_3037_24","url":null,"abstract":"<p><strong>Purpose: </strong>To compare cataract images obtained using portable slit-lamp devices with those taken from the standard slit-lamp built-in camera.</p><p><strong>Design: </strong>Prospective, single-center, comparative digital imaging validation study.</p><p><strong>Methods: </strong>A total of 198 slit-lamp images were taken from 66 patients with cataracts using a smartphone slit-lamp prototype (\"MIDAS\"), a tablet with a portable slit-lamp (\"I.C.P.\"), and a slit-lamp with a custom-mounted digital camera (\"ASC\"). An ophthalmologist, an optometrist, and a family medicine resident independently graded the images according to Nuclear Opalescence (NO) and Nuclear Colour (NC) of the Lens Opacities Classification System III. The intraclass correlation (ICC) for the devices was calculated. Graders' confidence and subjective assessment of image quality were assessed through a 5-point Likert scale questionnaire.</p><p><strong>Results: </strong>For NO, ICC was fair for MIDAS (0.619, 95% confidence interval [95% CI] = 0.426 to 0.754) and I.C.P. (0.585, 95% CI = 0.373 to 0.733) but poor for ASC (0.394, 95% CI = 0.088 to 0.609). For NC, ICC was excellent for all (MIDAS, 0.837, 95% CI = 0.755 to 0.895; I.C.P., 0.851, 95% CI = 0.775 to 0.904; ASC, 0.892, 95% CI = 0.837 to 0.930). Grader confidence was the highest for ASC images (85.5%), followed by I.C.P. (69.1%) and MIDAS (65.6%). Subjective assessment of image quality was the highest for ASC images (96.5%), followed by I.C.P. (77.3%) and MIDAS (74.2%).</p><p><strong>Conclusions: </strong>Portable slit-lamp devices had excellent ICC for assessing NC and fair ICC for assessing NO. Graders expressed greater confidence and higher perceived image quality for the standard slit-lamp built-in camera.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S59-S65"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current role of aflibercept in retinopathy of prematurity - A review.","authors":"Devesh Kumawat, Nawazish Shaikh, Parijat Chandra","doi":"10.4103/IJO.IJO_3323_25","DOIUrl":"10.4103/IJO.IJO_3323_25","url":null,"abstract":"<p><p>The introduction of intravitreal anti-vascular endothelial growth factor (VEGF) therapy has transformed the management of severe retinopathy of prematurity (ROP) in the zone I/zone II posterior region and aggressive ROP by enabling rapid disease regression while preserving peripheral retinal tissue and improving refractive outcomes compared with laser photocoagulation. Nevertheless, there is a risk of late disease recurrence, which has resulted in interest in longer-acting agents such as aflibercept. Aflibercept is a potent VEGF trap with high binding affinity and prolonged intraocular activity, with the possibility of reducing recurrence compared with other anti-VEGF agents. Early retrospective and prospective studies using 1 mg dose of intravitreal aflibercept have demonstrated high rates of initial regression and favorable refractive outcomes. Subsequently, the pivotal FIREFLEYE and BUTTERFLEYE randomized controlled trials evaluated low-dose aflibercept (0.4 mg) against laser, reporting comparable treatment success but higher recurrence with aflibercept, alongside advantages such as rapid disease regression, preservation of peripheral retina, and lower rates of high myopia. Reactivation following aflibercept generally occurs less frequently and later than with ranibizumab and at a similar or lower rate than bevacizumab; however, persistent avascular retina remains a significant concern, necessitating prolonged surveillance and, when indicated, adjunctive laser treatment. Available systemic safety data are very limited, including pharmacokinetic analyses, but suggest transient systemic exposure without evidence of short-term adverse effects on growth or neurodevelopmental outcomes. The following review focuses on the role of intravitreal aflibercept in ROP.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"74 5","pages":"735-747"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}