Indian Journal of Ophthalmology最新文献_第2页

Histopathological findings of anterior lens capsule in pediatric cataract. 小儿白内障患者晶状体前囊的组织病理学发现。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-05-20 DOI: 10.4103/IJO.IJO_2957_23

Ferhad Özer, İrem İnanç, Pınar B Kızıltunç, Hüban Atilla, Belgin Can

{"title":"Histopathological findings of anterior lens capsule in pediatric cataract.","authors":"Ferhad Özer, İrem İnanç, Pınar B Kızıltunç, Hüban Atilla, Belgin Can","doi":"10.4103/IJO.IJO_2957_23","DOIUrl":"10.4103/IJO.IJO_2957_23","url":null,"abstract":"Purpose: To investigate the histopathological findings of the anterior lens capsule in pediatric patients who had surgery for cataracts.Methods: This study is a prospective interventional study. Anterior capsule tissue samples that were obtained by the anterior capsulotomy method during phacoemulsification surgery were fixed and examined under a transmission electron microscope.Results: Twenty-two eyes of 19 patients who were diagnosed with congenital and juvenile cataracts were included in this study. Five patients had associated systemic diseases, including hydrocephalus, cerebral palsy, prematurity, juvenile myelomonocytic leukemia, and Down's syndrome. Electron microscopic evaluation demonstrated single-layered epithelium under the capsule, degenerated organelles with round-oval and prismatic-oval nuclei, and degenerated mitochondria and heterochromatin-rich nuclei. In the case with cerebral palsy, collagen fibrils of the connective tissue and fibroblast-like cells were observed replacing the epithelium that should be underneath the capsule in both eyes, and there was a disorganized distribution of collagen fibrils and vacuole structures in the cytoplasm of fibroblast-like cells.Conclusion: Similar histopathological findings were found in pediatric cataracts with or without systemic disease except in one cerebral palsy case. The absence of lens epithelium may have been a result of degeneration in this patient, and this can be attributed to the presence of systemic inflammation and gliosis in cerebral palsy. The absence of lens epithelium can play a role in the development of dense subcapsular fibrosis and cataract formation.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"1741-1744"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis - A retrospective study. 脱绒毛真菌性角膜炎的临床、微生物学和治疗效果 - 一项回顾性研究。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-05-20 DOI: 10.4103/IJO.IJO_1881_23

Niruban Ganesan, Shivananda Narayana, Joseph Gubert, Namrata K Bhosale, Balagiri Sundar

{"title":"Clinical, microbiologic, and treatment outcomes of dematiaceous fungal keratitis - A retrospective study.","authors":"Niruban Ganesan, Shivananda Narayana, Joseph Gubert, Namrata K Bhosale, Balagiri Sundar","doi":"10.4103/IJO.IJO_1881_23","DOIUrl":"10.4103/IJO.IJO_1881_23","url":null,"abstract":"Purpose: Dematiaceous fungi, the third most common causative organism of fungal keratitis, constitute 3.5% to 43.5% of fungal keratitis worldwide. Several studies on filamentous fungi ( Aspergillus and Fusarium ) are available as opposed to that on dematiaceous fungal keratitis. This study aims to describe the profile of dematiaceous fungal keratitis in South India.Methods: This institutional cohort study on culture-proven dematiaceous fungal keratitis was performed in a single ophthalmology referral center in South India for a 6-year period. Records were analyzed for demographic, clinical, microbiological, and treatment outcomes for 3 months from the date of presentation.Results: This study comprised 312 cases involving dematiaceous fungal keratitis (DFK). During the study period, DFK accounted for 10% of microbial keratitis and 24.6% of fungal keratitis cases. The mean (standard deviation) age was 54 (14) years. Males were commonly affected (73.4%). Keratitis was ≤1/3 rd depth in 47.8% of cases. Fifty-four cases (17.3%) demonstrated surface pigmentation, and 69 cases (22.1%) had endothelial plaque. Curvularia spp. (99 eyes, 31.7%) was the most common fungal isolate among the speciated fungi. Topical medications resulted in the healing of 63.5% of cases. A total of 193 cases (79%) healed, and 49 cases had to undergo therapeutic penetrating keratoplasty (TPK). Early TPK was performed for 20 cases (40.8%). Seventeen eyes (34.6%) maintained clear grafts at the end of 3 months.Conclusion: In this extensive study on DFK, we report a high incidence of this group of fungal keratitis. We found an excellent healing rate in our cohort of patients.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"1721-1727"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thickened photoreceptor outer segment layer in children with hyperopic anisometropic amblyopia. 远视性异向性弱视儿童感光器外节层增厚。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-07-11 DOI: 10.4103/IJO.IJO_3068_23

Wenli Zhang, Fan Yang, Shirong Chen, Tingkun Shi

{"title":"Thickened photoreceptor outer segment layer in children with hyperopic anisometropic amblyopia.","authors":"Wenli Zhang, Fan Yang, Shirong Chen, Tingkun Shi","doi":"10.4103/IJO.IJO_3068_23","DOIUrl":"10.4103/IJO.IJO_3068_23","url":null,"abstract":"Purpose: To quantitatively investigate the reflectivity and structure of the outer retinal layers in children with hyperopic anisometropic amblyopia by using swept-source optical coherence tomography (SS-OCT).Methods: Seventy-eight patients with amblyopia and 64 age-matched children with normal vision were included in this study. All participants underwent SS-OCT and detailed ophthalmic examinations. Longitudinal reflectance profile measurements were measured using Image J. The reflectivity of outer retinal layers was measured at the three selected positions: subfovea, 1 mm nasal to the fovea, and 1 mm temporal to the fovea. The reflectivity ratios were calculated by outer retinal layers divided by the nuclear layer (ONL) for normalization. Photoreceptor outer segment layer thickness was also measured. The results were compared between the amblyopia and normal controls. The possible effects of age, sex, and axial length on results were adjusted by generalized estimating equations.Results: Photoreceptor outer segment layer thickness was significantly greater in amblyopic eyes than in normal control eyes at all three regions (18.41 ± 1.83 vs. 16.84 ± 1.39, P < 0.001 at the fovea; 14.78 ± 1.34 vs. 14.19 ± 1.40, P = 0.030 at 1 mm nasal to the foveal; 14.92 ± 1.48 vs. 14.41 ± 1.32, P = 0.049 at 1 mm temporal to the fovea). The reflectivity ratio of outer segment/ONL was higher only at 1 mm nasal to the fovea (2.94 ± 0.61 vs. 2.70 ± 0.42, P = 0.02). Subfoveal OS thickness was positively correlated with choroidal thickness (r = 0.248, P = 0.018) but was not correlated with spherical equivalent, age, axial length, or logMAR visual acuity.Conclusion: Quantitative measurement of SS-OCT images revealed greater photoreceptor outer segments in both eyes of children with amblyopia than in normal control eyes. A thicker OS thickness is somehow related to amblyopia, and this may be a new useful diagnostic parameter for amblyopia.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"1750-1756"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical application and outcome of Tenon's patch graft: A comprehensive review. 腱膜补片移植的临床应用和效果：全面回顾。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.4103/IJO.IJO_783_24

Rakhi Kusumesh, Alisha Kishore, Anitha Venugopal, Sushmita G Shah, Murugesan Vanathi

{"title":"Clinical application and outcome of Tenon's patch graft: A comprehensive review.","authors":"Rakhi Kusumesh, Alisha Kishore, Anitha Venugopal, Sushmita G Shah, Murugesan Vanathi","doi":"10.4103/IJO.IJO_783_24","DOIUrl":"10.4103/IJO.IJO_783_24","url":null,"abstract":"Corneal perforations are potentially sight-threatening conditions if not promptly treated. Management depends on the size, location, cause, and severity of the perforation. Various methods, including tissue adhesives, amniotic membrane grafting (AMG), and keratoplasty, are available. However, the limited availability of donor tissue in emergencies poses a significant challenge. Recently, Tenon's patch grafting (TPG) has emerged as a promising treatment option due to its autologous nature, availability, and lack of immunogenicity. This review provides a comprehensive overview of various aspects of TPG, along with relevant images. A literature search using keywords such as \"Tenon's patch graft,\" \"Tenon's capsule,\" \"corneal patch graft,\" \"amniotic membrane,\" and \"corneal perforations\" yielded 37 articles, included in this review. TPG is suitable for cases involving corneal tissue degradation leading to perforation, impending perforation, or descemetocele, with lesion sizes ranging from 2 to 6 mm. For larger perforations, the procedure may be modified by combining it with AMG or tissue adhesives. Postoperatively, the graft undergoes characteristic changes, including epithelialization and collagen deposition, resulting in the formation of a thick scar. Complications such as delayed epithelialization, wound leaks, and graft dehiscence can occur. High success rates have been reported, ranging from 74% to 87%. However, TPG may result in suboptimal visual outcomes, particularly when the graft is centrally located, necessitating future keratoplasty for visual rehabilitation. Overall, TPG is a safe and cost-effective technique for restoring structural integrity in corneal thinning disorders and perforations, especially in emergency settings when donor tissue is unavailable.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"1714-1720"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary treatment failure in acute retinal necrosis - A comprehensive review. 急性视网膜坏死的初次治疗失败--全面回顾。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.4103/IJO.IJO_689_24

Ankush Kawali, Aayesha Khanum, Sai B Mishra, Srinivasan Sanjay, Padmamalini Mahendradas

{"title":"Primary treatment failure in acute retinal necrosis - A comprehensive review.","authors":"Ankush Kawali, Aayesha Khanum, Sai B Mishra, Srinivasan Sanjay, Padmamalini Mahendradas","doi":"10.4103/IJO.IJO_689_24","DOIUrl":"10.4103/IJO.IJO_689_24","url":null,"abstract":"Acute retinal necrosis (ARN) is a sight-threatening ophthalmic emergency that requires aggressive treatment to prevent irreversible vision loss. However, primary treatment failure (PTF), where the initial antiviral therapy is ineffective, is a common challenge in ARN management. This comprehensive review examines PTF in ARN, drawing insights from a systematic literature search spanning 1997 to 2022, which identified 35 relevant cases from 23 reports. The analysis focuses on drug resistance patterns, alternative antiviral agents, combination therapies, and emerging treatments. Potential causes of drug resistance, including host factors, viral mutations, and drug-related considerations, are elucidated. Alternative agents such as foscarnet, cidofovir, and brivudine, as well as combination approaches involving systemic and intravitreal administration, high-dose therapy, judicious use of steroids, and potential treatment-related complications, are discussed. The review also highlights emerging therapies, including vaccines, monoclonal antibodies, and natural compounds, offering insights into future directions for addressing this challenging condition.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"1694-1703"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of accommodative parameters between diabetics and hypertension case group with presbyopic age-matched control group.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-11-29 DOI: 10.4103/IJO.IJO_333_24

Nitesh Pradhan, Deepali Chodancar, Ugam P Usgaonkar

引用次数: 0

Authors' Response: Comparison of intraocular lens power prediction accuracy of formulas in American Society of Cataract and Refractive Surgery post-refractive surgery calculator in eyes with prior radial keratotomy.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-11-29 DOI: 10.4103/IJO.IJO_886_24

Naren Shetty, Priyanka Sathe, Aishwarya, Mathew Francis, Rohit Shetty

引用次数: 0

Trabeculectomy in eyes with implantable collamer lens in situ: Decision-making and outcomes.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-11-29 DOI: 10.4103/IJO.IJO_770_24

Gazella Bruce Warjri, Sirisha Senthil

引用次数: 0

Authors' Response: Risk factor-based models to predict severe retinopathy of prematurity in preterm Thai infants.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-11-29 DOI: 10.4103/IJO.IJO_1868_24

Sopapan Ngerncham

引用次数: 0

Authors' Response: The disastrous triple hit-taxane-induced retinal toxicity in a patient with breast cancer and a pathogenic USH2A variant.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-11-29 DOI: 10.4103/IJO.IJO_2079_24

Mayur R Moreker

引用次数: 0