Indian Journal of Ophthalmology最新文献

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The Flip and Fix internal limiting flap technique versus the classic temporal flap for macular hole repair. 黄斑孔修补术中的翻转固定内限制瓣技术与经典的颞部皮瓣对比。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-09-10 DOI: 10.4103/IJO.IJO_1155_24
Mohsen Abou Shousha, Mohamed M Lolah, Islam S H Ahmed
{"title":"The Flip and Fix internal limiting flap technique versus the classic temporal flap for macular hole repair.","authors":"Mohsen Abou Shousha, Mohamed M Lolah, Islam S H Ahmed","doi":"10.4103/IJO.IJO_1155_24","DOIUrl":"10.4103/IJO.IJO_1155_24","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a novel technique of macular hole (MH) repair and compare it to the perfluorocarbon liquid (PFCL)-assisted temporal internal limiting membrane (ILM) flap technique.</p><p><strong>Methods: </strong>Twenty-two eyes of 22 patients with MH were randomized on a 1:1 basis into two groups. Group A cases were treated using the Flip and Fix technique, in which the single-layer ILM flap was flipped, flattened over the macula using PFCL, and fixed in place using two drops of autologous nonheparinized blood over the superonasal and inferonasal edges of the flap (away from the MH center). Group B patients had the classic temporal ILM flap technique without using the PFCL or autologous blood. All patients were followed up for a period of 6 months after the surgery.</p><p><strong>Results: </strong>No significant difference was observed in initial and final visual acuities between Groups A and B. Intraoperative flap displacement did not occur in Group A and occurred in two eyes in Group B (18.2%). One of them showed failed MH closure and required reoperation. These two cases had a final (W shape) MH closure and a worse final vision than the remaining cases, which had either a U shape or V shape final MH closure.</p><p><strong>Conclusions: </strong>The study results show that the Flip and Fix technique is as effective as the PFCL-assisted temporal ILM flap technique and is associated with less ILM flap displacement risk for the repair of macular holes.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of hydroxybutyl chitosan and 5-fluorouracil on the procedure of endoscopic endonasal dacryocystorhinostomy. 羟丁基壳聚糖和 5-氟尿嘧啶对内窥镜鼻腔内泪囊鼻腔造口术的影响。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-09-10 DOI: 10.4103/IJO.IJO_3375_23
Jia Qi Lin, Jin Zhao, Xun Liu, Emmanuel Eric Pazo, Qing Wang, Li Zhu, Ting Lin
{"title":"The impact of hydroxybutyl chitosan and 5-fluorouracil on the procedure of endoscopic endonasal dacryocystorhinostomy.","authors":"Jia Qi Lin, Jin Zhao, Xun Liu, Emmanuel Eric Pazo, Qing Wang, Li Zhu, Ting Lin","doi":"10.4103/IJO.IJO_3375_23","DOIUrl":"10.4103/IJO.IJO_3375_23","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of hydroxybutyl chitosan (HBCS) with and without 5-fluorouracil (5-FU) during endoscopic endonasal dacryocystorhinostomy (Endo-DCR). In addition, the present study observed the impact of HBCS and 5-FU on the functions of the nasal mucosal cell population in vivo .</p><p><strong>Methods: </strong>Patients were randomized into HBCS (group A), HBCS combined with 5-FU (group B), and gelatin sponge control group (group C). 16S rRNA high-throughput sequencing technology examined the conjunctival sac and nasal flora changes. In addition, CCK8, cell scratching, and flow cytometry were used to investigate the effects of HBCS and 5-FU on the nasal mucosal cell populations.</p><p><strong>Results: </strong>Subjects in groups A, B, and C had anastomotic areas of 21.83 ± 12.69 mm 2 , 21.57 ± 14.53 mm 2 , and 12.45 ± 8.16 mm 2 , respectively ( P = 0.0359). Group A had less severe epiphora than the other two groups at 1-, 2-, and 12-week postoperative follow-up ( P < 0.05). Complications around the anastomosis in group A were the least severe of the three groups ( P = 0.0259). After surgery, the proportion of pathogenic bacteria in the conjunctival sac and nasal cavity was higher in groups A and B than in healthy adults. At the 2-week follow-up, the structure of nasal flora in group A was more similar to that of the healthy adults compared to group B.</p><p><strong>Conclusion: </strong>Intraoperative use of HBCS at the anastomose improves the postoperative outcome of En-DCR. 5-FU cannot give better postoperative results in En-DCR and is detrimental to the normalization of the postoperative flora in patients with chronic dacryocystitis. At the cellular level, both HBCS and 5-FU inhibit the migration of nasal mucosal cell populations, and 5-FU inhibits proliferation but does not promote apoptosis.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative assessment of intravitreal steroid implant with combination therapy for diabetic macular edema. 玻璃体内类固醇植入与糖尿病黄斑水肿联合疗法的比较评估。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-10-26 DOI: 10.4103/IJO.IJO_3024_22
Surbhi Agrawal, Rajesh Ramanjulu, P Mahesh Shanmugam, Ajith Havanje
{"title":"Comparative assessment of intravitreal steroid implant with combination therapy for diabetic macular edema.","authors":"Surbhi Agrawal, Rajesh Ramanjulu, P Mahesh Shanmugam, Ajith Havanje","doi":"10.4103/IJO.IJO_3024_22","DOIUrl":"https://doi.org/10.4103/IJO.IJO_3024_22","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of topical latanoprost 0.005% treatment on microvascular changes in the optic nerve head and macula. 0.005% 拉坦前列素局部治疗对视神经头和黄斑微血管变化的影响。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-10-25 DOI: 10.4103/IJO.IJO_648_24
Büşra D Yıldırım Erdal, Gözde Hondur, Serdar Bayraktar, Ufuk Elgin, Emine Şen
{"title":"The effects of topical latanoprost 0.005% treatment on microvascular changes in the optic nerve head and macula.","authors":"Büşra D Yıldırım Erdal, Gözde Hondur, Serdar Bayraktar, Ufuk Elgin, Emine Şen","doi":"10.4103/IJO.IJO_648_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_648_24","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective study aimed to assess the impact of topical latanoprost 0.005% treatment on the microvasculature of the macula and optic nerve head (ONH) in primary open-angle glaucoma (POAG).</p><p><strong>Methods: </strong>Fifty-seven eyes of 31 subjects were enrolled. ONH whole-image (wiVD), peripapillary (ppVD), and macular vascular density (VD) parameters were measured using optical coherence tomography angiography before treatment, at the 1st month, and at the 3rd month of treatment.</p><p><strong>Results: </strong>There was a significant reduction in IOP post treatment, with a decrease of 17.0 ± 2.3 mmHg in the 1st month and 16.3 ± 2.5 mmHg in the 3rd month (P < 0.001 for both). ONH wiVD and ppVD significantly increased at the post-treatment 1st month (P = 0.001 for both) but decreased by the 3rd month, returning to baseline levels (P < 0.001 for both), indicating a return to pre-treatment levels (P > 0.05 for both). Similarly, macular wiVD and perifoveolar VD (pefVD) increased significantly at the 1st month (P = 0.013 and P < 0.001, respectively) but returned to baseline by the 3rd month (P < 0.001 for both). No significant difference was observed between before-treatment and post-treatment 3rd month regarding the macular wiVD and pefVD (P > 0.05 for both). Deep capillary plexus and foveal avascular zone parameters did not change during follow-up (P > 0.05 for both).</p><p><strong>Conclusion: </strong>The initial increase in ONH and peripapillary VD, as well as macular VD, is attributed to the acute reduction in IOP from topical latanoprost 0.005%. However, the diminishment of sustained differences by the 3rd month indicates adaptation of the ONH and retinal microvasculature to decreased IOP through compensatory mechanisms.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations in the tear film and ocular surface in pediatric migraine patients. 小儿偏头痛患者泪膜和眼表的变化。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-05-20 DOI: 10.4103/IJO.IJO_2594_23
Abdulvahit Asik, Gözde Aksoy Aydemir, Emre Aydemir, Abdurrahman Bilen, Rojan Ipek, Hacı Ballı, Alper Halil Bayat, Bilge Aydın Türk
{"title":"Alterations in the tear film and ocular surface in pediatric migraine patients.","authors":"Abdulvahit Asik, Gözde Aksoy Aydemir, Emre Aydemir, Abdurrahman Bilen, Rojan Ipek, Hacı Ballı, Alper Halil Bayat, Bilge Aydın Türk","doi":"10.4103/IJO.IJO_2594_23","DOIUrl":"10.4103/IJO.IJO_2594_23","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the ocular surface (OS) parameters in the pediatric migraine patients (PMPs).</p><p><strong>Methods: </strong>This prospective case-control study consisted of 51 PMPs (PMP group) and 55 healthy pediatric patients (HPP group). In all participants, tear function was evaluated subjectively using the Ocular Surface Disease Index (OSDI) questionnaire, objectively using Schirmer tear test (STT) and tear film disintegration time (TBUT), and with clinical and laboratory examinations (conjunctival impression cytology). The PMP group was subdivided into two groups according to their aura.</p><p><strong>Results: </strong>The mean age and gender distribution of the study groups were almost the same ( P > 0.05 for both of them). In the PMP group, both the STT value and the TBUT value were significantly lower than those determined in the HPP group ( P = 0.021 and P = 0.018, respectively). In the PMP group, the OSDI scores were higher than those in the HPP group ( P = 0.032). In the PMP group, the goblet cell density values were lower than those in the HPP group ( P = 0.01). With regard to the aura, the TBUT and STT values were nonsignificantly lower in the PMP aura-positive group than in the PMP aura-negative group ( P > 0.05 for both of them). The OSDI assessment was similar in both the groups. With regard to the goblet cell count, it was observed to be less in the PMP aura-positive group than in the PMP aura-negative group ( P = 0.01).</p><p><strong>Conclusion: </strong>Influence of OS in children with migraine was also demonstrated using the samples taken from the conjunctiva. These changes were also demonstrated by objective tests such as STT and TBUT. Both clinical objective evaluations and pathologic changes were more prominent in the migraine with aura group.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of choroidal perfusion indices in thyroid eye disease by using optical coherence tomography. 利用光学相干断层扫描评估甲状腺眼病的脉络膜灌注指数。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-05-20 DOI: 10.4103/IJO.IJO_3315_23
Ruchi Goel, Shalin Shah, Uddeshya Yadav
{"title":"Assessment of choroidal perfusion indices in thyroid eye disease by using optical coherence tomography.","authors":"Ruchi Goel, Shalin Shah, Uddeshya Yadav","doi":"10.4103/IJO.IJO_3315_23","DOIUrl":"10.4103/IJO.IJO_3315_23","url":null,"abstract":"<p><strong>Purpose: </strong>To study choroidal vascularity changes in active and inactive TED orbits by using high-definition optical coherence tomography (HD-OCT) and correlate the changes with the duration and severity of TED and Barrets' index.</p><p><strong>Methods: </strong>A cross-sectional study wherein 37 TED orbits and 30 healthy control (HC) orbits were enrolled. Choroid was imaged using HD-OCT scans centered at the fovea, and subfoveal choroidal thickness (SFCT) was measured. The OCT images were analyzed using ImageJ software to calculate choroidal vascularity index (CVI) and associated choroidal perfusion indices.</p><p><strong>Results: </strong>The study included eight active, 13 non-inflammatory active (NIA), and 16 inactive TED orbits. The mean age was 39.73 ± 12.91 years, and the male: female ratio was 1.18:1. Intraocular pressure and CVI were higher, while SFCT was similar in TED on comparison to healthy orbits. CVI and SFCT were raised in active as compared to inactive TED. CVI and SFCT correlated positively with Barrets' index and negatively with the duration of thyroid disease. The area under curve of CVI (95% CI: 0.651-0.864, P < 0.001) helped in differentiating TED orbits from HC, while CVI (95% CI: 0.780-0.983, P < 0.001) had the maximum discriminatory power in predicting the activity of disease.</p><p><strong>Conclusions: </strong>CVI has greater sensitivity than SFCT in differentiating healthy from TED orbits. The blood flow stagnation in active orbits, which improves during the course of TED and tends to worsen with increase in Barret's index, can lead to choroidal vascularity changes. CVI and SFCT can act as adjunct to existing modalities for monitoring the disease activity.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of a new technique using 4-0 nylon thread as a guide for tube insertion of the Ahmed glaucoma valve into the ciliary sulcus. 使用 4-0 尼龙线作为将 Ahmed 青光眼瓣膜管插入睫状沟的导向器的新技术验证。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-05-20 DOI: 10.4103/IJO.IJO_3156_23
Keisuke Nitta, Tomoko Miyakubo, Shunsuke Tokui, Mayuko Takayama, Yoichiro Shinohara, Kazuma Saito, Tomomi Endo, Hideo Akiyama
{"title":"Validation of a new technique using 4-0 nylon thread as a guide for tube insertion of the Ahmed glaucoma valve into the ciliary sulcus.","authors":"Keisuke Nitta, Tomoko Miyakubo, Shunsuke Tokui, Mayuko Takayama, Yoichiro Shinohara, Kazuma Saito, Tomomi Endo, Hideo Akiyama","doi":"10.4103/IJO.IJO_3156_23","DOIUrl":"10.4103/IJO.IJO_3156_23","url":null,"abstract":"<p><p>In this study, we validated the new technique for inserting the tube of the Ahmed glaucoma valve (AGV) into the ciliary sulcus. AGV tube insertion was performed by introducing a 4-0 nylon thread into the anterior chamber from the corneal incision on the opposite side of the AGV. The thread was placed in the lumen of a 23-G needle that was inserted into the sclera and ciliary sulcus from the AGV side. Withdrawing the 23-G needle, the thread was led out of the eye from the scleral wound, passing through the ciliary sulcus. The thread was then placed in the AGV tube lumen, and the tube was inserted through the scleral wound into the ciliary sulcus by using the thread as a guide, as per the Seldinger technique. In all seven eyes, the tube was precisely inserted into the ciliary sulcus without serious intraoperative complications such as vitreous straying of the tube.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripapillary and subfoveal choroidal vascular index in patients with tension-type headache and migraine. 紧张型头痛和偏头痛患者的毛细血管周围和眼底脉络膜血管指数。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-07-11 DOI: 10.4103/IJO.IJO_3370_23
Mehmet Icoz, Merve Akdeniz
{"title":"Peripapillary and subfoveal choroidal vascular index in patients with tension-type headache and migraine.","authors":"Mehmet Icoz, Merve Akdeniz","doi":"10.4103/IJO.IJO_3370_23","DOIUrl":"10.4103/IJO.IJO_3370_23","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the choroidal vascular characteristics of patients followed up with different headache diagnoses.</p><p><strong>Design: </strong>Prospective comparative study.</p><p><strong>Methods: </strong>This study included 21 patients with migraine with visual aura (MwA), 20 with migraine without aura, 29 patients experiencing episodic tension-type headache, and 30 healthy participants. The participants was performed refraction values, axial length, and intraocular pressure were examined. Choroidal thickness was determined in all participants with HD-line optical coherence tomography (OCT) in the subfoveal, nasal, and temporal quadrants 500 µm from the fovea. Using special image processing software, luminal area (LA), stromal area, total choroidal area, and choroidal vascular index (CVI) values were calculated in both macular and peripapillary regions. OCT was also used to perform peripapillary retinal nerve fiber layer (pRNFL) thickness and optic disc head measurements.</p><p><strong>Results: </strong>Spherical refraction, axial length, and intraocular pressure values did not significantly differ among the four groups with similar gender and age distributions ( P > 0.05). The LA values in both macular and peripapillary regions were found to be statistically significantly lower in the MwA group ( P = 0.007 and P = 0.005, respectively). There was no statistically significant difference among the groups in terms of the remaining choroidal area parameters or CVI values ( P > 0.05). The groups also did not show any significant difference in the pRNFL or optic disc head measurements performed in different quadrants ( P > 0.05).</p><p><strong>Conclusion: </strong>While LA, one of the choroidal vascular parameters, was found to be lower in the MwA group in both the macular and peripapillary regions, there were no statistically significant differences between the groups in terms of the peripapillary or macular CVI values.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brolucizumab in patients with neovascular age-related macular degeneration: Real-life outcomes from a tertiary care eye hospital. 用于新生血管性老年黄斑变性患者的 Brolucizumab:一家三级眼科医院的实际治疗效果。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-09-10 DOI: 10.4103/IJO.IJO_562_24
Lorenzo Fabozzi, Saad Younis, Sagnik Sen, Inés López-Cuenca, Filomena Palmieri
{"title":"Brolucizumab in patients with neovascular age-related macular degeneration: Real-life outcomes from a tertiary care eye hospital.","authors":"Lorenzo Fabozzi, Saad Younis, Sagnik Sen, Inés López-Cuenca, Filomena Palmieri","doi":"10.4103/IJO.IJO_562_24","DOIUrl":"10.4103/IJO.IJO_562_24","url":null,"abstract":"<p><strong>Purpose: </strong>To report real-world clinical evidence of brolucizumab in treating neovascular age-related macular degeneration (nAMD).</p><p><strong>Methods: </strong>This study included 37 eyes with nAMD treated with intravitreal injections of brolucizumab. The main outcomes were best corrected visual acuity (BCVA) changes, central retinal thickness (CRT), and serious ocular adverse events. Intraretinal fluid (IRF) and subretinal fluid (SRF), subretinal hyperreflective material (SHRM), pigment epithelial detachments (PEDs), hyperreflective foci, macular atrophy, and retinal pigment epithelial tears were evaluated.</p><p><strong>Results: </strong>The mean BCVA of all patients showed a post-treatment value of 0.47 ± 0.33 log of minimum angle of resolution (LogMAR), compared to a baseline measure of 0.50 ± 0.28 LogMAR ( P = 0.372). For treatment-naïve patients, a non-statistically significant improvement in BCVA was observed ( P = 0.116). Both treatment-naive patients and the entire patient cohort exhibited a statistically significant improvement in the mean CRT after injections. Majority of patients exhibited improvements in optical coherence tomography findings, specifically in the resolution of IRF, SRF, SHRM, and PEDs. Four eyes experienced ocular adverse events in the form of intraocular inflammation.</p><p><strong>Conclusion: </strong>Brolucizumab did not yield a substantial improvement in BCVA, but it exhibited efficacy in reducing CRT in the entire study population and treatment-naive patients with nAMD. Our study identified intraocular inflammation as a significant adverse event with brolucizumab. Thus, precise patient selection, education, and vigilant inflammation monitoring are crucial for patients undergoing this treatment.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute intraoperative fluid misdirection managed with anterior approach irido-zonulo-hyaloido-vitrectomy. 通过前路虹膜-宗样体-视紫质-玻璃体切除术治疗术中急性液体误导。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-10-26 DOI: 10.4103/IJO.IJO_16_24
Siddharth Dikshit, Sushma Tuluva, Sirisha Senthil
{"title":"Acute intraoperative fluid misdirection managed with anterior approach irido-zonulo-hyaloido-vitrectomy.","authors":"Siddharth Dikshit, Sushma Tuluva, Sirisha Senthil","doi":"10.4103/IJO.IJO_16_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_16_24","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the causes of acute fluid misdirection (AFM) and the role of irido-zonulo-hyaloido-vitrectomy (IZHV) in the management of AFM.</p><p><strong>Methods: </strong>Among the 95,712 cataract surgeries performed between April 2017 and August 2022 at a tertiary center, six eyes of six patients developed intraoperative AFM and underwent IZHV through the anterior approach. AFM was diagnosed intraoperatively when there was sudden shallowing of the anterior chamber with markedly elevated intraocular pressures (IOPs) not attributable to external causes or choroidal effusion/hemorrhage. The condition resolved with deepening of AC following IZHV.</p><p><strong>Results: </strong>Five eyes had angle closure disease (one of them also had pseudoexfoliation), and one eye had open-angle glaucoma. The mean preop IOP was 25.8 ± 7.3 mmHg, with an IOP range of 18-36. The mean number of preop AGM was 3 ± 1.7. Four eyes developed AFM during combined cataract and trabeculectomy, and two eyes during cataract surgery. Four eyes had aqueous misdirection during or after cortical aspiration, and two eyes after creation of internal trabeculectomy ostium. IZHV was performed for all eyes through an anterior approach using a 23G vitrector, which resulted in instant resolution and deepening of the anterior chamber. The mean follow-up was 8.75 months (1-48 months), the mean postoperative IOP was 16.1 ± 2.6 mmHg, and the mean number of AGM at the last follow-up was 2.8 ± 2.2. The anterior chamber was deep, and IOP was under control in all eyes with four eyes needing AGM. One eye developed postoperative aqueous misdirection due to blockade of the IZHV opening.</p><p><strong>Conclusion: </strong>IZHV can be an effective solution for acute intraoperative AFM, which can be performed via an anterior approach by the anterior segment surgeon.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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