Indian Journal of Ophthalmology最新文献

{"title":"Analysis of factors leading to differences in the duration of each step of phacoemulsification: An observational study.","authors":"Kabilan Gautham","doi":"10.4103/IJO.IJO_925_25","DOIUrl":"10.4103/IJO.IJO_925_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1233"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paucity of optineurin gene variants in Indian juvenile open-angle glaucoma patients.","authors":"Manoj Yadav, Chand Singh Dhull, Sumit Sachdeva, Anshu Yadav, Aarti Bhardwaj, Vishal Panghal, Ankit Kumari, Ritu Yadav, Sapna Sharma, Mukesh Tanwar","doi":"10.4103/IJO.IJO_1512_24","DOIUrl":"10.4103/IJO.IJO_1512_24","url":null,"abstract":"<p><strong>Purpose: </strong>In the current study, we have screened the OPTN gene in a cohort of unrelated juvenile open-angle glaucoma (JOAG) patients negative for possible pathogenic variants in CYP1B1 and MYOC genes.</p><p><strong>Methods: </strong>Polymerase chain reaction (PCR) amplification and sequencing were employed to identify nucleotide variants within the coding sequence and intron-exon boundaries of the OPTN gene in 85 JOAG patients and 100 controls. A pathogenicity prediction of identified variants was performed by six distinct online algorithms. Possible structural alterations caused by pathogenic variants were investigated using GOR IV, PyMol, ChimeraX, and molecular dynamics simulations using Gromacs software.</p><p><strong>Results and discussion: </strong>PCR amplification and sequencing revealed a total of 27 variations, encompassing eight missense, six synonymous, and 13 intronic changes. Out of the 85 patients, three JOAG individuals exhibited possible pathogenic variants. A novel missense variant p.(Q518L) was also observed and registered at NCBI with accession number PP898303. Computational algorithms identified three potential pathogenic variants. These variants induce disruptions and structural alterations which in turn compromise their functionality. This ultimately leads to retinal ganglion cells death and the eventual manifestation of glaucomatous damage resulting in vision loss.</p><p><strong>Conclusion: </strong>This is the first report showing the involvement of pathogenic OPTN gene variants in JOAG cases from North Indian population which was unknown till now. This study provides population-specific data on genetic contribution of OPTN genes in JOAG pathogenesis. Genetic investigations like this may help in the understanding of disease pathogenesis and development of therapy for glaucoma management/treatment in the near future.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1181-1189"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival outcomes and globe salvage rates of retinoblastoma in India - A systematic review.","authors":"Shreyasi Das, Amita Mahajan, Sima Das, Santosh G Honavar","doi":"10.4103/IJO.IJO_3033_24","DOIUrl":"10.4103/IJO.IJO_3033_24","url":null,"abstract":"<p><strong>Purpose: </strong>The World Health Organization (WHO) CURE-ALL initiative highlights retinoblastoma (RB) as an index cancer, prompting Indian centers to collaborate for better RB outcomes. The current study is a systematic review of published RB survival outcomes from India till date, thereby providing a crucial roadmap for ongoing efforts.</p><p><strong>Methods: </strong>The PubMed and Google Scholar databases were searched till April 2024. The reference lists of selected articles were also searched manually for additional studies. Non-Indian articles, multicentric studies, case reviews, duplicates, and studies not mentioning outcomes were excluded. Fifteen eligible studies were shortlisted for review.</p><p><strong>Results: </strong>The total number of patients was 4147. Median age at diagnosis was between 24-36 months of age. Median lag time from symptom onset to diagnosis varied between 3-12 months. The overall globe salvage rates ranged from 13% to 54.7%, with early intraocular disease having greater rates of vision preservation. A higher proportion of vision salvage (>50%) was found in recently concluded studies, mainly due to the use of intra-arterial chemotherapy after 2019. The pooled 5-year overall survival (OS) was 78.7%. Reported relapse rates ranged from 7% to 36%. Treatment abandonment rates varied between 10% to 58%.</p><p><strong>Conclusion: </strong>Our review shows globe salvage rates for RB in India match other low-middle-income countries, but 5-year OS is lower than in developed nations. The relapse rates are similar to the global rates. Proposed measures to optimize RB outcomes include parental counseling for early recognition, efforts to limit treatment abandonment, and improving access to specialized treatment.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1116-1123"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of schizophrenia on retina.","authors":"M Purushottam Naidu, Mujawar Mahek, Swanandi Gawde, Keni Niyati, Rao Sankalp","doi":"10.4103/IJO.IJO_575_25","DOIUrl":"10.4103/IJO.IJO_575_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1231-1232"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Posterior lamellar wedge resection of lower eyelid margin lesions.","authors":"Shirali Gokharu, Marnya Lollen, Namita Kumari, Sima Das","doi":"10.4103/IJO.IJO_756_25","DOIUrl":"10.4103/IJO.IJO_756_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1228-1229"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors response to Comments on \"Acute intraoperative fluid misdirection managed with anterior approach irido-zonulo-hyaloido-vitrectomy\".","authors":"Siddharth Dikshit, Sushma Tulava, Sirisha Senthil","doi":"10.4103/IJO.IJO_1409_25","DOIUrl":"10.4103/IJO.IJO_1409_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1227-1228"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in surgical training of left-handed residents.","authors":"Ishan Tilak, Swathi Nagarajan, Rajalakshmi Adithyapuram Ramachandran","doi":"10.4103/IJO.IJO_303_25","DOIUrl":"10.4103/IJO.IJO_303_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1224-1225"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intralenticular gnathostomiasis: A rare parasitic invasion.","authors":"Haripriya Aravind, Anahita Shroff, Anand Rajendran, Eliza Anthony","doi":"10.4103/IJO.IJO_1759_24","DOIUrl":"10.4103/IJO.IJO_1759_24","url":null,"abstract":"<p><strong>Background: </strong>Intraocular gnathostomiasis is an exceptionally rare manifestation of Gnathostoma spinigerum infection. Ingested larvae from undercooked meat[1] can migrate to various body parts, causing significant morbidity. Intralenticular localization-where the larva is embedded within the crystalline lens-is extremely unique, with this video documenting the first reported global case.</p><p><strong>Purpose: </strong>To present the clinical, diagnostic, and surgical aspects of a unique case of intralenticular gnathostomiasis, providing educational value to ophthalmologists, parasitologists, and primary care physicians. This case emphasizes the importance of considering parasitic infections in differential diagnoses, particularly in patients with relevant dietary or travel histories.</p><p><strong>Synopsis: </strong>A foreign national presented with ocular irritation and gastrointestinal symptoms following the consumption of undercooked meat. Clinical findings included anterior chamber reaction, mild vitritis, optic disc edema, retinal hemorrhages, and curvilinear retinal scars. Endogenous endophthalmitis was initially suspected. On Day 18, a live worm was visualized within the lens on slit-lamp examination and anterior segment-optical coherence tomography (AS-OCT). The video illustrates the diagnostic journey and meticulous surgical extraction of the worm in toto. An animated segment demonstrates the presumed migratory path of the larva. Histopathology confirmed the species as Gnathostoma spinigerum.</p><p><strong>Highlights: </strong>• Diagnosis: Emphasizes the importance of detailed history-taking, including dietary habits and travel exposure. • Documentation: High-quality images of the motile worm within the lens aid future recognition and diagnosis. • Surgery: Demonstrates the technique to safely extract the worm, providing insights into managing such rare and delicate cases. • Postoperative Care: Discusses the importance of postoperative monitoring and care for full visual and systemic recovery.</p><p><strong>Video link: </strong>https://youtu.be/VAdj17UZVA0.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1239"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Contact lenses for visual rehabilitation in post-keratoplasty eyes: A review.","authors":"Nir Erdinest, Naomi London","doi":"10.4103/IJO.IJO_1099_25","DOIUrl":"10.4103/IJO.IJO_1099_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1225-1226"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of DMEK without peripheral iridotomy and a review of the literature.","authors":"Anchal Arora, Srikant Kumar Sahu, Umashankar Barik, Priyadarshini Parida, Sunita Chaurasia, Smruti Rekha Priyadarshini, Sujata Das","doi":"10.4103/IJO.IJO_1052_24","DOIUrl":"10.4103/IJO.IJO_1052_24","url":null,"abstract":"<p><strong>Purpose: </strong>To enlist the results of Descemet membrane endothelial keratoplasty (DMEK) without peripheral iridotomy (PI) and to analyze the risks and benefits associated with this approach.</p><p><strong>Methods: </strong>Medical records of 57 patients who underwent DMEK without PI between January 2019 and March 2023 were retrospectively reviewed. The primary outcome was the incidence of pupillary block (PB), and the secondary outcomes were graft detachment, rebubbling rates, and best-corrected logMAR distance visual acuity (BCDVA) at 6 months.</p><p><strong>Results: </strong>The median age (interquartile range (IQR)) of the participants was 66 years (range: 61-73 years). The median (IQR) BCDVA 6 months post-DMEK was 0.18 (IQR: 0.1-0.3); 82% of eyes achieved a BCDVA of >20/40. PB due to air bubble migration into the posterior chamber, resulting in appositional angle closure, was seen in 2/57 (3.5%) cases.</p><p><strong>Conclusion: </strong>DMEK without PI gives comparable long-term results regarding visual acuity and graft survival. Despite the predisposition of Caucasian eyes to angle-closure glaucoma, the incidence of PB was comparable to eyes undergoing DMEK with PI. Therefore, avoiding this step can save surgical time and prevent PI-related complications.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1197-1201"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}