Indian Journal of Ophthalmology最新文献

{"title":"Rapid one-tube RPA-coupled CRISPR/Cas12a-based RID-MyC assay for the diagnosis of fungal keratitis.","authors":"Hanith R Deivarajan, Kanmani Senthilkumar, Hari V Sekar, Vignesh Elamurugan, Jaishree Pandian, Anitha Venugopal, Dharmalingam Kuppamuthu, Lalitha Prajna, Venkatesh N Prajna, Siddharth Narendran","doi":"10.4103/IJO.IJO_1613_24","DOIUrl":"10.4103/IJO.IJO_1613_24","url":null,"abstract":"<p><strong>Purpose: </strong>This study introduces and evaluates the single-tube rapid identification of mycoses using CRISPR (ST-RID-MyC) assay. This novel diagnostic tool combines recombinase polymerase amplification (RPA) with CRISPR/Cas12a for the rapid and precise diagnosis of fungal keratitis (FK).</p><p><strong>Design: </strong>Prospective cross-sectional study.</p><p><strong>Methods: </strong>Corneal scrapings from 61 patients with suspected microbial keratitis were collected at the Cornea Department of a Tertiary Eye Care Center. The study assessed the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the ST-RID-MyC assay. Additional measures included concordance rates with traditional diagnostic methods and the time to diagnosis.</p><p><strong>Results: </strong>The ST-RID-MyC assay exhibited a sensitivity of 90% and a specificity of 90.48%, with a PPV of 94.74% and an NPV of 82.61%. The ST-RID-MyC showed substantial agreement with culture and microscopy and perfect concordance with conventional RID-MyC. The mean time to diagnosis was significantly reduced (P < 0.001) using the ST-RID-MyC assay, compared to the traditional RID-MyC assay (6 vs. 32 minutes). Visual assessments demonstrated a high level of inter-observer agreement (kappa = 0.832).</p><p><strong>Conclusions: </strong>The ST-RID-MyC assay, combining RPA and CRISPR/Cas12a in a single-tube system, offers a rapid, accurate, and resource-efficient diagnostic method for FK, potentially transforming clinical management of this condition by enabling faster therapeutic decisions.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1208-1212"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of various Intravenous Methylprednisolone regimens in Moderate to Severe Thyroid Eye Disease: A systematic review.","authors":"Ankita Aishwarya, Divanshi Shrivastava, Adarsh Kumar Singh, Rachna Agrawal","doi":"10.4103/IJO.IJO_1808_24","DOIUrl":"10.4103/IJO.IJO_1808_24","url":null,"abstract":"<p><p>This systematic review aims to assess the efficacy and safety of various intravenous methylprednisolone (IVMP) protocols for treating active moderate to severe thyroid eye disease (TED) and to find the most effective regimen with the least side effects. We conducted a comprehensive literature search adhering to PRISMA guidelines across PubMed, Medline, Embase, Web of Science, and Scopus databases from March 2008 to March 2024 to find relevant studies. Included studies were randomized controlled trials (RCTs), nonrandomized trials, cohort studies, case-control studies, case series, and case reports in English, investigating IVMP usage in adults with active moderate to severe TED. Outcomes focused on disease activity, exophthalmos improvement, diplopia resolution, recurrence, need of additional treatment, and associated adverse events. Of the 274 screened articles, 15 were included, involving 1065 participants. There were six RCTs (two multicentric), six retrospective studies, and three prospective case series from March 2008 to March 2024. Regimens were categorized into low dose (LD) ≤ 2.5 g, medium dose (MD) >2.5 g to 4.5 g, and high dose (HD) >4.5 g, with intervals of daily, weekly (most common), and monthly, over 4 to 26 weeks, typically 12 weeks. The MD (4.5 g) regimen was the most common followed, and it significantly improved Clinical Activity Score and quality of life with low side effects. The main limitations of this study are the heterogeneity of included studies, duration of follow-up, and IVMP regimens, which may affect the comparability and generalizability of the results. The weekly IVMP (4.5 g) regimen optimally treats moderate to severe TED. However, future research should focus on large-scale trials to determine the optimal IVMP regimen while addressing variability in managing recurrence, additional treatments, and the timing of rehabilitative surgeries.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1100-1107"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in pediatric eye care: Assessing the necessity and impact.","authors":"Venugopal Anitha, Meenakshi Ravindran","doi":"10.4103/IJO.IJO_899_25","DOIUrl":"10.4103/IJO.IJO_899_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1219-1221"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on: Bent ab interno needle goniectomy: Redefining the angle-based approach in glaucoma.","authors":"Manju R Pillai, Tosha Abhay Gujarathi","doi":"10.4103/IJO.IJO_1201_25","DOIUrl":"10.4103/IJO.IJO_1201_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1195-1196"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seek and ye shall find the cause!","authors":"Chitransha Jaluthariya, Atul Arora, Vishali Gupta","doi":"10.4103/IJO.IJO_358_25","DOIUrl":"10.4103/IJO.IJO_358_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1095-1096"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on: Acute intraoperative fluid misdirection managed with anterior approach irido-zonulo-hyaloido-vitrectomy.","authors":"Vanita Pathak-Ray","doi":"10.4103/IJO.IJO_1035_25","DOIUrl":"10.4103/IJO.IJO_1035_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1226-1227"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lag time for diagnosis and treatment in 1120 retinoblastoma children: Analysis from InPOG-RB-19-01.","authors":"Sima Das, Rachna Meel, Amita Mahajan, Rolika Bansal, Vijay Anand Reddy, Subhav Prasad, Neiwete Lomi, Sameer Bakhshi, Seema Kashyap, Kasturi Bhattacharjee, Devjyoti Tripathy, Nishant Verma, Usha Singh, Parag K Shah, Mobashir Sarfraz Ali, Asim Ghosh, Aakar Singh, Santosh G Honavar","doi":"10.4103/IJO.IJO_3031_24","DOIUrl":"10.4103/IJO.IJO_3031_24","url":null,"abstract":"<p><strong>Setting: </strong>Increased lag time for diagnosis and treatment is a key determinant of adverse retinoblastoma (RB) outcomes. Analysis from INPHOG-RB-19-01, a prospective, multicentric study of newly diagnosed RB with regard to lag time and its correlation with various variables, is presented.</p><p><strong>Patient or study population: </strong>All newly diagnosed RB patients treated at the participating centers during the study period were enrolled.</p><p><strong>Observation procedure: </strong>Lag time was subdivided into parent-lag time (symptom onset to first consult) and system-lag time (including diagnosis lag time, defined as first consult to diagnosis, and treatment lag time, defined as diagnosis to treatment initiation.). Multivariate logistic regression analysis was used to assess factors predictive of increased lag time.</p><p><strong>Main outcome measures: </strong>In all, 1120 patients from 20 centers were enrolled over a 36-month period. Extraocular or metastatic disease was present in 25.2% of patients at diagnosis. The mean lag time from symptom onset to treatment initiation was 4.2 months (range 0.5-61.6 months). Parental, diagnosis, and treatment lag time contributed to 44%, 26%, and 31% of the total lag time, respectively. Increased lag time had significant correlation with the stage at presentation (P < 0.05), lower socio-economic status (P = 0.006), increased distance from treating center (P = 0.001), younger maternal age at pregnancy (P < 0.05), family history of cancer (P = 0.031), and first consultation with a non-specialist (P = 0.001), and showed a negative correlation with improved maternal education. Parental lag time is the major contributor to the cascading delay in RB diagnosis and treatment initiation. Efforts for earlier diagnosis, therefore, need to be directed towards community awareness and routine screening during contact with healthcare professionals, such as at immunization.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1124-1131"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A curious case of Panuveitis with proptosis in a young girl.","authors":"Shilpa Viswanath, Atul Arora, Manpreet Singh, Manu Sharma, Vishali Gupta","doi":"10.4103/IJO.IJO_540_25","DOIUrl":"10.4103/IJO.IJO_540_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1098-1099"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Has COVID-19 affected the clinical profile of newly diagnosed myopes in tertiary eye care centers? A multicentric study from India.","authors":"Bhavika Bansal, Chintan Shah, Pradeep Agarwal, Rajat Kapoor, Anupam Sahu, Avinash Mahindrakar, Preeti Sharma, Lokesh Chauhan, Koduri Satya Durga Lalitha, Srivani Adabala, Pradhnya Sen, Atanu Majumdar, Suma Ganesh, Shailja Tibrewal","doi":"10.4103/IJO.IJO_1842_24","DOIUrl":"10.4103/IJO.IJO_1842_24","url":null,"abstract":"<p><strong>Purpose: </strong>The COVID-19 pandemic led to increase in near work and digital devices use among children mounting to increased development of myopia. Our study aimed to look for change in the incidence and clinical profile of newly diagnosed myopes who presented to six tertiary eye care centers in post-COVID period as compared to pre-COVID period.</p><p><strong>Methods: </strong>A retrospective observational multicentric study was conducted in two periods: pre-COVID (February 2019-January 2020) and post-COVID (August 2021-July 2022). All newly diagnosed myopes aged ≤18 years with cycloplegic spherical equivalent (SE) ≤-0.5 D who presented to the hospital during study periods were included. Patients with simple myopic astigmatism were excluded. Demographic data and clinical parameters, including type and severity of myopia, were compared between the two periods.</p><p><strong>Results: </strong>The study showed 937 newly diagnosed myopes in the pre-COVID and 1396 in the post-COVID period. The myopia incidence increased from 1.98% to 3.03% (P < 0.001). The gender distribution and mean age were comparable. There was a significant rise in myopia cases among children aged >5-≤10 years in the post-COVID period (P = 0.000). The average presenting SE was more myopic in the post-COVID period (P = 0.010). Moderate myopia showed a higher proportional increase in the age group >15-≤18 years, and severe myopia observed a higher proportional increase in the >5-≤10 years age group.</p><p><strong>Conclusion: </strong>The study reflects a higher incidence and severity of myopia at presentation in the post-COVID period, mainly in children aged >5-≤10 years. It emphasizes the urgent need for interventions to mitigate the rising burden of myopia.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1146-1152"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of viewing distance on vision tasks using virtual reality technology for children with intermittent exotropia.","authors":"Shengbei Weng, Mengxiang Guo, Feng Chen","doi":"10.4103/IJO.IJO_562_25","DOIUrl":"10.4103/IJO.IJO_562_25","url":null,"abstract":"<p><strong>Purpose: </strong>This study sought to investigate dynamic visual acuity (DVA), binocular functions, and perceptual eye position (PEP) measured via a virtual reality (VR) evaluation system in children with intermittent exotropia (IXT) at varying viewing distances.</p><p><strong>Design: </strong>Retrospective, case-control observational study.</p><p><strong>Methods: </strong>A retrospective study was conducted involving 118 children: 59 with IXT and 59 age-matched controls. Comprehensive ophthalmic assessments, including DVA, static and dynamic PEP, contour integration, and stereopsis, were performed using an intelligent VR-based visual perception platform. Testing was conducted at four viewing distances: 0.4 m, 0.7 m, 1 m, and 3 m.</p><p><strong>Results: </strong>Children with IXT demonstrated significantly higher rates of monocular DVA abnormalities across all distances compared to controls (all P < 0.001). Abnormal contour integration was markedly worse in the IXT group at 1 m (52.54% vs. 28.81%; P = 0.007). Both groups exhibited the poorest DVA and contour integration at the 3 m distance. Receiver operating characteristic (ROC) curve analysis identified optimal PEP thresholds for contour integration assessment in IXT and control groups, with high sensitivity and specificity.</p><p><strong>Conclusions: </strong>VR-based testing offers a novel, sensitive tool for detecting visuomotor deficits in children with IXT, particularly at critical distances. This methodology may enhance early diagnosis and individualized treatment planning for visual function deficits in pediatric populations.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"1166-1172"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}