Indian Journal of Ophthalmology最新文献

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Recent advances in neuro-ophthalmology. 神经眼科的最新进展。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-10-26 DOI: 10.4103/IJO.IJO_594_24
Shikha T Bassi, Nancy J Newman, John J Chen, Nanthaya Yui Tisavipat, Susan P Mollan, Heather E Moss, Dan Milea
{"title":"Recent advances in neuro-ophthalmology.","authors":"Shikha T Bassi, Nancy J Newman, John J Chen, Nanthaya Yui Tisavipat, Susan P Mollan, Heather E Moss, Dan Milea","doi":"10.4103/IJO.IJO_594_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_594_24","url":null,"abstract":"<p><p>This review article represents a collaborative effort across continents, bringing together the latest developments in neuro-ophthalmology with a focus on innovative diagnostic and therapeutic modalities that are shaping the future of the field. Among the most significant advancements is the rise of optical coherence tomography (OCT), now recognized as an indispensable tool in neuro-ophthalmological research, providing unparalleled insights into optic nerve and central nervous system pathologies. Gene therapy, particularly for conditions such as Leber's hereditary optic neuropathy, marks a new frontier in personalized medicine, offering hope for previously untreatable conditions. The article also examines the transformative role of telemedicine and artificial intelligence (AI) in clinical practice, which are revolutionizing patient care and enhancing diagnostic precision. Furthermore, it highlights the impact of novel serological biomarkers on the understanding and management of immune-mediated optic neuritis, and discusses the introduction of new therapeutic agents like Tocilizumab and Teprotumumab, which are redefining treatment paradigms. Collectively, these advancements reflect the profound influence of modern medicine on neuro-ophthalmology, paving the way for improved patient outcomes and fostering new avenues for research and clinical practice.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
India eliminates trachoma as a public health problem - What lies ahead? 印度消除了沙眼这一公共卫生问题--未来会怎样?
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-10-26 DOI: 10.4103/IJO.IJO_2444_24
Murugesan Vanathi
{"title":"India eliminates trachoma as a public health problem - What lies ahead?","authors":"Murugesan Vanathi","doi":"10.4103/IJO.IJO_2444_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2444_24","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of postoperative cyclosporine 2.0% versus betamethasone 0.1% eye drops following trabeculectomy: A randomized clinical trial. 小梁切除术后使用 2.0% 环孢素眼药水与 0.1% 倍他米松眼药水的比较:随机临床试验。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-10-25 DOI: 10.4103/IJO.IJO_345_24
Esmaeil Babaei, Alireza Eslampoor, Ramin Daneshvar
{"title":"Comparison of postoperative cyclosporine 2.0% versus betamethasone 0.1% eye drops following trabeculectomy: A randomized clinical trial.","authors":"Esmaeil Babaei, Alireza Eslampoor, Ramin Daneshvar","doi":"10.4103/IJO.IJO_345_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_345_24","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of cyclosporine A 2% eye drop following trabeculectomy on intraocular pressure (IOP) and surgical success compared to postoperative steroid drop.</p><p><strong>Study design: </strong>Prospective, randomized clinical trial in an institutional setting.</p><p><strong>Methods patients: </strong>Forty patients with primary open-angle glaucoma and candidates for trabeculectomy were included in this study. Standard fornix-based trabeculectomy augmented with mitomycin C was performed for all patients. None of the included subjects had a history of prior laser or intraocular surgery in that eye.</p><p><strong>Intervention: </strong>All included subjects were randomly assigned to either postoperative cyclosporine A 2% or betamethasone 0.1% eye drops.</p><p><strong>Main outcome measures: </strong>IOP measured by applanation tonometer and surgical success rate.</p><p><strong>Results: </strong>Seventy-five potentially eligible POAG patients were seen during the study period, and 40 met the study criteria and were randomly assigned to one of the study groups. Patients in the cyclosporine A 2% group had consistently lower IOP, fewer glaucoma medications, and higher success rates for at least 24 months after surgery (P < 0.0001). Complete success was more frequent in the cyclosporine group. Moreover, the cyclosporine A group had more diffuse and elevated bleb with less vascularity in the first 3 months after surgery (P ≤ 0.01). This was paralleled with fewer dry eye signs and symptoms in the cyclosporine group in the first 3 months (P < 0.03).</p><p><strong>Conclusion: </strong>Postoperative cyclosporine A 2% eye drop can be used instead of steroid drops and is associated with improved surgical success and decreased dry eye manifestations.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Nd:YAG laser posterior capsulotomy on higher order aberrations in different types of posterior capsule opacification: A prospective study. Nd:YAG 激光后囊切开术对不同类型后囊混浊的高阶像差的影响:前瞻性研究。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-10-25 DOI: 10.4103/IJO.IJO_3162_23
R Senthil Prasad, Tony A Koshy, R Sankarananthan, Logesh Balakrishnan, Kamatchi Nagu, Madhu Shekhar
{"title":"Effect of Nd:YAG laser posterior capsulotomy on higher order aberrations in different types of posterior capsule opacification: A prospective study.","authors":"R Senthil Prasad, Tony A Koshy, R Sankarananthan, Logesh Balakrishnan, Kamatchi Nagu, Madhu Shekhar","doi":"10.4103/IJO.IJO_3162_23","DOIUrl":"https://doi.org/10.4103/IJO.IJO_3162_23","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate higher order aberrations (HOA) in different types of posterior capsule opacification (PCO) and analyze its changes fosllowing Nd:YAG laser posterior capsulotomy (LPC).</p><p><strong>Settings: </strong>Tertiary care ophthalmic hospital.</p><p><strong>Design: </strong>Prospective, comparative, observational study.</p><p><strong>Methods: </strong>One hundred ninety-three pseudophakic eyes with PCO were evaluated over 3 months. PCO was classified into pearly, fibrous, and mixed types. Their uncorrected visual acuity (UCVA), corrected distance visual acuity (CDVA), intraocular pressure (IOP), evaluation of posterior capsule opacification (EPCO) scoring and root mean square values of HOA (total, coma, spherical, and trefoil) were measured using a wavefront aberrometer before and after LPC.</p><p><strong>Results: </strong>Pearly, fibrous, and mixed PCO were observed in 89 (46.1%), 47 (24.4%), and 57 (29.5%) eyes respectively. The UCVA and CDVA showed improvement in all types of PCO post-procedure. The total HOA was 0.48 ± 0.47, 0.43 ± 0.42, 0.37 ± 0.34, and 0.76 ± 0.53, the coma aberrations were 0.18 ± 0.15, 0.18 ± 0.14, and 0.19 ± 0.19, spherical aberrations were 0.07 ± 0.12, 0.09 ± 0.12, and 0.05 ± 0.06, whereas the trefoil aberrations were 0.35 ± 0.44, 0.24 ± 0.26, and 0.21 ± 0.20, 15-day post-Nd:YAG LPC in pearly, fibrous, and mixed PCO respectively, all of which showed a significant reduction. The EPCO score showed no significant difference between different subtypes of PCO and had no correlation with the HOA.</p><p><strong>Conclusions: </strong>Post Nd:YAG LPC showed improvement in visual acuity with significant reduction in HOA in all types of PCO.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The visual outcomes and corneal biomechanical properties after PRK and SMILE in low to moderate myopia. 中低度近视患者接受角膜屈光手术(PRK)和角膜磨镶术(SMILE)后的视觉效果和角膜生物力学特性。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-10-25 DOI: 10.4103/IJO.IJO_1250_24
Shivani Joshi, Aafreen Bari, Chetan Shakkarwal, Tushar Agarwal, Tanuj Dada, Rajesh Sinha, Jeewan Singh Titiyal, Namrata Sharma
{"title":"The visual outcomes and corneal biomechanical properties after PRK and SMILE in low to moderate myopia.","authors":"Shivani Joshi, Aafreen Bari, Chetan Shakkarwal, Tushar Agarwal, Tanuj Dada, Rajesh Sinha, Jeewan Singh Titiyal, Namrata Sharma","doi":"10.4103/IJO.IJO_1250_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1250_24","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the corneal biomechanical parameters, visual outcome, and epithelial remodeling after small-incision lenticule extraction (SMILE) and photorefractive keratectomy (PRK) for low to moderate myopia.</p><p><strong>Design: </strong>Prospective, interventional, randomized, comparative study.</p><p><strong>Methods: </strong>Eighty eyes of 40 patients undergoing bilateral SMILE or PRK for low to moderate myopia (<-5 D SE) were included. They were divided into two groups based on the planned refractive surgery. Visual acuity, corneal biomechanics using Corvis-ST, epithelial mapping via anterior segment optical coherence tomography, and higher-order aberrations were recorded both preoperatively and postoperatively at 6 months and compared.</p><p><strong>Results: </strong>At 6 months follow-up, the corrected distance visual acuity as well as the postoperative spherical equivalent of both the groups were comparable (P = 0.13 and P = 0.32, respectively). The biomechanical parameters like deformation amplitude ratio (P < 0.01), inverse concave radius (P = 0.006), integrated ratio (P < 0.01), stress-strain index (P < 0.01), Ambrosio's relational thickness (ArTH) (P < 0.01), and corneal biomechanical index-laser vision correction (P = 0.02) were altered more in the SMILE group than in the PRK group, while the biomechanically corrected intraocular pressure (P = 0.16) was comparable. Epithelial remodeling (P = 0.59), higher-order aberrations (P = 0.53), and stromal keratocyte loss (P = 0.16) in both the groups were comparable.</p><p><strong>Conclusion: </strong>Both SMILE and PRK are comparably effective procedures for correction of low to moderate myopia in terms of visual outcomes; however, the corneal biomechanical stability in PRK is superior than that in SMILE.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological profile and clinical characteristics of ocular and periocular tumors in North and Central India. 印度北部和中部眼部和眼周肿瘤的流行病学概况和临床特征。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-10-25 DOI: 10.4103/IJO.IJO_786_24
Chhavi Gupta, Narendra Patidar, Himanshu Gaikwad, Mihir Mishra, Sima Das
{"title":"Epidemiological profile and clinical characteristics of ocular and periocular tumors in North and Central India.","authors":"Chhavi Gupta, Narendra Patidar, Himanshu Gaikwad, Mihir Mishra, Sima Das","doi":"10.4103/IJO.IJO_786_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_786_24","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the epidemiological profile and clinical characteristics of ocular and periocular tumors in patients presenting to three tertiary care referral centers in North and Central India.</p><p><strong>Methods: </strong>Hospital-based consortium study.</p><p><strong>Settings and design: </strong>Retrospective, descriptive, observational study.</p><p><strong>Results: </strong>A total of 3184 patients were diagnosed with 3557 ocular and periocular tumors over 11 years from 2010 to 2021. Of these, 2395 (67.33%) were benign, 84 (2.36%) were premalignant, and 1078 (30.30%) were malignant. The most common location was the ocular surface (n = 1294, 37.09%), followed by the eyelid (n = 1185, 33.97%), intraocular (n = 624, 17.88%), and orbit (n = 454, 13.01%). The most common tumors were retinoblastoma (n = 483, 13.57%), ocular surface squamous neoplasia (OSSN) (n = 301, 8.46%), and dermoid cyst (n = 167, 4.69%). In the pediatric age group, retinoblastoma was the most common tumor (n = 483, 13.57%), while in adults, it was OSSN (n = 301, 8.46%). The stage at presentation for malignant tumors was divided into in-situ (57.14%), local spread (8.16%), and metastasis (32.83%). For specific tumor locations, the stages were 78.83%, 17.51%, and 2.18%, respectively, for eyelid tumors; 51.76%, 27.05%, and 17.64%, respectively, for orbital tumors; 88.37%, 5.81%, and 5.19%, respectively for ocular surface tumors; and 35.71%, 14.15%, and 50.28%, respectively, for intraocular tumors.</p><p><strong>Conclusions: </strong>Identifying the epidemiological characteristics of ocular and periocular tumors will aid in early diagnosis and timely intervention. Intraocular tumors showed delayed diagnosis, advanced stages at presentation, and required patients to travel longer distances for treatment, indicating the need for strengthened diagnostic and treatment facilities to improve access to care.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OSSN in South India: Clinical presentation, treatment outcomes, and histopathologic correlations. 南印度的 OSSN:临床表现、治疗效果和组织病理学相关性。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-10-25 DOI: 10.4103/IJO.IJO_909_24
P V Tejaswi Prasad, Shanti Radha Krishnan, Naveen Radhakrishnan, Sahithya Bhaskaran, N Venkatesh Prajna
{"title":"OSSN in South India: Clinical presentation, treatment outcomes, and histopathologic correlations.","authors":"P V Tejaswi Prasad, Shanti Radha Krishnan, Naveen Radhakrishnan, Sahithya Bhaskaran, N Venkatesh Prajna","doi":"10.4103/IJO.IJO_909_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_909_24","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the clinical presentation, treatment outcomes, and histopathology features of ocular surface squamous neoplasia (OSSN) in a South Indian population and correlate the area of lesions to the histopathological grade/severity of carcinoma in situ (CIN) and squamous cell carcinoma (SqCC) invasive and noninvasive tumors.</p><p><strong>Methods: </strong>The study was a retrospective cross-sectional study. The study reviewed electronic medical records (EMRs) of 99 eyes of 99 South Indian patients who underwent en bloc excision and biopsy for tumors in the corneal and conjunctival epithelium with suspicion of OSSN over 1 year from January 2019 to December 2019. Postoperatively, patients were treated with three cycles of topical 0.04% mitomycin C eye drops. Sixty-three had requisite EMR data with a follow-up period of 1 year.</p><p><strong>Results: </strong>Patients had equal gender distribution with an age range of 28-83 years. The most common clinical variant was leukoplakic lesion, and the area of the lesion was the only predicting factor for SqCC and CIN.</p><p><strong>Conclusion: </strong>Bigger (T2) lesions should be strongly suspected for OSSN and promptly excised. Histopathologic analysis should be performed, and post-op topical mitomycin C or interferon alpha 2b is administered to avoid recurrence. In this study, by correlating the area of the lesion, we introduce a new variable that may aid in clinical prognostication alongside the AJCC classification.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dry and neovascular "wet" age-related macular degeneration: Upcoming therapies. 干性和新生血管性 "湿性 "老年性黄斑变性:即将推出的疗法
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-10-25 DOI: 10.4103/IJO.IJO_1120_24
Audrey Yan, Nasiq Hasan, Jay Chhablani
{"title":"Dry and neovascular \"wet\" age-related macular degeneration: Upcoming therapies.","authors":"Audrey Yan, Nasiq Hasan, Jay Chhablani","doi":"10.4103/IJO.IJO_1120_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1120_24","url":null,"abstract":"<p><strong>Abstract: </strong>The age-related macular degeneration (AMD) field is witnessing promising advancements in therapeutic options. Breakthrough drugs such as pegcetacoplan and avacincaptad have been FDA-approved for dry AMD, marking a significant development as there were no treatment options until August 2023. While several antivascular endothelial growth factor (VEGF) inhibitors have been approved for wet AMD, challenges persist with the need for frequent dosing. New treatments such as gene therapy, cell therapy, WNT pathway agonists, complement inhibitors, and anti-VEGF combination drugs are under development to address these issues. These developments are exciting and hold promise for transforming the field of medicine, offering hope for improved outcomes and enhanced patient care in managing AMD.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of pregnancy on the clinical course and treatment outcomes of Vogt-Koyanagi-Harada disease. 怀孕对 Vogt-Koyanagi-Harada 病的临床过程和治疗效果的影响。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-10-25 DOI: 10.4103/IJO.IJO_1251_24
Navya Cherukuri, Somasheila I Murthy, Mudit Tyagi
{"title":"Effects of pregnancy on the clinical course and treatment outcomes of Vogt-Koyanagi-Harada disease.","authors":"Navya Cherukuri, Somasheila I Murthy, Mudit Tyagi","doi":"10.4103/IJO.IJO_1251_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1251_24","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical course and treatment outcomes of Vogt-Koyanagi-Harada (VKH) disease during pregnancy.</p><p><strong>Methods: </strong>This retrospective study compares the clinical course and outcomes in pregnant and nonpregnant women with VKH. All VKH patients who were pregnant at presentation or on follow up and age-matched nonpregnant female controls during the study period (2013-2022) were included. Their best-corrected visual acuity (BCVA), clinical presentations, and treatment outcomes were analyzed.</p><p><strong>Results: </strong>Among the 532 female VKH patients, nine (1.7%) were included. Thirty nonpregnant patients were included as control. At presentation, the mean age in the study group was 26 years ± 6.48 standard deviation (SD) compared to the control group (mean 25.1 years ± 3.04). The mean BCVA was comparable between the two groups at presentation (study group 1.35 logarithm of the minimum angle of resolution [logMAR] vs. control group 0.76 logMAR; P = 0.05) and the final follow-up (study group 0.65 logMAR vs. control group 0.35 logMAR; P = 0.15). Participants with anterior segment inflammation (study group 77.7% vs. control group 70%; P = 0.65), the disease stage (early-stage VKH: study group 88.8% vs. control group 73.3%; P = 0.33), and disease exacerbation (study group 33.3% vs. control group 26.6%; P = 0.69) were all comparable between the study and control groups. Following treatment, 66.6% and 46.6% of the study and control groups, respectively, had sunset glow fundus (P = 0.29). At the last follow-up, 44.4% and 26.6% of the study and control groups, respectively, had subretinal fibrosis (P = 0.31).</p><p><strong>Conclusion: </strong>Though pregnancy is an immunomodulatory state, the clinical course of VKH in pregnant patients can be similar to that of nonpregnant women and needs close monitoring and follow-up.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association of cytokine levels and postnatal factors with retinopathy of prematurity. 细胞因子水平和产后因素与早产儿视网膜病变的关系。
IF 2.1 4区 医学
Indian Journal of Ophthalmology Pub Date : 2024-10-25 DOI: 10.4103/IJO.IJO_515_24
Syatirah Abu Yazib, May May Choo, Nurliza Khaliddin, Christine Py Ong, Yao Mun Choo, Azanna Ahmad Kamar, Gopal G Lingam, Tengku A Kamalden
{"title":"The association of cytokine levels and postnatal factors with retinopathy of prematurity.","authors":"Syatirah Abu Yazib, May May Choo, Nurliza Khaliddin, Christine Py Ong, Yao Mun Choo, Azanna Ahmad Kamar, Gopal G Lingam, Tengku A Kamalden","doi":"10.4103/IJO.IJO_515_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_515_24","url":null,"abstract":"<p><strong>Purpose: </strong>Prematurity has been known to trigger several cellular pathways, leading to the clinical occurrence of retinopathy of prematurity (ROP). This study compared the levels of a panel of serum cytokines in premature infants with and without ROP.</p><p><strong>Methods: </strong>This is a prospective observational study. Premature infants at 36-38 weeks' gestational age were recruited, their clinical data recorded, and serum samples collected and assayed for 18 cytokines. Based on follow-up examinations, patients were divided into two groups: No ROP and ROP. The ROP group was further divided into two subgroups: non-vision-threatening ROP (non-VTROP), and vision-threatening ROP (VTROP).</p><p><strong>Results: </strong>On univariate analysis, among the clinical parameters, gestation age, birth weight, duration of invasive ventilation, and duration of stay in neonatal intensive care unit (NICU) were found to be significant. The univariate analysis also showed an association between raised levels of VEGF-D and IL-8 in the VTROP group. Multiple logistic regression indicated that gestation age was a significant risk factor across all subgroups. Additionally, VEGF-D levels were found to be significantly associated with VTROP.</p><p><strong>Conclusion: </strong>Higher VEGF-D levels are associated with an increased risk of severe ROP that requires treatment and could potentially be used as a biomarker.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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