Indian Journal of Ophthalmology最新文献

{"title":"Orbital Rhabdomyosarcoma: Clinicodemographic Features and Outcomes from Turkey.","authors":"Burak Ulas, Altan Atakan Ozcan, Saadi Aljundi","doi":"10.4103/IJO.IJO_921_24","DOIUrl":"10.4103/IJO.IJO_921_24","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical features, radiologic, and histopathologic characteristics of patients with orbital rhabdomyosarcoma (RMS).</p><p><strong>Methods: </strong>The records of 14 patients with histologically proven orbital rhabdomyosarcoma between November 2012 and January 2024 were evaluated retrospectively. The age, gender, referring diagnosis, year of diagnosis, clinical features, histopathological results, radiology reports, follow-up period, management plans, and prognosis were obtained from patient electronic files and descriptively presented.</p><p><strong>Results: </strong>A total of 14 patients with a mean age of 12.64 ± 6.68 years were evaluated. Ten were males 71.43%, and four were females 28.57%. Six (42.85%) patients presented initially with proptosis as the main presenting complaint, and all of the patients had some degree of proptosis. Eleven patients (78.57%) had embryonal RMS, and three patients (21.42%) had alveolar RMS subtypes. The follow-up period ranged between 6 months and 6 years (26.36 ± 21.55 months). In 10 (71.42%) patients, there was a good response to treatment with no orbital recurrence or progression of the lesion during the follow-up period. Two patients had (14.28%) mortality during follow-up.</p><p><strong>Conclusion: </strong>Rhabdomyosarcoma management and diagnosis are important for preventing its spread and threatening patients' life and visual survival. Orbital RMS is a rare but important diagnosis in the orbit, and differential diagnoses need to be considered because RMS may have presenting features resembling other inflammatory orbital conditions.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1132-1137"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography of lacrimal punctum: Practical problems.","authors":"Ritesh Verma","doi":"10.4103/IJO.IJO_198_25","DOIUrl":"10.4103/IJO.IJO_198_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1237-1238"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Triple support pocket\" for placing brachytherapy plaques for anterior segment tumors.","authors":"Neiwete Lomi, Deepsekhar Das, Bhavna Chawla, J Niranjana, Dhanabalan Rajasekaran, Radhika Tandon","doi":"10.4103/IJO.IJO_24_25","DOIUrl":"10.4103/IJO.IJO_24_25","url":null,"abstract":"<p><strong>Background: </strong>Anterior segment tumors are rare tumors with limited management options. In small-sized lesions, plaque brachytherapy is advisable. The placement techniques of plaques for anterior segment tumors are completely different from the techniques for posterior segment tumors.[1-4] In cases where the lesion is located in the medial, lateral, or inferior iris, the possibility of tilt or displacement of the plaque is higher. The gravitational pull, coupled with ocular movements, squeezes the plaque against the ocular surface and the eyelid. This leads to displacement of the plaque along with damage to the corneal epithelium. Although certain novel plaque designs have been described in the literature to prevent such complications.[5] Their regular availability in all brachytherapy units is limited.</p><p><strong>Purpose: </strong>The authors here demonstrate a novel technique of \"Triple support pocket\" in a case of inferior irido-ciliary melanoma.</p><p><strong>Synopsis: </strong>The video demonstrates the steps of the \"triple support pocket\" orientation of brachytherapy plaque placement, along with a surgical demonstration in a case of inferior irido-ciliary melanoma. The steps include first sectoral peritomy with conjunctival dissection and flap creation, followed by step 2, which involves placement of a figure of 8 pattern 5-0 ethibond suture. The points of suture entry and exit are determined by the size of the plaque. The entries and exits are 0.5-1 mm away from the plaque edge. The third step involves moving the conjunctival flap over the brachytherapy plaque. The fourth step is where a tarsorrhaphy is performed. A 42-year-old female patient presented with an inferior iris lesion, which was diagnosed as an irido-ciliary melanoma using the popular \"ABCDEF\" rule designed by Shield et al.[6] The tumor had a largest basal diameter of 7.32 mm and an apical thickness of 3.87 mm extending inferiorly from 6'o clock to 7'o clock. A radio-active Ruthenium 106 plaque of size 12 mm was used in the management. Centration was achieved by using ultrasound on the table. Care was taken to ensure that all the edges of the tumor is covered, and the center of the plaque corresponds to the maximum apical thickness. The authors have performed this procedure twice, and there has been no incidence of tilt of plaque or displacement. The mean duration of the two cases was 119.5 hours. Mean dose at the sclera and apex is 313 Gy and 80 Gy, respectively. At 3 months follow-up, there were no cornea-related side effects or glaucoma.</p><p><strong>Highlights: </strong>Triple support pocket orientation of plaque brachytherapy helps in the prevention of displacement or tilt of the brachytherapy plaque.</p><p><strong>Video link: </strong>https://youtu.be/6G2wIiCbteE.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 8","pages":"1239-1240"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of cyclophosphamide therapy in relentless placoid choroiditis: A descriptive case series.","authors":"Miguel Pedroza-Seres, Carlos E Rodríguez-López","doi":"10.4103/IJO.IJO_348_25","DOIUrl":"https://doi.org/10.4103/IJO.IJO_348_25","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical presentation and visual outcomes of relentless placoid choroiditis (RPC) in four patients treated with intravenous cyclophosphamide, a treatment not extensively studied in this condition.</p><p><strong>Background: </strong>RPC is a rare and recently described ocular disease characterized by a prolonged and progressive clinical course, widespread lesions, and unknown etiology. There is no consensus on its treatment, and the use of cyclophosphamide in RPC has not been extensively studied.</p><p><strong>Case presentation: </strong>Four RPC patients treated with intravenous cyclophosphamide showed significant visual improvement (mean best-corrected visual acuity [BCVA] improved from 20/125 to 20/32) with minimal side effects.</p><p><strong>Conclusion: </strong>This case series demonstrates favorable outcomes with intravenous cyclophosphamide in RPC, supporting its potential as a safe, effective, and cost-efficient treatment option.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of anterior chamber wash with adjuvant intracameral and intrastromal voriconazole in deep stromal fungal keratitis with endoexudates - A retrospective study.","authors":"Premjith Muraleedharan, Josephine S Christy, Naveen Radhakrishnan","doi":"10.4103/IJO.IJO_132_25","DOIUrl":"https://doi.org/10.4103/IJO.IJO_132_25","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Purpose: </strong>To analyze the clinical outcomes of patients with deep stromal fungal keratitis with endoexudates who received adjuvant anterior chamber (AC) wash with intracameral (IC) and intrastromal (IS) voriconazole.</p><p><strong>Methods: </strong>Demographics, risk factors, clinical course, microbiology, and visual outcomes of patients with deep-seated fungal keratitis who underwent AC wash with IC and IS voriconazole from January 2022 to December 2022 with at least 6 months post-op follow-up visits were analyzed.</p><p><strong>Results: </strong>The mean age of 40 patients was 53 ± 12 years, and the mean time to presentation was 12 ± 8 days. The mean size of the ulcer at presentation was 21 ± 11.7 square mm. Aspergillus flavus was the most isolated organism in 16 (40%) patients. Seven (17.5%) patients achieved complete resolution with scarring and 33 (82.5%) required therapeutic keratoplasty (TPK), out of which 10 (30.3%) had reinfection.</p><p><strong>Conclusion: </strong>AC wash with IC and IS voriconazole was ineffective as adjuvant therapy in cases of deep-seated fungal keratitis.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femtosecond laser-assisted corneal intrastromal negative meniscus lenticule implantation with accelerated collagen crosslinking (FILAC) in advanced keratoconus in Indian eyes: A prospective interventional study.","authors":"Rajesh Sinha, Shahnaz Anjum, Kartikeya Gupta, Tushar Agarwal, Namrata Sharma, Sridevi Nair, Shrishti Kapoor, Jeewan S Titiyal","doi":"10.4103/IJO.IJO_2139_24","DOIUrl":"10.4103/IJO.IJO_2139_24","url":null,"abstract":"<p><strong>Purpose: </strong>To study the outcomes of femtosecond laser-assisted intrastromal negative meniscus lenticule implantation with accelerated corneal collagen crosslinking (FILAC) in advanced keratoconus.</p><p><strong>Methods: </strong>A prospective, interventional study evaluated the outcomes of FILAC in eyes with progressive keratoconus of Amsler-Krumeich stage 4 with thinnest pachymetry of 320-400 microns. A total of 10 eyes of 10 patients were enrolled. A negative meniscus allogenic stromal lenticule of 8.5 mm diameter was implanted into a corneal pocket created by a femtosecond laser at 150 microns depth and simultaneous accelerated corneal collagen crosslinking (CXL). Outcomes assessed 12 months after the procedure included uncorrected distance visual acuity (UDVA) and best-corrected visual acuity (BCVA), subjective refraction, and corneal topography changes.</p><p><strong>Results: </strong>Mean UDVA improved from baseline to 12 months follow-up (1.43 ± 0.39 vs. 1.32 ± 0.31 logMAR, P = 0.49). Four patients did not accept contact lenses preoperatively, whereas all patients were successfully fitted with semi-scleral contact lenses postoperatively with a mean BCVA of 0.47 ± 0.14 logMAR at 12 months. Mean corneal topographic values showed improvement from baseline to 12 months follow-up: K1 (58.44 ± 5.59 to 55.57 ± 5.68), K2 (63.35 ± 6.86 to 59.35 ± 7.1), Kmax (71.07 ± 7.95 to 66.29 ± 7.54) and astigmatism (4.89 ± 3.35 to 3.88 ± 2.35) ( P > 0.05). The mean thinnest pachymetry improved significantly from baseline to 12 months follow-up (354.9 ± 28.52 vs. 462.5 ± 36.30 microns, P = 0.0001). There was a non-significant improvement in subjective refraction and aberrometry.</p><p><strong>Conclusion: </strong>This technique effectively halts disease progression and improves visual outcomes in advanced keratoconus.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"974-979"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of outcomes of two (popular) techniques of haptic exteriorization in scleral fixation intra-ocular lens surgery - A retrospective study.","authors":"Bhawesh Chandra Saha, Amit Kumar, Naila Aftab","doi":"10.4103/IJO.IJO_1739_24","DOIUrl":"10.4103/IJO.IJO_1739_24","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 7","pages":"1076"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal Belin-Ambrosio display difference map in keratoconus.","authors":"Rashmi Deshmukh","doi":"10.4103/IJO.IJO_2547_24","DOIUrl":"10.4103/IJO.IJO_2547_24","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 7","pages":"1083-1085"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of corneal tomography in determining the outcomes of descemet membrane endothelial keratoplasty in fuchs endothelial corneal dystrophy.","authors":"Mohamed Ibrahime Asif, Chandradevi Shanmugam, Suman Lata, Prafulla Kumar Maharana, Namrata Sharma","doi":"10.4103/IJO.IJO_919_24","DOIUrl":"10.4103/IJO.IJO_919_24","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 7","pages":"1076-1078"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of utilization rate and graft outcomes of corneas from cadaveric donors (CDs) versus multiorgan donors (MDs).","authors":"Aishwarya Rathod, Radhika Tandon, Murugesan Vanathi, Noopur Gupta, Neiwete Lomi, Nishat Hussain Ahmed, Abhijeet Beniwal, Deepak Gupta","doi":"10.4103/IJO.IJO_1899_24","DOIUrl":"10.4103/IJO.IJO_1899_24","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose is to compare the utilization rate and corneal graft outcomes from multiorgan donors (MDs) versus those from cadaveric donors (CDs).</p><p><strong>Methods: </strong>In this ambispective and observational study, 36 corneas obtained from MDs and 72 corneas from their age-matched and sex-matched voluntary donors under the Hospital Cornea Retrieval Program (HCRP) from an eye bank were assessed clinically using slit lamp and under a specular microscope for their suitability for utilization. The percent utilization for keratoplasties was noted and compared between the two donor sources as the primary outcome. The transplanted corneas were followed up for 18 months for the assessment of graft survival and other outcome parameters.</p><p><strong>Results: </strong>The utilization rate of corneas obtained from MDs (80.6%) was significantly higher than that of corneas obtained from CDs (68.1%). The mean endothelial cell density (ECD) was significantly higher in corneas from MD as compared to those from CD ( P = 0.037) at 18 months. The Kaplan-Meier survival analysis revealed a cumulative graft failure rate over 1.5 years as 10.3% for corneas obtained from MD and 16.3% for corneas obtained from CD. The microbiological analysis of the corneoscleral rim sent intraoperatively revealed three culture-positive specimens, two from CD, and one from MD.</p><p><strong>Conclusion: </strong>The donor source was a significant factor in determining the suitability of corneas for keratoplasty. Death preservation interval, cause of death, ECD, and processing had a modest influence on tissue suitability or quality. This data may help eye banks formulate policies that can maximize the procurement of corneas from MDs under HCRP.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"1031-1037"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}