Indian Journal of Ophthalmology最新文献

{"title":"Early outcomes of 5-0 Prolene gonioscopy-assisted transluminal trabeculotomy combined with phacoemulsification in eyes of Indian glaucoma patients.","authors":"Devendra Maheshwari, Madhavi Ramanatha Pillai, Nimrita Gyanchand Nagdev, Shivam Gupta, Rengappa Ramakrishnan, Mohideen Abdul Kader, Mohammed Sithiq Uduman","doi":"10.4103/IJO.IJO_3065_23","DOIUrl":"10.4103/IJO.IJO_3065_23","url":null,"abstract":"<p><strong>Purpose: </strong>To study the early postoperative efficacy and safety of 5-0 Prolene gonioscopy-assisted transluminal trabeculotomy (GATT) combined with phacoemulsification in Indian eyes.</p><p><strong>Methods: </strong>This was a prospective, interventional study. Patients with primary and secondary glaucoma who underwent GATT combined with phacoemulsification (Phaco-GATT) or standalone GATT were included. All patients were evaluated on postoperative days 1, 15, and 30, as well as 3 months and 6 months postoperatively. Baseline and follow-up visits were compared to determine the significant difference in the number of intraocular pressure (IOP), antiglaucoma medications (AGM), and best corrected visual acuity (BCVA). Other outcome measures included surgical success, complications, and interventions. A P value of < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>One hundred and five eyes (95 patients) were included. Seventy-five eyes underwent GATT along with phacoemulsification and 30 eyes underwent GATT. In the Phaco-GATT group, the mean IOP reduced significantly from 17.71 ± 6.85 to 12.29 ± 4.44, 12.33 ± 4.44, and 12.18 ± 3.49 mmHg and in the GATT group, it reduced from 21.67 ± 11.42 mmHg to 16.38 ± 8.42, 16.47 ± 10.26, and 13.10 ± 3.25 mmHg at 1, 3, and 6 months, respectively ( P < 0.001). The number of AGM also significantly reduced from 1.67 ± 1.22 to 0.41 ± 0.87 and 0.34 ± 0.82 in the phaco-GATT group and from 2.63 ± 1.19 to 0.67 ± 1.09 and 0.60 ± 1.25 in the GATT group at 3 and 6 months, respectively ( P < 0.001). Complete success (IOP > 6-≤21 mmHg/20% reduction without AGM) was 96.7% in the Phaco-GATT group and 91.2% in the GATT group. BCVA improved from log of minimum angle of resolution 0.30 to 0.00 ( P < 0.001) in phaco-GATT group. Hyphema was the most common complication. Macrohyphema (>1 mm) was seen in six patients, out of which two patients required anterior chamber wash. IOP spikes (>30 mmHg) were seen in three patients.</p><p><strong>Conclusion: </strong>In Indian eyes, GATT combined with phacoemulsification and standalone GATT are efficacious and safe with good surgical outcomes.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S287-S292"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical performance of enhanced monofocal intraocular lens in presence of low degree of corneal astigmatism.","authors":"Neha Neha, Aafreen Bari, Namrata Sharma, Rajesh Sinha, Prafulla Kumar Maharana, Manpreet Kaur, Jeewan Singh Titiyal, Tushar Agarwal","doi":"10.4103/IJO.IJO_1639_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1639_24","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the optical performance of an enhanced monofocal intraocular lens (IOL) in the presence of cataract and a low degree of corneal astigmatism.</p><p><strong>Methods: </strong>A prospective, comparative, nonrandomized study was conducted to compare the results of an enhanced monofocal IOL with a standard monofocal IOL in cases of cataract with corneal astigmatism ≥0.75 D and <1.5 D. A total of 38 patients meeting the inclusion criteria were enrolled in the study. Group A patients (19) were implanted with enhanced monofocal IOLs bilaterally, and Group B patients (19) received standard monofocal IOLs bilaterally. Both groups underwent standard procedures (phacoemulsification with IOL implantation in the capsular bag), and final outcomes were analyzed after a 3-month follow up. A P value < 0.05 was considered significant.</p><p><strong>Results: </strong>The binocular uncorrected intermediate visual acuity, near visual acuity, and contrast sensitivity at 3 months was better in the enhanced monofocal group compared to the standard monofocal group (P < 0.001, P < 0.001, P = 0.02 respectively). The binocular uncorrected distance visual acuity at 3 months was comparable between the groups (P = 0.2); however, a higher number of cases attained visual acuity better than 6/9 in the enhanced monofocal IOL group. Post-operative higher-order aberrations were comparable between the groups. (P = 0.125).</p><p><strong>Conclusion: </strong>Bilateral implantation of enhanced monofocal IOLs in patients with cataract and low degrees of corneal astigmatism demonstrates better tolerance to astigmatism compared to standard monofocal IOLs. In cases with <1 D corneal astigmatism, the enhanced monofocal IOL is the preferred choice over the standard monofocal IOL.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 3","pages":"377-381"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of a novel technique of flange formation using green laser in 4-flange scleral fixated intra-ocular lens implantation.","authors":"Teena Agrawal, Mahesh Agrawal, Sakshi Tiwari, Durgesh Shukla","doi":"10.4103/IJO.IJO_1119_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1119_24","url":null,"abstract":"<p><strong>Purpose: </strong>Scleral-fixated intraocular lens (SFIOL) is the mainstay of restoration of vision where natural lens or its support is absent for placing an IOL in the bag. The aim of the study was to clinically evaluate the novel four-flange SFIOL technique using 532 nm laser for flange making in a tertiary eye care center in central India.</p><p><strong>Methods: </strong>We reviewed total 33 patients who have undergone four-flanged SFIOL between January 2023 to October 2023. The clinical parameters like best corrected visual acuity (BCVA), intraocular pressure (IOP), spherical equivalent (SE), and postoperative complication like cystoid macular edema (CME) were evaluated. All the surgeries were performed by a senior vitreo-retinal (VR) surgeon in a tertiary eye care center.</p><p><strong>Results: </strong>The mean preoperative BCVA was improved from 0.7 log MAR unit to 0.21 log MAR unit postoperatively. The mean preoperative IOP and SE improved from 19.48 mmHg to 17.12 mm Hg and 8.98D to 0.63D on postoperative follow-up, respectively. Early complications, within 1 month of surgery, noted in 15 patients (45%) and includes corneal edema - six cases (18.18%), CME - three cases (9.09%), intraocular lens tilting - two cases (6.06%), flange exposure - two cases (6.06%), and one case (3.03%) each of vitreous hemorrhage and glaucoma.</p><p><strong>Conclusion: </strong>Four-flange SFIOL using green laser for flange formation is a safe and effective modification of sutured SFIOL with good outcome in long term.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 3","pages":"408-413"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on: How to achieve excellent rotational stability and posterior capsule adhesion for in the bag IOL implantation?","authors":"Arvind K Morya","doi":"10.4103/IJO.IJO_2442_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2442_24","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 3","pages":"400-402"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A partial-thickness 'scleral belt loop' for MicroShunt implant.","authors":"Michele Figus, Francesco Sartini, Martina Menchini, Gianluca Guidi, Giamberto Casini, Chiara Posarelli","doi":"10.4103/IJO.IJO_1212_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1212_24","url":null,"abstract":"<p><p>The purpose of this article is to introduce a new surgical technique for the PreserFloTM MicroShunt implant. This technique involves creating a partial-thickness scleral belt loop before repositioning the Tenon's capsule and the conjunctiva toward the limbus. The distal end of the device is passed under the lamellar belt of the sclera, but the tip remains open and not covered by the loop. With this surgical technique, the MicroShunt adheres perfectly to the scleral profile of all eyes. As a result, the device's end tip does not stress the Tenon's/conjunctival flap during postoperative eye movements, thereby minimizing conjunctival erosion and inflammation. This method is efficient, requiring very short additional time. Consequently, it can be seamlessly integrated into the standard MicroShunt implant procedure without incurring extra costs, ultimately trying to reduce the need for surgical revisions of the filtration bleb.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 Suppl 2","pages":"S336-S338"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-demographic profile and visual outcomes of pseudophakic bullous keratopathy in a multi-tier eyecare network in India.","authors":"Anthony Vipin Das, Soujanya Kaup, Sujata Das","doi":"10.4103/IJO.IJO_323_24","DOIUrl":"10.4103/IJO.IJO_323_24","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to present the clinico-demographic characteristics of pseudophakic bullous keratopathy (PBK), its visual outcomes, factors associated with the choice of treatment, and poor visual outcomes of PBK.</p><p><strong>Methods: </strong>In this hospital-based retrospective study, electronic medical records data of new patients who presented to a multi-tier ophthalmology hospital network in India (November 2010-June 2022) were extracted. Patients with at least 4 weeks of follow-up were analyzed for visual outcome data. Bivariate analysis and multivariate logistic regression were used to determine the factors associated with the treatment choice and poor visual outcomes.</p><p><strong>Results: </strong>Of the 3,323,247 electronic records (with an average follow-up of 293 days) examined, 10,522 eyes of 10,158 patients (0.3%) had PBK. The majority were managed non-surgically ( n = 7372; 70.1%), with increased odds of poor visual outcome by 3.46 times (AdjOR: 3.04-3.92, P < 0.001). Those belonging to the non-paying category had higher odds of poor visual outcome (AdjOR: 1.48, 95%CI: 1.29-1.69; P < 0.001). Surgical management improved vision by 0.72 logMAR (95%CI: 0.60-0.73; P < 0.001). A total of 41.2% ( n = 113/274) of cases that underwent Descemet's membrane endothelial keratoplasty and 18.4% ( n = 285/1551) of Descemet's stripping endothelial keratoplasty attained last follow-up visual acuity (LVA) of 6/18 or better.</p><p><strong>Conclusion: </strong>About three in every thousand patients had PBK. Surgical interventions improved visual acuity significantly. About four in ten patients who underwent DMEK attained a vision of 6/18 or better at the last follow-up visit. Markers of lower socioeconomic strata were independently associated with poor visual outcomes.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"363-369"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evaluation and derivation of the Kannada version of the modified (29-item model) Indian Vision Function Assessment Questionnaire.","authors":"Soujanya Kaup, Jyoshma Dsouza, Siddharudha Shivalli, Sheetal Savur, Vidya Hegde","doi":"10.4103/IJO.IJO_1773_24","DOIUrl":"10.4103/IJO.IJO_1773_24","url":null,"abstract":"<p><strong>Background/aims: </strong>India's linguistic and cultural diversity necessitates a region-specific validated Visual Functioning Questionnaire. The objective of this study was to translate the Indian Vision Function Questionnaire-33 (IND-VFQ-33) into the Kannada language and test its psychometric properties, underlying factor structure, and model fit.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 330 participants, and basic psychometric properties (reliability, convergent, discriminant, construct validity, responsiveness, etc.) were assessed. The underlying factor structure was evaluated by exploratory factor analysis (EFA) and model fit by confirmatory factor analysis (CFA).</p><p><strong>Results: </strong>The Kannada version of IND-VFQ-33 exhibited robust psychometric properties [excellent content validity, reliability (Cronbach α = 0.91), test-retest reliability (Rho S = 0.99; P < 0.001), convergent (Rho S = 0.58; P < 0.001), and discriminant validity (Rho S = 0.06; P = 0.274)]. On EFA, items in the general functioning subscale fell into two categories, namely \"Mobility\" (10 items: Q1, Q2, Q4-Q9, Q15, and Q16) and \"Daily Activities\" (8 items: Q3, Q10, Q11, and Q17-Q21), and two other subscales \"psycho-social impact\" subscale (Q22-Q26) and the \"visual symptoms\" subscale (Q27-Q32, excluding Q33). Thus, a new Kannada-translated VFQ-29 questionnaire was derived with excellent psychometric properties. All observed variables showed significant factor loadings on their respective latent constructs (>0.50), establishing convergent validity on CFA by using the structural equation model. The model-fit to the data assessed by various indices [Root Mean Squared Error of Approximation = 0.08 (90% CI: 0.081-0.091); Comparative Fit Index = 0.877; Tucker-Lewis Index = 0.866; Akaike's Information Criterion = 23447.133; Bayesian Information Criterion = 23800.45, and Coefficient of Determination = 0.998] demonstrated acceptable fit.</p><p><strong>Conclusion: </strong>The refined 29-item Kannada-translated IND-VFQ model not only offers an improved factor structure across four subscales but also consistently demonstrates excellent reliability, convergent and discriminant validity, and responsiveness.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"429-436"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year outcomes of selective laser trabeculoplasty for open-angle glaucoma in Indian eyes.","authors":"Anuj Sharma, Arpita Nayak, Shamika Ghaisas, K Vidya","doi":"10.4103/IJO.IJO_1434_24","DOIUrl":"10.4103/IJO.IJO_1434_24","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effectiveness of selective laser trabeculoplasty (SLT) in Indian eyes with open-angle glaucoma (OAG).</p><p><strong>Settings and design: </strong>Single-center, prospective, interventional study.</p><p><strong>Methods: </strong>Patients undergoing SLT from January 2014 to June 2018 for OAG were included in the study. Treatment-naive naive as well as patients on antiglaucoma medications (AGM) with suboptimal intraocular pressure (IOP) control were included. The main outcome measure was the percentage reduction in IOP. Complete success was defined as IOP reduction > 20% from baseline after 12 months or reduction in the number of AGM. Qualified success was defined as > 20% IOP reduction at 12 months with AGM. Secondary outcomes were occurrence of adverse events and factors predicting treatment outcomes.</p><p><strong>Results: </strong>A total of 104 eyes of 62 Indian patients underwent SLT for OAG. Eighty-three (79.81%) eyes were treatment-naïve, and 21 (20.19%) eyes were on AGM. The median (IQR) baseline IOP was 20 (16-26) mmHg. At 12 months, the median IOP was 16 (4-19) mmHg, the median decrease in IOP was 4 (0-6.5) mmHg, and the percentage reduction in IOP was 17.42% (0%-30.76%). Maximum IOP reduction was noted at 12 months. Overall, success was achieved in 48 (46.15%) patients. Five eyes (4.8%) experienced minor SLT-related complications. Age, gender, prior use of AGM, type of OAG, and higher baseline IOP were not found to be predictive factors for treatment outcome.</p><p><strong>Conclusion: </strong>SLT was found to be a relatively safe and effective procedure in Indian eyes with OAG.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S221-S225"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of sociodemographic profile of glaucoma patients with risk factors, subtypes, and disease severity in a tertiary eye care facility in Northern India.","authors":"Harsh Kumar, Sagarika Patyal, Swati Singh, Arun K Yadav, Madhu Bhoot, Praveen Kumar Seth, Surbi Taneja, Suman Bandil, Arushi Puri","doi":"10.4103/IJO.IJO_3114_23","DOIUrl":"10.4103/IJO.IJO_3114_23","url":null,"abstract":"<p><strong>Purpose: </strong>To study the different subtypes of glaucoma and to analyze the demographic and clinical profile of glaucoma patients along with associated risk factors in a multi-locational North Indian study.</p><p><strong>Methods: </strong>Newly diagnosed and known glaucoma patients on treatment were enrolled in the study. Complete history was taken, and clinical evaluation was done by senior glaucoma experts.</p><p><strong>Results: </strong>Five hundred and eighty-six patients (1121 eyes) were included with 383 males (65.4%) and 203 females (34.6%). Of these, 508 (86.7%) had primary glaucoma and 78 (13.3%) had secondary glaucoma. Also, 263 (44.9%) patients had primary open angle glaucoma (POAG) and 172 (29.4%) had primary angle closure glaucoma. Four hundred and fifty-one (77%) were graduates or postgraduates and 293 (50%) were dependents on family income. One hundred and forty-one (24%) had a positive family history. Secondary glaucoma patients had a lower average age (52.6 ± 16.8 years) and higher average intraocular pressure (IOP; 34.23 ± 13 mm) compared to primary glaucoma patients (26.6 ± 9.7 mm) ( P < 0.0001). Thirty-three (47.8%) out of 78 secondary glaucoma patients had advanced disease. Seventy-four (12.6%) were first-time diagnosed and 18 had advanced disease. In addition, 161 eyes had one or more glaucoma surgeries done (128 trabeculectomy and 28 phacotrabeculectomy). Ninety-five (16.2%) patients were advised surgery at our centers (46 trab, 26 phacotrab, 15 phaco, five Ahmed glaucoma valve implantation, and three pars plana vitrectomy). Disease progression was noted in 62 patients reporting good compliance to medicines.</p><p><strong>Conclusion: </strong>POAG was the most common variant in this study. Secondary glaucoma patients were youngest in age and had the highest IOP. Trabeculectomy was the most performed surgery. A good literacy rate did not prevent late presentations.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S244-S249"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' response to comments on The effect of 2% pilocarpine on depth of field in different time intervals among presbyopic subjects.","authors":"Ashith Tripathi, Sachitanand Singh, Iqra Jamal Khan, Krishnasri Padamandala, Sebin C Sebastian","doi":"10.4103/IJO.IJO_78_25","DOIUrl":"https://doi.org/10.4103/IJO.IJO_78_25","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 Suppl 2","pages":"S351-S352"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}