Indian Journal of Ophthalmology最新文献_第7页

Amniotic membrane graft (AMG) for persistent epithelial defects following infective corneal ulcers and keratitis - A systematic review. 羊膜移植（AMG）治疗感染性角膜溃疡和角膜炎后的持续性上皮缺损 - 系统综述。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2024-09-10 DOI: 10.4103/IJO.IJO_300_24

Thanigasalam Thevi, Adinegara L Abas, Harminder S Dua

{"title":"Amniotic membrane graft (AMG) for persistent epithelial defects following infective corneal ulcers and keratitis - A systematic review.","authors":"Thanigasalam Thevi, Adinegara L Abas, Harminder S Dua","doi":"10.4103/IJO.IJO_300_24","DOIUrl":"10.4103/IJO.IJO_300_24","url":null,"abstract":"Management of nonhealing corneal ulcers is challenging as it can lead to complications such as melting, descemetocele, and perforation, which can be prevented by amniotic membrane graft (AMG). The absence of any review (English language) on AMG for corneal ulcers prompted us to conduct this review. We looked for clinical trials (randomized and controlled) on the effect of AMG combined with other treatments, through various search engines utilizing the terms amniotic membrane and corneal ulcer. All patients who received AMG and/or conventional medication were included. Risk of bias tools derived from Cochrane collaboration were used to ascertain the standard and quality of the trials. Visual acuity and epithelial healing time were the main outcome measures studied. Three trials were finally selected for analysis. AMG was noted to be associated with better uncorrected visual acuity and reduction in neovascularization. There was no difference in best corrected visual acuity, epithelial healing time, and corneal opacity. There is evidence that the use of AMG is associated with improved uncorrected visual acuity as well as reduction in neovascularization of the cornea among patients with corneal ulcers, but there was no improvement in epithelial healing time or corneal opacity. Further multicenter randomized controlled trials are needed to elicit the beneficial effects of the intervention and augment the validity of this review.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S361-S368"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contact lenses for visual rehabilitation in post-keratoplasty eyes: A review. 角膜移植术后隐形眼镜用于视力康复的研究进展。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.4103/IJO.IJO_2394_24

Mohamed Ibrahime Asif, Nidhi Kalra, Manasi Tripathi, Mrinalini Anand Yadav, Shahnaz Anjum, Rajesh Sinha

{"title":"Contact lenses for visual rehabilitation in post-keratoplasty eyes: A review.","authors":"Mohamed Ibrahime Asif, Nidhi Kalra, Manasi Tripathi, Mrinalini Anand Yadav, Shahnaz Anjum, Rajesh Sinha","doi":"10.4103/IJO.IJO_2394_24","DOIUrl":"10.4103/IJO.IJO_2394_24","url":null,"abstract":"To assess the role of various types of contact lenses (CL) after penetrating and lamellar keratoplasty, we reviewed all studies that were related to CL fitting in post-keratoplasty (full-thickness and lamellar) eyes between 1990 and 2024 by using relevant search keywords. The demographic data, indications for CL fitting, duration between keratoplasty and CL fitting, CL design and fitting methodologies, refractive outcomes, topographic and biomechanical changes, aberrometry, specular microscopy, corneal thickness, graft survival, and complications were analyzed. A total of 32 original studies and seven case reports were evaluated. All studies showed favorable refractive outcomes. Complications, if any, were managed successfully with conservative treatment and temporary discontinuation of lens wear. Most authors preferred to use large-diameter multicurve rigid-gas permeable lenses and scleral lenses over hydrogels and hybrid or piggy-back varieties, with an inclination toward late fitting due to multiple factors. The lenses did not have any adverse effect on graft survival. CLs are a useful tool in post-keratoplasty visual rehabilitation. However, patients require meticulous workup, a thorough fitting methodology, attention to associated problems, and close follow-up to monitor for complications.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S369-S383"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of oral bio-enhanced curcumin in dry eye disease. 口服生物增强姜黄素在干眼病中的作用。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.4103/IJO.IJO_1572_24

Dikshit Kapil, Aafreen Bari, Namrata Sharma, Thirumurthy Velpandian, Rajesh Sinha, Prafulla Maharana, Manpreet Kaur, Tushar Agarwal

{"title":"Role of oral bio-enhanced curcumin in dry eye disease.","authors":"Dikshit Kapil, Aafreen Bari, Namrata Sharma, Thirumurthy Velpandian, Rajesh Sinha, Prafulla Maharana, Manpreet Kaur, Tushar Agarwal","doi":"10.4103/IJO.IJO_1572_24","DOIUrl":"10.4103/IJO.IJO_1572_24","url":null,"abstract":"Purpose: To assess the role of oral bio-enhanced curcumin in dry eye disease (DED).Design: Randomized, double-masked, placebo-controlled clinical study conducted at a tertiary eye center.Methods: Forty patients of bilateral mild to moderate DED were randomized in two groups - group A (topical carboxy methyl cellulose QID + oral placebo) and group B (topical carboxy methyl cellulose QID + oral bio-enhanced curcumin). The objective parameters of DED were quantified at baseline and compared at 3 months follow-up.Results: At three months follow-up, there was significant improvement in curcumin group in terms of Ocular Surface Disease Index (OSDI) score ( P = 0.002), tear meniscus height (TMH) ( P = 0.002), tear volume ( P = 0.006), tear break-up time (TBUT) ( P < 0.001), non-invasive break-up time (NIBUT) ( P = 0.026), lipid layer thickness (LLT) ( P = 0.01), and decrease in bulbar redness ( P = 0.002). There was no significant improvement in limbal redness ( P = 0.097), corneal-staining score ( P = 0.93), and Schirmer's test ( P = 0.42). Mild adverse drug reaction was observed in three cases of the curcumin group and one case of group A.Conclusions: Oral bio-enhanced curcumin is a safe and effective treatment modality in cases of mild to moderate DED. It effectively improves the tear film stability, LLT, and TMH and reduces the bulbar redness.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S428-S434"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK-STAT inhibitors in noninfectious uveitis - A review. JAK-STAT抑制剂在非感染性葡萄膜炎中的应用综述。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_61_25

Richa Pyare, Nawazish Shaikh, Ahana Sen, Rakshita Kene, Narendra Bagri, Mahesh Janarthanan, Rohan Chawla, Athimalaipet V Ramanan, Parthopratim Dutta Majumder

{"title":"JAK-STAT inhibitors in noninfectious uveitis - A review.","authors":"Richa Pyare, Nawazish Shaikh, Ahana Sen, Rakshita Kene, Narendra Bagri, Mahesh Janarthanan, Rohan Chawla, Athimalaipet V Ramanan, Parthopratim Dutta Majumder","doi":"10.4103/IJO.IJO_61_25","DOIUrl":"10.4103/IJO.IJO_61_25","url":null,"abstract":"The management of noninfectious uveitis (NIU) has involved the use of corticosteroids and immunomodulators (IMT). However, a certain subset of NIU patients does not respond to conventional IMT therapy, such as methotrexate and azathioprine. In these patients, biological IMT with specific targets is employed. One such example is the use of TNF-α inhibitors, such as adalimumab and infliximab. These biologics target specific inflammatory cytokines, unlike the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. JAK-STAT inhibitors (JAKinibs) are classified as targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs), which are small-molecule drugs that are chemically synthesized rather than biologically derived. In contrast to biologic DMARDs or bDMARDs, tsDMARDs are smaller molecules that are orally available, nonimmunogenic, and capable of crossing the cell membrane. JAKinibs can simultaneously block multiple cytokine-signalling pathways, such as those driven by IL-6, IL-12, IL-23 and IL-17, as they dampen Th1- and Th17-driven inflammation. This ability to target a broad range of inflammatory cytokines and immune pathways theoretically enables JAKinibs to be viable alternatives for the treatment of NIU resistant to conventional IMT and biologicals. JAK-STAT inhibitors, such as tofacitinib, baricitinib, upadacitinib, peficitinib, delgocitinib, and filgotinib have been FDA-approved for use in autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and inflammatory bowel disease. The available literature suggests the potential efficacy of these drugs in controlling uveitic inflammation; however, their use in NIU is still under investigation, with no randomized controlled trials providing Level I evidence.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 6","pages":"807-815"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating anti-VEGF responses in diabetic macular edema: A systematic review with AI-powered treatment insights. 评估糖尿病黄斑水肿的抗vegf反应：人工智能治疗见解的系统综述

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_1810_24

S Tamilselvi, M Suchetha, Dhanashree Ratra, Janani Surya, S Preethi, Rajiv Raman

{"title":"Evaluating anti-VEGF responses in diabetic macular edema: A systematic review with AI-powered treatment insights.","authors":"S Tamilselvi, M Suchetha, Dhanashree Ratra, Janani Surya, S Preethi, Rajiv Raman","doi":"10.4103/IJO.IJO_1810_24","DOIUrl":"10.4103/IJO.IJO_1810_24","url":null,"abstract":"Recent advances in deep learning and machine learning have greatly increased the capabilities of extracting features for evaluating the response to anti VEGF treatment in patients with Diabetic Macular Edema (DME). In this review, we explore how these algorithms can be used for discriminating between responders and non-responders to anti vascular endothelial growth factor (VEGF) injections. Electronic databases, including PubMed, IEEE Xplore, BioMed, JAMA, and Google Scholar, were searched, and reference lists from relevant publications were also considered from inception till August 31, 2023, based on the inclusion and exclusion criteria. Data extraction was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The results focus on keywords such as DME, OCT, anti VEGF, and patient responses after anti VEGF injections. The article measures the effectiveness of different machine learning and deep learning algorithms, including linear discriminant analysis (LDA), ResNet-50, CNN with attention, quadratic discriminant analysis (QDA), random forest (RF), and support vector machines (SVM), in analyzing eyes that could tolerate extended interval dosing. According to a review of 50 relevant papers published between 2016 and 2023, the algorithms achieved an average automated sensitivity of 74% (95% CI: 0.55-0.92) in detecting treatment responses.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 6","pages":"797-806"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OCTA in retina practice - Has it come of age? 视网膜治疗中的OCTA——成熟了吗？

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_711_25

Muna Bhende

引用次数: 0

Ocular cues to a larger picture! 眼睛暗示着更大的图景！

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_2077_24

Aruja Gangwani, Meghna Ganesh, Vinod Kumar

引用次数: 0

Post-chemotherapy sudden vision loss. 化疗后突然失明。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_89_25

Janani Sreenivasan, Henna Valakkadavil Vinayan

引用次数: 0

The impact of genetic testing in retinitis pigmentosa on reproductive medicine. 视网膜色素变性基因检测对生殖医学的影响。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.4103/IJO.IJO_48_25

Bansari Sorthiya, Puja Maitra

引用次数: 0

Validation of ocular trauma score (OTS) in open- and closed-globe injuries in Indian patients. 眼外伤评分（OTS）在印度患者开闭眼损伤中的验证。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-06-01 Epub Date: 2025-05-30 DOI: 10.4103/IJO.IJO_2737_24

Fatema J Noble, Sumeet T Lahane, Tatyarao P Lahane, Ragini H Parekh, Sayalee T Lahane, Priyanka P Dhaytadak, Ashish K Jain

{"title":"Validation of ocular trauma score (OTS) in open- and closed-globe injuries in Indian patients.","authors":"Fatema J Noble, Sumeet T Lahane, Tatyarao P Lahane, Ragini H Parekh, Sayalee T Lahane, Priyanka P Dhaytadak, Ashish K Jain","doi":"10.4103/IJO.IJO_2737_24","DOIUrl":"10.4103/IJO.IJO_2737_24","url":null,"abstract":"Purpose: To validate the predictive value of the ocular trauma score (OTS) in open- and closed-globe eye injuries in the Indian context.Design: Prospective interventional case series.Methods: This study, conducted at a tertiary healthcare institute from January 2018 to June 2019, included 150 eyes of 150 patients with open- and closed-globe injuries. Inclusion criteria were patients with globe injuries who provided informed consent and had complete OTS data. Exclusion criteria included electric, chemical, and thermal injuries, prior surgery, pre-existing poor visual acuity (VA), and severe systemic injuries. There was no randomization. Demographic details, initial and final VA, injury type, and OTS variables were recorded. Patients were classified into OTS categories preoperatively based on Kuhn et al.'s system, and VA distribution was compared with the original study. The main outcome was to assess the correlation between the final BCVA at 6 months post-intervention and the predicted VA based on the OTS category.Results: A total of 150 patients (72% open globe, 28% closed globe) were included, with a male-to-female ratio of 4.5:1. The mean age ± SD was 29.34 ± 17.49 years. OTS classification showed 6% in OTS 1, 17% in OTS 2, 67% in OTS 3, 4% in OTS 4, and 6% in OTS 5. Final VA was ≤20/40 (41%), 20/50-20/200 (20%), 20/200-1/200 (15%), HM/PL (15%), and NLP (9%). Final VA post-treatment correlated with predicted VA as per the OTS category (Spearman's r = 0.53, P < 0.001).Conclusion: OTS provides reliable prognostic information and has fair predictive value for final VA in open- and closed-globe injuries.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 Suppl 3","pages":"S498-S501"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0