Indian Journal of Ophthalmology最新文献_第4页

Reflections - For today leads into tomorrow.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-12-23 DOI: 10.4103/IJO.IJO_3040_24

Murugesan Vanathi

引用次数: 0

Red-free visualization enhances ease of laser therapy for retinopathy of prematurity.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-12-24 DOI: 10.4103/IJO.IJO_2108_24

Shakha, Parijat Chandra

引用次数: 0

Variations in clinical manifestations of post-fever retinitis during the COVID-19 pandemic.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-12-24 DOI: 10.4103/IJO.IJO_1702_24

Alok Sen, Pranav Saluja, Amruta More, Sachin B Shetty, Priyansha Multani

引用次数: 0

Erratum: Bedside bilateral sequential intravitreal anti-VEGF injections for retinopathy of prematurity. 勘误：床旁双侧序贯玻璃体内抗血管内皮生长因子注射治疗早产儿视网膜病变。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-12-24 DOI: 10.4103/IJO.IJO_2278_24

引用次数: 0

Gut and intraocular fluid dysbiosis in people with type 2 diabetes-related retinopathy in India: A case for further research. 印度 2 型糖尿病相关视网膜病变患者的肠道和眼内液菌群失调：需要进一步研究。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.4103/IJO.IJO_966_24

Taraprasad Das, Brijesh Takkar, Shalem R Padakandala, Sisinthy Shivaji

{"title":"Gut and intraocular fluid dysbiosis in people with type 2 diabetes-related retinopathy in India: A case for further research.","authors":"Taraprasad Das, Brijesh Takkar, Shalem R Padakandala, Sisinthy Shivaji","doi":"10.4103/IJO.IJO_966_24","DOIUrl":"10.4103/IJO.IJO_966_24","url":null,"abstract":"Purpose: To explore the relationship between gut microbiome, gut mycobiome, and intraocular (aqueous humor) microbiome dysbiosis in people with type 2 diabetes (T2DM) and diabetic retinopathy (DR).Design: Multiple case-control studies.Methods: We evaluated three groups of people: healthy controls (HC), people with T2DM without retinopathy, and those with DR. The study samples included fecal matter (30-50 g) and aqueous humor (0.05-0.1 mL). After amplicon sequencing, we analyzed microbiome profiles (V3-V4 region of bacterial 16S rRNA gene) and mycobiome (ITS2 region of fungal rRNA gene). The main outcome measures were relative abundance, α and β diversity, and dysbiotic bacteria and fungi, analyzed based on the inferred functions of the taxa.Results: We recruited 82 people for gut microbiome (30 HC, 24 DM, and 28 DR); 75 people for gut mycobiome (30 HC, 21 DM, and 24 DR); and 12 people for aqueous humor microbiome (4 each HC, DM, and DR) studies. Generally, there was an increased abundance of pro-inflammatory and pathogenic microorganisms and a decreased abundance of anti-inflammatory and probiotic microorganisms. The differences were higher between HC and DM/DR than between DM and DR. In aqueous humor, there was a wider separation in microbiome profiles of people with DR than their gut microbiome.Conclusion: The gut and aqueous humor microbiota of people with diabetes and DR may differ from those without diabetes. Given these unique observations in individuals living in one region of India, further research involving people from different regions is required to identify indices for possible regional or global use.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S144-S150"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of cytokine levels and postnatal factors with retinopathy of prematurity. 细胞因子水平和产后因素与早产儿视网膜病变的关系。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.4103/IJO.IJO_515_24

Syatirah Abu Yazib, May May Choo, Nurliza Khaliddin, Christine Py Ong, Yao Mun Choo, Azanna Ahmad Kamar, Gopal G Lingam, Tengku A Kamalden

{"title":"The association of cytokine levels and postnatal factors with retinopathy of prematurity.","authors":"Syatirah Abu Yazib, May May Choo, Nurliza Khaliddin, Christine Py Ong, Yao Mun Choo, Azanna Ahmad Kamar, Gopal G Lingam, Tengku A Kamalden","doi":"10.4103/IJO.IJO_515_24","DOIUrl":"10.4103/IJO.IJO_515_24","url":null,"abstract":"Purpose: Prematurity has been known to trigger several cellular pathways, leading to the clinical occurrence of retinopathy of prematurity (ROP). This study compared the levels of a panel of serum cytokines in premature infants with and without ROP.Methods: This is a prospective observational study. Premature infants at 36-38 weeks' gestational age were recruited, their clinical data recorded, and serum samples collected and assayed for 18 cytokines. Based on follow-up examinations, patients were divided into two groups: No ROP and ROP. The ROP group was further divided into two subgroups: non-vision-threatening ROP (non-VTROP), and vision-threatening ROP (VTROP).Results: On univariate analysis, among the clinical parameters, gestation age, birth weight, duration of invasive ventilation, and duration of stay in neonatal intensive care unit (NICU) were found to be significant. The univariate analysis also showed an association between raised levels of VEGF-D and IL-8 in the VTROP group. Multiple logistic regression indicated that gestation age was a significant risk factor across all subgroups. Additionally, VEGF-D levels were found to be significantly associated with VTROP.Conclusion: Higher VEGF-D levels are associated with an increased risk of severe ROP that requires treatment and could potentially be used as a biomarker.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S139-S143"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractory acute retinal necrosis presenting as peripapillary choroiditis - A diagnostic and therapeutic challenge. 表现为毛细血管周围脉络膜炎的难治性急性视网膜坏死--诊断和治疗难题。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-08-14 DOI: 10.4103/IJO.IJO_894_24

Ankush Kawali, Sai Bhakti Mishra, Padmamalini Mahendradas, Rohit Shetty

引用次数: 0

Corneal densitometry changes post-CXL for keratoconus: Comparative evaluation of epithelium-off, contact lens-assisted, and transepithelial techniques. 角膜塑形镜（CXL）治疗角膜炎后角膜密度的变化：上皮脱落、隐形眼镜辅助和经上皮技术的比较评估。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-09-10 DOI: 10.4103/IJO.IJO_485_24

Barkha Gupta, Chintan Malhotra, Supriya Dhar, Khushdeep Abhyapal, Arun K Jain, Amit Gupta

{"title":"Corneal densitometry changes post-CXL for keratoconus: Comparative evaluation of epithelium-off, contact lens-assisted, and transepithelial techniques.","authors":"Barkha Gupta, Chintan Malhotra, Supriya Dhar, Khushdeep Abhyapal, Arun K Jain, Amit Gupta","doi":"10.4103/IJO.IJO_485_24","DOIUrl":"10.4103/IJO.IJO_485_24","url":null,"abstract":"Purpose: To evaluate changes in corneal backscattering after collagen cross-linking (CXL) for progressive keratoconus and compare its course with different techniques - standard epithelium-off CXL (SCXL), contact lens-assisted CXL (CACXL), and transepithelial CXL (TECXL).Setting: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.Design: Retrospective comparative study.Methods: Ninety-four eyes (SCXL: 47, CACXL: 30, and TECXL: 17) were compared. Corneal haze was quantified using Scheimpflug tomography, pre- and post-CXL at 1, 3, 6, and 12 months.Results: The baseline mean density score of the central anterior stromal layer was 16.14 ± 7.07, 15.85 ± 7.89 and 15.89 ± 7.21 in SCXL, CACXL, and TECXL groups, respectively ( P 0.93). After SCXL, the score increased to 28.83 and 31.34 at 1 and 3 months, respectively (both P < 0.001) and dropped at 6 months (28.66, P < 0.001) and 12 months (23.72, P 0.003). Post-CACXL, the mean densitometry peaked at 3 months (20.35, P 0.14) and returned toward baseline at 6 months (18.82, P 0.15). After TECXL, it increased slightly at 1 month (18.47, P 0.17), decreased at 3 months (14.88, P 0.7), and plateaued over 1 year. No correlation with visual acuity was seen.Conclusion: Corneal haze increased significantly after SCXL, peaking at 3 months, declining over 6-12 months, and returning to baseline at 12 months. In contrast, post-TECXL and -CACXL, there was an insignificant increase in anterior corneal haze, which returned to baseline within 3-6 months.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"102-109"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of current methods of preparation and distribution of DMEK graft at the eye banks.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-12-23 DOI: 10.4103/IJO.IJO_243_24

Shalini Singh, Priyanka Pantola, Sunita Chaurasia, Sujata Das, Somasheila Murthy

引用次数: 0

12-month outcomes of ziv-aflibercept for neovascular age-related macular degeneration in eyes previously treated with aflibercept.

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-12-24 DOI: 10.4103/IJO.IJO_627_24

Wajiha J Kheir, Mahdi Hassoun, Rola N Hamam, Ziad Fayez Bashshur

{"title":"12-month outcomes of ziv-aflibercept for neovascular age-related macular degeneration in eyes previously treated with aflibercept.","authors":"Wajiha J Kheir, Mahdi Hassoun, Rola N Hamam, Ziad Fayez Bashshur","doi":"10.4103/IJO.IJO_627_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_627_24","url":null,"abstract":"Purpose: To investigate the 12-month outcomes of ziv-aflibercept for neovascular age-related macular degeneration (nAMD) in eyes previously treated with aflibercept.Methods: Retrospective chart review of patients with nAMD previously treated with aflibercept for at least 12 months and subsequently transitioned to ziv-aflibercept between January 1, 2019, and December 31, 2022, for a period of at least 12 months. Participants were identified, and their clinical and imaging information was extracted from our electronic health records system. Data on best corrected visual acuity (BCVA), intraocular pressure, injection intervals, central retinal thickness (CRT), volume cube presence of subretinal fluid (SRF), and intraretinal fluid (IRF) were obtained. Main outcome measures included changes in BCVA, injection intervals, CRT, SRF, and IRF before and after 12 months of ziv-aflibercept treatment.Results: Fifty-four eyes of 44 patients were included in the study. After 12 months of ziv-aflibercept treatment, BCVA decreased by 0.84 ETDRS letters (P = 0.424) compared to BCVA at the last visit prior to conversion from aflibercept. Injection intervals decreased by 1.18 weeks (P = 0.489). CRT significantly decreased by 15.66 µm (P = 0.005). SRF was present initially in 31.5% of eyes and decreased to 22.2% (P = 0.125). IRF was present initially in 42.6% of eyes and decreased to 35.2% (P = 0.219).Conclusion: Ziv-aflibercept demonstrated effectiveness in maintaining treatment outcomes in nAMD eyes previously treated with aflibercept. The treatment was well-tolerated with no reported adverse events. Ziv-aflibercept may be a cost-effective alternative and a potential solution to the financial burden associated with conventional anti-VEGF agents.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 Suppl 1","pages":"S78-S82"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0