Indian Journal of Ophthalmology最新文献_第4页

Bacterial 16S rRNA gene alterations in the conjunctival sac and lacrimal sac in chronic dacryocystitis. 慢性泪囊炎患者结膜囊和泪囊细菌16S rRNA基因的改变。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_1314_24

Jie Chen, Fangzheng Shi, Siya Chen, Yulu Liu, Yuxin Xu

{"title":"Bacterial 16S rRNA gene alterations in the conjunctival sac and lacrimal sac in chronic dacryocystitis.","authors":"Jie Chen, Fangzheng Shi, Siya Chen, Yulu Liu, Yuxin Xu","doi":"10.4103/IJO.IJO_1314_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1314_24","url":null,"abstract":"Purpose: Dysbiosis of the microbial community in the lacrimal sac has been associated with the occurrence and development of chronic dacryocystitis. The aim of this study was to investigate the microbial characteristics of the conjunctival sac and lacrimal sac in patients with chronic dacryocystitis using 16S rRNA sequencing and explore their relevance to this condition.Methods: This was achieved through the application of Illumina MiSeq technology for the comprehensive sequencing of 16S rRNA genes in bacterial DNA samples isolated from the conjunctival and lacrimal sacs of 20 patients with chronic dacryocystitis.Results: The conjunctival sac microbiota showed slightly higher diversity compared to the lacrimal sac. However, their microbial communities were similar. In the cohort representing the lacrimal sac, there was a notable reduction in the relative abundance of Proteobacteria. Conversely, an increase in the relative richness of phyla such as Firmicutes, Actinobacteria, and Bacteroidetes was observed. Linear discriminant analysis and effect size analysis elucidated a significant enrichment of the Methylobacterium and Cetobacterium genera within the conjunctival sac cohort, in contrast to the lacrimal sac cohort. The dominant pathway in both sites was biosynthesis according to Kyoto Encyclopedia of Genes and Genomes analysis.Conclusion: In individuals suffering from chronic dacryocystitis, the microbiota of the lacrimal sac exhibits a reduced α-diversity and a comparable β-diversity, alongside exhibiting distinct taxonomic profiles when contrasted with the microbiota of the conjunctival sac.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Retilight, a portable LED endo-illuminator. 这是一款便携式LED内照灯。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_2234_24

Prithvi Chandrakanth, Shishir Verghese, Aishwarya Naik, K Chandrakanth

引用次数: 0

The clinical spectrum of bulbar conjunctival rhinosporidiosis. 球结膜鼻孢子虫病的临床特征。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_52_24

Prasansha Narnoli, Suryasnata Rath, Samir Mohapatra, Mukesh Jain, Devjyoti Tripathy

{"title":"The clinical spectrum of bulbar conjunctival rhinosporidiosis.","authors":"Prasansha Narnoli, Suryasnata Rath, Samir Mohapatra, Mukesh Jain, Devjyoti Tripathy","doi":"10.4103/IJO.IJO_52_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_52_24","url":null,"abstract":"Purpose: To report the clinical spectrum of bulbar conjunctival rhinosporidiosis at a tertiary eye care oculoplastics facility.Methods: Retrospective chart review of biopsy-proven ocular and adnexal rhinosporidiosis over a five-year period (2017-2022). Demographic details, clinical presentation, management interventions, and outcomes in a series of cases with bulbar conjunctival rhinosporidiosis were documented and analyzed.Results: A total of 14 cases of biopsy-proven bulbar conjunctival rhinosporidiosis were included in this study. These formed 22.2% of all cases of ocular adnexal rhinosporidiosis and 46.7% of all conjunctival cases diagnosed within the study period. All the cases underwent surgical excision of the conjunctival mass with five (35.7%) requiring a scleral patch graft for scleral thinning with or without staphyloma formation. Most patients had a good outcome on medium to long-term follow-up.Conclusions: Even though tarsal conjunctival involvement is reported as the most common form of conjunctival rhinosporidiosis in the literature, in our series, bulbar conjunctival disease comprised nearly half of all conjunctival cases, and over 20% of all adnexal cases. Most appear to do well with complete surgical excision of the granuloma. Rarely, long-standing cases may develop scleral thinning with or without staphyloma formation which may need major tectonic support to protect the integrity of the eyeball. Most of these also appear to do well on medium to long-term follow-up.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and effectiveness of brolucizumab in patients with neovascular age-related macular degeneration: A phase IV study from India. brolucizumab在新生血管性年龄相关性黄斑变性患者中的安全性和有效性：来自印度的一项IV期研究

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_1914_24

Asim K Ghosh, Debdulal Chakraborty, Aditya Sudhalkar, Rohan Chawla, Simar R Singh, Atul K Sahu, Ramesh Venkatesh, Vishal Raval, Sonali Shah, Padma Preetha, Maulik Bhavsar, Sandip Patil, Isha Khadke, Anup Thorat

{"title":"Safety and effectiveness of brolucizumab in patients with neovascular age-related macular degeneration: A phase IV study from India.","authors":"Asim K Ghosh, Debdulal Chakraborty, Aditya Sudhalkar, Rohan Chawla, Simar R Singh, Atul K Sahu, Ramesh Venkatesh, Vishal Raval, Sonali Shah, Padma Preetha, Maulik Bhavsar, Sandip Patil, Isha Khadke, Anup Thorat","doi":"10.4103/IJO.IJO_1914_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1914_24","url":null,"abstract":"Purpose: The purpose of this study is to evaluate the safety and effectiveness of brolucizumab intravitreal injections (IVI) in Indian patients with neovascular age-related macular degeneration (nAMD).Methods: This prospective, interventional, single-arm, open-label phase IV study included 105 treatment-naïve nAMD patients prescribed brolucizumab as per the local prescribing information, across ten centers. The treatment period consisted of 56 weeks, including loading doses at Weeks 0, 4, and 8, followed by disease activity assessment at Week 16, evaluating patients for 12-weekly (q12w) or 8-weekly (q8w) dosing. The primary endpoint was the incidence and characteristics of treatment-emergent adverse events (TEAEs) during 56 weeks. Secondary endpoints included changes in effectiveness variables - visual acuity, intraretinal fluid (IRF), subretinal fluid (SRF), and central subfield thickness (CST), at 16 and 56 weeks.Results: Post-Week 16, 74 (70.5%) patients received q12w, and 27 (25.7%) patients received q8w dosing. Four TEAEs were reported in three (2.9%) patients, all ocular: vitritis in two patients who were discontinued and retinal vasculitis and uveitis in one patient who completed the study. No TEAEs were severe, and there were no serious adverse events. Best corrected visual acuity (BCVA) improved significantly by seven letters (95% CI: 5.0, 10.0) at Week 16 and by 15 letters (95% CI: 10.0, 18.0) at Week 56 (P < 0.0001 for both). All anatomical parameters also showed significant reductions over the study period.Conclusions: Brolucizumab 6 mg IVI, given as per the prescribing information, demonstrated a positive benefit/risk profile in Indian patients with nAMD, with no new safety signals.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of topical nepafenac 0.1% and 0.3% on aqueous flare and macular thickness in patients with pseudoexfoliation following cataract surgery. 0.1%和0.3%外用尼泊芬酸对白内障手术后假性角膜脱落患者水光斑和黄斑厚度的影响。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_2916_24

Yusuf B Akbas, Fahri O Aydin, Merve Kelebek, Semih Cakmak, Ali Ceylan, Zeynep Serikoglu Akbas, Yusuf Yildirim, Burcin Kepez Yildiz

{"title":"Comparison of topical nepafenac 0.1% and 0.3% on aqueous flare and macular thickness in patients with pseudoexfoliation following cataract surgery.","authors":"Yusuf B Akbas, Fahri O Aydin, Merve Kelebek, Semih Cakmak, Ali Ceylan, Zeynep Serikoglu Akbas, Yusuf Yildirim, Burcin Kepez Yildiz","doi":"10.4103/IJO.IJO_2916_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2916_24","url":null,"abstract":"Purpose: To evaluate and compare the efficacy of topical nepafenac 0.1% administered three times daily versus nepafenac 0.3% administered once daily in patients with pseudoexfoliation syndrome (PEX) following routine cataract surgery.Methods: In this retrospective cohort study, patients with PEX undergoing routine cataract surgery were divided into two groups for analysis. Group 1 received nepafenac 0.1% three times daily, while Group 2 received nepafenac 0.3% once daily. In both groups, nepafenac was started 1 day before surgery and continued for 2 weeks postoperatively. Anterior chamber flare was quantified using laser flare photometry (LFP), and central macular thickness (CMT) was measured using optical coherence tomography. Measurements were taken preoperatively, at 1 week, and at 6 weeks postoperatively.Results: The study included 85 eyes from 85 patients, with 39 eyes in Group 1 and 46 eyes in Group 2. During the first postoperative week, Group 2 showed a significant reduction in LFP measurements (P = 0.047) compared to Group 1. Notably, no significant difference was observed between the groups at the preoperative visit or at postoperative week 6. Comparisons of preoperative, 1-week, and 6-week postoperative CMT values also revealed no significant differences between the groups.Conclusion: Nepafenac 0.3% used in routine cataract surgery in patients with PEX was shown to be at least as effective as nepafenac 0.1% in terms of aqueous flare and CMT. Aqueous flare values were more favorable with nepafenac 0.3% during the first week. In addition, the convenience of once-daily dosing may offer further advantages.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of utilization rate and graft outcomes of corneas from cadaveric donors (CDs) versus multiorgan donors (MDs). 尸体供体（cd）与多器官供体（MDs）角膜移植的利用率和移植结果比较。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_1899_24

Aishwarya Rathod, Radhika Tandon, Murugesan Vanathi, Noopur Gupta, Neiwete Lomi, Nishat Hussain Ahmed, Abhijeet Beniwal, Deepak Gupta

{"title":"Comparison of utilization rate and graft outcomes of corneas from cadaveric donors (CDs) versus multiorgan donors (MDs).","authors":"Aishwarya Rathod, Radhika Tandon, Murugesan Vanathi, Noopur Gupta, Neiwete Lomi, Nishat Hussain Ahmed, Abhijeet Beniwal, Deepak Gupta","doi":"10.4103/IJO.IJO_1899_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1899_24","url":null,"abstract":"Purpose: The purpose is to compare the utilization rate and corneal graft outcomes from multiorgan donors (MDs) versus those from cadaveric donors (CDs).Methods: In this ambispective and observational study, 36 corneas obtained from MDs and 72 corneas from their age-matched and sex-matched voluntary donors under the Hospital Cornea Retrieval Program (HCRP) from an eye bank were assessed clinically using slit lamp and under a specular microscope for their suitability for utilization. The percent utilization for keratoplasties was noted and compared between the two donor sources as the primary outcome. The transplanted corneas were followed up for 18 months for the assessment of graft survival and other outcome parameters.Results: The utilization rate of corneas obtained from MDs (80.6%) was significantly higher than that of corneas obtained from CDs (68.1%). The mean endothelial cell density (ECD) was significantly higher in corneas from MD as compared to those from CD (P = 0.037) at 18 months. The Kaplan-Meier survival analysis revealed a cumulative graft failure rate over 1.5 years as 10.3% for corneas obtained from MD and 16.3% for corneas obtained from CD. The microbiological analysis of the corneoscleral rim sent intraoperatively revealed three culture-positive specimens, two from CD, and one from MD.Conclusion: The donor source was a significant factor in determining the suitability of corneas for keratoplasty. Death preservation interval, cause of death, ECD, and processing had a modest influence on tissue suitability or quality. This data may help eye banks formulate policies that can maximize the procurement of corneas from MDs under HCRP.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wound morphologies of sclerotomies closed with scleral massage and scleral needling techniques: A comparative study. 巩膜按摩与巩膜针刺缝合巩膜切开术创面形态的比较研究。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_2184_24

Ebubekir Durmuş, Alev Kose, Veysel Aykut, Nursal Melda Yenerel, Halit Oğuz, Fehim Esen

{"title":"Wound morphologies of sclerotomies closed with scleral massage and scleral needling techniques: A comparative study.","authors":"Ebubekir Durmuş, Alev Kose, Veysel Aykut, Nursal Melda Yenerel, Halit Oğuz, Fehim Esen","doi":"10.4103/IJO.IJO_2184_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2184_24","url":null,"abstract":"Background: This prospective study aimed to compare scleral needling with the conventional scleral massage technique for sclerotomy closure, using anterior segment optical coherence tomography (AS-OCT) to assess postoperative wound morphology.Methods: Thirty eyes of 30 patients undergoing pars plana vitrectomy with a 25G vitrectomy system (Constellation; Alcon Laboratories, Fort Worth, TX, USA) were included. In each eye, one superior sclerotomy site (superonasal or superotemporal) was closed with scleral needling (Group A), while the other was closed with scleral massage (Group B), eliminating the impact of individual variability.Results: Most sclerotomies (80%) could be closed with a single attempt of needling (mean 1.2 ± 0.4). The mean outer and inner sclerotomy incision diameters on the postoperative first day were 119 ± 22 and 94 ± 17 μm, respectively, for group A, and 118 ± 19 and 94 ± 16 μm, respectively, for group B (P = 0.658 and 0.871, respectively). Sclerotomy wound diameters of both groups A and B decreased significantly on postoperative day 14 (P < 0.001 and P < 0.001, respectively). None of the patients developed postoperative hypotony or any severe complication. A conjunctival bleb in four Group A patients resolved by day 3.Conclusion: The newly described scleral needling technique was as successful and safe as the conventional scleral massage technique. AS-OCT imaging also confirmed that scleral needling did not cause any disruption on wound morphology.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OCT angiography findings in type 2 macular telangiectasia: A meta-analysis. 2型黄斑毛细血管扩张的OCT血管造影结果：荟萃分析。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_962_24

Vahid Zare Hosseinabadi, Fatemeh Abdi, Sadaf Parvin, Sara Hemmati, Samira Chaibakhsh

{"title":"OCT angiography findings in type 2 macular telangiectasia: A meta-analysis.","authors":"Vahid Zare Hosseinabadi, Fatemeh Abdi, Sadaf Parvin, Sara Hemmati, Samira Chaibakhsh","doi":"10.4103/IJO.IJO_962_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_962_24","url":null,"abstract":"Abstract: This meta-analysis evaluates optical coherence tomography angiography (OCTA) results in macular telangiectasia (MacTel) type 2, a rare retinal condition marked by vascular abnormalities. We analyzed 26 studies for OCTA findings in MacTel type 2. We examined parameters like best corrected visual acuity (BCVA), foveal avascular zone (FAZ), and superficial and deep capillary plexus densities. The pooled mean BCVA was 0.37 log of minimum angle of resolution (20/50). FAZ enlargement was observed, with a pooled mean FAZ size of 0.39 mm2. Foveal deep vascular density (FDVD) and parafoveal superficial vascular density (PSVD) were significantly reduced (P = 0.021 and P < 0.001, respectively). Parafoveal deep vascular density (PDVD) and foveal superficial vascular density (FSVD) did not decrease significantly (P = 0.067 and 0.114, respectively). MacTel type 2 has unique OCTA characteristics, including reduced FDVD, PSVD, and enlarged FAZ. However, FSVD and PDVD did not statistically decrease in patients. Future studies using more parameters are required to expand our understanding.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraocular lens position outcomes in modified Yamane's technique: The comparison of anterior vitrectomy versus pars plana vitrectomy. 改良Yamane技术对人工晶状体位置的影响：玻璃体前体切除术与玻璃体平面部切除术的比较。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_2927_24

Cemile Ucgul Atilgan, Kemal Tekin, Merve Temmuz Aydugan, Pinar Kosekahya, Ali Kosekahya, Mehmet Citirik

{"title":"Intraocular lens position outcomes in modified Yamane's technique: The comparison of anterior vitrectomy versus pars plana vitrectomy.","authors":"Cemile Ucgul Atilgan, Kemal Tekin, Merve Temmuz Aydugan, Pinar Kosekahya, Ali Kosekahya, Mehmet Citirik","doi":"10.4103/IJO.IJO_2927_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2927_24","url":null,"abstract":"Purpose: To evaluate the differences in intraocular lens (IOL) decentration, tilt, and lenticular astigmatism between Yamane's IOL fixations combined with pars plana vitrectomy (PPV) or anterior vitrectomy (AV), as well as compare those results with standard phacoemulsification surgery at the sixth month.Methods: This prospective longitudinal comparative study included 20 eyes treated with Yamane's IOL fixation combined with AV (AV group), 20 eyes treated with Yamane's IOL fixation combined with PPV (PPV group), and 20 eyes that underwent standard phacoemulsification with the implantation of a foldable IOL in the capsular bag as controls (Phaco group). IOL decentration, tilt, and lenticular astigmatism values were compared between the groups.Results: The horizontal tilt angle was statistically significantly lower in the Phaco group compared to the PPV and AV groups, while no significant differences existed between the PPV and AV groups. The mean values of horizontal decentration, vertical decentration, and vertical tilt 6 months postoperatively showed no statistically significant differences between the three groups (P > 0.05 for all), while all parameters were lower in the Phaco group. Moreover, no statistically significant differences existed in accordance with the mean lenticular astigmatism 6 months postoperatively between the three groups (P = 0.969).Conclusion: AV or PPV combined with Yamane's technique exhibited similar IOL decentration, tilt, and lenticular astigmatism at 6 months.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced glycation end products are biomolecular biomarkers for proliferative diabetic retinopathy. 晚期糖基化终产物是增殖性糖尿病视网膜病变的生物分子标志物。

IF 2.1 4区医学

Indian Journal of Ophthalmology Pub Date : 2025-04-17 DOI: 10.4103/IJO.IJO_2115_24

Nibha Mishra, Sandeep Saxena, Rajendra K Shukla, Anshul Tiwari

{"title":"Advanced glycation end products are biomolecular biomarkers for proliferative diabetic retinopathy.","authors":"Nibha Mishra, Sandeep Saxena, Rajendra K Shukla, Anshul Tiwari","doi":"10.4103/IJO.IJO_2115_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2115_24","url":null,"abstract":"Abstract: The present study examines the role of advanced glycation end products (AGEs) as biomolecular biomarkers for proliferative diabetic retinopathy (PDR). A cross-sectional study with a total of 80 consecutive cases of type 2 diabetes mellitus (DM) was divided into no retinopathy (NoDR) (n = 20), non-proliferative diabetic retinopathy (NPDR) (n = 20), PDR (n = 20), and controls (n = 20). AGEs were assessed by assay of N-carboxymethyl-lysine (Nε-CML). Nε- CML was evaluated using receiver operating characteristic curve (ROC) curve analysis, and the area under curve (AUC) was determined. The mean levels of Nε-CML were 31.3 ± 21.2 ng/mL, 73.9 ± 35.0 ng/mL, 91.2 ± 66.7 ng/mL, and 132.0 ± 84.0 ng/mL in control, NoDR, NPDR, and PDR, respectively. On analysis of variance (ANOVA), the Ne-CML level was significantly different between the study groups (control, NoDR, NPDR, and PDR) (P < 0.001). Best-corrected visual acuity decreased with disease progression and increased levels of Ne-CML (P < 0.001). On AUC analysis, the following values were obtained NoDR = 0.67, NPDR = 0.69, and PDR = 0.84, showing that AGEs are the most sensitive biomarkers for PDR in DR. AGEs serve as biomolecular biomarkers for PDR and can indicate disease conversion from NPDR to PDR. They are new-age tools of translational medicine.","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0