Indian Journal of Ophthalmology最新文献

{"title":"Comment on: Association of eGFR with stages of diabetic retinopathy and age-related macular degeneration in Indian population.","authors":"Rui Yao, Tao Tian, Xiaoxi Yao","doi":"10.4103/IJO.IJO_1951_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1951_24","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 Suppl 1","pages":"S176"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bedside bilateral sequential intravitreal anti-VEGF injections for retinopathy of prematurity.","authors":"Priya Bajgai, Susree Satavisa, Taraprasad Das, Subhadra Jalali, Balakrushna Samanataray, Sameera Nayak, Tapas Ranjan Padhi","doi":"10.4103/IJO.IJO_558_24","DOIUrl":"10.4103/IJO.IJO_558_24","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the outcome and ocular adverse events of bedside bilateral sequential intravitreal anti-vascular endothelial growth factor injections for retinopathy of prematurity (ROP) (BBSIR).</p><p><strong>Methods: </strong>This retrospective interventional study included infants who received BBSIR with a follow-up of at least 1 month. Clinical history, intravitreal injection details, indications, intraoperative and postoperative ocular adverse events, and outcomes were analyzed.</p><p><strong>Results: </strong>The study cohort included 192 babies (384 eyes) spread over 9 years. The mean gestational age was 30.2 ± 2.6 weeks (28.8-34.1), and the birth weight was 1098.11 ± 271.65 g (650-2000). The indications for BBSIR were as follows: 73.4% (n = 141 infants) were too sick to transfer to an ophthalmic unit, 10.9% (n = 21 infants) due to the parents' inconvenience of traveling to the ophthalmic center, and 15. 6% (n = 30 infants) due to both reasons. The injections were given by an ROP specialist/ROP-trained ophthalmologist after due parental consent, considering each eye as a fresh eye with separate scrubbing and draping. Light from the head-worn indirect ophthalmoscope served as the source of illumination. The retinopathy was regressing/regressed in 92.4% of babies until the last follow-up. The major ocular complication was cataract in 2 eyes (0.5%). There was no incidence of endophthalmitis till last follow-up (median 5.7 months).</p><p><strong>Conclusions: </strong>As per this study, BBSIR was observed to be effective and safe if given by those fully trained in the management of ROP. Though the rate of complications like cataract is small, they can pose management challenges and impact vision in a growing child.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S112-S118"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of reactivation between ranibizumab and bevacizumab in aggressive retinopathy of prematurity: A retrospective case series.","authors":"Anil Babanrao Gangwe, Chibuzo B Ekumankama, Abhishek Singh, Swapnil Madhukar Parchand, Deepshikha Agrawal, Raj Vardhan Azad","doi":"10.4103/IJO.IJO_161_24","DOIUrl":"10.4103/IJO.IJO_161_24","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the incidence, type, interval for reactivation, and structural outcomes in infants with aggressive retinopathy of prematurity (A-ROP) treated with ranibizumab or bevacizumab.</p><p><strong>Method: </strong>It is a single-center, retrospective, consecutive, case series. We included infants with A-ROP which were initially treated with either intravitreal ranibizumab (IVR, 0.25 mg) or intravitreal bevacizumab (IVB, 0.625 mg) between January 2017 and December 2023. The infants were followed up for reactivation. The demographic and clinical data were collected. The time, zone, type of reactivation, its treatment, type of final structural outcome, and factors associated with reactivation were analyzed.</p><p><strong>Results: </strong>One hundred eight among the 322 infants with A-ROP were included in the study. Fifty-five received IVR, while 53 received IVB. Infants treated with IVR had higher incidence of reactivation (92.7% vs 52.8%, P < 0.001) at an earlier interval than IVB (7.7 weeks vs 12.8 weeks, P < 0.001). Infants treated with IVR had approximately 3.3 times higher possibility of reactivation than those treated with IVB. Three infants (5.9%) in the IVR group and five (9.4%) in the IVB group attained complete vascularization of the retina ( P = 0.72). More infants treated with IVB had regression with a persistent avascular retina (PAR) than IVR (52.8% vs 15.7%, P < 0.001). Infants in the IVB group had 10 times higher possibility of regression with PAR.</p><p><strong>Conclusion: </strong>Infants of A-ROP treated with IVR have a higher incidence and earlier reactivation, while those treated with IVB have less incidence and delayed reactivation, albeit with a higher possibility of regression with a PAR.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S119-S125"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of subfoveal choroidal thickness in pre-eclamptic, healthy pregnant, and non-pregnant women.","authors":"Aarshi Naharwal, Ramanuj Samanta, Ajai Agrawal, Latika Chawla, Amrita Gaurav, Sreeram Jayaraj","doi":"10.4103/IJO.IJO_767_24","DOIUrl":"10.4103/IJO.IJO_767_24","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of the study was to compare the choroidal thickness (CT) in pre-eclamptic (PE), healthy pregnant, and age-matched healthy non-pregnant females by spectral-domain optical coherence tomography (SD-OCT) and to investigate any possible correlation between subfoveal CT (SFCT) and mean arterial pressure (MAP) in PE.</p><p><strong>Methods: </strong>This was a hospital-based, comparative study. A total of 90 females (30 in each group) aged 20-40 years were recruited prospectively over 1 year. Females with refractive error beyond ±3 D, intraocular pressure >21 mmHg, prior ocular trauma or surgeries, systemic diseases, pregnancy-related complications (except PE), and poor OCT scans were excluded. Following comprehensive ophthalmic evaluation, CT was measured bilaterally using SD-OCT (EDI) at the subfoveal region and at 1500 µm nasal and temporal to fovea. Systolic and diastolic blood pressures were recorded in all.</p><p><strong>Results: </strong>The PE group had significantly thinner choroid (SFCT: 337.5 ± 49.8 OD, 333.0 ± 50.8 OS) as compared to the healthy non-pregnant group (SFCT: 351.6 ± 34.4 OD, 365.3 ± 33.6 OS) and healthy pregnant group (SFCT: 374.2 ± 44.1 OD, 377.2 ± 49.5 OS) ( P < 0.05) in all locations (nasal, temporal, and subfoveal) in both eyes (except for OD nasal CT). However, there was no significant correlation between SFCT and MAP in the PE group.</p><p><strong>Conclusion: </strong>Significantly lower CT in PE without any direct correlation between SFCT and MAP may implicate that choroidal thinning in PE is governed by multifactorial choroidal vasospasm and endothelial dysfunction, instead of MAP solely.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"S151-S157"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual outcomes with implantable Collamer lens versus small incision lenticule extraction in moderate-high myopia: A pilot study.","authors":"Rajesh Sinha, Juhi Daga, Pranita Sahay, Vinay Gupta, Tushar Agarwal, Namrata Sharma, Prafulla K Maharana, Sudarshan K Khokhar, Jeewan S Titiyal","doi":"10.4103/IJO.IJO_908_24","DOIUrl":"10.4103/IJO.IJO_908_24","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the visual outcomes of implantable Collamer lens (ICL) with small incision lenticule extraction (SMILE) in cases of moderate-high myopia.</p><p><strong>Methods: </strong>A prospective comparative study was conducted on 60 eyes of 30 patients with moderate-high myopia (-3D to -8D with astigmatism ≤1 D) at a tertiary eye care center. Patients underwent either SMILE or ICL in both eyes and had a postoperative follow-up of 1 year.</p><p><strong>Results: </strong>The manifest refractive spherical equivalent was -5.22 ± 1.05 D and -5.4 ± 1.17 D in the SMILE and ICL groups, respectively ( P = 0.53). The mean sphere and cylinder were comparable between the groups. The mean uncorrected visual acuity improved from 1.18 ± 0.19 logMAR to 0.03 ± 0.07 logMAR in SMILE and 1.14 ± 0.25 logMAR to 0.011 ± 0.04 logMAR in the ICL group. The efficacy for SMILE was 83.3% and that for ICL was 93.3%. Safety and predictability (±0.5D) for both was 100%. A significant increase was observed in ocular aberration with a decrease in modular transfer function in the eyes that underwent SMILE, whereas no significant change in the eyes that underwent ICL. A significant difference was observed in all parameters of ocular aberration except corneal trefoil, corneal astigmatism, and PSF between the two groups at the final follow-up. The contrast sensitivity at final follow-up was higher in ICL cases when compared to SMILE. The quality of vision (QoV) score suggested a better QoV with ICL; however, the difference was not statistically significant.</p><p><strong>Conclusion: </strong>Both SMILE and ICL are safe in patients with moderate-high myopia. The efficacy, contrast sensitivity, and postoperative ocular aberration profile are better in cases undergoing ICL.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"115-121"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wavefront-guided pupilloplasty in patients following penetrating keratoplasty: Optimizing results.","authors":"Vijay K Sharma, G N Divyashree, Preeti, Vikas Ambiya, Ashok Kumar, Srishti Khullar, Vipin Rana","doi":"10.4103/IJO.IJO_3346_23","DOIUrl":"10.4103/IJO.IJO_3346_23","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the role of wavefront-guided pupilloplasty in improving visual quality and wavefront parameters in post-keratoplasty patients with pathologically irregular, mydriatic pupils.</p><p><strong>Methods: </strong>A total of 13 eyes of post-penetrating keratoplasty patients with pathologically irregular mydriatic pupil were included in this prospective interventional study. Preoperative wavefront analysis was done with the actual pupil size, and predicted wavefront values were analyzed by setting the postoperative pupil size to 2 mm. Patients showing significant improvement between preoperative and predicted postoperative wavefront values underwent single-pass four-throw pupilloplasty, and all wavefront parameters were again evaluated after 1 week. Preoperative and postoperative best corrected visual acuity (BCVA), pupil size, and wavefront parameters were analyzed.</p><p><strong>Results: </strong>Mean BCVA improved from a preoperative value of 1.03 ± 0.32 log of minimum angle of resolution (logMAR) units to 0.24 ± 0.09 logMAR units. Mean preoperative pupil size was 6.077 ± 0.787 mm, whereas the achieved postoperative pupil size after pupilloplasty was 2.538 ± 0.139 mm. Mean astigmatism root mean square (RMS) value improved from 4.169 ± 3.876 to 0.875 ± 0.926 µm ( P < 0.05), and mean coma value changed from 1.525 ± 1.962 to 0.128 ± 0.152 µm ( P < 0.05). Mean point spread function Stehl ratio value improved from 0.056 ± 0.032 to 0.223 ± 0.102. Mean RMS (optical path difference) value changed from 6.248 ± 4.721 to 0.943 ± 0.947 µm ( P < 0.001), Mean RMS (high orders) value changed from 3.788 ± 3.537 to 0.328 ± 0.256 µm ( P value 0.003), and the mean spherical aberration value changed from 0.646 ± 0.873 to 0.223 ± 0.102 µm ( P value 0.024). All postoperative wavefront parameters showed statistically significant improvement from the preoperative parameters.</p><p><strong>Conclusion: </strong>Wavefront-guided pupilloplasty can predict and improve wavefront parameters and visual quality in post-keratoplasty patients with pathologically irregular mydriatic pupils.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":"73-76"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on efficacy, safety, and tolerability of Lifitegrast 5% eye drops: A randomized, double-blind, active-controlled trial in Indian patients with dry eye disease.","authors":"Krishnagopal Srikanth, V Sridhanya","doi":"10.4103/IJO.IJO_2424_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_2424_24","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 1","pages":"154"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trifold technique for pupil reconstruction in large non-appositional iris defects.","authors":"Dhivya Ashok Kumar, Amar Agarwal, Soosan Jacob, Ashvin Agarwal","doi":"10.4103/IJO.IJO_1319_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1319_24","url":null,"abstract":"<p><p>Large iris defects are challenging to close due to shortage of tissue and opposite vector force. By using two pupilloplasty methods, we can close large iris defects with less tractional force or tethering. The trifold technique is a combination of trocar-assisted iris repair and single-pass four-throw (SFT) pupilloplasty for non-appositional large iris defects. The initial two trocar-assisted iris repair sutures oppose the unopposed iris ends and the subsequent SFT seals the defect. The combination procedure is less manipulative with no complications for the iris and pupil diaphragm.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 1","pages":"146-148"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial reduction of inter-pupillary distance with indirect ophthalmoscope and effect on stereo-acuity.","authors":"Priya Saraf, Shweta Viswanath, Sanchita Mehta, Saksham Mathur, Amber Amar Bhayana","doi":"10.4103/IJO.IJO_1340_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_1340_24","url":null,"abstract":"","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 Suppl 1","pages":"S180-S181"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting corneal decompensation in Fuchs endothelial corneal dystrophy with Scheimpflug tomography and clinical parameters.","authors":"Nilufer Yesilirmak, Vaël Souédan, Aurélie Pison, Jean Louis Bourges","doi":"10.4103/IJO.IJO_828_24","DOIUrl":"https://doi.org/10.4103/IJO.IJO_828_24","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the efficacy of various tomographic indices, both established and novel, in predicting endothelial decompensation leading to either spontaneous corneal transplantation or transplantation following cataract surgery in patients with Fuchs endothelial corneal dystrophy (FECD).</p><p><strong>Methods: </strong>In this cross-sectional, retrospective study, we reviewed the files of 93 eyes from 54 FECD patients undergoing regular follow-up. We recorded clinical metrics such as morning visual disturbance (MVD) and corrected distance visual acuity. In addition, we extracted topographic measurements including central corneal thickness (CCT); corneal volumes (CVs) within 3, 5, and 7 mm diameters (CV3, CV5, CV7); corneal central-to-peripheral volume ratios (CPVRs) for 3/5 mm (CPVR-3/5) and 3/7 mm (CPVR-3/7); peripheral volume index; thinnest point; corneal thickness spatial profile at 2, 4, 6, and 8 mm (CTSP2, CTSP4, CTSP6, CTSP8); corneal central-to-peripheral thickness ratio at 4 mm (CPTR4); and percentage of thickness increase at 2, 4, and 6 mm (PTI2, PTI4, PTI6), loss of regular isopachs (LRI), displacement of the thinnest point (DTP), and focal posterior surface depression (FPSD).</p><p><strong>Results: </strong>Receiver operating characteristic curves revealed a CCT area under the curve (AUC) of 0.732, with an optimal threshold of 596.5 µm yielding 79.7% sensitivity and 63.6% specificity. CTSP4 demonstrated an AUC of 0.706 with a 616.5-µm threshold (77.4% sensitivity, 60.6% specificity), and CPTR4 showed an AUC of 0.588 with a 0.963 threshold (62.3% sensitivity, 60.6% specificity). Notably, MVD presented a statistically significant odds ratio of 4.63 (95% confidence interval = 1.76-12.86). In univariate analyses, LRI, DTP, and FPSD were risk factors for progression, whereas in multivariate analyses, LRI was an independent risk factor for progression.</p><p><strong>Conclusion: </strong>The findings suggest that MVD and LRI serve as most significant predictive markers, while CCT, CTSP4, and CPTR4 were average predictive markers for FECD progression, underscoring their potential in guiding clinical decisions and interventions.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":"73 1","pages":"52-58"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}