OCT angiography findings in type 2 macular telangiectasia: A meta-analysis.

Abstract: This meta-analysis evaluates optical coherence tomography angiography (OCTA) results in macular telangiectasia (MacTel) type 2, a rare retinal condition marked by vascular abnormalities. We analyzed 26 studies for OCTA findings in MacTel type 2. We examined parameters like best corrected visual acuity (BCVA), foveal avascular zone (FAZ), and superficial and deep capillary plexus densities. The pooled mean BCVA was 0.37 log of minimum angle of resolution (20/50). FAZ enlargement was observed, with a pooled mean FAZ size of 0.39 mm2. Foveal deep vascular density (FDVD) and parafoveal superficial vascular density (PSVD) were significantly reduced (P = 0.021 and P < 0.001, respectively). Parafoveal deep vascular density (PDVD) and foveal superficial vascular density (FSVD) did not decrease significantly (P = 0.067 and 0.114, respectively). MacTel type 2 has unique OCTA characteristics, including reduced FDVD, PSVD, and enlarged FAZ. However, FSVD and PDVD did not statistically decrease in patients. Future studies using more parameters are required to expand our understanding.