Outcomes of anterior chamber wash with adjuvant intracameral and intrastromal voriconazole in deep stromal fungal keratitis with endoexudates - A retrospective study.

IF 1.8 4区医学 Q2 OPHTHALMOLOGY

Indian Journal of Ophthalmology Pub Date : 2025-10-01 Epub Date: 2025-07-18 DOI:10.4103/IJO.IJO_132_25

Premjith Muraleedharan, Josephine S Christy, Naveen Radhakrishnan

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引用次数: 0

Abstract

Study design: Retrospective observational study.

Purpose: To analyze the clinical outcomes of patients with deep stromal fungal keratitis with endoexudates who received adjuvant anterior chamber (AC) wash with intracameral (IC) and intrastromal (IS) voriconazole.

Methods: Demographics, risk factors, clinical course, microbiology, and visual outcomes of patients with deep-seated fungal keratitis who underwent AC wash with IC and IS voriconazole from January 2022 to December 2022 with at least 6 months post-op follow-up visits were analyzed.

Results: The mean age of 40 patients was 53 ± 12 years, and the mean time to presentation was 12 ± 8 days. The mean size of the ulcer at presentation was 21 ± 11.7 square mm. Aspergillus flavus was the most isolated organism in 16 (40%) patients. Seven (17.5%) patients achieved complete resolution with scarring and 33 (82.5%) required therapeutic keratoplasty (TPK), out of which 10 (30.3%) had reinfection.

Conclusion: AC wash with IC and IS voriconazole was ineffective as adjuvant therapy in cases of deep-seated fungal keratitis.

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前房冲洗与辅助伏立康唑治疗深部间质真菌性角膜炎伴内渗出物的疗效回顾性研究。

研究设计：回顾性观察性研究。目的：分析深层间质真菌性角膜炎伴内渗出患者行前房（AC）辅助冲洗的临床效果。方法：分析2022年1月至12月，应用IC和IS伏立康唑进行AC清洗，术后随访至少6个月的深部真菌性角膜炎患者的人口统计学、危险因素、临床病程、微生物学和视力结果。结果：40例患者平均年龄53±12岁，平均发病时间12±8天。溃疡出现时的平均大小为21±11.7平方毫米。16例（40%）患者中分离到的细菌最多的是黄曲霉。7名（17.5%）患者疤痕完全消失，33名（82.5%）患者需要治疗性角膜移植（TPK），其中10名（30.3%）患者再次感染。结论：AC洗液联合伏立康唑辅助治疗深度真菌性角膜炎效果不佳。

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来源期刊

Indian Journal of Ophthalmology OPHTHALMOLOGY-

CiteScore

3.80

自引率

19.40%

发文量

1963

审稿时长

38 weeks

期刊介绍： Indian Journal of Ophthalmology covers clinical, experimental, basic science research and translational research studies related to medical, ethical and social issues in field of ophthalmology and vision science. Articles with clinical interest and implications will be given preference.