Safety and efficacy of simultaneous photorefractive keratectomy and corneal cross-linking in managing suspected keratoconus.

IF 2.1 4区 医学 Q2 OPHTHALMOLOGY
Ali Dal, Mehmet Canleblebici, Murat Erdağ
{"title":"Safety and efficacy of simultaneous photorefractive keratectomy and corneal cross-linking in managing suspected keratoconus.","authors":"Ali Dal, Mehmet Canleblebici, Murat Erdağ","doi":"10.4103/IJO.IJO_1941_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety and efficacy of combining photorefractive keratectomy (PRK) and corneal cross-linking (CXL) in patients with suspected keratoconus.</p><p><strong>Methods: </strong>This retrospective, non-randomized study included patients who underwent simultaneous PRK and CXL between March 2020 and March 2023. Patients were divided into two groups: group 1 (PRK only without keratoconus) and group 2 (PRK + CXL with suspected keratoconus). Eligibility criteria included stable refractive error for at least 1 year, spherical equivalent refractive error not exceeding -4.0 D, and central corneal thickness between 470 and 500 μm. Exclusion criteria included corneal ectasia, previous ocular surgeries, systemic diseases, and pregnancy. Preoperative and postoperative assessments included uncorrected distance visual acuity (UCVA), best-corrected visual acuity (BCVA), spherical equivalent, corneal topography, and endothelial cell count.</p><p><strong>Results: </strong>The study included 98 eyes from 98 patients, with 47 eyes in group 1 and 51 eyes in group 2. Significant improvements in UCVA and BCVA were observed in both groups 12 months postoperatively (P < 0.001). Similar reductions in cycloplegic spherical and cylindrical refraction values were observed in both groups (P < 0.01). No cases of corneal ectasia were reported. Grade 1 corneal haze was observed in 8.5% of eyes in group 1 and 9.8% of eyes in group 2, all of which resolved within the 12-month follow-up period.</p><p><strong>Conclusion: </strong>The combination of PRK and CXL is a safe and effective treatment option for patients with suspected keratoconus, providing significant improvements in visual acuity and refractive stability without increasing the risk of corneal ectasia.</p>","PeriodicalId":13329,"journal":{"name":"Indian Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/IJO.IJO_1941_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: To evaluate the safety and efficacy of combining photorefractive keratectomy (PRK) and corneal cross-linking (CXL) in patients with suspected keratoconus.

Methods: This retrospective, non-randomized study included patients who underwent simultaneous PRK and CXL between March 2020 and March 2023. Patients were divided into two groups: group 1 (PRK only without keratoconus) and group 2 (PRK + CXL with suspected keratoconus). Eligibility criteria included stable refractive error for at least 1 year, spherical equivalent refractive error not exceeding -4.0 D, and central corneal thickness between 470 and 500 μm. Exclusion criteria included corneal ectasia, previous ocular surgeries, systemic diseases, and pregnancy. Preoperative and postoperative assessments included uncorrected distance visual acuity (UCVA), best-corrected visual acuity (BCVA), spherical equivalent, corneal topography, and endothelial cell count.

Results: The study included 98 eyes from 98 patients, with 47 eyes in group 1 and 51 eyes in group 2. Significant improvements in UCVA and BCVA were observed in both groups 12 months postoperatively (P < 0.001). Similar reductions in cycloplegic spherical and cylindrical refraction values were observed in both groups (P < 0.01). No cases of corneal ectasia were reported. Grade 1 corneal haze was observed in 8.5% of eyes in group 1 and 9.8% of eyes in group 2, all of which resolved within the 12-month follow-up period.

Conclusion: The combination of PRK and CXL is a safe and effective treatment option for patients with suspected keratoconus, providing significant improvements in visual acuity and refractive stability without increasing the risk of corneal ectasia.

同时光屈光性角膜切除术和角膜交联治疗疑似圆锥角膜的安全性和有效性。
目的:评价光屈光性角膜切除术(PRK)联合角膜交联术(CXL)治疗疑似圆锥角膜的安全性和有效性。方法:这项回顾性、非随机研究纳入了2020年3月至2023年3月期间同时接受PRK和CXL的患者。患者分为两组:1组(PRK + CXL,无圆锥角膜)和2组(PRK + CXL,疑似圆锥角膜)。合格标准包括稳定屈光不超过1年,球面等效屈光不超过-4.0 D,角膜中央厚度在470 - 500 μm之间。排除标准包括角膜扩张、既往眼部手术、全身性疾病和妊娠。术前和术后评估包括未矫正距离视力(UCVA)、最佳矫正视力(BCVA)、球面等效、角膜地形图和内皮细胞计数。结果:共纳入98例患者98只眼,1组47只眼,2组51只眼。两组患者术后12个月UCVA和BCVA均有显著改善(P < 0.001)。两组患者的圆筒形和球形屈光值均有相似的降低(P < 0.01)。无角膜扩张病例报告。1组和2组的1级角膜混浊率分别为8.5%和9.8%,均在12个月的随访期内消失。结论:PRK联合CXL治疗疑似圆锥角膜患者是一种安全有效的治疗方案,在不增加角膜扩张风险的情况下,可显著改善视力和屈光稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.80
自引率
19.40%
发文量
1963
审稿时长
38 weeks
期刊介绍: Indian Journal of Ophthalmology covers clinical, experimental, basic science research and translational research studies related to medical, ethical and social issues in field of ophthalmology and vision science. Articles with clinical interest and implications will be given preference.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信