南印度患者急性视网膜坏死的临床概况和治疗结果。

IF 2.1 4区 医学 Q2 OPHTHALMOLOGY
Vidya S Mooss, Krishna R Murthy, Kalpana Babu, Aniruddha A Tirumalai
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引用次数: 0

摘要

目的:观察三级眼科保健中心急性视网膜坏死(ARN)病例的临床概况、治疗方法和结果。方法:回顾性分析2016年1月至2023年12月住院的ARN病例。评估了人口统计学细节、临床表现、并发症、处理和视觉结果。结果:18例20只眼纳入研究。平均年龄40.77±16.38岁,男女比例为2:1,11.11%为双侧发病。葡萄膜炎平均病程3.312±0.95个月。最常见的是VZV(50%),其次是HSV(45%)。除全身抗病毒药物和口服类固醇外,所有病例均给予玻璃体内注射更昔洛韦。平均玻璃体内注射次数为5.53±3.87次。所有病例持续口服伐昔洛韦维持剂量(500 mg,每日2次),平均疗程5.61±3.79个月。最常见的并发症是视网膜脱离(50%),其次是视神经萎缩(44.44%)。视网膜炎的程度与并发症的发生无显著相关性(P = 0.215)。然而,HSV组和VZV组之间的并发症发生率有显著差异,VZV组的并发症发生率更高(P = 0.04)。研究开始时平均视力为0.87±0.85 logMAR,研究结束时平均视力为0.65±0.67 logMAR。结论:及时诊断、玻璃体内注射更昔洛韦进行积极的初始治疗并联合全身抗病毒药物以及全身抗病毒药物的长期维持治疗是ARN获得最佳视力预后和预防终身残疾的关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical profile and treatment outcomes in acute retinal necrosis in a South Indian patient population.

Purpose: To look at the clinical profile, treatment methods, and outcomes in cases of acute retinal necrosis (ARN) from a tertiary eye care center.

Methods: Hospital-based retrospective observational study wherein cases of ARN presented between January 2016 and December 2023 were reviewed. Demographic details, clinical presentation, complications, management, and visual outcome were evaluated.

Results: Twenty eyes of 18 cases were included in the study. Mean age was 40.77 ± 16.38 years, male to female ratio was 2:1, and 11.11% had bilaterality at presentation. Mean duration of uveitis was 3.312 ± 0.95 months. The most commonly found organism was VZV (50%), followed by HSV (45%). All cases were given intravitreal ganciclovir in addition to systemic antivirals and oral steroids. The mean number of intravitreal injections was 5.53 ± 3.87. Maintenance dose of oral valacyclovir (500 mg twice daily) was continued in all cases for an average duration of 5.61 ± 3.79 months. The most common complications noted were retinal detachment (50%) followed by optic atrophy (44.44%). No significant association was noted between the extent of retinitis and the development of complications ( P = 0.215). However, there was a significant difference seen in the rate of complications between the HSV and VZV groups, with more complication rates seen with the VZV group ( P = 0.04). The mean visual acuity was 0.87 ± 0.85 logMAR at presentation and 0.65 ± 0.67 logMAR at the end of the study.

Conclusion: Timely diagnosis, aggressive initial treatment with intravitreal ganciclovir along with systemic antivirals and long-term maintenance therapy with systemic antivirals are crucial in ARN to obtain the best visual prognosis achievable and prevent lifelong disabilities.

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来源期刊
CiteScore
3.80
自引率
19.40%
发文量
1963
审稿时长
38 weeks
期刊介绍: Indian Journal of Ophthalmology covers clinical, experimental, basic science research and translational research studies related to medical, ethical and social issues in field of ophthalmology and vision science. Articles with clinical interest and implications will be given preference.
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