IEEE Transactions on NanoBioscience最新文献_第4页

IEEE Transactions on NanoBioscience Publication Information 电气和电子工程师学会《纳米生物科学论文集》出版信息

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-07-01 DOI: 10.1109/TNB.2024.3415191

引用次数: 0

Design and Probing of Prism-Based SPR Nano-Biosensor for Human Sperm Detection. 用于人类精子检测的棱镜式 SPR 纳米生物传感器的设计与探测

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-06-26 DOI: 10.1109/TNB.2024.3419571

Yesudasu Vasimalla, Baljinder Kaur, Suman Maloji, Santosh Kumar

{"title":"Design and Probing of Prism-Based SPR Nano-Biosensor for Human Sperm Detection.","authors":"Yesudasu Vasimalla, Baljinder Kaur, Suman Maloji, Santosh Kumar","doi":"10.1109/TNB.2024.3419571","DOIUrl":"https://doi.org/10.1109/TNB.2024.3419571","url":null,"abstract":"Human sperm functioning is crucial for maintaining natural reproduction, but its sterility is enhanced by variations in environmental conditions. Because of these agitating properties, powerful computer-aided devices are required, but their precision is inadequate, particularly when it comes to samples with low sperm concentrations. Therefore, for the first time, this article introduces the sulfide material-based structure for the detection of human sperm samples using the prism-based surface plasmon resonance sensor (SPR) Nano-biosensor. The proposed structure is designed on the basis of a prism-based Kretschmann configuration and includes silver, silicon, a sulfide layer, black phosphorus, and a sensing medium. This work takes advantage of the excitement of surface plasmons and evanescent waves in the metal dielectric region. For the detection process, seven sperm samples are taken, with their concentration, mobility, and refractive index measured by the refractometer. The proposed structure provides a maximum sensitivity of 409.17°/RIU, QF of 97.45RIU-1 and a DA of 1.37. The results provide a substantial improvement in comparison to the reported work in the literature.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141456449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning-enhanced predictive modeling for arbitrary deterministic lateral displacement design and test. 用于任意确定性侧向位移设计和测试的机器学习增强型预测建模。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-06-17 DOI: 10.1109/TNB.2024.3415365

Yidan Zhang, Junchao Wang, Jinkai Chen, Guodong Su, Wen-Sheng Zhao, Jun Liu

{"title":"Machine learning-enhanced predictive modeling for arbitrary deterministic lateral displacement design and test.","authors":"Yidan Zhang, Junchao Wang, Jinkai Chen, Guodong Su, Wen-Sheng Zhao, Jun Liu","doi":"10.1109/TNB.2024.3415365","DOIUrl":"10.1109/TNB.2024.3415365","url":null,"abstract":"The separation of biological particles like cells and macromolecules from liquid samples is vital in clinical medicine, supporting liquid biopsies and diagnostics. Deterministic Lateral Displacement (DLD) is prominent for sorting particles in microfluidics by size. However, the design, fabrication, and testing of DLDs are complex and time-consuming. Researchers typically rely on finite element analysis to predict particle trajectories, which are crucial in evaluating the performance of DLD. Traditional particle trajectory predictions through finite element analysis often inaccurately reflect experimental results due to manufacturing and experimental variabilities. To address this issue, we introduced a machine learning-enhanced approach, combining past experimental data and advanced modeling techniques. Our method, using a dataset of 132 experiments from 40 DLD chips and integrating finite element simulation with a microfluidic-optimized particle simulation algorithm (MOPSA) and a Random Forest model, improves trajectory prediction and critical size determination without physical tests. This enhanced accuracy in simulation across various DLD chips speeds up development. Our model, validated against three DLD chip designs, showed a high correlation between predicted and experimental particle trajectories, streamlining chip development for clinical applications.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A label free fluorescent aptamer sensor based on the combined action of Graphene oxide and SYBR Green I for the detection of Aflatoxin B1. 基于氧化石墨烯和 SYBR Green I 联合作用的无标记荧光拟合传感器，用于检测黄曲霉毒素 B1。

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-05-20 DOI: 10.1109/TNB.2024.3403158

Mengyang Hu, Meng Cheng, Na Wang, Yidan Sang, Yafei Dong, Luhui Wang

{"title":"A label free fluorescent aptamer sensor based on the combined action of Graphene oxide and SYBR Green I for the detection of Aflatoxin B1.","authors":"Mengyang Hu, Meng Cheng, Na Wang, Yidan Sang, Yafei Dong, Luhui Wang","doi":"10.1109/TNB.2024.3403158","DOIUrl":"10.1109/TNB.2024.3403158","url":null,"abstract":"Here, based on the characteristics of Graphene oxide(GO) and SYBR Green I(SGI) dye, an enzyme-free and label-free fluorescent biosensor with signal amplification through DNA strand reaction is proposed for the detection of Aflatoxin B1(AFB1) in food safety. Firstly, without the addition of AFB1, the substrate in the system includes a double stranded Apt-S with a long sticky end and two hairpins H1 and H2. Although the complementary pairing of bases may exhibit fluorescence due to the insertion of SGI dyes, the use of GO, which is highly capable of adsorbing single stranded parts and quenching fluorescence, cleverly reduces the background fluorescence. Adding the target AFB1 triggers DNA inter chain reactions, generating a large amount of long double stranded DNA H1-H2, thereby generating strong fluorescence signals under the action of SGI. More importantly, logical theory verification and computer simulation were conducted before biological experiments, providing a theoretical basis for the implementation of the biosensor. After analysis, the fluorescence biosensor exhibits a good linear relationship with AFB1 concentration in the range of 5-50nM, with a detection limit of 0.76nM. It also has good specificity, anti-interference ability, and practical application ability, and has broad application prospects in the field of food safety.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired Quantum Oracle Circuits for Biomolecular Solutions of the Maximum Cut Problem 最大切割问题生物分子解决方案的生物启发量子甲骨文电路

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-04-30 DOI: 10.1109/TNB.2024.3395420

Weng-Long Chang;Renata Wong;Yu-Hao Chen;Wen-Yu Chung;Ju-Chin Chen;Athanasios V. Vasilakos

{"title":"Bioinspired Quantum Oracle Circuits for Biomolecular Solutions of the Maximum Cut Problem","authors":"Weng-Long Chang;Renata Wong;Yu-Hao Chen;Wen-Yu Chung;Ju-Chin Chen;Athanasios V. Vasilakos","doi":"10.1109/TNB.2024.3395420","DOIUrl":"10.1109/TNB.2024.3395420","url":null,"abstract":"Given an undirected, unweighted graph with n vertices and m edges, the maximum cut problem is to find a partition of the n vertices into disjoint subsets \u0000<inline-formula> <tex-math>${V}_{{1}}$ </tex-math></inline-formula>\u0000 and \u0000<inline-formula> <tex-math>${V}_{{2}}$ </tex-math></inline-formula>\u0000 such that the number of edges between them is as large as possible. Classically, it is an NP-complete problem, which has potential applications ranging from circuit layout design, statistical physics, computer vision, machine learning and network science to clustering. In this paper, we propose a biomolecular and a quantum algorithm to solve the maximum cut problem for any graph G. The quantum algorithm is inspired by the biomolecular algorithm and has a quadratic speedup over its classical counterparts, where the temporal and spatial complexities are reduced to, respectively, \u0000<inline-formula> <tex-math>${O}text {(}sqrt {{2}^{n}/{r}}text {)}$ </tex-math></inline-formula>\u0000 and \u0000<inline-formula> <tex-math>${O}text {(}{m}^{{2}}text {)}$ </tex-math></inline-formula>\u0000. With respect to oracle-related quantum algorithms for NP-complete problems, we identify our algorithm as optimal. Furthermore, to justify the feasibility of the proposed algorithm, we successfully solve a typical maximum cut problem for a graph with three vertices and two edges by carrying out experiments on IBM’s quantum simulator.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"499-506"},"PeriodicalIF":3.7,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140835568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary Exploration of the Biophysical Mechanisms of Pulsed Magnetic Field- Induced Cell Permeabilization 脉冲磁场诱导细胞渗透的生物物理机制初探

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-04-16 DOI: 10.1109/TNB.2024.3385413

Chi Ma;Mengnan Zhang;Fei Teng;Wei Zheng;Yan Mi

{"title":"Preliminary Exploration of the Biophysical Mechanisms of Pulsed Magnetic Field- Induced Cell Permeabilization","authors":"Chi Ma;Mengnan Zhang;Fei Teng;Wei Zheng;Yan Mi","doi":"10.1109/TNB.2024.3385413","DOIUrl":"10.1109/TNB.2024.3385413","url":null,"abstract":"Pulsed magnetic field treatment can enhance cell membrane permeability, allowing large molecular substances that normally cannot pass through the cell membrane to enter the cell. This research holds significant prospects for biomedical applications. However, the mechanism underlying pulsed magnetic field-induced cell permeabilization remains unclear, impeding further progress in research related to pulsed magnetic field. Currently, hypotheses about the mechanism are struggling to explain experimental results. Therefore, this study developed a parameter-adjustable pulsed magnetic field generator and designed experiments. Starting from the widely accepted hypothesis of “induced electric fields by pulsed magnetic field,” we conducted a preliminary exploration of the biophysical mechanisms underlying pulsed magnetic field-induced cell permeabilization. Finally, we have arrived at an intriguing conclusion: under the current technical parameters, the impact of the pulsed magnetic field itself is the primary factor influencing changes in cell membrane permeability, rather than the induced electric field. This conclusion holds significant implications for understanding the biophysical mechanisms behind pulsed magnetic field therapy and its potential biomedical applications.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"482-490"},"PeriodicalIF":3.7,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140612766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benchmarking Power Generation From Multiple Wastewater Electrolytes in Microbial Fuel Cells With 3D Printed Disk-Electrodes 微生物燃料电池中多种废水电解质的发电基准与 3D 打印磁盘电极

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-04-08 DOI: 10.1109/TNB.2024.3385739

Yuvraj Maphrio Mao;Khairunnisa Amreen;Sanket Goel

{"title":"Benchmarking Power Generation From Multiple Wastewater Electrolytes in Microbial Fuel Cells With 3D Printed Disk-Electrodes","authors":"Yuvraj Maphrio Mao;Khairunnisa Amreen;Sanket Goel","doi":"10.1109/TNB.2024.3385739","DOIUrl":"10.1109/TNB.2024.3385739","url":null,"abstract":"Microbial Fuel Cells (MFCs) have recently gained attention, as they are inexpensive, green in nature, and sustainable. As per the report, by Allied Market Research the global market size of MFCs will increase from \u0000<inline-formula> <tex-math>${$}$ </tex-math></inline-formula>\u0000 264.8 million in 2021 to \u0000<inline-formula> <tex-math>${$}$ </tex-math></inline-formula>\u0000 452.2 million in 2030, growing at a CAGR of 4.5%. The present work is a comparative study of various types of electrolytes that can be used in MFCs. The working electrodes were printed using conducting graphene-based Polylactic Acid (PLA) filaments with the help of a 3D printer under the principle of the fused deposition method. Simulated electrolytes and natural environmental microbial electrolytes were used here. Also, electrolytes of pure E. coli culture were studied. Lake water reported the highest power density of 8.259 mW/cm2 while Stale E. Coli reported the lowest around 0.184 mW/cm2. The study comprehensively lists potential wastewaters that can fuel the MFCs. With the pioneering of various comparative studies of electrolytes, one can insight into the recruitment of electrolytes with high-performance benchmarks for miniaturized energy storage and other microelectronics applications.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"491-498"},"PeriodicalIF":3.7,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Molecular Communication Perspective on Synchronization of Coupled Microfluidic-Spectroscopy 微流控光谱耦合同步的分子通讯视角

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-04-02 DOI: 10.1109/TNB.2024.3384082

Xuewen Qian;Stefan Angerbauer;Malcolm Egan;Marco Di Renzo;Werner Haselmayr

{"title":"A Molecular Communication Perspective on Synchronization of Coupled Microfluidic-Spectroscopy","authors":"Xuewen Qian;Stefan Angerbauer;Malcolm Egan;Marco Di Renzo;Werner Haselmayr","doi":"10.1109/TNB.2024.3384082","DOIUrl":"10.1109/TNB.2024.3384082","url":null,"abstract":"A challenge for real-time monitoring of biochemical processes, such as cells, is detection of biologically relevant molecules. This is due to the fact that spectroscopy methods for detection may perturb the cellular environment. One approach to overcome this problem is coupled microfluidic-spectroscopy, where a microfluidic output channel is introduced in order to observe biologically relevant molecules. This approach allows for non-passive spectroscopy methods, such as mass spectrometry, to identify the structure of molecules released by the cell. Due to the non-negligible length of the microfluidic channel, when a sequence of stimuli are applied to a cell it is not straightforward to determine which spectroscopy samples correspond to a given stimulus. In this paper, we propose a solution to this problem by taking a molecular communication (MC) perspective on the coupled microfluidic-spectroscopy system. In particular, assignment of samples to a stimulus is viewed as a synchronization problem. We develop two new algorithms for synchronization in this context and carry out a detailed theoretical and numerical study of their performance. Our results show improvements over maximum-likelihood synchronization algorithms in terms of detection performance when there are uncertainties in the composition of the microfluidic channel.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"458-471"},"PeriodicalIF":3.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IEEE Transactions on NanoBioscience Publication Information 电气和电子工程师学会《纳米生物科学论文集》出版信息

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-28 DOI: 10.1109/TNB.2024.3378371

引用次数: 0

IEEE Transactions on NanoBioscience Information for Authors 电气和电子工程师学会《纳米生物科学学报》为作者提供的信息

IF 3.9 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-28 DOI: 10.1109/TNB.2024.3378375

引用次数: 0