IEEE Transactions on NanoBioscience最新文献_第5页

Production of Targeted Estrone Liposomes Using a Herringbone Micromixer 使用人字形微搅拌器生产靶向雌酮脂质体

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-26 DOI: 10.1109/TNB.2024.3382203

Mohamed Agam;Vinod Paul;Mohamed Abdelgawad;Ghaleb A. Husseini

{"title":"Production of Targeted Estrone Liposomes Using a Herringbone Micromixer","authors":"Mohamed Agam;Vinod Paul;Mohamed Abdelgawad;Ghaleb A. Husseini","doi":"10.1109/TNB.2024.3382203","DOIUrl":"10.1109/TNB.2024.3382203","url":null,"abstract":"Liposomes are spherical vesicles formed from bilayer lipid membranes that are extensively used in targeted drug delivery as nanocarriers to deliver therapeutic reagents to specific tissues and organs in the body. Recently, we have reported using estrone as an endogenous ligand on doxorubicin-encapsulating liposomes to target estrogen receptor (ER)-positive breast cancer cells. Estrone liposomes were synthesized using the thin-film hydration method, which is a long, arduous, and multistep process. Here, we report using a herringbone micromixer to synthesize estrone liposomes in a simple and rapid manner. A solvent stream containing the lipids was mixed with a stream of phosphate buffer saline (PBS) inside a microchannel integrated with herringbone-shaped ridges that enhanced the mixing of the two streams. The small scale involved enabled rapid solvent exchange and initiated the self-assembly of the lipids to form the required liposomes. The effect of different parameters on liposome size, such as the ratio between the flow rate of the solvent and the buffer solutions (FRR), total flow rate, lipid concentrations, and solvent type, were investigated. Using this commercially available chip, we obtained liposomes with a radius of 66.1 ± 11.2 nm (mean ± standard deviation) and a polydispersity of 22% in less than 15 minutes compared to a total of \u0000<inline-formula> <tex-math>$sim $ </tex-math></inline-formula>\u000011 hours using conventional techniques. Calcein was encapsulated inside the prepared liposomes as a model drug and was released by applying ultrasound at different powers. The size of the prepared liposomes was stable over a period of one month. Overall, using microfluidics to synthesize estrone liposomes simplified the procedure considerably and improved the reproducibility of the resulting liposomes.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"472-481"},"PeriodicalIF":3.7,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10479533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140293429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability Analysis for Large-Scale Multi-Agent Molecular Communication Systems 大规模多代理分子通信系统的稳定性分析。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-23 DOI: 10.1109/TNB.2024.3404592

Taishi Kotsuka;Yutaka Hori

{"title":"Stability Analysis for Large-Scale Multi-Agent Molecular Communication Systems","authors":"Taishi Kotsuka;Yutaka Hori","doi":"10.1109/TNB.2024.3404592","DOIUrl":"10.1109/TNB.2024.3404592","url":null,"abstract":"Molecular communication (MC) is recently featured as a novel communication tool to connect individual biological nanorobots. It is expected that a large number of nanorobots can form large multi-agent MC systems through MC to accomplish complex and large-scale tasks that cannot be achieved by a single nanorobot. However, most previous models for MC systems assume a unidirectional diffusion communication channel and cannot capture the feedback between each nanorobot, which is important for multi-agent MC systems. In this paper, we introduce a system theoretic model for large-scale multi-agent MC systems using transfer functions, and then propose a method to analyze the stability for multi-agent MC systems. The proposed method decomposes the multi-agent MC system into multiple single-input and single-output (SISO) systems, which facilitates the application of simple analysis technique for SISO systems to the large-scale multi-agent MC system. Finally, we demonstrate the proposed method by analyzing the stability of a specific large-scale multi-agent MC system and clarify a parameter region to synchronize the states of nanorobots, which is important to make cooperative behaviors at a population level.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"507-517"},"PeriodicalIF":3.7,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monodirectional Tissue P Systems With Proteins on Cells 细胞上带有蛋白质的单向组织 P 系统。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-23 DOI: 10.1109/TNB.2024.3404396

Bosheng Song;Chuanlong Hu;Xiangxiang Zeng

引用次数: 0

Design of DNA Storage Coding Scheme With LDPC Codes and Interleaving 利用 LDPC 编码和交错设计 DNA 存储编码方案。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-21 DOI: 10.1109/TNB.2024.3379976

Jae-Won Kim;Jaeho Jeong;Hee-Youl Kwak;Jong-Seon No

引用次数: 0

Electrochemical Synthesis of Molecularly Imprinted Polymers for L-Tyrosine Detection 用于检测 L-酪氨酸的分子印迹聚合物的电化学合成。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-20 DOI: 10.1109/TNB.2024.3379588

K. Ramya;K. S. Jaya Lakshmi;Khairunnisa Amreen;Sanket Goel

{"title":"Electrochemical Synthesis of Molecularly Imprinted Polymers for L-Tyrosine Detection","authors":"K. Ramya;K. S. Jaya Lakshmi;Khairunnisa Amreen;Sanket Goel","doi":"10.1109/TNB.2024.3379588","DOIUrl":"10.1109/TNB.2024.3379588","url":null,"abstract":"L-Tyrosine (L-Tyr), a critical amino acid whose aberrant levels impact melanin and dopamine levels in human body while also increasing insulin resistance thereby increasing the risk of type 2 diabetes. The objective of this study was to detect the amount of L-Tyr in human fluids by tailored electrochemical synthesis of well adhered, homogenous and thin molecularly imprinted polymers (MIPs) by the electro-polymerization of pyrrole on glassy carbon electrode modified functionalized multi-walled carbon nanotubes. The key benefits of this procedure over previous imprinting techniques were the elimination of expensive materials like Au and tedious multi-step synthesis, for L-Tyr detection using a handheld potentiostat. The developed particles were characterized using Fourier Transform Infrared Spectroscopy, Scanning Electron Microscope, Chronoamperometry, and Cyclic Voltammetry. With strong reproducibility and stability, this optimized approach provides a rapid and effective method of preparing and sensing MIPs for the target analyte with a broad linear range of \u0000<inline-formula> <tex-math>$1~mu text{M}$ </tex-math></inline-formula>\u0000 to \u0000<inline-formula> <tex-math>$2000~mu text{M}$ </tex-math></inline-formula>\u0000. The Limit of Detection and Limit of Quantification were \u0000<inline-formula> <tex-math>$0.4~mu text{M}$ </tex-math></inline-formula>\u0000 and \u0000<inline-formula> <tex-math>$1.47~mu text{M}$ </tex-math></inline-formula>\u0000, respectively. The engineered sensor was validated for quantifying the concentrations of L-Tyr in human blood and serum samples, yielding satisfactory recovery and can be expanded in future to detect analytes simultaneous.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"410-417"},"PeriodicalIF":3.7,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance Analysis and ISI Mitigation With Imperfect Transmitter in Molecular Communication 分子通信中不完美发射机的性能分析和 ISI 缓解。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-14 DOI: 10.1109/TNB.2024.3375933

Dongliang Jing;Lin Lin;Andrew W. Eckford

引用次数: 0

Analysis of Tapered Fibre Optic Surface Plasmon Resonance Bio-Sensor Chip With Highly Perturbed Taper Profiles 分析锥形光纤表面等离子体共振生物传感器芯片的高扰动锥形轮廓。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-13 DOI: 10.1109/TNB.2024.3376824

Sanjeev Kumar Raghuwanshi

引用次数: 0

Biomedical Applications of Green Synthesized Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Using Aqueous Extract of Ziziphus Oxyphylla Leaves 利用氧化锌叶水提取物绿色合成氧化锌和掺镁氧化锌纳米粒子的生物医学应用

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-12 DOI: 10.1109/TNB.2024.3373777

Suliman Syed;Arshad Islam;Muhammad Shabeer;Akhtar Nadhman;Farhan Ahmad;Nadia Irfan;Shaila Mehwish;Ajmal Khan

{"title":"Biomedical Applications of Green Synthesized Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Using Aqueous Extract of Ziziphus Oxyphylla Leaves","authors":"Suliman Syed;Arshad Islam;Muhammad Shabeer;Akhtar Nadhman;Farhan Ahmad;Nadia Irfan;Shaila Mehwish;Ajmal Khan","doi":"10.1109/TNB.2024.3373777","DOIUrl":"10.1109/TNB.2024.3373777","url":null,"abstract":"Zinc oxide (ZnO) and magnesium-doped zinc oxide (Mg-doped ZnO) nanoparticles (NPs) were synthesized using Ziziphus oxyphylla ’s aqueous leaf extract as reducing agent. UV-Vis absorption peaks at 324 nm and 335 nm were indicative of ZnO and Mg-doped ZnO, respectively. FTIR absorption bands observed at 3238, 1043, 1400, 1401, 2186 and 2320 cm\u0000<inline-formula> <tex-math>$^{-1}$ </tex-math></inline-formula>\u0000 suggested the presence of phenols, alcohols, saturated hydrocarbons, and possibly alkynes. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) spectroscopy revealed pure, spherical and agglomerated NPs with average size of 35.9 nm (ZnO) and 56.8 nm (Mg-doped ZnO). Both NPs remained active against all bacterial strains with the highest inhibition zones observed against Proteus vulgaris (21.16±1.25 mm for ZnO and 24.1±0.76 mm for Mg-doped ZnO. EtBr fluorescence (cartwheel assay) indicated efflux pump blockage, suggesting its facilitation in the bacterial growth inhibition. Antioxidant potential, determined via DPPH radical scavenging assay, revealed stronger antioxidant potential for Mg-doped ZnO (IC\u0000<inline-formula> <tex-math>$_{{50}}~21.53pm 0.76~mu text{g}$ </tex-math></inline-formula>\u0000/mL) than pure ZnO (IC\u0000<inline-formula> <tex-math>$_{{50}}~30.32pm 0.73~mu text{g}$ </tex-math></inline-formula>\u0000/mL). Furthermore, both NPs showed antileishmanial activity against Leishmania tropica promastigotes (IC\u0000<inline-formula> <tex-math>$_{{50}}~47.23pm 3.22~mu text{g}$ </tex-math></inline-formula>\u0000/mL for Mg-doped ZnO and 64.34±6.56 for ZnO), while neither NP exhibited significant hemolysis, indicating biocompatibility and further assessment for their drugability.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"418-427"},"PeriodicalIF":3.7,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Measurement of Urea Concentration With an In-Fiber SPR-MZI Sensor 利用纤维内 SPR-MZI 传感器现场测量尿素浓度。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-09 DOI: 10.1109/TNB.2024.3398807

Liangliang Cheng;Wanlu Zheng;Ya-Nan Zhang;Xuegang Li;Yong Zhao

引用次数: 0

On the Target Detection Performance of a Molecular Communication Network With Multiple Mobile Nanomachines 关于具有多个移动纳米机器的分子通信网络的目标探测性能。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2024-03-09 DOI: 10.1109/TNB.2024.3399188

Nithin V. Sabu;Abhishek K. Gupta

{"title":"On the Target Detection Performance of a Molecular Communication Network With Multiple Mobile Nanomachines","authors":"Nithin V. Sabu;Abhishek K. Gupta","doi":"10.1109/TNB.2024.3399188","DOIUrl":"10.1109/TNB.2024.3399188","url":null,"abstract":"A network of nanomachines (NMs) can be used to build a target detection system for a variety of promising applications. They have the potential to detect toxic chemicals, infectious bacteria, and biomarkers of dangerous diseases such as cancer within the human body. Many diseases and health disorders can be detected early and efficiently treated in the future by utilizing these systems. To fully grasp the potential of these systems, mathematical analysis is required. This paper describes an analytical framework for modeling and analyzing the performance of target detection systems composed of multiple mobile nanomachines of varying sizes with passive/absorbing boundaries. We consider both direct contact detection, in which NMs must physically contact the target to detect it, and indirect sensing, in which NMs must detect the marker molecules emitted by the target. The detection performance of such systems is calculated for degradable and non-degradable targets, as well as mobile and stationary targets. The derived expressions provide various insights, such as the effect of NM density and target degradation on detection probability.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"524-536"},"PeriodicalIF":3.7,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0