IEEE Transactions on NanoBioscience最新文献

{"title":"IEEE Transactions on NanoBioscience Publication Information","authors":"","doi":"10.1109/TNB.2026.3662952","DOIUrl":"https://doi.org/10.1109/TNB.2026.3662952","url":null,"abstract":"","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"C2-C2"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11472786","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Relaxation-Based Bio-Sensing Performance of Magnetic Nanoparticles Using Magnetic Particle Spectroscopy","authors":"Hafiz Ashfaq Ahmad;Jungwon Yoon","doi":"10.1109/TNB.2025.3640088","DOIUrl":"10.1109/TNB.2025.3640088","url":null,"abstract":"Magnetic Particle Spectroscopy (MPS) is a highly sensitive, label-free technique for detecting biomolecular interactions through the nonlinear magnetization of magnetic nanoparticles (MNPs). This study presents a comparative performance evaluation of four commercial carboxyl-functionalized MNPs as: Synomag®, Perimag®, Resovist®, and SHP-30 (Ocean NanoTech), to assess their biosensing suitability using MPS. Measurements at 5, 15, and 25 kHz in water, glycerol, and agarose characterized medium- and frequency-dependent relaxation: SHP-30 exhibited predominantly Brownian relaxation with the highest sensitivity to hydrodynamic size changes; Perimag showed slower Brownian behavior with reduced sensitivity; Resovist was predominantly Néel-dominated; and Synomag displayed mixed relaxation. For biosensing efficiency, all four MNPs were conjugated with H1N1 hemagglutinin protein via EDC–NHS chemistry, and bio-conjugation was confirmed by FT-IR (amide I/II) and DLS (increased hydrodynamic size). ICP-MS quantified the retained iron content after conjugation and washing, and all samples were normalized to the same iron mass for MPS measurement. Frequency-tuned MPS measurements identified that SHP-30 exhibited significantly greater signal suppression at low frequencies (~7.74 kHz) upon protein binding, enabling protein detection limit down to 10 nM. Collectively, these findings establish SHP-30 as a highly sensitive and efficient candidate for biomarker-conjugated MPS diagnostics, with potential utility in infectious disease detection and point-of-care applications.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"191-202"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IEEE Transactions on NanoBioscience Information for Authors","authors":"","doi":"10.1109/TNB.2026.3662956","DOIUrl":"https://doi.org/10.1109/TNB.2026.3662956","url":null,"abstract":"","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"C3-C3"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11472606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147588214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling the Impact of Hollow Microneedle Geometry on Iontophoretic Drug Transport Through Age-Variant Skin Surfaces","authors":"Ananya Bhattacharjee;Muhammad A. Alam;Ratul K. Baruah","doi":"10.1109/TNB.2025.3638648","DOIUrl":"10.1109/TNB.2025.3638648","url":null,"abstract":"Transdermal drug delivery has emerged as a promising alternative to conventional invasive methods, offering advantages such as reduced pain, lower infection risk, and improved patient compliance. However, the influence of age-related skin topography, particularly wrinkle-induced variations, on delivery efficacy in terms of time delay and geometry-dependent total dose remains underexplored. This study presents a computational investigation of iontophoretic drug transport using hollow conical microneedles, focusing on age-variant skin profiles characterized by sinusoidal wrinkle patterns. The transdermal delivery of the ionic dermatological agent Dexamethasone Sodium Phosphate is modeled at initial concentrations of 1-5 mg/L, using microneedle lengths of <inline-formula> <tex-math>$100~mu $ </tex-math></inline-formula>m and <inline-formula> <tex-math>$150~mu $ </tex-math></inline-formula>m. The spatial and temporal concentration profiles of drug diffusion within the dermis are simulated over a 30-minute period. COMSOL Multiphysics is employed to optimize microneedle and electrode design parameters by analyzing applied power, terminal resistance, and the time constant of drug permeation. Skin resistance is modeled across a <inline-formula> <tex-math>$1000~mu $ </tex-math></inline-formula>m surface span under three distinct skin conditions: a) smooth/flat skin, b) increased wrinkle amplitude (deeper crests), and c) increased wrinkle frequency (denser undulations). The results provide quantitative insights into how microneedle geometry and age-related skin surface morphology influence iontophoretic transport efficiency. This study offers design guidelines for age-responsive microneedle systems and informs future regulatory considerations in developing transdermal biomedical devices.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"172-181"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145632861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Quali-Quantitative Analysis of Biosensing and Biotransducing Systems for Cardiovascular Monitoring: Pacemakers Active and Passive Stress","authors":"J. Tene Koyazo;Aimé Lay-Ekuakille;Michele Bellino;Gennaro Galasso;Ornella Piazza;K. Srinivasa Rao","doi":"10.1109/TNB.2025.3645728","DOIUrl":"10.1109/TNB.2025.3645728","url":null,"abstract":"The global health burden of cardiovascular diseases, including MI (myocardial infarction), CAD (coronary artery disease), heart arrhythmias, cerebrovascular disease, and HF (heart failure), is substantial. As a primary cause of mortality, there is a pressing need for continuous and real-time heart monitoring to identify and treat irregular heart rhythms. PPMs (permanent pacemakers) constantly monitor the heart’s spontaneous electrical activity and only activate when it is either defiant or absent. The PPMs under investigation in our research are special implantable biosensors and biotransducers with nanoscale components. The PPMs do not generally contain biochemical reactants but they interact with physiological fluids to be considered as biosensors, and nanobiosensors if they encompass nanomaterials, as for our case. The objective of this study is to determine the reliability of PPM structures that have been implanted in patients who are suffering from one of the cardiovascular diseases over time. Even though the PPMs have been certified for the above use, however, natural patient conditions such as changes in body posture, temperature, or even changes in metabolic demand, can affect their operating modes. The sidewall roughness surface of PPMs is analyzed using atomic force microscopic 3D structural reconstruction, which is based on the grey images of PPMs from CT scanning for each patient. The angular equivocation (also known as angular entropy) approach is implemented to quantify the uncertainty in the distribution of edge or gradient orientation in PPMs images. Then, in order to address nonlinearities and interactions caused by metallic components in the PPM that introduce harmonic and distortions from biological tissues and device motion, we have conducted a bispectral analysis followed by contour representation plots. Different results obtained are of interest for monitoring the state of implantable devices in activity based on CT cardiac examinations in order to preserve the patient’s extended life.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"241-248"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Emerging Electrospun Techniques for Cutting-Edge Delivery of Biopharmaceuticals","authors":"Mamta Bishnoi;Shiv Kumar Prajapati;Divya Sharma;Ajay Pal Singh;Teena Teena;Ankit Jain","doi":"10.1109/TNB.2025.3639054","DOIUrl":"10.1109/TNB.2025.3639054","url":null,"abstract":"Electrospinning is a technique that utilizes high voltage to produce polymer nanofibers with adjustable morphology, extensive surface area, and interconnected porosity, rendering them highly suitable for biomedical applications. A prominent application of these fibers is in localized drug delivery, where they enable prolonged and targeted release. This review discusses various ELS techniques, each offering distinct advantages for incorporating small molecules, proteins, nucleic acids, either during the fiber formation process or through subsequent processing. Critical formulation factors such as polymer type, solvent, molecular weight, flow rate, and environmental conditions significantly influence fiber properties and drug release patterns. The review also highlights material selections and therapeutic applications in areas such as ocular, oral, dermal, and probiotic delivery, as well as in wound healing and tissue engineering.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"160-171"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145652985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Biodegradable Cell-Laden Microgels Assembly by Stop-Flow Lithography","authors":"Jakub Zlatník;Eliška Pazderková;Alina Mamedova;Jindřich Kropáček;Mario Rothbauer;Zdeněk Slouka;Ondřej Kašpar;Viola Tokárová;Ivan Řehoř","doi":"10.1109/TNB.2025.3644496","DOIUrl":"10.1109/TNB.2025.3644496","url":null,"abstract":"This study presents a novel approach for the synthesis of biodegradable cell-laden microgels using stop-flow lithography (SFL), addressing critical challenges in the field of tissue engineering. Traditional methods for creating 3D cell cultures often rely on non-biodegradable materials, which limit their application and raise concerns about cell viability. In this work, we successfully replace poly(ethylene glycol) diacrylate (PEGDA) with dextran-2-hydroxyethyl methacrylate (dex-HEMA), a biocompatible and biodegradable alternative. Furthermore, we introduce a technical solution for sterile cell encapsulation, validated through assessments of cell growth and viability alongside the biodegradation rate of the microgel matrix. Our results demonstrate the potential of the self-assembly technique to form organized structures with high spatial resolution. By encapsulating relevant cell lines, Caco-2 and HT-29, within distinct microgel types, we pave the way for the development of sophisticated 3D co-culture models. These advancements hold significant promise for replicating the structural and functional complexities found in native tissues, thereby enhancing the relevance of in vitro studies in biomedical research.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"232-240"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11301805","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDCSNPS: A Fast Division Calculation SNP System","authors":"Ping Guo;Xiong Chen;Xiaotong Liu;Hongsen Zhang;Ye Yan","doi":"10.1109/TNB.2025.3649201","DOIUrl":"10.1109/TNB.2025.3649201","url":null,"abstract":"Spiking Neural P system (SNP system) is a distributed parallel computing model inspired by the information processing of biological neurons. The SNP system has emerged as a research hotspots in the field of membrane computing, being utilized to tackle NP-hard problems and widely applied in solving practical issues. In this paper, we introduce a SNP system, Fast Division Calculation Spiking Neural P System (FDCSNPS), which is designed to reduce division operation time and minimize the number of spiking neurons. The system flow, input, control, and functional modules of FDCSNPS are discussed in detail. At the same time, the complexity of the system is analyzed, and its feasibility is verified by an example. Compared with the division SNP system based on multiple subtractions, which requires a time slice O(<inline-formula> <tex-math>$2^{mathbf {k}}$ </tex-math></inline-formula>), FDCSNPS only needs O(k<inline-formula> <tex-math>${}^{mathbf {{2}}}$ </tex-math></inline-formula>) time slices to complete k-bit binary division.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"249-258"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145855860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Analysis of Two-Layer Coding Scheme for DNA-Based Data Storage","authors":"Jiayao Zhang;Shancheng Zhao","doi":"10.1109/TNB.2025.3648790","DOIUrl":"10.1109/TNB.2025.3648790","url":null,"abstract":"DNA-based data storage has emerged as a compelling alternative to traditional media due to its ultra-high information density and long-term stability. However, the high read cost caused by the error-prone synthesis, storage, and sequencing processes remains a major bottleneck for practical deployment. To address this challenge, this paper proposes a read-cost-efficient coding framework that enhances reliability without increasing total redundancy. First, a novel two-layer intra-oligo coding scheme based on Bose–Chaudhuri–Hocquenghem (BCH) codes is presented, where index bits and data bits are respectively protected to mitigate base-level errors. Second, a semi-analytical optimization method based on the normal approximation of the finite-length coding rate is developed to allocate redundancy between index and data bits optimally under a fixed total code rate. The inter-oligo protection is further achieved through low-density parity-check (LDPC) codes to combat sequence-level errors. We then present extensive analytical and numerical results to show the effectiveness of the proposed analysis. Finally, we present numerical results to demonstrate that the concatenated code based on the optimized two-layer coding scheme significantly outperforms the concatenated code based on the single-layer coding scheme in terms of frame error rate (FER) under the same sequencing depth and total redundancy. These results underscore the advantages of the two-layer coding scheme and the optimization method for DNA-based data storage systems.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"259-269"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model","authors":"Samer S. Sarkis;Sherif Ismail;Ali Wadi;Mamoun F. Abdel-Hafez;Ghaleb A. Husseini","doi":"10.1109/TNB.2025.3641838","DOIUrl":"10.1109/TNB.2025.3641838","url":null,"abstract":"Ultrasound-triggered liposomes designed for specific targeting show promise as a drug delivery system, with the potential to enhance the effectiveness of chemotherapy while minimizing related side effects in clinical settings. This paper aims to model the drug release rate of seven targeted liposomes using a second-order discrete equation rather than the previously used first-order equation. By modeling the rate as second-order, different variants of the Kalman Filter can be applied to estimate the drug release rate. After modeling the equations and fitting the data to a second-order model, the Kalman filter variants, including the Extended Kalman Filter (EKF), Cubature Kalman Filter (CKF), and the Variational Bayesian-Based Correntropy Cubature Kalman Filter (VBMCCKF), were used to estimate the drug release rate. By applying those variants, we can see that the VBMCCKF yields the best tracking performance, combining the Variational Bayesian KF (VBKF’s) adaptive estimation of measurement noise with the MCCKF’s setting of the filter gain to a very small value when an abnormal measurement is detected. As a result, the VBMCCKF yielded the lowest Mean Squared Error (MSE) and Root Mean Squared Error (RMSE).","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"25 2","pages":"203-212"},"PeriodicalIF":4.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11284883","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}