IEEE Transactions on NanoBioscience最新文献

Green Synthesis of Selenium Nanoparticles Using Equisetum diffusum: Characterization, Antibacterial Potential, Effects on Plant Growth. 利用弥散木贼绿色合成纳米硒：表征、抗菌潜力及对植物生长的影响。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-05-06 DOI: 10.1109/TNB.2025.3567327

Nasir Assad, Hina Ahmad, Azhar Abbas, Muhammad Fayyaz Ur Rehman, Muhammad Naeem-Ul-Hassan, Muhammad Sher, Tehreem Riaz, Marzia Batool Laila, Iram Zahra, Farhad Ullah, Yasir Assad

{"title":"Green Synthesis of Selenium Nanoparticles Using Equisetum diffusum: Characterization, Antibacterial Potential, Effects on Plant Growth.","authors":"Nasir Assad, Hina Ahmad, Azhar Abbas, Muhammad Fayyaz Ur Rehman, Muhammad Naeem-Ul-Hassan, Muhammad Sher, Tehreem Riaz, Marzia Batool Laila, Iram Zahra, Farhad Ullah, Yasir Assad","doi":"10.1109/TNB.2025.3567327","DOIUrl":"https://doi.org/10.1109/TNB.2025.3567327","url":null,"abstract":"This study explores the green synthesis of selenium nanoparticles (SeNPs) using Equisetum diffusum (D ED) aqueous extract and evaluates their nanofertilizer and antibacterial potential. The synthesized SeNPs were characterized by UV-Vis spectroscopy, FTIR, XRD, SEM, EDX, DLS, TGA, and DSC, confirming their stability, spherical morphology, and high purity. The UV-Vis spectrum established a peak at 371 nm, and SEM analysis revealed an average particle size of 18.66 nm. The zeta potential measurement of -52.34 mV indicated excellent dispersion stability. The impact of SeNPs on plant growth was assessed through a five-week experiment with tomato plants. Plants treated with low and medium concentrations of SeNPs (Group 3 and 4) showed significant improvements in growth parameters, with 120.75 % and 120.03 %, respectively, compared to 101.37 % in the negative control. Leaf length and width also demonstrated notable enhancements. The antibacterial activity of SeNPs was tested against phytopathogens, Xanthomonas spp Citrus limetta and Solanum lycopersicum, along with human pathogens, Listeria monocytogenes, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli. The SeNPs exhibited substantial inhibitory effects, with zones of inhibition measuring 26, 21, 31, 24, 36, and 24 mm, respectively. The MIC values ranged from 20 to 30 μL, and MBC values ranged from 30 to 40 μL. These results show the potential of biogenic SeNPs as effective nanofertilizer that enhance crop productivity and as antibacterial agents, offering a sustainable and environmental friendly alternative for agricultural and microbial management applications.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size-Dependent Effects of Phyllanthus niruri Nanoemulsions on Blood-Testis Barrier Integrity and Cellular Responses in TM4 Sertoli Cells. 毛茛纳米乳剂对血睾丸屏障完整性和TM4支持细胞反应的影响。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-05-05 DOI: 10.1109/TNB.2025.3566910

Ebrahim Sadaqa, Diky Mudhakir

{"title":"Size-Dependent Effects of Phyllanthus niruri Nanoemulsions on Blood-Testis Barrier Integrity and Cellular Responses in TM4 Sertoli Cells.","authors":"Ebrahim Sadaqa, Diky Mudhakir","doi":"10.1109/TNB.2025.3566910","DOIUrl":"https://doi.org/10.1109/TNB.2025.3566910","url":null,"abstract":"The therapeutic benefits of Phyllanthus niruri (PN) are well-known, particularly in traditional medicine. Nanoemulsion technology has enhanced its bioavailability and efficacy, but potential nanotoxic effects, especially on male reproductive health, are not fully understood. This study examines the cytotoxic and genotoxic impacts of Phyllanthus niruri nanoemulsions (PNNE) of different sizes on TM4 Sertoli cells, focusing on their effects on the blood-testis barrier (BTB). PNNE of two distinct sizes, were prepared using spontaneous emulsification. The cytotoxicity of these formulations was assessed using a Cell Counting Kit-8 (CCK-8) assay, while genotoxicity was evaluated through an alkaline comet assay. Additionally, the expression of BTB proteins, claudin 11 and connexin 43, was examined via immunofluorescence analysis. PNNE were synthesized with droplet sizes of 16.9 ± 3.31 nm and 163.7 ± 8.53 nm. The smaller PNNE exhibited higher cytotoxicity (IC50 = 160.6 ± 8.3 μg/mL) compared to the larger PNNE (IC50 = 324.4 ± 12.5 μg/mL) and caused more significant DNA damage, as evidenced by the comet assay Both sizes led to a reduction in BTB protein expression, with the smaller nanoparticles causing more pronounced disruption. The study highlights the crucial role of nanoparticle size in determining the biological effects of PNNE on TM4 Sertoli cells. Smaller PNNE were found to be more detrimental to BTB integrity and cellular health, emphasizing the need for careful size optimization in the development of nanoemulsion-based therapies. These findings contribute to the understanding of nanotoxicity in the context of male reproductive health.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in immunological impact of chemically and biologically synthesized silver nanoparticles. 化学和生物合成纳米银的免疫影响差异。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-04-28 DOI: 10.1109/TNB.2025.3564822

Vlasta Demeckova, Veronika Demcakova, Jana Sedlakova-Kadukova

{"title":"Differences in immunological impact of chemically and biologically synthesized silver nanoparticles.","authors":"Vlasta Demeckova, Veronika Demcakova, Jana Sedlakova-Kadukova","doi":"10.1109/TNB.2025.3564822","DOIUrl":"https://doi.org/10.1109/TNB.2025.3564822","url":null,"abstract":"Silver nanoparticles (AgNPs) are widely used for their antimicrobial properties but pose risks like environmental contamination and potential harm to human health. Nanoparticles' small size facilitates translocation within the body, often bringing them into contact with blood. Most toxicological research focuses on chemically synthesized AgNPs (CAgNPs) and their effects on microbes and animal cells. Fewer studies explore biologically synthesized AgNPs (BAgNPs) on animal cells, and their impact on blood components is uncertain with varied findings due to differences in size and stability. This study examined BAgNPs' effects on blood components in healthy and diseased states, using algae Parachlorella kessleri for synthesis. Nanoparticle size and morphology were assessed via TEM and UV-Vis spectrophotometry. Exposure to BAgNPs resulted in an increased number of echinocytes, reduced neutrophils, and decreased leukocyte viability. Unlike CAgNPs, BAgNPs did not increase macrophage proliferation. Differences in biological properties between BAgNPs and CAgNPs stem from their colloidal stability in varying environments. CAgNPs, stabilized electrostatically, exhibited greater aggregation in environments with higher salinity and lower pH, diminishing their biological effects in human blood. Hence, electrostatically stabilized chemically produced AgNPs may not be suitable for biomedical applications.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of Silver and Zinc Oxide Nanoparticles Using Platostoma palustre Aqueous Extract for Biomedical Applications. 生物医学应用中利用palostoma palustre水萃取物生物合成氧化银和氧化锌纳米粒子。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-04-24 DOI: 10.1109/TNB.2025.3563382

Hoang Phuong Uyen Nguyen, Hoang Van Huy Dai, Anh Hue Luong, Wei-Chih Lin

{"title":"Biosynthesis of Silver and Zinc Oxide Nanoparticles Using Platostoma palustre Aqueous Extract for Biomedical Applications.","authors":"Hoang Phuong Uyen Nguyen, Hoang Van Huy Dai, Anh Hue Luong, Wei-Chih Lin","doi":"10.1109/TNB.2025.3563382","DOIUrl":"https://doi.org/10.1109/TNB.2025.3563382","url":null,"abstract":"This study highlights the structural, antioxidant, antibacterial, and anti-inflammatory properties of silver nanoparticles (AgNPs) and zinc oxide nanoparticles (ZnONPs), synthesized successfully using Hsiantsao aqueous extract as an eco-friendly alternative to traditional chemical methods. The antioxidant activity of the nanoparticles was assessed through DPPH, ABTS, and FRAP assays. The XRD spectra of biosynthesized silver nanoparticles (AgNPs) and zinc oxide nanoparticles (ZnONPs) are showed size average of 7 nm and 24-44 nm, respectively. AgNPs demonstrated notable antioxidant properties, achieving 70%±0.68 DPPH scavenging and 75%±0.82 ABTS inhibition at 0.1 mg/mL. ZnONPs showed superior efficacy, with 47.43%± 0.68 DPPH scavenging and 80%±0.82 ABTS inhibition, as well as robust reducing power in the FRAP assay, comparable to standard ascorbic acid. Antibacterial assays revealed that AgNPs were particularly effective against Gram-positive bacteria, while ZnONPs exhibited activity against both Grampositive and Gram-negative strains. Additionally, ZnONPs demonstrated exceptional anti-inflammatory potential, inhibiting protein denaturation by up to 91% at 0.01 mg/mL. These structural and functional characteristics position AgNPs and ZnONPs as promising candidates for biomedical applications. These findings underscore the versatility of AgNPs and ZnONPs in advancing modern healthcare solutions.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and Characterization of ZnO/Graphene Thin Film Alcohol Sensor. ZnO/石墨烯薄膜酒精传感器的制备与表征。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-04-23 DOI: 10.1109/TNB.2025.3563456

Routu Santosh, Anuriddh Bahadur Yadav, Ball Mukund Mani Tripathi, Rahul Checker, Pankaj Kumar

引用次数: 0

Exploring the Antibacterial, Anticoagulant, and Hemolytic Potential of Green-Synthesized Fe₂O₃ Nanoparticles by Cucurbita pepo pulp. 利用葫芦果肉制备绿色纳米Fe2O3的抗菌、抗凝血和溶血性能研究。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-04-22 DOI: 10.1109/TNB.2025.3563307

Hansa Gul, Haris Ahmed Khan, Zahida Nasreen, Nasir Assad, Syed Ali Turab, Muhammad Hanif

{"title":"Exploring the Antibacterial, Anticoagulant, and Hemolytic Potential of Green-Synthesized Fe2O3 Nanoparticles by Cucurbita pepo pulp.","authors":"Hansa Gul, Haris Ahmed Khan, Zahida Nasreen, Nasir Assad, Syed Ali Turab, Muhammad Hanif","doi":"10.1109/TNB.2025.3563307","DOIUrl":"https://doi.org/10.1109/TNB.2025.3563307","url":null,"abstract":"Iron oxide nanoparticles (Fe2O3 NPs) were successfully Synthesized in a green manner using Cucurbita pepo pulp extract as a natural capping and reducing agent. UV-vis spectroscopy verified the synthesis with a distinct absorption peak at 285 nm, while FTIR analysis revealed functional groups responsible for reduction and stabilization. X-ray diffraction (XRD) analysis confirmed the crystalline nature of the nanoparticles, with an average size of 21.5 nm. SEM and EDX analyses further validated the nanoparticles' spherical morphology and elemental composition. Biosynthesized IONPs exhibited notable antibacterial activity against multidrug-resistant bacterial strains such as Klebsiella pneumoniae and Pseudomonas aeruginosa. The inhibition zones ranged between 5-22 mm for Klebsiella pneumoniae and from 4 to 12 mm for Pseudomonas aeruginosa, depending on the concentration of the nanoparticles. Hematological evaluations demonstrated strong anticoagulant and thrombolytic properties. Iron oxide nanoparticles effectively inhibited blood coagulation at 40 μg/mL and showed significant thrombolytic activity by dissolving preformed clots at 50 μg/mL. The biosynthesized IONPs showed remarkable antioxidant activity that was comparable to standard. This study underscores the potential of Cucurbita pepo as a sustainable and eco-friendly resource for synthesizing multifunctional IONPs. The results suggest promising applications to address antibiotic resistance and manage blood-related disorders. Furthermore, the findings highlight the critical role of green nanotechnology in the advancement of environmentally sustainable and biocompatible nanomaterials for diverse biomedical applications.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel linear machine learning method based on DNA hybridization reaction circuit. 一种新的基于DNA杂交反应电路的线性机器学习方法。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-04-15 DOI: 10.1109/TNB.2025.3559480

Chengye Zou, Qiang Zhang, Bin Wang, Changjun Zhou, Yongwei Yang, Xuncai Zhang

{"title":"A novel linear machine learning method based on DNA hybridization reaction circuit.","authors":"Chengye Zou, Qiang Zhang, Bin Wang, Changjun Zhou, Yongwei Yang, Xuncai Zhang","doi":"10.1109/TNB.2025.3559480","DOIUrl":"https://doi.org/10.1109/TNB.2025.3559480","url":null,"abstract":"DNA hybridization reaction is a significant technology in the field of semi-synthetic biology and holds great potential for use in biological computation. In this study, we propose a novel machine learning model based on a DNA hybridization reaction circuit. This circuit comprises a computation training component, a test component, and a learning algorithm. Compared to conventional machine learning models based on semiconductors, the proposed machine learning model harnesses the power of DNA hybridization reaction, with the learning algorithm implemented based on the unique properties of DNA computation, enabling parallel computation for the acquisition of learning results. In contrast to existing machine learning models based on DNA circuits, our proposed model constitutes a complete synthetic biology computation system, and utilizes the \"dual-rail\" mechanism to achieve the DNA compilation of the learning algorithm, which allows the weights to be updated to negative values. The proposed machine learning model based on DNA hybridization reaction demonstrates the ability to predict and fit linear functions. As such, this study is expected to make significant contributions to the development of machine learning through DNA hybridization reaction circuits.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective IDS Error Correction Algorithms for DNA Storage Channels with Multiple Output Sequences. 多输出序列DNA存储通道的有效IDS纠错算法。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-04-08 DOI: 10.1109/TNB.2025.3558853

Caiyun Deng, Guojun Han, Pengchao Han, Yi Fang

{"title":"Effective IDS Error Correction Algorithms for DNA Storage Channels with Multiple Output Sequences.","authors":"Caiyun Deng, Guojun Han, Pengchao Han, Yi Fang","doi":"10.1109/TNB.2025.3558853","DOIUrl":"https://doi.org/10.1109/TNB.2025.3558853","url":null,"abstract":"DNA data storage is a cutting-edge storage technique due to its high density, replicability, and long-term capability. It involves encoding, insertion, deletion, and substitution (IDS) channels for data synthesis and sequencing, and decoding processes. The IDS channels that feature multiple output sequences are prone to IDS errors, complicating the decoding process and degrading the performance of DNA data storage. To address this issue, we investigate effective IDS error correction algorithms considering two encoding schemes in DNA data storage. Specifically in the encoding process, we use marker codes (MC) and embedded marker codes (EMC) as inner codes, respectively, both connected to low-density parity-check (LDPC) codes as outer codes. First, we propose the segmented progressive matching (SPM) algorithm to infer the consensus sequence from multiple output sequences, thereby facilitating the decoding processes. Moreover, when using MC as the inner code, we propose a synchronous decoding algorithm based on the Hidden Markov Model (SDH) to infer the a posteriori probability (APP) of base symbols, which supports the external decoding algorithm. Furthermore, when the inner code is EMC, we propose the iterative external decoding (IED) algorithm. IED integrates synchronous decoding with embedded normalized min-sum decoding (ENMS) to achieve an enhanced APP for external decoding, enabling lower bit-error rate (BER) transmission. Meanwhile, we reduce the complexity of the external decoder by minimizing checksum node computations. Comparing the two schemes reveals that the SDH algorithm with MC as the inner code offers a lightweight solution for DNA data storage. In contrast, the IED with EMC demonstrates superior decoding performance with a linear complexity scale by the number of iterations. Compared with existing studies, simulation results show that our proposed decoding algorithm reduces the BER by 21.72% ~ 99.75%.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IEEE Transactions on NanoBioscience Publication Information IEEE纳米生物科学学报

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-03-26 DOI: 10.1109/TNB.2025.3551707

引用次数: 0

IEEE Transactions on NanoBioscience Information for Authors IEEE纳米生物科学信息汇刊

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-03-26 DOI: 10.1109/TNB.2025.3551711

引用次数: 0