IEEE Transactions on NanoBioscience最新文献

IEEE Transactions on NanoBioscience Publication Information

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-03-26 DOI: 10.1109/TNB.2025.3551707

引用次数: 0

IEEE Transactions on NanoBioscience Information for Authors

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-03-26 DOI: 10.1109/TNB.2025.3551711

引用次数: 0

Carbon Nitride-Supported Copper Oxide for Non-Enzymatic Glucose Sensor: A Multi-Platform Approach Utilizing Electrochemical, Field Effect Transistor and Microcontroller-based IoT Systems.

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-03-21 DOI: 10.1109/TNB.2025.3553622

Chandan Saha, Pooja Kumari, Lungelo Mgenge, Sarit Ghosh, Venkata Perla, Harishchandra Singh, Kaushik Mallick

{"title":"Carbon Nitride-Supported Copper Oxide for Non-Enzymatic Glucose Sensor: A Multi-Platform Approach Utilizing Electrochemical, Field Effect Transistor and Microcontroller-based IoT Systems.","authors":"Chandan Saha, Pooja Kumari, Lungelo Mgenge, Sarit Ghosh, Venkata Perla, Harishchandra Singh, Kaushik Mallick","doi":"10.1109/TNB.2025.3553622","DOIUrl":"10.1109/TNB.2025.3553622","url":null,"abstract":"The new generation of glucose biosensors has attracted significant research interest due to its fast response, high stability, reproducibility, portability and low detection limit. In this work, various types of high-performance non-enzymatic glucose sensors are proposed, based on carbon nitride supported copper oxide nanoparticles (CNCO). The hybrid system was synthesized using a modified deposition-precipitation route where the copper oxide nanoparticles were dispersed on the carbon nitride matrix. The X-ray diffraction pattern revealed that the copper oxide nanoparticles exhibit a high degree of crystallinity with a monoclinic structure. The synthesized hybrid material was used as a catalyst for the electrochemical detection of glucose in the range of 0 to 15.6 mM, demonstrating a detection limit of 0.59 mM and a sensitivity of 0.53 mA.mM-1.cm-2. The CNCO based extended gate field effect transistor, at different glucose concentrations (1-9 mM), showed limit of detection and sensitivity values of 0.59 mM and 0.065 mA.mM-1.cm-2, respectively. A microcontroller-based glucose sensor was also implemented in this study that exhibited the sensitivity value of 1.46 mV/mM within the concentration range of 2-8 mM. The carbon nitride-supported copper oxide-based glucose sensors exhibit excellent reproducibility, sufficient stability and high selectivity, making them a promising candidate for real-life sensing applications.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Redundant Residue Number System Codes for Reliable Diffusive Molecular Communication.

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-03-20 DOI: 10.1109/TNB.2025.3553183

Liwei Mu

{"title":"Enhanced Redundant Residue Number System Codes for Reliable Diffusive Molecular Communication.","authors":"Liwei Mu","doi":"10.1109/TNB.2025.3553183","DOIUrl":"10.1109/TNB.2025.3553183","url":null,"abstract":"This paper introduces an improved redundant residue number system (RRNS) encoding method to enhance the reliability of information transmission in diffusive molecular communication (DMC). In addressing the 2-1 mapping issue in RRNS encoding, we propose a simplified low-mapping solution that effectively avoids the 2-1 mapping problem, thereby simplifying the decoding process. Leveraging the superior performance of the low-mapping algorithm, we further developed a direct decision algorithm that further simplifies the decoding algorithm by omitting the traditional minimum distance decision-making steps. Furthermore, this study delves into the impact of modulus selection on RRNS decoding performance and provides guidelines for optimizing code construction. Through simulation experiments on DMC channels, we have validated the effectiveness of the proposed RRNS encoding method, especially when employing binary concentration shift keying (BCSK) modulation and considering intersymbol interference (ISI). The simulation results show that the proposed encoding method not only significantly reduces the bit error rate (BER) but also fully meets the requirements of DMC systems, offering a promising new direction for the development of molecular communication technology. With these improvements, our method not only enhances the reliability of information transmission in DMC systems but also lays a solid foundation for future research and applications in molecular communication technology.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A High Sensitive Nanomaterial Coated Side Polished Fiber Sensor for Detection of Cardiac Troponin I Antibody.

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-03-06 DOI: 10.1109/TNB.2025.3548823

M Valliammai, J Mohanraj, Balasubramanian Esakki, Lung-Jieh Yang, Chua-Chin Wang, A Bakiya

{"title":"A High Sensitive Nanomaterial Coated Side Polished Fiber Sensor for Detection of Cardiac Troponin I Antibody.","authors":"M Valliammai, J Mohanraj, Balasubramanian Esakki, Lung-Jieh Yang, Chua-Chin Wang, A Bakiya","doi":"10.1109/TNB.2025.3548823","DOIUrl":"https://doi.org/10.1109/TNB.2025.3548823","url":null,"abstract":"The advent of evanescent field based fiber optic biosensor and advancements in nanotechnology has create an excellent opportunity in label-free detection of biomarkers which plays vital role in the early, rapid and accurate diagnosis of acute diseases. In this work, we demonstrate a high sensitive Molybdenum Tungsten Disulfide (MoWS2) coated side polished fiber (SPF) biosensor for accurate and early diagnosis of cardio vascular disease (CVD). The Cardiac Troponins I (cTnI) is identified as a biomarker of interest for early and rapid diagnonis of CVD. The proposed SPF biosensor exhibits surface plasmonic resonance (SPR) detection due to the evanescent field interaction between MoWS2 nano coated side polished region and anti-CTnI. The proposed SPF biosensor possess the high sensitivity of 82% to detect the cTnI antibody with a limit of detection (LOD) about 17.5 pg/mL. The peak SPR shift have been calculated as 61 nm for analyte concentrations of 500 pg/mL Moreover, the proposed SPF biosensor possess the high degree of selectivity and environmental stability to CTnI among three analytes such as CTnI, Estrogen and Glucose. The hydrophobic interactions of MoWS2 and cTnI antibody leads to chemical free biofunctionalization of antibody in the sensing region. Hence, the simulation results shows the surface interaction strength calculated as 1.29 KJ mol-1/nm2 in order to evaluate the hydrophobic interactions. Thus, the proposed optical biosensor is a promising candidate for \"point-of-care\" testing of CVD disorders and preclinical assessments.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of heteroatom doped polymer coated nanomaterials for slow and controlled drug release in the physiological microenvironment.

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-03-06 DOI: 10.1109/TNB.2025.3548916

Nargish Parvin, Tapas Kumar Mandal, Sang Woo Joo

{"title":"Synthesis of heteroatom doped polymer coated nanomaterials for slow and controlled drug release in the physiological microenvironment.","authors":"Nargish Parvin, Tapas Kumar Mandal, Sang Woo Joo","doi":"10.1109/TNB.2025.3548916","DOIUrl":"https://doi.org/10.1109/TNB.2025.3548916","url":null,"abstract":"Objective: This study aimed to develop doped carbon dots and coat them with carboxyl-polymer to explore their applications in imaging living tissue cells and achieving targeted drug release, particularly for tumor therapy.Methods: The synthesis of NP-CDs involved a one-pot hydrothermal reaction of seaweed powder, ethylene diamine, and phosphoric acid at atmospheric pressure. Subsequently, the NP-CDs were coated with carboxyl-mounted PEG to create PEG@NP-CDs, serving as a nano carrier for delivering the anti-cancer drug Doxorubicin (DOX). The drug delivery capabilities of PEG@NP-CDs were assessed, and their sensitivity to variations in pH value was studied.Results: The hydrothermal reaction successfully yielded NP-CDs with distinctive fluorescence properties, exhibiting green fluorescence at 430 nm and varying emission peaks depending on the excitation wavelength used. The subsequent coating of NP-CDs with carboxyl-mounted PEG resulted in PEG@NP-CDs, which demonstrated biocompatibility and potential for drug delivery applications. The MTT assay confirmed the high biocompatibility of PEG@NP-CDs, rendering them suitable for biomedical applications.Conclusions: The study successfully developed a straightforward method to synthesize CDs doped with nitrogen and phosphorus, which exhibited green fluorescence and sensitivity to excitation wavelengths. These nanomaterials have potential for imaging living tissue cells and achieving slow drug release. Their drug delivery capabilities, especially pH sensitivity, make them promising for targeted therapy, particularly in tumors. The biocompatibility of PEG@NP-CDs further supports their safe biomedical use. Overall, PEG@NP-CDs offer a valuable tool for simultaneous imaging and drug delivery, with promising applications in tumor detection and therapy.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Pattern Switching Strategy: a Successful Application in the Bimolecular Model.

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-02-28 DOI: 10.1109/TNB.2025.3546665

Yifeng Luan, Min Xiao, Jinling Liang, Wenwu Yu, Wei Xing Zheng

{"title":"Spatial Pattern Switching Strategy: a Successful Application in the Bimolecular Model.","authors":"Yifeng Luan, Min Xiao, Jinling Liang, Wenwu Yu, Wei Xing Zheng","doi":"10.1109/TNB.2025.3546665","DOIUrl":"https://doi.org/10.1109/TNB.2025.3546665","url":null,"abstract":"The formation of spatial patterns plays a crucial role in the study of system spatiotemporal dynamics. Previous research has demonstrated that spatial patterns can effectively characterize the macro-scopic spatial structure of the reaction-diffusion system. While specific pattern structures, such as the hexagonal, mixed, and stripe pattern, have been identified, the interconnection between these patterns appears to be isolated and invariant. To facilitate the selection and switching between individual spatial patterns, the hybrid control strategy is applied to the bimolecular model for the first time. For the classical bimolecular model of the chemical reaction-diffusion system, the incorporation of two-dimensional diffusion extends its reaction space to the two-dimensional plane. The Turing instability conditions are obtained for the controlled bimolecular system. Through the weakly nonlinear analysis, the amplitude equations are derived near the Turing bifurcation threshold. Furthermore, we investigate the impact of each control parameter on the Turing bifurcation threshold and determine the distribution of spatial patterns and their stability through the amplitude equations. Simulation results indicate that by selecting appropriate control parameters, we can suppress the occurrence of Turing instability and facilitate transitions between the spatial patterns. The findings of the analysis offer valuable insights into the dynamics and control of pattern formation in reaction-diffusion systems.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High fault-tolerant DNA image storage system based on VAE. 基于 VAE 的高容错 DNA 图像存储系统。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-02-21 DOI: 10.1109/TNB.2025.3544401

Yuyang Lu, Zhihao Zhang, Jing Yang, Cheng Zhang

{"title":"High fault-tolerant DNA image storage system based on VAE.","authors":"Yuyang Lu, Zhihao Zhang, Jing Yang, Cheng Zhang","doi":"10.1109/TNB.2025.3544401","DOIUrl":"10.1109/TNB.2025.3544401","url":null,"abstract":"DNA-based storage has emerged as a promising storage paradigm due to its immense storage potential. However, the error-prone nature of DNA sequencing and synthesis processes limits this potential. Image data is typically compressed before storage, and even a single mismatch can lead to catastrophic error propagation during decompression, rendering the image unrecoverable. To reduce the error rate of DNA storage-based image compression, we have designed a high fault-tolerant DNA image storage system and applied it to image compression for DNA storage. This system achieves significant improvements in both image data compression ratio and resilience through three key innovations: 1) Using a Variational Autoencoder (VAE) to compress the image into uniformly sized latent variable blocks, followed by further compression via Singular Value Decomposition (SVD); 2) Quantizing the floating-point numbers in the latent variable blocks and applying rotational coding to the resulting ternary sequences, effectively ensuring positive constraints on homopolymer run lengths and GC content; 3) Optimizing the error-correction scheme to best recover each type of error by quantizing it back to its original value. Through image scaling, we adjust the compression ratio, and the comparative results of image compression simulations demonstrate the performance of the proposed model, highlighting its superiority in fault tolerance and storage density.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA-CBIR: DNA Translation Inspired Codon Pattern-based Deep Image Feature Extraction for Content-based Image Retrieval.

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-02-10 DOI: 10.1109/TNB.2025.3540102

Jitesh Pradhan, Hathiram Nenavath

{"title":"DNA-CBIR: DNA Translation Inspired Codon Pattern-based Deep Image Feature Extraction for Content-based Image Retrieval.","authors":"Jitesh Pradhan, Hathiram Nenavath","doi":"10.1109/TNB.2025.3540102","DOIUrl":"10.1109/TNB.2025.3540102","url":null,"abstract":"DNA is emerging as a promising medium for storing huge volumes of data in a confined space that remains intact for thousands of years. Although this technique is very efficient, especially for multimedia data like images, there is a lack of efficient searching and retrieval technique. This paper addresses this issue and proposes a novel Content Based Image Retrieval (CBIR) technique to retrieve similar images from the generated DNA-based image feature vectors. The features are obtained by a novel encoding scheme that uses the three Most-Significant Bits from the images and converts them into a string of nucleotides that follow run length and GC constraints to form DNA planes stored in a DNA medium. The nucleotides in these planes are interpreted through three consecutive sequences forming codons. The codon-based features are then utilized to perform instance-based image retrieval. The DNA planes are further adapted and implemented on diverse deep learning architectures, including ResNet-50, VGG-16, VGG-19, and Inception V3, to facilitate classification-based image retrieval tasks. The system's performance has been assessed using a range of datasets, encompassing coral, medical, and multi-label images. Experimental results demonstrate that the proposed approach achieves notable improvements when compared to existing state-of-the-art methods.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Miniaturized MgO Multi-Sensor Device Based on A Flexible Printed Circuit Board for Glucose and pH Detection. 基于柔性印刷电路板的微型氧化镁多传感器设备，用于检测葡萄糖和 pH 值。

IF 3.7 4区生物学

IEEE Transactions on NanoBioscience Pub Date : 2025-01-30 DOI: 10.1109/TNB.2025.3536456

Po-Hui Yang, Jyun-Ming Huang, Jung-Chuan Chou, Chih-Hsien Lai, Po-Yu Kuo, Yu-Hsun Nien, Wei-Shun Chen, Ming-Tai Hsu, Chi-Han Liao

{"title":"A Miniaturized MgO Multi-Sensor Device Based on A Flexible Printed Circuit Board for Glucose and pH Detection.","authors":"Po-Hui Yang, Jyun-Ming Huang, Jung-Chuan Chou, Chih-Hsien Lai, Po-Yu Kuo, Yu-Hsun Nien, Wei-Shun Chen, Ming-Tai Hsu, Chi-Han Liao","doi":"10.1109/TNB.2025.3536456","DOIUrl":"https://doi.org/10.1109/TNB.2025.3536456","url":null,"abstract":"This study proposed a miniaturized multi-sensor device prepared using a flexible printed circuit board (FPCB) and applied to detect glucose (Glu) and pH value, where both the readout circuit board and the sensors possess flexible characteristics. Additionally, this work implemented the potentiometric readout circuit. It integrated the die onto the readout circuit board using wire bonding techniques, while the area of the readout circuit board is 5.5 cm × 4.0 cm. The readout circuit board is equipped with a power supply, a readout circuit chip, and a multi-sensor. It is worth mentioning that this study designs the multi-sensor in a double-sided manner. The advantage of this design lies in the fact that both sides of the sensor can be utilized as a working electrode or reference electrode, providing convenience to users during measurement analysis. In addition, the magnesium oxide (MgO) multi-sensor is interconnected with the readout circuit board using slot type. This means the MgO multi-sensor can also be used as a disposable sensor. In this study, the multi-sensor system can measure hydrogen ions and Glu at the same time. The sensitivity of the two is 25.27 mV/pH and 16.78 mV/mM, respectively, and the linearity can reach 99.9 %.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"PP ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0