IBRO Neuroscience Reports最新文献

{"title":"The reduction in locomotor activity induced by restraint stress in young male mice involves the downregulation of hippocampal serotonergic and dopaminergic markers","authors":"Megumi Furukawa ,&nbsp;Nobuo Izumo ,&nbsp;Masahiro Toho ,&nbsp;Ryoken Aoki ,&nbsp;Hiroki Nishijima ,&nbsp;Yusuke Nakamura ,&nbsp;Yumi Sakai ,&nbsp;Yukiko Ishibashi ,&nbsp;Haruna Kurono ,&nbsp;Takayuki Manabe ,&nbsp;Hideo Matsuzaki","doi":"10.1016/j.ibneur.2025.04.017","DOIUrl":"10.1016/j.ibneur.2025.04.017","url":null,"abstract":"<div><div>The novel coronavirus (COVID-19) pandemic led to widespread restrictions on human activities, including limits on physical activity and public gatherings. In particular, the physical and mental effects of restricting childhood activities such as exercise and play urgently need to be elucidated. In this study, we analyzed the effects of restraint stress on young (4-week-old) and adult (10-week-old) mice using behavioral experiments and gene expression analysis. Restraint stress did not cause a decrease in the expression of BDNF, a depression marker, in the hippocampus, suggesting that it may be a relatively mild form of stress. In young mice, restraint stress caused significant reductions in locomotor activity and sucrose preference. In contrast, in adult mice, no significant difference was observed in locomotor activity or sucrose preference. Increased expression of the <em>XBP-1</em> gene might be involved in the resistance to endoplasmic reticulum stress and resilience to restraint stress in adult mice. Moreover, serotoninergic and dopaminergic markers were significantly downregulated in young mice exposed to restraint stress. These findings strongly suggest an increased vulnerability to stress during early childhood, which may substantially impact subsequent brain development in children.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 726-731"},"PeriodicalIF":2.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum","authors":"Parsa Saberian ,&nbsp;Hamide Nasiri ,&nbsp;Fatemeh Kaffashian ,&nbsp;Parisa Nasiriansari ,&nbsp;Fatemeh Nazari Nasab ,&nbsp;Niusha Mehrvarz ,&nbsp;Fatemeh Talebizadeh ,&nbsp;Shayan Shakeri ,&nbsp;Mahsa Mayeli ,&nbsp;for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.ibneur.2025.04.018","DOIUrl":"10.1016/j.ibneur.2025.04.018","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer’s disease (AD) is a complex neurodegenerative disorder marked by progressive cognitive decline and disrupted brain network connectivity, particularly within the default mode network (DMN). Neurofilament light chain (NfL) serves as a biomarker for axonal injury, but the role of genetic predisposition, assessed via the Polygenic Hazard Score (PHS), in mediating the association between plasma NfL and DMN connectivity remains unclear. This study investigates whether PHS mediates the association between plasma NfL levels and DMN connectivity in individuals across different cognitive stages, including cognitively normal (CN), mild cognitive impairment (MCI), and AD.</div></div><div><h3>Methods</h3><div>Data were extracted from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Plasma NfL concentrations were measured using the Simoa assay, and resting-state fMRI (rs-fMRI), assessed DMN connectivity. The cohort included 102 participants (nCN=28, nMCI=52, and nAD=22). Partial correlation analyses and mediation models were performed, adjusting for age and gender. Statistical significance was set at p &lt; 0.05, after corrections for multiple comparisons.</div></div><div><h3>Results</h3><div>Plasma NfL levels were significantly higher in AD group compared to CN and MCI groups (p = 0.030). DMN connectivity showed substantial declines in the AD group, particularly in the posterior and ventral regions. Significant negative correlations were observed between plasma NfL and ventral DMN connectivity in AD. However, mediation analysis indicated no significant indirect effect of PHS, suggesting that genetic risk does not mediate the plasma NfL-DMN association.</div></div><div><h3>Conclusion</h3><div>These findings suggest that elevated plasma NfL levels are associated with disrupted ventral DMN connectivity in AD, reflecting neurodegeneration-related network dysfunction. However, the lack of a mediating effect by PHS indicates that this relationship is likely independent of genetic risk burden.</div></div><div><h3>Clinical Trial Number</h3><div>not applicable.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 732-738"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in apoptotic pathways and expression of miR-134, miR-181, and miR-497 induced by Wharton’s jelly-derived mesenchymal stem cells in a rat model of ischemic brain injury","authors":"Tahereh Alizamir ,&nbsp;Ali Fathi Jouzdani ,&nbsp;Fatemeh Attari ,&nbsp;Leila Arab ,&nbsp;Zeinab Ashaari ,&nbsp;Alireza Komaki ,&nbsp;Gholamreza Hassanzadeh","doi":"10.1016/j.ibneur.2025.04.015","DOIUrl":"10.1016/j.ibneur.2025.04.015","url":null,"abstract":"<div><h3>Background</h3><div>MicroRNAs (miRNAs) play crucial roles in regulating cell survival and signaling pathways. Mesenchymal stem cells (MSCs), particularly those derived from Wharton’s Jelly (WJ-MSCs), have shown potential in promoting cell survival and reducing apoptosis. This study evaluates the effects of WJ-MSCs on miRNA expression and apoptosis markers in an ischemic brain injury model.</div></div><div><h3>Methods</h3><div>Male Wistar rats (n = 30) were divided into control, sham, WJ-MSCs, Middle Cerebral Artery Occlusion (MCAO), and MCAO+WJ-MSCs groups. After 60 minutes of ischemia and 24 hours of reperfusion, WJ-MSCs were administered intracerebroventricularly. Post-surgical brain samples were analyzed using immunohistochemistry, TUNEL assay, and qRT-PCR to measure Bax/Bcl-2 ratios and miRNA (miR-497, miR-134, miR-181) expression in the cortex.</div></div><div><h3>Results</h3><div>Immunohistochemistry revealed that the Bax/Bcl-2 ratio was significantly increased in the MCAO group, reflecting a pro-apoptotic state. In contrast, WJ-MSC treatment significantly reduced the Bax/Bcl-2 ratio in the ischemic cortex, suggesting a shift towards anti-apoptotic activity. Additionally, analysis of miRNA expression showed significantly elevated levels of miR-497, miR-134, and miR-181 in the brains of ischemic rats, which were associated with increased neuronal cell death. WJ-MSC treatment effectively modulated these miRNAs, resulting in a marked reduction in their expression. Furthermore, the TUNEL assay confirmed a substantial reduction in the number of apoptotic cells in the MCAO+WJ-MSCs group compared to the MCAO group. In the cortex, apoptotic cells were observed in WJ-MSC-treated rats, indicating enhanced neuronal survival.</div></div><div><h3>Conclusion</h3><div>WJ-MSCs mitigate ischemic brain injury by modulating miRNA expression and apoptotic markers, promoting neuronal survival. These findings highlight their potential as a therapeutic strategy for ischemic brain injuries.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 759-770"},"PeriodicalIF":2.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of perioperative hyperglycemia on postoperative cognitive function: A comprehensive review","authors":"Jiale Song ,&nbsp;Shuqin Li ,&nbsp;Heng Zhao ,&nbsp;Qian Hao ,&nbsp;Hongyuan Sui ,&nbsp;Hongmei Zhou ,&nbsp;Jian Lu","doi":"10.1016/j.ibneur.2025.04.010","DOIUrl":"10.1016/j.ibneur.2025.04.010","url":null,"abstract":"<div><div>Hyperglycemia, commonly triggered by the physiological stress of surgery, is exacerbated by counter-regulatory hormonal responses and can lead to significant complications including Postoperative Cognitive Dysfunction (POCD) and delirium. These conditions not only extend hospitalization and increase healthcare costs but also negatively impact long-term patient well-being. This review addresses multiple objectives by conducting a comprehensive literature review that synthesizes existing research across various surgical disciplines to assess the impact of hyperglycemia on cognitive outcomes. This involves integrating findings from both observational studies and clinical trials to offer a nuanced perspective on the current knowledge landscape. Secondly, it identifies significant gaps in research, including inconsistencies in outcomes and methodological shortcomings. Highlighting these gaps emphasizes the need for a more standardized approach to understanding hyperglycemia's cognitive effects post-surgery. Lastly, the review proposes future research directions, advocating for innovative research methodologies and clinical interventions aimed at mitigating the cognitive impairments associated with perioperative hyperglycemia. By providing an exhaustive examination of these aspects, the review seeks to enhance scholarly discourse and inform clinical practice, ultimately aiming to refine perioperative care protocols. This will protect cognitive functions and improve overall patient outcomes, bridging the gap between theoretical research and practical application, thereby setting the stage for advancements that could transform perioperative management standards.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 698-704"},"PeriodicalIF":2.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The miR-133b and miR-206 serum levels as a candidate biomarker in Alzheimer's patients with dyslipidemia","authors":"Shahram Darabi ,&nbsp;Enam Alhagh Gorgich ,&nbsp;Auob Rustamzadeh ,&nbsp;Nafiseh Mohebi ,&nbsp;Hossein Mozhdehipanah","doi":"10.1016/j.ibneur.2025.04.014","DOIUrl":"10.1016/j.ibneur.2025.04.014","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by cognitive decline. Dyslipidemia, a risk factor for AD, may influence the expression of microRNAs (miRs) involved in AD pathogenesis. Thus, the aim of this study was to investigate the effect of dyslipidemia on the expression levels of miR-133b and miR-206 in AD patients with mild cognitive impairment. This study recruited a total of 45 subjects, who were subsequently divided into three distinct groups: the AD group (n = 15), the AD dyslipidemia group (n = 15), and the dyslipidemia group with normal cognitive status (n = 15). The Aβ_42/40 serum ratio was measured using an enzyme-linked immunosorbent assay. miR expression levels were determined by RT-qPCR. Clinicopathological characteristics, including Mini-Mental State Examination (MMSE) scores, Clinical Dementia Rating (CDR), and HDL levels, were also assessed. miR-133b levels were significantly reduced in the AD dyslipidemia group compared to the other two groups (p &lt; 0.001), while miR-206 levels were markedly elevated (p &lt; 0.001). Spearman correlation analysis revealed that miR-133b expression levels were positively associated with the Aβ_42/40 ratio (r = 0.799), MMSE scores (r = 0.578), and HDL levels (r = 0.768), while negatively associated with miR-206 levels (r = -0.461), CDR score (r = -0.539), and AD duration (r = -0.569). Conversely, miR-206 levels positively correlated with CDR and disease duration, but were inversely associated with miR-133b, MMSE, Aβ_42/40, and HDL. Serum miR-133b and miR-206 levels appear to be associated with AD pathology and clinical parameters in the early stages of the disease. The studied miR expression levels could serve as reliable biomarkers in AD patients with dyslipidemia.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 672-678"},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of modified scooter board therapy on trunk control and hip muscle activation in children with cerebral palsy – A pilot randomised control study","authors":"Shreekanth D. Karnad ,&nbsp;Amitesh Narayan ,&nbsp;Nutan Kamath ,&nbsp;Bhamini Krishna Rao ,&nbsp;Monika Sharma ,&nbsp;Vijaya Kumar K","doi":"10.1016/j.ibneur.2025.04.009","DOIUrl":"10.1016/j.ibneur.2025.04.009","url":null,"abstract":"<div><div>Cerebral palsy (CP), with an incidence rate of 2.95, is one of the leading causes of disability in children. The excessive tone in several muscle groups causes significant movement deficits and secondary impairments, such as hip displacement, affecting quality of life. Although age-related functional positioning treatment is effective, it does not prevent secondary deficits. Literature recommends the use of task-based training with an emphasis on the functional elongation of these spastic muscle groups. Thus, a therapy that is engaging, parent-inclusive, and addresses hip-related deficits is needed. Hence, this study aimed to develop and evaluate a therapy targeting adductor overactivity and trunk control. Modified Scooter Board Therapy (MSBT) is an intervention that uses a specially designed scooter board device, allowing children to propel themselves forward while positioned prone with hip abduction and neutral hip rotation. A convenient sample of eight children with CP were assigned to either the MSBT or conventional exercise group. The intervention lasted eight weeks, and electromyographic (EMG) recordings at rest and during volitional activity were obtained at baseline and after eight weeks. Non-parametric statistical analysis, with a significance level of p &lt; 0.05, showed no statistically significant differences between the groups at the end of the eight weeks. However, volitional hip adductor activity significantly changed in the MSBT group, indicated by a reduction in mean motor unit potential at rest. Additionally, parents preferred MSBT for its ease of use. Thus, MSBT appears to be a clinically promising intervention to reduce adductor hypertonicity and improve active control, highlighting the importance of prone positioning with active elongation for better motor function.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 705-713"},"PeriodicalIF":2.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Mapping of Brain COX-1 with [11C]PS13: Pharmacokinetic Evidence from human PET Imaging","authors":"Kiana Orangi ,&nbsp;Kimiya Batebi ,&nbsp;Farnoosh Vosough ,&nbsp;Mahdiyeh Nozad Varjovi ,&nbsp;Fatemeh Salehian ,&nbsp;Sahar Mesbah ,&nbsp;Mehrnaz Salahi ,&nbsp;Sajjad Hajihosseini ,&nbsp;Mohammad Yousef Fazel ,&nbsp;Saman Zaman ,&nbsp;Reza Hossein Zadeh ,&nbsp;Alaleh Alizadeh ,&nbsp;Mahsa Asadi Anar ,&nbsp;Niloofar Deravi","doi":"10.1016/j.ibneur.2025.04.012","DOIUrl":"10.1016/j.ibneur.2025.04.012","url":null,"abstract":"<div><h3>Background and aim</h3><div>Arachidonic acid is converted by cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) to prostaglandin H2, which has proinflammatory properties. The new PET radioligand [11 C]PS13 exhibits superior in vivo selectivity for COX-1 in nonhuman primates compared to COX-2. This study aimed to investigate [11 C]PS13 pharmacologically selectivity and substantial binding to COX-1 in the human brain.</div></div><div><h3>Material and methods</h3><div>Eight healthy volunteers had baseline [11 C]PS13 brain PET scans, and then images were blocked with either aspirin, celecoxib, or ketoprofen. The participants underwent two 90-minute [11 C]PS13 PET scans with radio metabolite-corrected arterial input function at baseline and approximately two hours after they received 75 mg of ketoprofen orally</div></div><div><h3>Result</h3><div>This study on [11 C]PS13 brain PET scans showed that ketoprofen and celecoxib selectively bind to COX-1 in the human brain. The occupancy plot showed a positive correlation with plasma ketoprofen concentration, with the highest binding potentials in the calcarine and lingual gyrus of the occipital region. The occupancy for COX-1 was about 49 % and 27 % for ketoprofen and celecoxib, respectively.</div></div><div><h3>Conclusion</h3><div>Ketoprofen demonstrated the highest selectivity for COX-1, while celecoxib exhibited partial occupancy likely due to dose- or time-dependent COX-1 inhibition. Aspirin showed minimal effect. Given the small sample size (n = 8), further studies with larger cohorts are warranted to confirm these findings and assess pharmacokinetic influences more thoroughly.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 657-662"},"PeriodicalIF":2.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic characterization of maturing neurons from human neural stem cells across developmental time points","authors":"Kimia Hosseini ,&nbsp;Gaëtan Philippot ,&nbsp;Sara B. Salomonsson ,&nbsp;Andrea Cediel-Ulloa ,&nbsp;Elnaz Gholizadeh ,&nbsp;Robert Fredriksson","doi":"10.1016/j.ibneur.2025.04.013","DOIUrl":"10.1016/j.ibneur.2025.04.013","url":null,"abstract":"<div><div>Neurodevelopmental studies employing animal models encounter challenges due to interspecies differences and ethical concerns. Maturing neurons of human origin, undergoing several developmental stages, present a powerful alternative. In this study, human embryonic stem cell (H9 cell line) was differentiated into neural stem cells and subsequently matured into neurons over 30 days. Ion AmpliSeq™ was used for transcriptomic characterization of human stem cell-derived neurons at multiple time points. Data analysis revealed a progressive increase of markers associated with neuronal development and astrocyte markers, indicating the establishment of a co-culture accommodating both glial and neurons. Transcriptomic and pathway enrichment analysis also revealed a more pronounced GABAergic phenotype in the neurons, signifying their specialization toward this cell type. The findings confirm the robustness of these cells across different passages and demonstrate detailed progression through stages of development. The model is intended for neurodevelopmental applications and can be adapted to investigate how genetic modifications or exposure to chemicals, pharmaceuticals, and other environmental factors influence neurons and glial maturation.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 679-689"},"PeriodicalIF":2.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gliogenesis but not neurogenesis occurs during the acute phase of vestibular compensation after unilateral vestibular neurectomy","authors":"Liang-Wei Chen ,&nbsp;Kenneth Lap-Kei Wu ,&nbsp;Kin-Wai Tam ,&nbsp;Chun-Wai Ma ,&nbsp;Yat-Ping Tsui ,&nbsp;Chun-Hong Lai ,&nbsp;Ying-Shing Chan ,&nbsp;Daisy Kwok-Yan Shum","doi":"10.1016/j.ibneur.2025.04.008","DOIUrl":"10.1016/j.ibneur.2025.04.008","url":null,"abstract":"<div><div>Following unilateral loss of vestibular input, recovery of motor symptoms is achieved within 2 weeks in rodents. Given that neurogenesis was only reported at 1 month post-lesion, whether there is neurogenesis in this early phase of vestibular compensation remains to be investigated. If not, what then is the major cell type that participates in this timeframe? We show abundant nestin-positive cells in the ipsilesional but not contralesional vestibular nucleus (VN) of rats after ablating cell bodies of vestibular nerve at the Scarpa’s ganglion, as confirmed by both magnetic resonance imaging after surgery and histology. Bromodeoxyuridine (BrdU) uptake indicated that these cells actively proliferated. A high proportion of the cells were double-positive for nestin and GFAP as early as 4 days, and up to 2 weeks post-lesion, in contrast to none in control preparations. In contrast, the number of NeuN-positive neural lineage cells in the VN remained constant in both the control and lesioned rats. Furthermore, NeuN-positive cells were not positive for BrdU. However, a small number of proliferating cells stained positive for the immature neuron progenitor marker doublecortin. Taken together, we show that unilateral loss of vestibular input stimulates proliferation of neuroglial progenitors, and provide evidence that argues against occurrence of neurogenesis within the 2 week period in which recovery of postural and motor symptoms occurs.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 690-697"},"PeriodicalIF":2.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventions","authors":"Kang Lin ,&nbsp;Pei Li ,&nbsp;Pei-zhu Zhang ,&nbsp;Ping Jin ,&nbsp;Xin-feng Ma ,&nbsp;Guang-an Tong ,&nbsp;Xiao Wen ,&nbsp;Xue Bai ,&nbsp;Gong-qiang Wang ,&nbsp;Yong-zhu Han","doi":"10.1016/j.ibneur.2025.04.003","DOIUrl":"10.1016/j.ibneur.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>Despite clinical observations of emotion-tremor interactions in Parkinson’s disease (PD), the neurophysiological mechanisms mediating this relationship remain poorly characterized.</div></div><div><h3>Methods</h3><div>This study employs a multimodal approach integrating 16-channel electroencephalography (EEG) and inertial motion sensors to investigate emotion-modulated postural tremor dynamics in 20 PD patients and 20 healthy controls (HCs) during standardized video-induced emotional states (positive/neutral/negative).</div></div><div><h3>Results</h3><div>Key findings demonstrate impaired negative emotional processing in PD, manifested as paradoxical increases in subjective valence (pleasure-displeasure ratings) coupled with reduced physiological arousal. Tremor variability predominantly correlated with negative emotional states, showing a negative association with valence scores and positive correlation with arousal levels. EEG analysis identified differential beta-band power modulation in prefrontal (Fp1/Fp2) and temporal (T3/T4) regions during negative emotion processing. These results suggest that emotion-driven tremor fluctuations in PD originate from dysfunctional integration of limbic and motor networks.</div></div><div><h3>Conclusion</h3><div>These findings establish emotion-modulated tremor as a distinct PD phenotype, informing the development of closed-loop biofeedback systems for personalized neuromodulation.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"18 ","pages":"Pages 663-671"},"PeriodicalIF":2.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}