Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease

IF 2 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2025-02-26 DOI:10.1016/j.ibneur.2025.02.009

François Cossais , Marie Christin Hörnke , Katja Schröder , Ralph Lucius , Martina Böttner , Jan-Hendrik Egberts , Florian Richter , Thilo Wedel

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Abstract

Background

Phosphorylated alpha-synuclein (P-aSyn) is a biomarker for Parkinson’s disease (PD), with potential relevance in intestinal inflammatory disorders.

Objectives

This study examines the distribution of P-aSyn in colonic tissues of patients with diverticular disease (DD) compared to age-matched controls.

Methods

P-aSyn distribution was analyzed in colon samples of 45 patients with diverticulitis (D-itis), 12 with diverticulosis (D-osis), and 30 controls via immunohistochemistry.

Results

P-aSyn immunoreactivity was found along enteric neurons of the myenteric and submucosal plexus in 93.1 % of participants, with similar distribution across D-itis, D-osis, and controls. Elevated reactivity appeared in 16.7 % of D-osis, 19.6 % of D-itis, and 30.0 % of controls.

Conclusion

P-aSyn presence in colonic tissue did not significantly differ between DD patients and controls, suggesting that DD-related inflammation does not notably affect P-aSyn expression. Further research is warranted to explore aSyn roles within the enteric nervous system in intestinal inflammatory disorders and their relation with neurodegenerative diseases.

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