IBRO Neuroscience Reports最新文献

{"title":"The combined effects of motor imagery and motor practice are influenced by differences in working memory function: Examination of brain, spinal cord, and muscle performance data","authors":"Yuki Fukumoto ,&nbsp;Hiroki Bizen ,&nbsp;Marina Todo ,&nbsp;Naoki Yoshida ,&nbsp;Toshiaki Suzuki","doi":"10.1016/j.ibneur.2025.06.016","DOIUrl":"10.1016/j.ibneur.2025.06.016","url":null,"abstract":"<div><div>The ability to perform motor imagery is affected by differences in short-term memory storage capacity in terms of the activation of working memory. Therefore, from the viewpoint of the simultaneous measurement of brain activation and spinal motor neuron excitability, we examined differences in the combined effects of motor practice and motor imagery due to differences in working memory function. 20 healthy individuals were classified into Normal (score of ≤5–6 digits) and Good (score of ≥7 digits) groups based on working memory in a digit span test. Following this, participants performed six sets of repetitive exercises combining motor practice and motor imagery, and changes in neural activity patterns in the brain and spinal cord, as well as changes in finger dexterity, were tracked. In brain network analysis, the first execution of the imagery showed high Betweenness Centrality in the frontal pole cortex, which shifted to the dorsolateral prefrontal cortex with repeated imagery. The involvement of the frontal pole may reflect introspection of motor behavior in the initial stage, while the dorsolateral prefrontal cortex consistently participated in imagery generation throughout the entire motor imagery process. In addition, both groups showed improvement in finger dexterity after intervention, but during repetitive motor imagery, a decrease in amplitude F/M ratio was observed in the Good Working Memory group, and a decrease in activation of the right primary motor cortex was observed in the Normal Working Memory group. In terms of working memory, especially in aspects of the phonological loop, those with higher function may execute motor imagery more distinctly.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 210-222"},"PeriodicalIF":2.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological analysis of distal, proximal, and dual compression of the median nerve","authors":"Qiongfang Zhang ,&nbsp;Yongfeng Liu ,&nbsp;Jinhuan Zhang ,&nbsp;Yirong Chen ,&nbsp;Xingxian Huang ,&nbsp;Haibo Yu","doi":"10.1016/j.ibneur.2025.06.010","DOIUrl":"10.1016/j.ibneur.2025.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>Both distal and proximal compression of the median nerve can lead to hand numbness inpatients.This study aimed to dissect the electrophysiological characteristics of median nerve motor fibers inpatients with carpal tunnel syndrome (CTS) caused by distal median nerve compression, C8 - T1 nerve root - type cervical spondylosis (CRS) resulting from proximal median nerve compression, and double - compression syndrome (DCS) with CTS combined with C8 - T1 CRS, so as to verify the double - nerve compression theory, provide evidence-based basis for clinical treatment.</div></div><div><h3>Methods</h3><div>Retrospective analysis of 30 subjects per group (CTS, CRS, DCS, controls) from a neurophysiological database. Parameters included distal motor latency (DML1-wrist, DML2-elbow), compound muscle action potential (CMAP1, CMAP2), wrist-elbow motor conduction velocity (MCV), and F-wave latency.</div></div><div><h3>Results</h3><div>For each indicator, both the CTS group and the DCS group showed statistically significant differences from the normal group. When comparing between the CTS group and the DCS group, there were no statistically significant differences in all data indicators. When comparing the CRS group with the normal group, there were no statistically significant differences in DML1 and DML2, but there were statistically significant differences in the shortest latency of the F wave and the motor conduction velocity (MCV).</div></div><div><h3>Conclusion</h3><div>Double compression does not cause more severe damage to the nerve compared with simple distal compression. Distal compression of the median nerve causes more severe damage to the peripheral nerve than proximal compression. For patients with double compression syndrome, clinical treatment should prioritize the treatment of the distal compression site.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 205-209"},"PeriodicalIF":2.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptakes of boronophenylalanine in the in vitro and in situ glioblastoma and the potential efficacy of boron neutron capture therapy","authors":"Shining Zhang ,&nbsp;Yujie Wei ,&nbsp;Wenjiao Gu ,&nbsp;Shuangyi Li ,&nbsp;Ting Liu ,&nbsp;Limei Shuai ,&nbsp;Yu Tang ,&nbsp;Ying Jiang ,&nbsp;Xiaochun Zhou ,&nbsp;Yucai Wei ,&nbsp;Guan Wang ,&nbsp;Long Gu ,&nbsp;Yumin Li ,&nbsp;Futian Tang ,&nbsp;Daiying Zuo","doi":"10.1016/j.ibneur.2025.06.014","DOIUrl":"10.1016/j.ibneur.2025.06.014","url":null,"abstract":"<div><div>Human glioblastoma (GBM) is the most malignant brain tumor. Boron neutron capture therapy (BNCT) is proved to be a new technology for the effective treatment of GBM. We previously reported that boronophenylalanine (BPA), the boron drug used in BNCT prefers to the tumor of a mouse subcutaneous tumor model injected U87 and GL261, two GBM cell lines. The present study was designed to investigate the distribution of BPA in the tumor of a mouse <em>in situ</em> brain tumor model injected U87 and GL261 in the brain. The tumor model was evaluated by using small animal magnetic resonance imaging (MRI) and confirmed with the morphological observations. The boron concentration indicative of BPA in cells and tumor was measured using inductively coupled plasma atomic emission spectroscopy (ICP-AES). The results revealed that the protein of L-type amino acid transporter (LAT1) was highly expressed in both U87 and GL261 cells. In addition, boron concentration in U87 and GL261 cells was increased 1, 2, 3, 5 and 7 h after addition of BPA in a time-dependently manner. However, the boron concentration in the cells was rapidly decreased when the BPA in the medium was withdrawn for 1 h at each time point, reaching almost the same levels between the time points. In one mouse <em>in situ</em> brain tumor model injected U87 cells, the concentration of boron in the tumor tissue (25.529 μg/g) was higher than that in brain tissue (8.973 μg/g), blood (11.407 μg/g), heart (13.131 μg/g), liver (11.271 μg/g), spleen (15.631 μg/g) and lung (16.226 μg/g) respectively, having ratios of tumor/normal tissue 2.845, 2.238, 1.944, 2.265, 1.633 and 1.537 respectively. Similarly, in another mouse <em>in situ</em> brain tumor model injected GL261 cells, the concentration of boron in the tumor tissue (23.039 μg/g) was higher than that in brain tissue (8.141 μg/g), blood (9.573 μg/g), heart (12.119 μg/g), liver (9.609 μg/g), spleen (15.852 μg/g) and lung (12.565 μg/g) respectively, having ratios of tumor/normal tissue 2.831, 2.407, 1.901, 2.398, 1.453 and 1.834 respectively. The results suggest that uptakes of BPA in two cell lines occur in a time-dependent manner and that BPA preferred to distribute in brain tumor tissue than other normal tissues, having potential efficacy of BNCT.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 192-197"},"PeriodicalIF":2.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage","authors":"Nicolas Eden ,&nbsp;Marius Marc-Daniel Mader ,&nbsp;Jan Bremer ,&nbsp;Jennifer Sauvigny ,&nbsp;Jörn Grensemann ,&nbsp;Marlene Fischer ,&nbsp;Nils Schweingruber ,&nbsp;Jens Gempt ,&nbsp;Patrick Czorlich","doi":"10.1016/j.ibneur.2025.06.008","DOIUrl":"10.1016/j.ibneur.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of classical music on CBFV and other physiological parameters in patients suffering from aneurysmal subarachnoid hemorrhage (SAH).</div></div><div><h3>Methods</h3><div>Twenty patients with SAH were subjected to up to three interventions, in which the patients listened to <em>W. A. Mozart's Symphony No. 40 in G minor</em>. In parallel, CBFV in the right middle cerebral artery (MCA) was continuously measured using transcranial Doppler (TCD). TCD values were averaged per minute, normalized, and analyzed with a mixed-effects linear regression model. In addition, other physiological and laboratory parameters were evaluated.</div></div><div><h3>Results</h3><div>A total of 55 interventions were successfully carried out. The mixed-effects linear regression model revealed significant associations with both time (p &lt; 0.001) and session (p = 0.002), specifically, with each minute of classical music played, there was a 0.3 % reduction in CBFV (95 % confidence interval (CI): 0.2–0.4 %). Heart rate (HR) and respiratory rate (RR) decreased by 0.1 % (95 % CI: −0.2–0.0 %; p = 0.043) 0.3 % (95 % CI: −0.6 % to −0.1 %; p = 0.001), respectively, per minute of exposure. Each additional session resulted in a reduction of HR by 4.3 % and RR by 22.3 % from the baseline at the start of the intervention to minute 25 (both p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Our pilot study shows only a very small effect of classical music such as Mozart's Symphony No. 40 in G <em>minor</em> in patients with SAH.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 198-204"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of sleep quality and its determinants among individuals with diabetes mellitus and/or hypertension: A cross-sectional study","authors":"John Dogah ,&nbsp;Ansumana Bockarie ,&nbsp;Eric Kwame Kunkah ,&nbsp;Adwoa Abrafi Boampong ,&nbsp;George Nkrumah Osei ,&nbsp;Kwasi Baffour Gyimah ,&nbsp;Stephen Teye ,&nbsp;Esther Marfo ,&nbsp;David Mawutor Donkor ,&nbsp;David Larbi Simpong","doi":"10.1016/j.ibneur.2025.06.015","DOIUrl":"10.1016/j.ibneur.2025.06.015","url":null,"abstract":"<div><h3>Background</h3><div>Sleep difficulties are common, especially among people with chronic illnesses like diabetes mellitus and hypertension, which significantly impact health and survival. This study assessed sleep quality and factors associated with poor sleep quality in individuals with diabetes mellitus (DM) and/or hypertension.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at Mampong Government Hospital. Socio-demographic and lifestyle data, including age, sex, occupation, marital status, alcohol consumption, and physical activity levels, were collected via a structured questionnaire. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and data analysis was performed using Chi-square tests and binary logistic regression with IBM SPSS version 27.</div></div><div><h3>Results</h3><div>The study included 201 participants, with findings indicating that 41.3 % experienced poor sleep. Poor sleep was most prevalent among individuals with both DM and hypertension, affecting 37 out of 88 participants. Analysis of the PSQI components indicated that participants consistently scored above 1 in subjective sleep quality, sleep latency, and sleep disturbance, reflecting considerable sleep challenge. Married participants showed a higher prevalence of poor sleep (55.4 %), while those involved in mild physical activity reported the highest prevalence of poor sleep (69.9 %). Poor sleep was significantly associated with marital status, education level, and intensity of physical activity. Among participants with both diabetes mellitus and hypertension, those aged 41–60 had significantly higher odds of poor sleep compared to those aged 20–40 (aOR = 10.584, p = 0.043, 95 % CI: 1.081–103.592).</div></div><div><h3>Conclusion</h3><div>Poor sleep is common among individuals with diabetes mellitus and hypertension. The findings reinforce the importance of integrating sleep quality assessments into the management of chronic conditions to support overall health and well-being.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 143-147"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PKD1-mediated phosphorylation at dopamine D2 receptor serine 365 site in dorsal striatum underlies cocaine-induced locomotor hyperactivity","authors":"Xinyu Zhang ,&nbsp;Ziran Zhang ,&nbsp;Ying Wang ,&nbsp;Linlin Sun ,&nbsp;Ning Wang","doi":"10.1016/j.ibneur.2025.06.013","DOIUrl":"10.1016/j.ibneur.2025.06.013","url":null,"abstract":"<div><div>Locomotor hyperactivity is an early behavioural adaptation in cocaine use disorder, driven by increased dopamine levels in the striatum. The expression, sensitivity, and availability of dopamine D2 receptor (D2R) are significantly associated with cocaine use disorder. However, neither D2R agonists nor antagonists are optimal for clinical intervention because of their side effects. Therefore, targeting regulatory proteins that can effectively disrupt cocaine-induced D2R malfunction may offer improved strategies for cocaine use disorder. Here, we report that knockdown of protein kinase D1 (PKD1) in the rat dorsal striatum attenuates cocaine-induced locomotor hyperactivity. PKD1 phosphorylates the serine 365 site (S365) of D2R, reduces its surface localisation, and enhances downstream extracellular signal-regulated kinase (ERK) signalling. Tat-S365, an engineered Tat fusion-peptide blocked S365 phosphorylation in D2R, thereby decreasing the pERK levels. <em>In vivo</em> injection of peptide Tat-S365 into the rat dorsal striatum successfully inhibited cocaine-induced locomotor hyperactivity. Thus, targeting S365 of D2R presents a promising strategy for developing pharmacotherapeutic treatments for cocaine sensitisation and other disorders that result from dopamine imbalances.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 124-132"},"PeriodicalIF":2.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charting neuroethics discourse in Africa: A scoping review of ethical issues of neuroscience research in Africa","authors":"Oluyinka Oyeniji,&nbsp;Kutoma Wakunuma,&nbsp;Adebowale Owoseni","doi":"10.1016/j.ibneur.2025.06.002","DOIUrl":"10.1016/j.ibneur.2025.06.002","url":null,"abstract":"<div><div>The global neuroethics discourse has gained prominence since the beginning of the 21st century. Perspectives on neuroethics have been drawn from USA, Asia, the European Union etc. In Africa, the discourse has been largely influenced by neurogenomics research and collaborations across countries in the region. As neuroethicists continue to propose considerations for framing neuroethics discourse in Africa, ethical issues arise from not only largescale neurogenomics research, but such other neuroscience and brain research projects conducted in heterogeneous societies on the continent. Such neuroscience research projects carried out in academic institutions and medical facilities are yet to be subjected to an investigation of ethical issues arising therefrom. This paper therefore took a departure from neuroethics discourse being shaped in neurogenomics and international collaborations to consider what ethical issues arise from neuroscience broadly across parts of Africa. We conducted a scoping review of neuroscience research and neuroethics publications, complemented by the snowballing method to investigate ethical issues arising from such research endeavors. The research was grounded in ubuntu principles as lens through which ethical, legal and social implications of African neuroscience research were viewed. Findings established ethical issues peculiar within the African neuroscience research context including inequitable access to neuroscience research, distrust, lack of research funding, imposition of foreign methods without standardisation within contexts, violence and use of restraints, threat to life and morbidity, etc as ethical issues of neuroscience in Africa.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 174-191"},"PeriodicalIF":2.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theobromine prevents affective symptoms of nicotine withdrawal by modulating the neuroendocrine and immune systems, as well as the glutathione mechanism in the hippocampus","authors":"Qi Zhang ,&nbsp;Yu Tian ,&nbsp;Baojiang He ,&nbsp;Wenjuan Zhang ,&nbsp;Xingyu Liu ,&nbsp;Jufang Hao","doi":"10.1016/j.ibneur.2025.06.011","DOIUrl":"10.1016/j.ibneur.2025.06.011","url":null,"abstract":"<div><div>Currently, nicotine withdrawal symptoms pose a significant challenge in tobacco cessation efforts, particularly withdrawal affective symptoms, such as anxiety and depression like behavior. However, the underlying mechanisms of these symptoms remain poorly understood. Emerging evidence implicates the hippocampus, a key region in the limbic system, involved in emotional regulation. In this study, we employed transcriptome sequencing, untargeted metabolomics, and integrative multi-omics analysis to elucidate the molecular mechanisms underlying nicotine withdrawal-induced affective symptoms in the hippocampus of male C57BL/6J mice. Our findings corroborate previous research linking nicotine withdrawal symptoms to dysregulation of neuroendocrine pathways and inflammatory processes within the brain. Importantly, we identify impaired glutathione metabolism as a significant contributing factor to the development of these symptoms. Furthermore, our investigation reveals that theobromine, a principal psychoactive compound found in cocoa, exerts a potent therapeutic effect in alleviating nicotine withdrawal affective symptoms through diverse mechanisms. In addition to its modulation of neuroendocrine pathways and inflammation, theobromine's ability to restore glutathione metabolism in the hippocampus emerges as a pivotal aspect of its pharmacological action.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 160-173"},"PeriodicalIF":2.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared time-resolved spectroscopy reveals task-induced emotions by measuring cerebral blood oxygenation changes in the frontal pole during creative activity using a real object","authors":"Yumi Oboshi ,&nbsp;Kazuki Tamura ,&nbsp;Yasuko Fukushi ,&nbsp;Seiji Yamamoto","doi":"10.1016/j.ibneur.2025.06.009","DOIUrl":"10.1016/j.ibneur.2025.06.009","url":null,"abstract":"<div><div>Creative activities trigger enjoyable feelings, induce motivation, and are applied in clinical settings such as rehabilitation. Emotion and creativity are interrelated because they depend on a common neural network, with the prefrontal cortex playing a crucial role in both. Emotions affect creative thinking, and creative activities elicit emotions. Near-infrared spectroscopy (NIRS) provides a real-time assessment of emotion generated in a natural setting. Furthermore, near-infrared time-resolved spectroscopy (NIR-TRS) can measure brain activity that is less susceptible to extracerebral tissue. We measured oxyhemoglobin (Oxy-Hb) concentrations in the frontal pole, which is involved in emotion processing using NIR-TRS during creative and simple tasks utilizing real objects. Oxy-Hb concentrations in the frontal pole significantly increased during and after the creative task compared with the simple task. The autonomic function indices (heart rate and stress indices) were inversely correlated with the Oxy-Hb increase associated with the creative task performance, indicating that sympathetic nervous system hyperactivity did not cause this Oxy-Hb increase. A subjective survey revealed that positive emotions during the creative activity were significantly higher and correlated well with the increased Oxy-Hb level, indicating an increased frontal pole activity because of the enjoyability of the creative task. Our results indicate that NIR-TRS imaging can be employed for noninvasively measuring cerebral blood oxygenation changes in participants who experience various emotions during creative activities.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 148-159"},"PeriodicalIF":2.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-apoptotic effects of the medicinal plant Sterculia setigera in a model of serum deprivation-induced PC12 cells death","authors":"Yendubé T. Kantati ,&nbsp;Magloire K. Kodjo ,&nbsp;Benjamin Lefranc ,&nbsp;Kwashie Eklu-Gadegbeku ,&nbsp;Jérôme Leprince ,&nbsp;David Vaudry","doi":"10.1016/j.ibneur.2025.06.007","DOIUrl":"10.1016/j.ibneur.2025.06.007","url":null,"abstract":"<div><div><em>Sterculia setigera</em> is a medicinal plant of Togolese flora. We have previously reported that <em>S. setigera</em> leaves dry hydroethanolic extract (SSE) protects <em>in vitro</em> cerebellar granule neurons against H₂O₂ and 6-OHDA-induced cell death and <em>in vivo</em> against ethanol neurotoxicity on the cerebellar cortex of 8-day-old Wistar rats. The present study aimed to extend our knowledge of the protective effects of SSE by exploring its anti-apoptotic mechanisms on cultured PC12 cells. Apoptosis was induced by serum depletion before treatment with various concentrations (5–100 µg/mL) of SSE. SSE (20 µg/mL) significantly protected PC12 cells (+51.8 %) against serum depletion-induced PC12 cell death and inhibited Caspase-3/7 (-65.1 %) activity. SSE also significantly increased the expression of the anti-apoptotic factor <em>Bcl-2</em>. Conversely, it repressed the expression of <em>Casp-3</em>, <em>Tp53</em> and <em>Ddit3</em>. Taken together, these results indicate that inhibition of apoptosis appears to be one of the main mechanisms of <em>S. setigera</em> neuroprotective effects.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 110-116"},"PeriodicalIF":2.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}