小睡可以恢复因睡眠不足而受损的工作记忆和大脑活动

IF 2.9 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2025-09-25 DOI:10.1016/j.ibneur.2025.09.013

Anping Ouyang , Jun Jiang , Lin Wu , Xinxin Lin , Lingling Wang , Qiutao Yan , Xuqian Diao , Yan Li , Yuanqiang Zhu , Lingli Zeng , Jiaxi Peng , Qianqian Dong , Wei He , Peng Fang

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引用次数: 0

摘要

睡眠剥夺（SD）会损害工作记忆（WM），然而白天短暂小睡的恢复潜力仍未得到充分探索。本研究探讨了小睡如何通过行为和神经成像机制抵消sd诱导的WM缺陷，重点关注任务正性网络和默认模式网络（DMN）动力学。方法在受试者fMRI研究中，对50名受试者在基线清醒、30小时SD后和午睡后恢复三种情况下进行2-back WM任务。使用重复测量方差分析和混合效应模型分析行为指标（反应时间、准确性）和fMRI激活模式，以评估SD和午睡的影响。结果aps部分恢复sd诱导的WM下降，提高反应时间和准确性。小睡后，小脑、脑岛和丘脑（注意/执行区域）的激活减少，小睡后恢复。SD减弱DMN抑制（额叶中回、楔前叶、颞上回），午睡后DMN抑制最大。改进的WM性能与重新激活的任务正性网络相关。结论白天小睡通过重新平衡小脑、丘脑的任务正网络激活和增强DMN抑制来减轻sd相关的WM缺陷。这些发现阐明了睡眠-认知相互作用的神经生理机制，支持小睡作为sd诱导的认知障碍的实际干预措施

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Napping restores working memory and brain activation impaired by sleep deprivation

Background

Sleep deprivation (SD) impairs working memory (WM), yet the restorative potential of brief daytime naps remains underexplored. This study examines how naps counteract SD-induced WM deficits through behavioral and neuroimaging mechanisms, focusing on task-positive networks and default mode network (DMN) dynamics.

Method

A within-subject fMRI study employed 2-back WM tasks in 50 participants under three conditions: baseline wakefulness, post-30h SD, and post-nap recovery. Behavioral metrics (reaction times, accuracy) and fMRI activation patterns were analyzed using repeated-measures ANOVA and mixed-effects models to assess SD and nap effects.

Result

Naps partially restored SD-induced WM declines, improving reaction times and accuracy. Post-SD, reduced activation in the cerebellum, insula, and thalamus (attention/executive regions) rebounded post-nap. SD weakened DMN suppression (middle frontal gyrus, precuneus, superior temporal gyrus), with maximal DMN suppression post-nap. Improved WM performance correlated with reactivated task-positive networks.

Conclusion

Daytime naps mitigate SD-related WM deficits by rebalancing task-positive network activation (cerebellum, thalamus) and enhancing DMN suppression. These findings elucidate neurophysiological mechanisms of sleep-cognition interactions, supporting naps as a practical intervention for SD-induced cognitive impairment

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