IBRO Neuroscience Reports最新文献

{"title":"Synergistic effects of PAR2 and TrkA exacerbate visceral hypersensitivity induced by chronic pancreatitis in rats","authors":"Zhiyun Liu ,&nbsp;Jiao Zhu ,&nbsp;Qianbo Chen ,&nbsp;Kunming Tao ,&nbsp;Kai Wei ,&nbsp;Xiaodan Wu ,&nbsp;Haibo Qiu ,&nbsp;Zhijie Lu","doi":"10.1016/j.ibneur.2025.06.012","DOIUrl":"10.1016/j.ibneur.2025.06.012","url":null,"abstract":"<div><h3>Background</h3><div>Abdominal pain is the most severe symptom of chronic pancreatitis. However, till date, there are only a few studies on the mechanism of pain in chronic pancreatitis. Previous research has reported that mast cells are enriched around nerve fibers and are associated with visceral pain. In this study, we aimed to investigate the molecular mechanisms by which protease-activated receptor 2 (PAR2) and tropomyosin receptor kinase A (TrkA) exacerbate pain in chronic pancreatitis.</div></div><div><h3>Methods</h3><div>A chronic pancreatitis animal model was established by injecting dibutyltin dichloride into the tail vein of Wistar rats. The von Frey test was performed to evaluate pain behavior in the rats. Hematoxylin and eosin staining, western blotting, immunofluorescence histochemistry, retrograde labeling, culture of dorsal root ganglion (DRG) neurons, and whole-cell patch clamp recordings were performed to illustrate the mechanisms.</div></div><div><h3>Results</h3><div>The pancreatic structures were destroyed, including inflammatory cell infiltration and acinar atrophy, and mast cells were dramatically recruited to the pancreatic tissue in chronic pancreatitis. Systemic administration of the mast cell stabilizer ketotifen alleviated chronic pancreatitis-induced visceral hypersensitivity in the Wistar rat model. In contrast, the mast cell secretagogue compound 48/80 dose-dependently exacerbated chronic pancreatitis pain. Furthermore, the number of DRG neurons projected into the pancreas was significantly increased by injecting Dil stain in chronic pancreatitis rat models and normal rats. The co-expression of PAR2 and TrkA was only observed in small-diameter DRG neurons containing transient receptor potential vanilloid 1 channel and was significantly higher than those in normal rats. Finally, we demonstrated the functional interaction between PAR2 and TrkA by whole-cell patch clamp recordings.</div></div><div><h3>Conclusions</h3><div>Mast cells contribute to chronic pancreatitis pain through enrichment and degranulation. The interaction of PAR2 and TrkA exacerbates chronic pancreatitis pain, which may be a potential strategy for the treatment of chronic pancreatitis -induced visceral pain.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 235-244"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of genotypes at single-nucleotide polymorphisms in IL-28B, TGF-β1, TP53, MTHFR and GSTP1 gene and their combinations with ischemic stroke: A case-control study","authors":"Saba Shakoor ,&nbsp;Muhammad Latif ,&nbsp;Kam-Hong Kam ,&nbsp;Ayesha Nasir ,&nbsp;Rashid Mehmood ,&nbsp;Mehnaz Akhtar ,&nbsp;Maryam Akhlaq ,&nbsp;Alisha Batool ,&nbsp;Meesam Ali ,&nbsp;Kasim Sakran Abass ,&nbsp;Burhan Pasha ,&nbsp;Adil Khan ,&nbsp;Chien-Chin Chen ,&nbsp;Furhan Iqbal","doi":"10.1016/j.ibneur.2025.11.005","DOIUrl":"10.1016/j.ibneur.2025.11.005","url":null,"abstract":"<div><h3>Objective</h3><div>Ischemic stroke is a complex pathological condition in which the brain is damaged due to blockage of blood vessel(s) supplying blood to the brain. This study investigates the genotype and allelic frequency at the single-nucleotide polymorphism (SNP) rs8099917 in <em>IL-28B</em>, rs1800470 and rs1800472 in <em>TGF-β1</em>, <em>rs1042522</em> in <em>TP53,</em> rs180133 in <em>MTHFR</em> and rs1695 in <em>GSTP1</em> gene and correlates them individually or in various combinations with the incidence of ischemic stroke.</div></div><div><h3>Methods</h3><div>A total of 156 clinically confirmed ischemic stroke patients and 156 age and sex matched controls were enrolled from Multan District in Pakistan during September 2024 till February 2025. Tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS PCR) approach was used to determine the genotype at the screened SNPs.</div></div><div><h3>Results</h3><div>Significant associations of polymorphic TT genotype at rs8099917 in <em>IL-28B,</em> wildtype CC genotype at rs1800472 in <em>TGF-β1,</em> polymorphic TT and heterozygous CT genotypes at rs1800472 in <em>TGF-β1</em>, wild genotype GG at rs8099917 in <em>IL-28B</em>, polymorphic CC at rs1042522 in <em>TP53</em> and wild genotype CC at rs180133 in <em>MTHFR</em> gene were observed with ischemic stroke. Smokers were more prone to the disease. While genotypes at rs1800470 in <em>TGF-β1</em> and at rs1695 in <em>GSTP1</em> as well as age and sex of the subject were not associated with the incidence of ischemic stroke.</div></div><div><h3>Conclusion</h3><div>Our results indicated that genotypes at the analyzed SNPs were associated with ischemic stroke in the screened Pakistani population.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 919-930"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG entropy modulation as a biomarker of emotion regulation and resilience","authors":"W. Tanner Creel,&nbsp;Richard E. Hartman","doi":"10.1016/j.ibneur.2025.10.013","DOIUrl":"10.1016/j.ibneur.2025.10.013","url":null,"abstract":"<div><div>A fundamental challenge in clinical neuropsychology is the objective assessment of emotion regulation and resilience. Current reliance on self-report is hampered by bias, creating a critical need for brain-based biomarkers that can capture the dynamics of emotional functioning. This review advances EEG entropy modulation as a theoretically appealing and emerging candidate. Converging research indicates that neural complexity, quantified by entropy measures, reflects the flexible information processing that underpins adaptive self-regulation. We synthesize evidence demonstrating diminished neural complexity in emotional dysregulation and anxiety, while interventions like mindfulness may work by restoring it. Moving beyond static, resting-state analysis, we argue that the modulation of entropy during cognitive-emotional tasks provides a far more powerful and ecologically valid marker of regulatory capacity. This dynamic approach, enhanced by emerging methods for capturing EEG in real-world settings, captures the brain’s flexible response to challenges. Future research will benefit from exploring task-based entropy modulation in key regulatory hubs like the prefrontal cortex. Integrating these data with machine and deep learning approaches is a critical frontier, poised to identify distinct 'entropy profiles' of dysregulation and predict therapeutic response with an objectivity current methods lack. This interdisciplinary agenda seeks to bridge the gap between subjective experience and objective physiology, transforming how we assess and improve mental health outcomes.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 947-954"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of L-theanine on cerebellar granule cell migration related to cognitive disorders","authors":"Mai Ibrahim ,&nbsp;Matsuda Tomoko ,&nbsp;Kuriya Kenji ,&nbsp;Ozeki Makoto ,&nbsp;Abe Aya ,&nbsp;Hayato Umekawa ,&nbsp;Masahiro Nishio","doi":"10.1016/j.ibneur.2025.05.015","DOIUrl":"10.1016/j.ibneur.2025.05.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Cerebellar granule cell migration plays a crucial role in cerebellum development, and any abnormalities in CGC migration can lead to significant neurological disorders such as anxiety, a common psychological disorder that impacts a person's emotional, physical, and social health. <em>L</em>-theanine, an amino acid found in green tea, demonstrates neuroprotective properties and regulates the release of neurotransmitters by stimulating CGC migration. This study investigated the impact of <em>L</em>-theanine on CGC migration related to cognitive disorders.</div></div><div><h3>Methods</h3><div><em>ddY</em> male mice treated with a single oral dose of <em>L</em>-theanine at varying concentrations (10 mg/kg) were assessed for anxiety, learning, and memory using the maze test and the Morris Water Maze test, where the average completion time and escape time of the mice were considered indicators of cognitive performance. CGC microexplants were isolated from newly born <em>C57BL/N6</em> mice and treated with a series of increasing concentrations of <em>L</em>-theanine. The migration distance of the CGC under the different <em>L</em>-theanine concentrations was assessed after 24, 48, and 72 h post-treatment using phase-contrast microscopy and image analysis software.</div></div><div><h3>Results and conclusion</h3><div>Mice's anxiety symptoms improved based on their performance on the maze test after treatment with <em>L</em>-theanine at 5 mg/ml. However, <em>L</em>-theanine at 0.05 mg/ml enhanced learning and memory abilities. Compared to other concentrations, <em>L</em>-theanine at 1 µM yielded the longest migration distance for CGC <em>in vitro</em>. Therefore, <em>L</em>-Theanine may serve as a potential therapeutic agent in supporting cerebellar development and enhancing cognitive skills. Further investigation is required to fully elucidate the molecular mechanisms and therapeutic potential of <em>L</em>-theanine in neurodevelopmental disorders.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 63-71"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic administration of gold nanoparticles attenuates anxiety-related behaviors and enhances spatial learning performance in rats","authors":"Farideh Bahrami ,&nbsp;Sajjad Rahimzadeh ,&nbsp;Mahdi Mashhadi Akbar Boojar ,&nbsp;Ahad Baqeri ,&nbsp;Maryam Ghorbani ,&nbsp;Mehdi Saberi","doi":"10.1016/j.ibneur.2025.08.004","DOIUrl":"10.1016/j.ibneur.2025.08.004","url":null,"abstract":"<div><h3>Background</h3><div>Due to the unique characteristics of gold nanoparticles, including low toxicity, tissue compatibility, high surface-to-volume ratio, excellent stability, lack of immunogenicity, and the ability to cross the blood-brain barrier, gold nanoparticles can affect brain cells and impact neuronal functions. This study aimed to investigate the effect of gold nanoparticles (AuNPs) on rats' anxiety, memory, and learning ability.</div></div><div><h3>Method</h3><div>This study was conducted on 35 male Wistar rats that were obtained from the Animal Center of Baqiyatallah University. In order to measure the anxiety level of rats, an open field test and elevated maze were used. To measure the spatial learning of rats, the Barnes maze test was used. Also, to measure active avoidance behavior, the shuttle box was used. Data analysis was done using one-way ANOVA and P &lt; 0.05 was considered significant.</div></div><div><h3>Results</h3><div>The results of the study showed that gold nanoparticles with doses of 200 and 300 μg/ml had a significant effect on memory and learning, which was observed both in the Barnes maze and the shuttle box test. Also, gold nanoparticles with a dose of 100 μg/ml reduced the induced anxiety of the animal, which had a significant difference with the control group (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The study revealed that gold nanoparticles can impact rats' anxiety, memory, and learning. This suggests gold nanoparticles could be a new therapy to help with anxiety and cognitive issues in rodents, with potential benefits for humans.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 409-416"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycated hemoglobin levels and geriatric depression impact cognitive status in an Indian urban elderly community","authors":"Bhaktee Dongaonkar ,&nbsp;Arman Deep Singh ,&nbsp;Swathi B. Hurakadli ,&nbsp;Ashwini Godbole","doi":"10.1016/j.ibneur.2025.08.008","DOIUrl":"10.1016/j.ibneur.2025.08.008","url":null,"abstract":"<div><div>This study explored the cognitive status of community-dwelling Indian older adults. Our objective was to observe the association of age-related cognitive change with other physiological health parameters like, glycated hemoglobin (HbA1c), and vitamin B12 in older adults in India. Urban community dwelling, consenting older adults (55–85years, n = 123), with no clinical history of cognitive or neurological problems participated in the study. The participants underwent a detailed demographic documentation and cognitive assessment comprising of tests from different cognitive domains and blood-based assessment of glycated hemoglobin (HbA1c) and vitamin B12. As expected, performance in all cognitive domains declined with increasing age. HbA1c levels correlated inversely with processing speed and executive function. Vitamin B12 levels did not correlate with performance on any cognitive test. Interestingly, geriatric depression correlated inversely with visuospatial abilities. A stepwise multiple regression revealed that HbA1c and geriatric depression contributed to 28 % variance on Montreal Cognitive Assessment while age did not qualify as a significant contributor. Using Petersen’s criteria, Mild Cognitive Impairment (MCI) was observed in 17 % of participants. Participants classified as MCI had higher levels of HbA1c and geriatric depression, and lower performance in all cognitive domains compared to non-MCI participants. In conclusion, although cognitive performance declined with age, HbA1c and geriatric depression had a greater role in cognitive decline than age. With a high incidence of diabetes in India, this study highlights the prevalence of metabolism-linked changes in cognition, which are often ignored in community dwelling older adults in India.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 426-436"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of action observation training on hand function, upper extremity strength and fatigue in individuals with multiple sclerosis","authors":"Fatemeh Savaedi ,&nbsp;Omid Anbiyaee ,&nbsp;Akram Ansari ,&nbsp;Fatemeh chichagi ,&nbsp;Nazanin Moeini ,&nbsp;Eftekhar Azarm ,&nbsp;Mahsa Fadavighaffari ,&nbsp;Sara Khosravi ,&nbsp;Meimanat Akbari","doi":"10.1016/j.ibneur.2025.08.021","DOIUrl":"10.1016/j.ibneur.2025.08.021","url":null,"abstract":"<div><h3>Background</h3><div>Multiple sclerosis (MS) is a chronic autoimmune condition that affects the central nervous system, frequently resulting in upper limb impairment, which considerably affects activities of daily living and quality of life. Action Observation Training (AOT) is a novel neurorehabilitation method that utilizes the mirror neuron system to improve motor performance. This study aimed to evaluate the effectiveness of AOT in improving hand function, grip strength, and reducing fatigue in individuals with MS.</div></div><div><h3>Methods</h3><div>A non-randomized, single-blind clinical experiment was conducted involving 30 multiple sclerosis patients, who were allocated to either an intervention group (AOT in conjunction with standard physical therapy) or a control group (standard physical therapy alone). The primary outcome was evaluated utilizing the Arm Function in Multiple Sclerosis Questionnaire (AMSQ). Secondary objectives included grip and pinch strength (assessed by dynamometry) and Fatigue Severity Scale (FSS). Evaluations were conducted at baseline and following four weeks of intervention. Data were evaluated utilizing Analysis of Covariance (ANCOVA) with significance established at p &lt; 0.05.</div></div><div><h3>Results</h3><div>The intervention group showed significantly greater improvements in AMSQ scores (adjusted mean difference = −29.5, ± 4.5 SE, p &lt; 0.05), power grip strength (MD = 10.54, ± 3.20 SE, p = 0.003 for the affected hand), pinch strength (MD = 1.46, ± 0.45 SE, p = 0.003 for the affected hand), and fatigue (MD = −9.60, ± 4.13 SE, p = 0.028), compared to the control group. These findings suggest that AOT is an effective intervention for improving upper limb function and reducing fatigue in individuals with MS.</div></div><div><h3>Conclusion</h3><div>AOT significantly improves hand function, grip strength, and fatigue levels in individuals with MS, suggesting its potential as an effective rehabilitation tool. Future investigations should examine the enduring advantages of AOT and its amalgamation with alternative neurorehabilitation methodologies.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 580-586"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the role of omega-3 fatty acids in nicotine-induced neurotoxicity in pregnant Wistar rats and their pups","authors":"Joseph Gbenga Omole ,&nbsp;Quadri Kunle Alabi ,&nbsp;Mayowa Grace Elemile ,&nbsp;Ayodeji Aturamu ,&nbsp;Modinat Adebukola Adefisayo ,&nbsp;Gbenga Olatunde Omotosho ,&nbsp;Samson Mokolade Ige ,&nbsp;Orji Eunice Ibiye ,&nbsp;Tokunbo Olorunfemi Samuel ,&nbsp;Fisayo Nathaniel Ogunleye ,&nbsp;Peace Kehinde Olamilosoye ,&nbsp;Oladele Abiodun Ayoka","doi":"10.1016/j.ibneur.2025.07.003","DOIUrl":"10.1016/j.ibneur.2025.07.003","url":null,"abstract":"<div><div>This study investigated maternal and their pup neurobehaviour following nicotine exposure during gestational and postnatal periods and neuroprotective effect of Omega-3 fatty acids. Thus, the study used thirty pregnant female Wistar rats for this study. Groups I and II (nonpregnant and pregnant) were treated with 1 ml/kg/day of normal saline for 42 days; III was treated with 4 mg/kg/day of nicotine for 42 days; IV-VI were co-administered nicotine 4 mg/kg and 100, 300, 600 mg/kg/day of Omega-3 fatty acids respectively for 42 days. Results: The beam walk time of the mother rats in groups III and IV were significantly higher when compared with other groups. Similarly, the beam walks time of the pups of groups III and IV were significantly higher when compared with the pups of the mother rats in other groups. The brain dopamine and serotonin levels of mother rats in groups III, IV and V were significantly higher when compared with other groups. Also, the brain dopamine and serotonin levels of the pups in groups III and IV were significantly higher when compared with the pups in other groups. The reduced glutathione and catalase of mother and pup rats in groups III and IV were significantly lower when compared with other groups. Photomicrographs of cerebellum and hippocampus of the rats treated with nicotine showed scattered arrangement of pyramidal cells with vacuolated neurons. These alterations were significantly reversed with Omega-3 fatty acids following nicotine exposure. Conclusions. Omega-3 fatty acids at 300 and 600 mg/kg ameliorated nicotine-induced neurotoxicity in mother rats and their pups.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 272-289"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and physiological benefits of alpha-pinene in adult rats experiencing chronic stress: A focus on depression and oxidative stress","authors":"Seyed Shahriyar Hosseini ,&nbsp;Zohreh Ghotbeddin ,&nbsp;Seyed Reza Fatemi Tabatabaei ,&nbsp;Kaveh Rahimi","doi":"10.1016/j.ibneur.2025.11.014","DOIUrl":"10.1016/j.ibneur.2025.11.014","url":null,"abstract":"<div><div>To investigate the protective effects of alpha-pinene, an antioxidant compound, on depressive-like behaviors, social interactions, and biochemical markers in adult rats exposed to chronic stress through maternal separation during early development. Forty-nine Wistar rats were divided into seven groups: control (receiving solvent only), two alpha-pinene treatment groups (5 and 10 mg/kg), a stress group (maternal separation for 6 h daily for 21 days), two combined treatment groups (alpha-pinene with stress), and a positive control group (imipramine hydrochloride, 10 mg/kg). Behavioral assessments included forced swimming tests, sucrose preference tests, elevated plus maze tests, and social interaction tests. Serum corticosterone levels and oxidative stress markers (MDA and GPx activity) in brain tissue were measured. The stress group showed significant increases in immobility time, anxiety behaviors, and serum corticosterone levels, with decreased sucrose preference and altered social interactions. Biochemical analysis revealed increased MDA levels and decreased GPx activity in the stress group, indicating heightened oxidative stress. Alpha-pinene treatment at both doses significantly improved behavioral outcomes, reduced corticosterone levels, decreased MDA levels, and increased GPx activity in stressed rats, with effects comparable to imipramine. Alpha-pinene significantly protects against chronic stress-induced behavioral and biochemical alterations in rats. These findings suggest that alpha-pinene may improve behavioral performance through antioxidant mechanisms and by modulating HPA axis activity, as evidenced by reduced corticosterone levels. This study provides preliminary evidence for alpha-pinene's potential therapeutic value in stress-related disorders.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 1017-1023"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145620039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of sleep quality and its determinants among individuals with diabetes mellitus and/or hypertension: A cross-sectional study","authors":"John Dogah ,&nbsp;Ansumana Bockarie ,&nbsp;Eric Kwame Kunkah ,&nbsp;Adwoa Abrafi Boampong ,&nbsp;George Nkrumah Osei ,&nbsp;Kwasi Baffour Gyimah ,&nbsp;Stephen Teye ,&nbsp;Esther Marfo ,&nbsp;David Mawutor Donkor ,&nbsp;David Larbi Simpong","doi":"10.1016/j.ibneur.2025.06.015","DOIUrl":"10.1016/j.ibneur.2025.06.015","url":null,"abstract":"<div><h3>Background</h3><div>Sleep difficulties are common, especially among people with chronic illnesses like diabetes mellitus and hypertension, which significantly impact health and survival. This study assessed sleep quality and factors associated with poor sleep quality in individuals with diabetes mellitus (DM) and/or hypertension.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at Mampong Government Hospital. Socio-demographic and lifestyle data, including age, sex, occupation, marital status, alcohol consumption, and physical activity levels, were collected via a structured questionnaire. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and data analysis was performed using Chi-square tests and binary logistic regression with IBM SPSS version 27.</div></div><div><h3>Results</h3><div>The study included 201 participants, with findings indicating that 41.3 % experienced poor sleep. Poor sleep was most prevalent among individuals with both DM and hypertension, affecting 37 out of 88 participants. Analysis of the PSQI components indicated that participants consistently scored above 1 in subjective sleep quality, sleep latency, and sleep disturbance, reflecting considerable sleep challenge. Married participants showed a higher prevalence of poor sleep (55.4 %), while those involved in mild physical activity reported the highest prevalence of poor sleep (69.9 %). Poor sleep was significantly associated with marital status, education level, and intensity of physical activity. Among participants with both diabetes mellitus and hypertension, those aged 41–60 had significantly higher odds of poor sleep compared to those aged 20–40 (aOR = 10.584, p = 0.043, 95 % CI: 1.081–103.592).</div></div><div><h3>Conclusion</h3><div>Poor sleep is common among individuals with diabetes mellitus and hypertension. The findings reinforce the importance of integrating sleep quality assessments into the management of chronic conditions to support overall health and well-being.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 143-147"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}