磷酸化α -突触核蛋白在憩室病患者结肠肠神经系统中的分布

IF 2.9 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2025-02-26 DOI:10.1016/j.ibneur.2025.02.009

François Cossais , Marie Christin Hörnke , Katja Schröder , Ralph Lucius , Martina Böttner , Jan-Hendrik Egberts , Florian Richter , Thilo Wedel

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引用次数: 0

摘要

磷酸化α -突触核蛋白（P-aSyn）是帕金森病（PD）的生物标志物，在肠道炎症性疾病中具有潜在的相关性。目的：本研究探讨P-aSyn在憩室病（DD）患者结肠组织中的分布，并与年龄匹配的对照组进行比较。方法采用免疫组化方法分析45例憩室炎（D-itis）患者、12例憩室病（D-osis）患者和30例对照患者结肠样本中sp - asyn的分布。结果在93.1% %的参与者中，沿肌肠丛和粘膜下丛的肠神经元发现sp - asyn免疫反应性，在D-itis， D-osis和对照组中分布相似。反应性升高出现在16.7% %的D-osis， 19.6% %的D-itis和30.0% %的对照组。结论DD患者与对照组结肠组织中P-aSyn的表达无显著差异，提示DD相关炎症对P-aSyn表达无显著影响。进一步的研究需要探索肠神经系统中aSyn在肠道炎症性疾病中的作用及其与神经退行性疾病的关系。

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Phosphorylated alpha-synuclein distribution in the colonic enteric nervous system of patients with diverticular disease

Background

Phosphorylated alpha-synuclein (P-aSyn) is a biomarker for Parkinson’s disease (PD), with potential relevance in intestinal inflammatory disorders.

Objectives

This study examines the distribution of P-aSyn in colonic tissues of patients with diverticular disease (DD) compared to age-matched controls.

Methods

P-aSyn distribution was analyzed in colon samples of 45 patients with diverticulitis (D-itis), 12 with diverticulosis (D-osis), and 30 controls via immunohistochemistry.

Results

P-aSyn immunoreactivity was found along enteric neurons of the myenteric and submucosal plexus in 93.1 % of participants, with similar distribution across D-itis, D-osis, and controls. Elevated reactivity appeared in 16.7 % of D-osis, 19.6 % of D-itis, and 30.0 % of controls.

Conclusion

P-aSyn presence in colonic tissue did not significantly differ between DD patients and controls, suggesting that DD-related inflammation does not notably affect P-aSyn expression. Further research is warranted to explore aSyn roles within the enteric nervous system in intestinal inflammatory disorders and their relation with neurodegenerative diseases.

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