IBRO Neuroscience Reports最新文献

{"title":"Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage","authors":"Nicolas Eden ,&nbsp;Marius Marc-Daniel Mader ,&nbsp;Jan Bremer ,&nbsp;Jennifer Sauvigny ,&nbsp;Jörn Grensemann ,&nbsp;Marlene Fischer ,&nbsp;Nils Schweingruber ,&nbsp;Jens Gempt ,&nbsp;Patrick Czorlich","doi":"10.1016/j.ibneur.2025.06.008","DOIUrl":"10.1016/j.ibneur.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of classical music on CBFV and other physiological parameters in patients suffering from aneurysmal subarachnoid hemorrhage (SAH).</div></div><div><h3>Methods</h3><div>Twenty patients with SAH were subjected to up to three interventions, in which the patients listened to <em>W. A. Mozart's Symphony No. 40 in G minor</em>. In parallel, CBFV in the right middle cerebral artery (MCA) was continuously measured using transcranial Doppler (TCD). TCD values were averaged per minute, normalized, and analyzed with a mixed-effects linear regression model. In addition, other physiological and laboratory parameters were evaluated.</div></div><div><h3>Results</h3><div>A total of 55 interventions were successfully carried out. The mixed-effects linear regression model revealed significant associations with both time (p &lt; 0.001) and session (p = 0.002), specifically, with each minute of classical music played, there was a 0.3 % reduction in CBFV (95 % confidence interval (CI): 0.2–0.4 %). Heart rate (HR) and respiratory rate (RR) decreased by 0.1 % (95 % CI: −0.2–0.0 %; p = 0.043) 0.3 % (95 % CI: −0.6 % to −0.1 %; p = 0.001), respectively, per minute of exposure. Each additional session resulted in a reduction of HR by 4.3 % and RR by 22.3 % from the baseline at the start of the intervention to minute 25 (both p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Our pilot study shows only a very small effect of classical music such as Mozart's Symphony No. 40 in G <em>minor</em> in patients with SAH.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 198-204"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of sleep quality and its determinants among individuals with diabetes mellitus and/or hypertension: A cross-sectional study","authors":"John Dogah ,&nbsp;Ansumana Bockarie ,&nbsp;Eric Kwame Kunkah ,&nbsp;Adwoa Abrafi Boampong ,&nbsp;George Nkrumah Osei ,&nbsp;Kwasi Baffour Gyimah ,&nbsp;Stephen Teye ,&nbsp;Esther Marfo ,&nbsp;David Mawutor Donkor ,&nbsp;David Larbi Simpong","doi":"10.1016/j.ibneur.2025.06.015","DOIUrl":"10.1016/j.ibneur.2025.06.015","url":null,"abstract":"<div><h3>Background</h3><div>Sleep difficulties are common, especially among people with chronic illnesses like diabetes mellitus and hypertension, which significantly impact health and survival. This study assessed sleep quality and factors associated with poor sleep quality in individuals with diabetes mellitus (DM) and/or hypertension.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at Mampong Government Hospital. Socio-demographic and lifestyle data, including age, sex, occupation, marital status, alcohol consumption, and physical activity levels, were collected via a structured questionnaire. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and data analysis was performed using Chi-square tests and binary logistic regression with IBM SPSS version 27.</div></div><div><h3>Results</h3><div>The study included 201 participants, with findings indicating that 41.3 % experienced poor sleep. Poor sleep was most prevalent among individuals with both DM and hypertension, affecting 37 out of 88 participants. Analysis of the PSQI components indicated that participants consistently scored above 1 in subjective sleep quality, sleep latency, and sleep disturbance, reflecting considerable sleep challenge. Married participants showed a higher prevalence of poor sleep (55.4 %), while those involved in mild physical activity reported the highest prevalence of poor sleep (69.9 %). Poor sleep was significantly associated with marital status, education level, and intensity of physical activity. Among participants with both diabetes mellitus and hypertension, those aged 41–60 had significantly higher odds of poor sleep compared to those aged 20–40 (aOR = 10.584, p = 0.043, 95 % CI: 1.081–103.592).</div></div><div><h3>Conclusion</h3><div>Poor sleep is common among individuals with diabetes mellitus and hypertension. The findings reinforce the importance of integrating sleep quality assessments into the management of chronic conditions to support overall health and well-being.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 143-147"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PKD1-mediated phosphorylation at dopamine D2 receptor serine 365 site in dorsal striatum underlies cocaine-induced locomotor hyperactivity","authors":"Xinyu Zhang ,&nbsp;Ziran Zhang ,&nbsp;Ying Wang ,&nbsp;Linlin Sun ,&nbsp;Ning Wang","doi":"10.1016/j.ibneur.2025.06.013","DOIUrl":"10.1016/j.ibneur.2025.06.013","url":null,"abstract":"<div><div>Locomotor hyperactivity is an early behavioural adaptation in cocaine use disorder, driven by increased dopamine levels in the striatum. The expression, sensitivity, and availability of dopamine D2 receptor (D2R) are significantly associated with cocaine use disorder. However, neither D2R agonists nor antagonists are optimal for clinical intervention because of their side effects. Therefore, targeting regulatory proteins that can effectively disrupt cocaine-induced D2R malfunction may offer improved strategies for cocaine use disorder. Here, we report that knockdown of protein kinase D1 (PKD1) in the rat dorsal striatum attenuates cocaine-induced locomotor hyperactivity. PKD1 phosphorylates the serine 365 site (S365) of D2R, reduces its surface localisation, and enhances downstream extracellular signal-regulated kinase (ERK) signalling. Tat-S365, an engineered Tat fusion-peptide blocked S365 phosphorylation in D2R, thereby decreasing the pERK levels. <em>In vivo</em> injection of peptide Tat-S365 into the rat dorsal striatum successfully inhibited cocaine-induced locomotor hyperactivity. Thus, targeting S365 of D2R presents a promising strategy for developing pharmacotherapeutic treatments for cocaine sensitisation and other disorders that result from dopamine imbalances.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 124-132"},"PeriodicalIF":2.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of PAR2 and TrkA exacerbate visceral hypersensitivity induced by chronic pancreatitis in rats","authors":"Zhiyun Liu ,&nbsp;Jiao Zhu ,&nbsp;Qianbo Chen ,&nbsp;Kunming Tao ,&nbsp;Kai Wei ,&nbsp;Xiaodan Wu ,&nbsp;Haibo Qiu ,&nbsp;Zhijie Lu","doi":"10.1016/j.ibneur.2025.06.012","DOIUrl":"10.1016/j.ibneur.2025.06.012","url":null,"abstract":"<div><h3>Background</h3><div>Abdominal pain is the most severe symptom of chronic pancreatitis. However, till date, there are only a few studies on the mechanism of pain in chronic pancreatitis. Previous research has reported that mast cells are enriched around nerve fibers and are associated with visceral pain. In this study, we aimed to investigate the molecular mechanisms by which protease-activated receptor 2 (PAR2) and tropomyosin receptor kinase A (TrkA) exacerbate pain in chronic pancreatitis.</div></div><div><h3>Methods</h3><div>A chronic pancreatitis animal model was established by injecting dibutyltin dichloride into the tail vein of Wistar rats. The von Frey test was performed to evaluate pain behavior in the rats. Hematoxylin and eosin staining, western blotting, immunofluorescence histochemistry, retrograde labeling, culture of dorsal root ganglion (DRG) neurons, and whole-cell patch clamp recordings were performed to illustrate the mechanisms.</div></div><div><h3>Results</h3><div>The pancreatic structures were destroyed, including inflammatory cell infiltration and acinar atrophy, and mast cells were dramatically recruited to the pancreatic tissue in chronic pancreatitis. Systemic administration of the mast cell stabilizer ketotifen alleviated chronic pancreatitis-induced visceral hypersensitivity in the Wistar rat model. In contrast, the mast cell secretagogue compound 48/80 dose-dependently exacerbated chronic pancreatitis pain. Furthermore, the number of DRG neurons projected into the pancreas was significantly increased by injecting Dil stain in chronic pancreatitis rat models and normal rats. The co-expression of PAR2 and TrkA was only observed in small-diameter DRG neurons containing transient receptor potential vanilloid 1 channel and was significantly higher than those in normal rats. Finally, we demonstrated the functional interaction between PAR2 and TrkA by whole-cell patch clamp recordings.</div></div><div><h3>Conclusions</h3><div>Mast cells contribute to chronic pancreatitis pain through enrichment and degranulation. The interaction of PAR2 and TrkA exacerbates chronic pancreatitis pain, which may be a potential strategy for the treatment of chronic pancreatitis -induced visceral pain.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 235-244"},"PeriodicalIF":2.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charting neuroethics discourse in Africa: A scoping review of ethical issues of neuroscience research in Africa","authors":"Oluyinka Oyeniji,&nbsp;Kutoma Wakunuma,&nbsp;Adebowale Owoseni","doi":"10.1016/j.ibneur.2025.06.002","DOIUrl":"10.1016/j.ibneur.2025.06.002","url":null,"abstract":"<div><div>The global neuroethics discourse has gained prominence since the beginning of the 21st century. Perspectives on neuroethics have been drawn from USA, Asia, the European Union etc. In Africa, the discourse has been largely influenced by neurogenomics research and collaborations across countries in the region. As neuroethicists continue to propose considerations for framing neuroethics discourse in Africa, ethical issues arise from not only largescale neurogenomics research, but such other neuroscience and brain research projects conducted in heterogeneous societies on the continent. Such neuroscience research projects carried out in academic institutions and medical facilities are yet to be subjected to an investigation of ethical issues arising therefrom. This paper therefore took a departure from neuroethics discourse being shaped in neurogenomics and international collaborations to consider what ethical issues arise from neuroscience broadly across parts of Africa. We conducted a scoping review of neuroscience research and neuroethics publications, complemented by the snowballing method to investigate ethical issues arising from such research endeavors. The research was grounded in ubuntu principles as lens through which ethical, legal and social implications of African neuroscience research were viewed. Findings established ethical issues peculiar within the African neuroscience research context including inequitable access to neuroscience research, distrust, lack of research funding, imposition of foreign methods without standardisation within contexts, violence and use of restraints, threat to life and morbidity, etc as ethical issues of neuroscience in Africa.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 174-191"},"PeriodicalIF":2.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theobromine prevents affective symptoms of nicotine withdrawal by modulating the neuroendocrine and immune systems, as well as the glutathione mechanism in the hippocampus","authors":"Qi Zhang ,&nbsp;Yu Tian ,&nbsp;Baojiang He ,&nbsp;Wenjuan Zhang ,&nbsp;Xingyu Liu ,&nbsp;Jufang Hao","doi":"10.1016/j.ibneur.2025.06.011","DOIUrl":"10.1016/j.ibneur.2025.06.011","url":null,"abstract":"<div><div>Currently, nicotine withdrawal symptoms pose a significant challenge in tobacco cessation efforts, particularly withdrawal affective symptoms, such as anxiety and depression like behavior. However, the underlying mechanisms of these symptoms remain poorly understood. Emerging evidence implicates the hippocampus, a key region in the limbic system, involved in emotional regulation. In this study, we employed transcriptome sequencing, untargeted metabolomics, and integrative multi-omics analysis to elucidate the molecular mechanisms underlying nicotine withdrawal-induced affective symptoms in the hippocampus of male C57BL/6J mice. Our findings corroborate previous research linking nicotine withdrawal symptoms to dysregulation of neuroendocrine pathways and inflammatory processes within the brain. Importantly, we identify impaired glutathione metabolism as a significant contributing factor to the development of these symptoms. Furthermore, our investigation reveals that theobromine, a principal psychoactive compound found in cocoa, exerts a potent therapeutic effect in alleviating nicotine withdrawal affective symptoms through diverse mechanisms. In addition to its modulation of neuroendocrine pathways and inflammation, theobromine's ability to restore glutathione metabolism in the hippocampus emerges as a pivotal aspect of its pharmacological action.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 160-173"},"PeriodicalIF":2.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared time-resolved spectroscopy reveals task-induced emotions by measuring cerebral blood oxygenation changes in the frontal pole during creative activity using a real object","authors":"Yumi Oboshi ,&nbsp;Kazuki Tamura ,&nbsp;Yasuko Fukushi ,&nbsp;Seiji Yamamoto","doi":"10.1016/j.ibneur.2025.06.009","DOIUrl":"10.1016/j.ibneur.2025.06.009","url":null,"abstract":"<div><div>Creative activities trigger enjoyable feelings, induce motivation, and are applied in clinical settings such as rehabilitation. Emotion and creativity are interrelated because they depend on a common neural network, with the prefrontal cortex playing a crucial role in both. Emotions affect creative thinking, and creative activities elicit emotions. Near-infrared spectroscopy (NIRS) provides a real-time assessment of emotion generated in a natural setting. Furthermore, near-infrared time-resolved spectroscopy (NIR-TRS) can measure brain activity that is less susceptible to extracerebral tissue. We measured oxyhemoglobin (Oxy-Hb) concentrations in the frontal pole, which is involved in emotion processing using NIR-TRS during creative and simple tasks utilizing real objects. Oxy-Hb concentrations in the frontal pole significantly increased during and after the creative task compared with the simple task. The autonomic function indices (heart rate and stress indices) were inversely correlated with the Oxy-Hb increase associated with the creative task performance, indicating that sympathetic nervous system hyperactivity did not cause this Oxy-Hb increase. A subjective survey revealed that positive emotions during the creative activity were significantly higher and correlated well with the increased Oxy-Hb level, indicating an increased frontal pole activity because of the enjoyability of the creative task. Our results indicate that NIR-TRS imaging can be employed for noninvasively measuring cerebral blood oxygenation changes in participants who experience various emotions during creative activities.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 148-159"},"PeriodicalIF":2.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-apoptotic effects of the medicinal plant Sterculia setigera in a model of serum deprivation-induced PC12 cells death","authors":"Yendubé T. Kantati ,&nbsp;Magloire K. Kodjo ,&nbsp;Benjamin Lefranc ,&nbsp;Kwashie Eklu-Gadegbeku ,&nbsp;Jérôme Leprince ,&nbsp;David Vaudry","doi":"10.1016/j.ibneur.2025.06.007","DOIUrl":"10.1016/j.ibneur.2025.06.007","url":null,"abstract":"<div><div><em>Sterculia setigera</em> is a medicinal plant of Togolese flora. We have previously reported that <em>S. setigera</em> leaves dry hydroethanolic extract (SSE) protects <em>in vitro</em> cerebellar granule neurons against H₂O₂ and 6-OHDA-induced cell death and <em>in vivo</em> against ethanol neurotoxicity on the cerebellar cortex of 8-day-old Wistar rats. The present study aimed to extend our knowledge of the protective effects of SSE by exploring its anti-apoptotic mechanisms on cultured PC12 cells. Apoptosis was induced by serum depletion before treatment with various concentrations (5–100 µg/mL) of SSE. SSE (20 µg/mL) significantly protected PC12 cells (+51.8 %) against serum depletion-induced PC12 cell death and inhibited Caspase-3/7 (-65.1 %) activity. SSE also significantly increased the expression of the anti-apoptotic factor <em>Bcl-2</em>. Conversely, it repressed the expression of <em>Casp-3</em>, <em>Tp53</em> and <em>Ddit3</em>. Taken together, these results indicate that inhibition of apoptosis appears to be one of the main mechanisms of <em>S. setigera</em> neuroprotective effects.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 110-116"},"PeriodicalIF":2.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative splicing and the aging brain in AfrAbia: New frontiers in dementia research","authors":"Suliyat Abiodun Aremu","doi":"10.1016/j.ibneur.2025.06.006","DOIUrl":"10.1016/j.ibneur.2025.06.006","url":null,"abstract":"<div><div>AfrAbia (Sub-Saharan Africa and Arab world), is undergoing a significant demographic shift characterized by increased longevity and rising dementia rates. Despite this, molecular insights into brain aging in these regions, especially in RNA processing pathways like alternative splicing (AS), are virtually absent. AS promotes transcriptomic and proteomic complexity and is pivotal for brain function, with its dysregulation connected to neurodegenerative diseases such as Alzheimer’s disease (AD), frontotemporal dementia (FTD), and Parkinson’s disease (PD). However, current knowledge is overwhelmingly derived from Western populations, limiting global applicability. This perspective synthesizes the mechanisms and regulatory elements of AS, its role in aging and neurodegeneration, and emerging biomarkers and therapeutic strategies. Special attention is paid to ancestry-associated splicing variants and fluid biomarker development in AfrAbian cohorts. We argue for inclusive, population-specific molecular studies to bridge disparities in dementia diagnosis, treatment, and prevention.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 101-109"},"PeriodicalIF":2.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: A meta-analysis","authors":"Fatemeh Sedghi ,&nbsp;Elaheh Foroughi ,&nbsp;Farzad Sheikhzadeh ,&nbsp;Mahya Ahmadpour Youshanlui ,&nbsp;Ata Akhtari Kohnehshahri ,&nbsp;Omid Karimzadeh ,&nbsp;Sayedeh-Fatemeh Sadat-Madani ,&nbsp;Hani Ghadri ,&nbsp;Peyman Parhiz ,&nbsp;Amirhesam Amirbeyk ,&nbsp;Shaghayegh Afshari ,&nbsp;Yegane Ebrahimnia ,&nbsp;Mahsa Soleimanzadeh ,&nbsp;Mahsa Asadi Anar ,&nbsp;Parviz Aghaei Borzabad ,&nbsp;Niloofar Deravi","doi":"10.1016/j.ibneur.2025.05.010","DOIUrl":"10.1016/j.ibneur.2025.05.010","url":null,"abstract":"<div><h3>Background &amp; Aim</h3><div>Educational attainment has been proposed as a critical factor influencing cognitive resilience in the face of neurodegenerative diseases. However, its relationship with amyloid deposition across different stages of cognitive decline remains unclear. This systematic review and meta-analysis aimed to investigate the correlation between educational background and amyloid accumulation in individuals ranging from cognitively normal to those diagnosed with Alzheimer’s disease (AD) or mild cognitive impairment (MCI).</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in January 2025 across PubMed, Scopus, and Google Scholar to identify observational studies examining the association between educational attainment and amyloid deposition. Studies were included if they reported relevant data on this relationship; reviews, interventional studies, and those with insufficient outcome reporting were excluded. Data were analyzed using RStudio (version 4.3.1), employing random-effects or fixed-effects models based on the degree of heterogeneity. Effect sizes were expressed as Pearson’s correlation coefficients (r).</div></div><div><h3>Results</h3><div>Out of 6988 initially identified records, four cohort studies met the inclusion criteria, comprising a total of 288 participants from Canada and Japan. Meta-analysis revealed a significant positive correlation between educational attainment and amyloid deposition among individuals with MCI (r = 0.34, 95 % CI [0.05, 0.63]), although substantial heterogeneity was observed (I² = 86 %, p &lt; 0.01). In contrast, an inverse association was found in patients with AD (r = -0.16, 95 % CI [-0.28, −0.03]), with minimal heterogeneity (I² = 0.0 %, p = 0.8101). Funnel plot analyses indicated no significant evidence of publication bias.</div></div><div><h3>Conclusion</h3><div>These findings suggest a stage-dependent relationship between educational attainment and amyloid accumulation: higher education is associated with greater amyloid deposition in individuals with MCI, but with reduced amyloid burden in those with AD. This pattern supports the cognitive reserve hypothesis, which posits that education may bolster compensatory neural mechanisms, delaying the clinical onset of dementia symptoms. However, the presence of substantial heterogeneity and the limited sample size call for further longitudinal research to elucidate underlying causal pathways and inform targeted strategies for dementia prevention.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 133-142"},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}