IBRO Neuroscience Reports最新文献_第7页

Post-stroke effects of IC87201 on neurobehavioral function and brain injuries: A stereological study IC87201 对中风后神经行为功能和脑损伤的影响：一项立体学研究

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IBRO Neuroscience Reports Pub Date : 2024-11-24 DOI: 10.1016/j.ibneur.2024.11.012

Maryam Mohammadian , Aminollah Bahaoddini , Mohammad Reza Namavar

{"title":"Post-stroke effects of IC87201 on neurobehavioral function and brain injuries: A stereological study","authors":"Maryam Mohammadian , Aminollah Bahaoddini , Mohammad Reza Namavar","doi":"10.1016/j.ibneur.2024.11.012","DOIUrl":"10.1016/j.ibneur.2024.11.012","url":null,"abstract":"<div><h3>Objectives</h3><div>Stroke is the second leading cause of global death and is characterized by excitotoxic neuronal death caused by NMDA (N-Methyl-D-Aspartate) receptor overactivation. The present study was conducted to investigate the therapeutic potential of IC87201, a novel small molecule interfering with the NMDA receptor intracellular signaling pathway, in reducing the extent of ischemic stroke-induced brain damage.</div></div><div><h3>Materials and Methods</h3><div>Cerebral ischemia was induced by the middle cerebral artery occlusion (MCAO) method in 24 anesthetized adult male rats for one hour. The animals were randomized into sham, MCAO, MCAO+ DXM (Dextromethorphan hydrobromide monohydrate) as an NMDA antagonist, and MCAO+ IC87201 groups which in the last two groups, DXM (50 mg/kg) and IC87201 (10 mg/kg) were injected intraperitoneally after ischemia. The neurobehavioral scores were appraised for 7 days and after that, brain tissue was appropriately prepared to perform the stereological evaluations.</div></div><div><h3>Results</h3><div>The administration of IC87201 significantly recovered post-ischemia damages, including neurobehavioral function, reduction of volume of the total hemisphere, cortex, and striatum in rat brain, and the percentage of infarcted areas. Additionally, in the striatum region, IC87201 caused an increase in the total number of neuronal and non-neuronal cells as well as a decrease in the total number of dead cells. Some of these parameters were improved by DXM, but in general, IC87201 outperformed that.</div></div><div><h3>Conclusions</h3><div>IC87201 was successful in minimizing ischemia-induced damage, especially in the striatal region. In addition, IC87201, as a molecule that acts on the intracellular signaling cascade of the NMDA receptor, performed better than DXM, as an antagonist of this receptor.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"17 ","pages":"Pages 463-470"},"PeriodicalIF":2.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophrenia 精神分裂症患者感染率和 COVID-19 死亡率增加的原因和对策

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IBRO Neuroscience Reports Pub Date : 2024-11-15 DOI: 10.1016/j.ibneur.2024.11.009

Zhen-Ying Li , Yu-Qian Li , Jing-Ru Zhou , Jie Wang , Kun-Ze Liu , Peng Wang , Chun-Mei Gong , Han Wang , Yu-Jing Zhang , Yu Cao , Yue Gu , Han-Bo Zhang , Hui Lu , Li-Fang Lu , Ren-Jun Feng

{"title":"Causes and countermeasures for the increased infection and COVID-19 mortality rates in patients with schizophrenia","authors":"Zhen-Ying Li , Yu-Qian Li , Jing-Ru Zhou , Jie Wang , Kun-Ze Liu , Peng Wang , Chun-Mei Gong , Han Wang , Yu-Jing Zhang , Yu Cao , Yue Gu , Han-Bo Zhang , Hui Lu , Li-Fang Lu , Ren-Jun Feng","doi":"10.1016/j.ibneur.2024.11.009","DOIUrl":"10.1016/j.ibneur.2024.11.009","url":null,"abstract":"<div><div>Schizophrenia (SCZ) is a common psychiatric disorder that has a complex pathological mechanism. During the Coronavirus disease 2019 (COVID-19) epidemic, patients with SCZ had substantially higher rates of infection with SARS-CoV-2, the virus that causes COVID-19, as well as higher COVID-19 mortality relative to patients with other mental disorders. However, the reasons for these increased rates in patients with SCZ remain unknown. In this review, we hypothesize that certain molecular pathways exhibit abnormal function in both COVID-19 and SCZ, with a focus on those related to energy metabolism dysregulation, immune system disruption, and abnormalities of the central nervous system. We review that dysregulation of energy metabolism can result in disruptions to the immune system and abnormalities within the central nervous system (CNS). Furthermore, immune system disturbances may also contribute to CNS abnormalities in both SCZ and COVID-19. We also discuss macro-factors associated with the high infection and mortality rates of COVID-19 in patients with SCZ, including sociodemographic factors, reduced access to psychiatric healthcare, structural barriers to COVID-19 vaccination, and proposed approaches to mitigate these macro-factors.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"17 ","pages":"Pages 456-462"},"PeriodicalIF":2.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in Neuroligin-2 and BDNF proteins associated with anxiety-like behavior in salicylate-induced tinnitus rats 神经ligin-2和BDNF蛋白的变化与水杨酸诱导的耳鸣大鼠的焦虑样行为有关

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IBRO Neuroscience Reports Pub Date : 2024-11-13 DOI: 10.1016/j.ibneur.2024.11.007

Saeid Mahmoudian , Ali Fathi Jouzdani , Ahmadreza Nazeri , Kasra Bagherian , Mohadeseh Beiranvand , Zeinab Akbarnejad

{"title":"Alterations in Neuroligin-2 and BDNF proteins associated with anxiety-like behavior in salicylate-induced tinnitus rats","authors":"Saeid Mahmoudian , Ali Fathi Jouzdani , Ahmadreza Nazeri , Kasra Bagherian , Mohadeseh Beiranvand , Zeinab Akbarnejad","doi":"10.1016/j.ibneur.2024.11.007","DOIUrl":"10.1016/j.ibneur.2024.11.007","url":null,"abstract":"<div><div>Given the high prevalence of tinnitus and anxiety among patients, understanding the mechanisms that increase anxiety is crucial. Neuroligin 2 (NLGN2) is an anxiety-related protein that has received much attention in recent years. On the other hand, the Brain-Derived Neurotrophic Factor (BDNF) affects various neurotransmitter systems, neuropeptides, and intracellular signaling pathways. These are neurochemical systems that, if out of balance, could lead to anxiety behavior. This is the first study to investigate whether changes in protein expression in the amygdala nucleus are associated with high anxiety in tinnitus. After inducing and confirming tinnitus in rats using gap-prepulse inhibition of the acoustic startle (GPIAS) and Pre-pulse inhibition (PPI), the Elevated Plus Maze (EPM) and the Open Field Test (OFT) were used to assess anxiety levels in both groups. Subsequently, amygdala tissue samples were collected from both groups and analyzed for NLGN2 and BDNF protein expression. The GPIAS score decreased following sodium salicylate administration in the tinnitus group, while the PPI score did not change. Additionally, the tinnitus group exhibited higher anxiety levels than the control group in both behavioral tests. Moreover, NLGN2 protein expression was increased in the amygdala nucleus of sodium salicylate-induced tinnitus rats compared to controls, while BDNF protein expression was reduced. These findings suggest that increased NLGN2 and decreased BDNF protein levels in the amygdala nucleus contribute to tinnitus-related anxiety and identify these proteins as potential therapeutic targets for tinnitus.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"17 ","pages":"Pages 407-414"},"PeriodicalIF":2.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the influence of digital technology on human cognitive functions: A narrative review 了解数字技术对人类认知功能的影响：叙述性综述

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IBRO Neuroscience Reports Pub Date : 2024-11-13 DOI: 10.1016/j.ibneur.2024.11.006

Eugénia Correia de Barros

引用次数: 0

Neonatal maternal separation impairs cognitive function and synaptic plasticity in adult male CD-1 mice 新生儿期母体分离会损害成年雄性 CD-1 小鼠的认知功能和突触可塑性

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IBRO Neuroscience Reports Pub Date : 2024-11-09 DOI: 10.1016/j.ibneur.2024.11.001

Zhen-Yu Hu , Ru-Meng Wei , Fei-Hu , Ke Yu , Shi-Kun Fang , Xue-Yan Li , Yue-Ming Zhang , Gui-Hai Chen

{"title":"Neonatal maternal separation impairs cognitive function and synaptic plasticity in adult male CD-1 mice","authors":"Zhen-Yu Hu , Ru-Meng Wei , Fei-Hu , Ke Yu , Shi-Kun Fang , Xue-Yan Li , Yue-Ming Zhang , Gui-Hai Chen","doi":"10.1016/j.ibneur.2024.11.001","DOIUrl":"10.1016/j.ibneur.2024.11.001","url":null,"abstract":"<div><div>Maternal separation (MS) increases the risk of occurrence of anxiety, depression, and learning and memory impairment in offspring. However, the underlying molecular biological mechanisms remain unclear. In the current study, offspring CD-1 mice were separated from their mothers from postnatal day 4 to postnatal day 21. At 3 months of age, the male offspring were selected for the evaluation of anxiety- and depression-like behaviors and learning and memory function. Western blotting and RT-PCR were used to examine the expression levels of brain-derived neurotrophic factor, tyrosine kinase receptor B, postsynaptic density-95, and synaptophysin. Long-term potentiation (LTP) and long-term depression (LTD) were recorded at Schaffer collateral/CA1 synapses. Furthermore, basal synaptic transmission was evaluated via the recording of the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs). The results showed that adult offspring CD-1 mice displayed anxiety- and depressive-like behaviors as well as impaired spatial learning and memory abilities. Electrophysiological analysis indicated that MS impaired LTP, enhanced LTD, and reduced the frequency of mEPSCs in pyramidal neurons in the CA1 region. Our findings suggested that MS can lead to anxiety, depression, and cognitive deficits, and these effects are associated with alterations in the levels of synaptic plasticity-associated proteins, consequently, also synaptic plasticity.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"17 ","pages":"Pages 431-440"},"PeriodicalIF":2.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valproic acid attenuates the severity of astrogliosis in the hippocampus of animal models of temporal lobe epilepsy 丙戊酸可减轻颞叶癫痫动物模型海马星形胶质细胞病变的严重程度

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IBRO Neuroscience Reports Pub Date : 2024-11-08 DOI: 10.1016/j.ibneur.2024.11.003

Hu Feng, Jiamin Luo, Zhiwei Li, Yuxiao Zhao, Yamei Liu, Hongyan Zhu

{"title":"Valproic acid attenuates the severity of astrogliosis in the hippocampus of animal models of temporal lobe epilepsy","authors":"Hu Feng, Jiamin Luo, Zhiwei Li, Yuxiao Zhao, Yamei Liu, Hongyan Zhu","doi":"10.1016/j.ibneur.2024.11.003","DOIUrl":"10.1016/j.ibneur.2024.11.003","url":null,"abstract":"<div><div>Reactive astrogliosis is one of the most frequency neuropathological alterations in the hippocampus of animal models and patients with temporal lobe epilepsy (TLE). Valproic acid (VPA), a widely used antiepileptic drug (AED), acts by blocking ion channels and enhancing GABAergic activity. This study investigated the effects of VPA on hippocampal astrogliosis in a rat model of TLE. The results demonstrated that chronic administration of VPA at a dose of 200 mg/kg significantly reduced the severity of astrogliosis and ameliorated neuronal loss in the hippocampus at the early and middle stages post-status epilepticus (SE), while also improving cognitive impairments at the middle and late stages in KA-SE rats. Long-term administration of VPA at 400 mg/kg attenuated astrogliosis in the hippocampus at the middle stage post-SE, but lacked neuroprotective effects and exacerbated cognitive impairments at the late stage. These findings suggest that VPA at an appropriate dose could mitigate hippocampal astrogliosis, potentially offering a new antiepileptic mechanism for its long-term use.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"17 ","pages":"Pages 471-479"},"PeriodicalIF":2.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential of probiotics in Alzheimer's disease and gut dysbiosis 探索益生菌在阿尔茨海默病和肠道菌群失调中的潜力

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IBRO Neuroscience Reports Pub Date : 2024-11-08 DOI: 10.1016/j.ibneur.2024.11.004

Sowmiya S , Dhivya L.S. , Praveen Rajendran , Harikrishnan N , Ankul Singh S

引用次数: 0

Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer’s diseases 以人血清白蛋白融合蛋白为靶点的高磷酸化 tau 作为治疗阿尔茨海默病的药物

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IBRO Neuroscience Reports Pub Date : 2024-11-07 DOI: 10.1016/j.ibneur.2024.11.005

Sookhee Bang, Jeong Kuen Song, Kwan Hee Lee

{"title":"Hyperphosphorylated tau targeting human serum albumin Fusion protein as therapeutics for Alzheimer’s diseases","authors":"Sookhee Bang, Jeong Kuen Song, Kwan Hee Lee","doi":"10.1016/j.ibneur.2024.11.005","DOIUrl":"10.1016/j.ibneur.2024.11.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Neurofibrillary tangles (NFTs) are composed of hyperphosphorylated forms of microtubule-associated protein tau (Tau), which is responsible for neurodegeneration in Alzheimer’s disease (AD). The hippocampal region has been a major focus of AD research because the deposits of phosphorylated tau protein in these regions are correlated with early memory deficits. Despite extensive studies, therapeutic strategies to reduce tau hyperphosphorylation and NFTs deposition remain unclear. AL04, a recently developed recombinant fusion protein comprising Cystatin C, human serum albumin, and a novel blood brain barrier (BBB) penetrating peptide, is currently under investigation. Previous studies have demonstrated its effectiveness in reducing amyloid beta plaques in AD mouse model.</div></div><div><h3>Methods</h3><div>In this study, we investigated the effects of AL04 on lowering hyperphosphorylated tau and NFTs in JNPL3 mouse model harboring human tau-P301L mutation. 3-month-old female mice intraperitoneally received AL04 (5 mg/kg) or PBS treatment every other week for 24 weeks. We used confocal microscopy and western blot to visualize and analyze changes in hyperphosphorylated tau Ser202/Thr205 labeled with AT8 antibody in the brain.</div></div><div><h3>Results</h3><div>We found that the AL04 treatment decreases hyperphosphorylated tau at PP2A-sensitive epitope Ser202/Thr205 in the hippocampus of the brain. In the brain lysates of AL04 treated mice, we observed the reduction of I2PP2A, inhibitor of PP2A, and the induction of autophagy receptor proteins such as SQSTM-1/p62 and OPTN.</div></div><div><h3>Conclusion</h3><div>Our data suggests that AL04 can be used as an AD prophylactic/therapeutic agent as it lowers the hyperphosphorylated tau by downregulating I2PP2A. We also propose that AL04 can induce the degradation of hyperphosphorylated tau aggregates through the upregulation of the autophagy pathway.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"17 ","pages":"Pages 423-430"},"PeriodicalIF":2.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive transcranial magnetic stimulation as add-on the rapyin persistent postural-perceptual dizziness 重复性经颅磁刺激作为持续性姿势感知性头晕的附加疗法

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IBRO Neuroscience Reports Pub Date : 2024-10-29 DOI: 10.1016/j.ibneur.2024.10.005

Yao Jia , Hongbin Wang , Dan Li , Xingli Wu , Jiawen Yang , Weifei Min , Ting Ma , He Huang , Rui Li

{"title":"Repetitive transcranial magnetic stimulation as add-on the rapyin persistent postural-perceptual dizziness","authors":"Yao Jia , Hongbin Wang , Dan Li , Xingli Wu , Jiawen Yang , Weifei Min , Ting Ma , He Huang , Rui Li","doi":"10.1016/j.ibneur.2024.10.005","DOIUrl":"10.1016/j.ibneur.2024.10.005","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to evaluate the clinical effectiveness of repetitive transcranial magnetic stimulation (rTMS) when used as an add-on therapy for individuals with persistent postural-perceptual dizziness (PPPD).</div></div><div><h3>Methods</h3><div>In this randomized controlled, double-blind trial conducted at Shangluo Central Hospital, patients with PPPD diagnosed in the neurology departments were included. Participants were randomized into a rTMS treatment group and a control group in a 1:1 ratio by the randomized grouping method. Patients in both groups received conventional treatment, with the rTMS treatment group underwent daily rTMS sessions, whereas the control group received sham rTMS treatments following the same schedule. The effectiveness of the treatments was primarily assessed using the Dizziness Handicap Inventory (DHI), Hamilton Anxiety Rating Scale (HAMA), and Hamilton Depression Rating Scale (HAMD), which measured symptoms of vertigo, anxiety, and depression at baseline, after two weeks, and at the end of four weeks.</div></div><div><h3>Findings</h3><div>Of the 46 participants recruited, 2 were excluded due to contraindications, 22 were randomly assigned to the rTMS treatment group, and 22 were assigned to the control group. Ultimately, 2 withdrew for personal reasons, and data from 42 participants were included in the outcome analysis. HAMA, HAMD and DHI scores were significantly lower in the rTMS treatment group than in the control group after 4 weeks of treatment (p<0.05). A positive correlation was also observed between DHI scores and HAMA or HAMD scores.</div></div><div><h3>Conclusions</h3><div>This pilot study demonstrated that rTMS is a beneficial add-on therapy for patients with PPPD.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"17 ","pages":"Pages 382-388"},"PeriodicalIF":2.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transgenerational of Oxidative Damage Induced by Prenatal Ethanol Exposure on Spatial Learning/Memory and BDNF in the of Male Rats 产前暴露于乙醇诱导的氧化损伤对雄性大鼠空间学习/记忆和 BDNF 的跨代影响

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IBRO Neuroscience Reports Pub Date : 2024-10-28 DOI: 10.1016/j.ibneur.2024.09.001

Mousa Shaabani Ghahremanlo, Vida Hojati , Gholamhassan Vaezi, Shahram Sharafi

{"title":"Transgenerational of Oxidative Damage Induced by Prenatal Ethanol Exposure on Spatial Learning/Memory and BDNF in the of Male Rats","authors":"Mousa Shaabani Ghahremanlo, Vida Hojati , Gholamhassan Vaezi, Shahram Sharafi","doi":"10.1016/j.ibneur.2024.09.001","DOIUrl":"10.1016/j.ibneur.2024.09.001","url":null,"abstract":"<div><div>Alcohol consumption during pregnancy harms fetal development, leading to various physical and behavioral issues. This study investigates how prenatal ethanol exposure triggers oxidative stress (OS) and affects neurotrophic factors (NTFs), particularly brain-derived growth factor (BDNF) gene expression in the hippocampus, influencing learning and memory decline across two generations of male offspring from ethanol-exposed female rats. A rat model of fetal alcohol spectrum disorder (FASD) was initially generated to reflect on the deficits in the first generation, and then those transmitted via the male germline to the unexposed male ones. The pregnant rats were thus divided into four groups, namely, the control group (CTRL) receiving only distilled water (DW), and three groups being exposed to ethanol (20 %, 4.5 g/kg) by oral gavage, during the first 10-day gestation (FG), the second 10-day gestation (SG), and the entire gestation (EG) periods. Subsequent Morris water maze (MWM) tests on male offspring revealed spatial learning deficits during the second and entire gestational periods in both generations. Analysis of antioxidant enzyme activity including glutathione peroxidase (GPx), superoxide dismutase (SOD), and malondialdehyde (MDA), and BDNF gene expression in the hippocampus further highlighted the impacts of prenatal ethanol exposure. The study results demonstrated that prenatal ethanol exposure caused spatial learning/memory deficits during the SG and EG, altered antioxidant enzyme activity, and reduced BDNF gene expression in both generations. The findings underscore the role of OS in developmental and behavioral issues in FASD rat models and suggest that lasting transgenerational effects in the second generation may stem from alcohol-induced changes.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"17 ","pages":"Pages 398-406"},"PeriodicalIF":2.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0