IBRO Neuroscience Reports最新文献

{"title":"Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis","authors":"E.E.A. van Egmond ,&nbsp;K. van der Hiele ,&nbsp;M.J. de Rooij ,&nbsp;D.A.M. van Gorp ,&nbsp;P.J. Jongen ,&nbsp;J.J.L. van der Klink ,&nbsp;M.F. Reneman ,&nbsp;E.A.C. Beenakker ,&nbsp;J.J.J. van Eijk ,&nbsp;S.T.F.M. Frequin ,&nbsp;K. de Gans ,&nbsp;E. Hoitsma ,&nbsp;O.H.H. Gerlach ,&nbsp;J.P. Mostert ,&nbsp;W.I.M. Verhagen ,&nbsp;L.H. Visser ,&nbsp;H.A.M. Middelkoop","doi":"10.1016/j.ibneur.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.ibneur.2024.04.002","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate longitudinal relationships between employment status and disease-related, (neuro)psychological, and work-related factors in people with multiple sclerosis (MS).</p></div><div><h3>Methods</h3><p>170 employed people with MS underwent yearly neurological and neuropsychological examinations to assess MS-related disability and cognitive functioning. Additionally, they completed yearly questionnaires assessing depression, anxiety, fatigue, cognitive complaints, workplace support and coping. Multilevel models for change were fitted to examine progression of these factors over three years, and to assess possible relationships with change in employment status.</p></div><div><h3>Results</h3><p>People with a deteriorated employment status after three years reported more depression (<em>p=</em>0.009), a higher impact of fatigue (<em>p&lt;</em>0.001), more cognitive complaints (<em>p&lt;</em>0.001) and less workplace support (<em>p=</em>0.001) at baseline than people with a stable employment status. There were no differences in progression over time of the examined variables between people with a stable or deteriorated employment status.</p></div><div><h3>Conclusion</h3><p>More depression, a higher impact of fatigue, more cognitive complaints and less workplace support are predictive of a deteriorated employment status after three years in individuals with MS. How these factors progress over time is not different between those with a stable or deteriorated employment. MS-related disability, anxiety, objective cognition and coping were not related to a deterioration in employment status.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 518-526"},"PeriodicalIF":1.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000368/pdfft?md5=8315bfc67abd2fad550a0a94709ab5fd&pid=1-s2.0-S2667242124000368-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140557815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role of nitric oxide in the anticonvulsant effects of betulin in pentylenetetrazole (PTZ)-induced seizures in mice","authors":"Fatemeh Eghbali,&nbsp;Hossein Tahmasebi Dehkordi,&nbsp;Hossein Amini-Khoei,&nbsp;Zahra Lorigooini,&nbsp;Mohammad Rahimi-Madiseh","doi":"10.1016/j.ibneur.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.ibneur.2024.04.003","url":null,"abstract":"<div><p>Epilepsy poses a significant challenge, especially for drug-resistant cases, necessitating novel treatment avenues. This study explores the potential interplay between nitric oxide (NO) and the anticonvulsant effects of betulin, a triterpene with promising neuroprotective properties. While betulin exhibits anticonvulsant effects, the specific involvement of NO remains inadequately understood, constituting a pivotal gap in current knowledge. One hundred NMRI mice were randomly assigned to diverse treatment groups, with seizures induced by pentylenetetrazol (PTZ). Parameters such as seizure threshold, nitrite levels, total antioxidant capacity (TAC), malondialdehyde (MDA) levels, and iNOS/nNOS gene expressions were assessed. Betulin significantly increased seizure thresholds and mitigated PTZ-induced NO levels. These findings suggest a potential modulation of NO-related pathways, emphasizing betulin's anti-inflammatory and antioxidant attributes. The study sheds light on betulin's multifaceted impact on oxidative stress, NO regulation, and iNOS/nNOS gene expressions. The ability of betulin to suppress iNOS/nNOS gene expressions, leading to reduce NO production, underscores its potential as an anticonvulsant.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 527-534"},"PeriodicalIF":1.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266724212400037X/pdfft?md5=d16b8a24de01ac7fdeb89a0114e878bc&pid=1-s2.0-S266724212400037X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140643965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive rehabilitation in bipolar spectrum disorder: A systematic review","authors":"Mahdiye Sarrafe Razavi ,&nbsp;Mazyar Fathi ,&nbsp;Elham Vahednia,&nbsp;Amir Rezaei Ardani,&nbsp;Sara Honari,&nbsp;Farzad Akbarzadeh,&nbsp;Ali Talaei","doi":"10.1016/j.ibneur.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.ibneur.2024.04.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Neurocognitive deficits in bipolar disorder (BD) have a negative impact on the quality of life, even during the euthymic phase. And many studies conducted to improve cognitive deficits in bipolar disorder. This systematic review aims to summarize studies on cognitive rehabilitation (CR) conducted in bipolar patients and evaluate its impact on neurocognitive deficits. The primary objective is to explore how CR interventions can enhance cognitive functioning, treatment outcomes, and overall quality of life in this population.</p></div><div><h3>Methods</h3><p>A comprehensive search was conducted on PubMed, Google Scholar, Scopus, Embase, and PsycINFO databases from 1950 to 2023, following the 2015 PRISMA-P guidelines, using search terms related to BD and CR.</p></div><div><h3>Results</h3><p>The initial search yielded 371 titles across the five databases. After applying inclusion and exclusion criteria through screening, a total of 23 articles were included in the study. The selected articles evaluated verbal memory, attention, executive functions, and social cognition.</p></div><div><h3>Conclusion</h3><p>The findings suggest that CR can be an effective treatment approach for bipolar patients, aimed at enhancing their cognitive abilities, treatment outcomes, and overall quality of life. The primary finding of this study indicates that cognitive-behavioral therapy (CBT) protocols, skill training, and homework exercises, which offer a daily structure, social support, and opportunities for exchanging coping strategies, are more effective in enhancing cognitive functions. However, it is important to acknowledge the notable limitations of this review. Firstly, we did not assess the methodological rigor of the included studies. Additionally, there was a lack of detailed analysis regarding specific cognitive rehabilitation approaches that adhere to core CR principles, resulting in increased heterogeneity within the reviewed studies.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 509-517"},"PeriodicalIF":1.5,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000356/pdfft?md5=ffd92f8df9fa26876ffaead6c588c96d&pid=1-s2.0-S2667242124000356-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140557814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective role of the ginsenoside Rg1 against methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear and cortical antioxidant levels in mice offspring","authors":"Ali Sanaiee ,&nbsp;Shahin Hassanpour ,&nbsp;Bita Vazir","doi":"10.1016/j.ibneur.2024.03.010","DOIUrl":"10.1016/j.ibneur.2024.03.010","url":null,"abstract":"<div><p>Ginsenoside Rg1(Rg1), a monomer of a tetracyclic triterpenoid derivative, possesses diverse medicinal properties attributed to its unique chemical structure and may have beneficial effects on fetal development. This study aimed to investigate the protective effects of prenatal exposure to Rg1 against Methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear, and cortical antioxidant levels in mouse offspring.40 female virgin mice and 12 male NMRI mice were assigned to four groups: group 1 served as the control, group 2 received Methimazole(MMI) at a concentration of 0.02% in their drinking water, group 3 received Rg1(150 mg/kg), and group 4 received both MMI and Rg1.Groups of 2–4 were administered the substances from days 1–9 of gestation. After delivery, pups were selected, and reflexive motor behaviors and conditioned fear were assessed. Additionally, levels of brain tissue catalase(CAT), malondialdehyde(MDA), superoxide dismutase(SOD), and glutathione peroxidase(GPx) levels were measured. Furthermore, postpartum immobility time in the forced swimming test (FST), tail suspension test (TST), and the number of squares crossed in the open field test (OFT)were determined. The results demonstrated that maternal exposure to Rg1 improved ambulation score, hind-limb suspension score, grip strength, front-limb suspension, hind-limb foot angle, negative geotaxis, surface righting, and conditioned fear in hypothyroidism-induced offspring(<em>P</em>&lt;0.05). Rg1 decreased immobility time in the FST, and TST, and increased the number of squares crossed in the OFT in postpartum hypothyroidism-induced mice(<em>P</em>&lt;0.05). Moreover, Rg1 reduced brain tissue MDA levels and increased brain tissue CAT, SOD, and GPx levels in mice and their offspring(<em>P</em>&lt;0.05). These findings indicate that Rg1 mitigated postpartum depression in mice and improved reflexive motor behaviors in their pups.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 485-496"},"PeriodicalIF":1.5,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000344/pdfft?md5=b83d5d63972e56511aa23e3614e23e1b&pid=1-s2.0-S2667242124000344-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the neural substrate variations between easy and challenging creative association tasks during product design within an fMRI scanner","authors":"Wei-Chin Hsu ,&nbsp;Yu-chu Yeh","doi":"10.1016/j.ibneur.2024.03.006","DOIUrl":"10.1016/j.ibneur.2024.03.006","url":null,"abstract":"<div><p>In practice, individuals strive to develop highly original and valuable creative products within specific limitations. However, previous functional Magnetic Resonance Imaging (fMRI) studies focused on divergent-thinking tasks without considering the \"valuableness\" of an idea. Additionally, different types of creative tasks (e.g., the easier association vs. the harder association task) may engage distinct cognitive processes. This study aimed to investigate the underlying neural mechanisms associated with different types of creative thinking, specifically focusing on the generation of the most original and valuable creative product within an fMRI scanner. Twenty-one college students participated in a block design study. During each trial, participants were instructed to draw the most original and valuable product inspired by a given figure. The findings revealed that, in comparison to the harder association task, the easier association task led to broader activation across multiple brain regions. However, this broader activation resulted in inefficient thinking and poorer creative performance. Notably, the orbitofrontal cortex exhibited activation across various creativity tasks and displayed connectivity with several seed brain regions, highlighting the importance of decision-making when only one original and valuable product design is allowed. Furthermore, the complex functional connectivity observed between different brain networks reflects the intricate nature of creative thinking. To conclude, widespread activation of brain regions does not necessarily indicate superior creativity. Instead, optimal creative performance within constraints is achieved through an efficient utilization of association for generating innovative ideas, inhibition for suppressing unoriginal ideas, and decision-making to select the most creative idea.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 550-559"},"PeriodicalIF":1.5,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000307/pdfft?md5=d8d0dc8fa2b9489de2be71ad351a6bd3&pid=1-s2.0-S2667242124000307-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140406889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rat ventral caudal nerve as a model for long distance regeneration","authors":"Ivo Vanický ,&nbsp;Juraj Blaško ,&nbsp;Zoltán Tomori ,&nbsp;Zuzana Michalová ,&nbsp;Eva Székiová","doi":"10.1016/j.ibneur.2024.03.008","DOIUrl":"10.1016/j.ibneur.2024.03.008","url":null,"abstract":"<div><p>In the rat, tail nerves are the longest peripheral nerves in their body. We suggest that ventral caudal nerve (VCN) may serve as a model for studying nerve injury and long distance regeneration. For this purpose, we have studied the anatomy and morphometry of the VCN in control animals. 10 cm long segment of the VCN was removed, and transversal sections were collected at 10 mm distances. The myelinated axons were counted, and the series of data were used to characterize the craniocaudal tapering of the nerve. In a separate group of animals, retrograde tracing with Fluorogold was used to localize and quantitate the spinal neurons projecting their axons into the VCN. After complete nerve transection, the time course of histopathological changes in the distal segment was studied. The primary goal was to define the time needed for axonal disintegration. In later periods, axonal debris removal and rearrangement of tissue elements was documented. After compression injury (axonotmesis), Wallerian degeneration was followed by spontaneous regeneration of axons. We show that the growing axons will span the 10 cm distance within 4–8 weeks. After different survival periods, the numbers of regenerating axons were counted at 10 mm distances. These data were used to characterize the dynamics of axonal regeneration during 4 months’ survival period. In the present study we show that axonal regeneration across 10 cm distance can be studied and quantitatively analyzed in a small laboratory animal.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 476-484"},"PeriodicalIF":1.5,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000320/pdfft?md5=03171e018bc508f9c18d55ca3117ce51&pid=1-s2.0-S2667242124000320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140274724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human pluripotent stem cell (hPSC)-derived microglia for the study of brain disorders. A comprehensive review of existing protocols","authors":"Fionicca Teo ,&nbsp;Catherine Yen Li Kok ,&nbsp;Mao-Jia Tan ,&nbsp;H. Shawn Je","doi":"10.1016/j.ibneur.2024.03.005","DOIUrl":"10.1016/j.ibneur.2024.03.005","url":null,"abstract":"<div><p>Microglia, resident immune cells of the brain that originate from the yolk sac, play a critical role in maintaining brain homeostasis by monitoring and phagocytosing pathogens and cellular debris in the central nervous system (CNS). While they share characteristics with myeloid cells, they are distinct from macrophages. In response to injury, microglia release pro-inflammatory factors and contribute to brain homeostasis through activities such as synapse pruning and neurogenesis. To better understand their role in neurological disorders, the generation of <em>in vitro</em> models of human microglia has become essential. These models, derived from patient-specific induced pluripotent stem cells (iPSCs), provide a controlled environment to study the molecular and cellular mechanisms underlying microglia-mediated neuroinflammation and neurodegeneration. The incorporation or generation of microglia into three-dimensional (3D) organoid cultures provides a more physiologically relevant environment that offers further opportunities to study microglial dynamics and disease modeling. This review describes several protocols that have been recently developed for the generation of human-induced microglia. Importantly, it highlights the promise of these <em>in vitro</em> models in advancing our understanding of brain disorders and facilitating personalized drug screening.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 497-508"},"PeriodicalIF":1.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000290/pdfft?md5=ba26b6df5aa0bae9b2dab5f4653410a9&pid=1-s2.0-S2667242124000290-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140281617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of prenatal calabash chalk geophagy on the developing brain of Wistar rats","authors":"Moses B. Ekong ,&nbsp;Anna Andrioli ,&nbsp;Imaobong E. Israel ,&nbsp;Edemeka I. Ifot ,&nbsp;Samuel E. Dickson ,&nbsp;Ilaria Scambi ,&nbsp;Paolo F. Fabene ,&nbsp;Giuseppe Bertini ,&nbsp;Marina Bentivoglio","doi":"10.1016/j.ibneur.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.ibneur.2024.03.007","url":null,"abstract":"<div><p>Calabash chalk (CaC) is an aluminium silicate hydroxide compound with heavy metal constituents, making it a potential neurotoxicant. Pregnant women often consume CaC as an antiemetic, which may interfere with the normal development of the foetal brain. Here, we evaluated the effects of CaC administration in pregnant rats on the brain of the offspring. Wistar rat dams were assigned to one of three groups: control, 200 mg/kg and 800 mg/kg of a CaC suspension. Administrations lasted 14 days (gestation days 7–20). On day 14, 5-bromo-2′-deoxyuridine (BrdU) was administered and dams were allowed to term. Behavioural tests were performed on different days as the pups matured, and they were sacrificed on post-natal days 30 and 60. Brains were processed for histology and Western blotting. Results showed no significant differences in surface righting reflex, cliff avoidance, negative geotaxis and open-field activity. No hippocampal and somatosensory cortical cytoarchitectonic alterations and no significant signs of glial fibrillary acidic protein (GFAP) activation were observed. Neuronal nuclei counts showed variability in the somatosensory cortex and hippocampus of the CaC group. BrdU-positive cells were significantly lower in the 200 mg/kg group and higher in the 800 mg/kg group. Doublecortin-X-positive cells were not different in all the CaC groups. Astrocytes and microglia Western blotting quantification confirmed no significant increase in pup glial cells in adulthood. Prenatal consumption of CaC at indicated dosages may not be deleterious to the developing brain, especially after cessation of exposure and during maturation of the animal. However, the differences in neuronal and glial populations may be due to their ability to cope with CaC.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 443-454"},"PeriodicalIF":1.5,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000319/pdfft?md5=846fa7cdce85e0506ea4d8c3db4a5fd8&pid=1-s2.0-S2667242124000319-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140160593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic exercise improves depressive symptoms in the unilateral 6-OHDA-lesioned rat model of Parkinson’s disease","authors":"Hannah Loughlin ,&nbsp;Jacob Jackson ,&nbsp;Chloe Looman ,&nbsp;Alayna Starll ,&nbsp;Jeremy Goldman ,&nbsp;Zhiying Shan ,&nbsp;Chunxiu Yu","doi":"10.1016/j.ibneur.2024.03.004","DOIUrl":"https://doi.org/10.1016/j.ibneur.2024.03.004","url":null,"abstract":"<div><p>Aerobic exercise has been shown to have established benefits on motor function in Parkinson's disease (PD). However, the impact of exercise on depressive symptoms in PD remains unclear. This study aimed to investigate the effects of regular exercise, specifically using a forced running wheel, on both motor performance and the prevalence of depression in a unilateral 6-OHDA-lesioned rat model of PD. The behavioral outcomes of exercise were assessed through the rotarod test (RT), forelimb adjusting step test (FAST), sucrose consumption test (SCT), and novelty sucrose splash test (NSST). Our data revealed evident depressive symptoms in the PD animals, characterized by reduced sucrose consumption in the SCT and diminished exploratory activity in the NSST compared to the naïve control group. Specifically, after 11 weeks of exercise, the PD exercise group demonstrated the most significant improvements in sucrose consumption in the SCT. Additionally, this group exhibited reduced immobility and increased exploratory behavior compared to the PD control group in the NSST. Furthermore, the PD exercise group displayed the greatest improvement in correcting forelimb stepping bias. Our results suggested that a regimen of running wheel exercise enhances motor abilities and mitigates the occurrence of depressive behaviors caused by 6-OHDA dopamine depletion in the PD rat model.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 468-475"},"PeriodicalIF":1.5,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000289/pdfft?md5=82898c742ed3421dcb4e574bf95525ce&pid=1-s2.0-S2667242124000289-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140188270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P3b correlates of inspection time","authors":"Yilai Pei ,&nbsp;Zhaoxin Wang ,&nbsp;Tatia M.C. Lee","doi":"10.1016/j.ibneur.2024.03.002","DOIUrl":"https://doi.org/10.1016/j.ibneur.2024.03.002","url":null,"abstract":"<div><p>Both P3b and the inspection time (IT) are related with intelligence, yet the P3b correlates of IT are not well understood. This event-related potential study addressed this question by asking participants (N = 28) to perform an IT task. There were three IT conditions with different levels of discriminative stimulus duration, i.e., 33 ms, 67 ms, and 100 ms, and a control condition with no target presentation (0 ms condition). We also measured participants' processing speed with four Elementary Cognitive Tests (ECTs), including a Simple Reaction Time task (SRT), two Choice Reaction Time tasks (CRTs), and a Pattern Discrimination task (PD). Results revealed that an increase in P3b latency with longer duration of the discriminative stimulus. Moreover, the P3b latency was negatively correlated with the accuracy of the IT task in the 33 ms condition, but not evident in the 67 and 100 ms conditions. Furthermore, the P3b latency of the 33 ms condition was positively correlated with the RT of the SRT, but not related with the RTs of CRTs or PD. A significant main effect of duration on the amplitude of P1 was also found. We conclude that the present study provides the neurophysiological correlates of the IT task, and those who are able to accurately perceive and process very briefly presented stimuli have a higher speed of information process, reflected by the P3b latency, yet this relationship is more obvious in the most difficult condition. Combined, our results suggest that P3b is related with the closure of a perceptual epoch to form the neural representation of a stimulus, in support of the “context closure” hypothesis.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"16 ","pages":"Pages 428-435"},"PeriodicalIF":1.5,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000265/pdfft?md5=bf22aad0bdf6df4f275cd820a6fa0ec5&pid=1-s2.0-S2667242124000265-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140113247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}