焦虑和抑郁情绪参与体位性心动过速综合征的发病机制

IF 2 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2025-04-05 DOI:10.1016/j.ibneur.2025.04.001

Hongxia Li PhD , Wei Shao MM , Lu Gao MM , Zhenhui Han MM , Yanyan Xiao MD

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引用次数: 0

摘要

目的探讨体位性心动过速综合征（POTS）患儿焦虑、抑郁的意义。研究入组首都医科大学附属北京儿童医院和开封儿童医院诊断为POTS的患儿71例，年龄13岁 ± 2岁；采用抑郁自评量表（SDS）、焦虑自评量表（SAS）、汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）对pot儿童进行测定。根据上述量表得分将pot儿童分为两组：焦虑/抑郁组和非焦虑/抑郁组。心率（HR）和血压（BP）由Dash 2000多铅生理监测仪监测。结果20例POTS患儿为焦虑/抑郁组。女孩12例，男孩8例，平均年龄14岁 ± 2岁。非焦虑/抑郁组包括51名年龄为12岁 ± 2岁的POTS儿童。26个是女孩，25个是男孩。体重、性别、收缩压（SBP）、舒张压（DBP）、HR均无统计学差异。焦虑/抑郁组的年龄和身高均高于非焦虑/抑郁组。焦虑/抑郁组患者直立或倾斜10 min最大心率（HRmax）、仰卧向直立心率变化（ΔHR）、症状评分均显著高于非焦虑/抑郁组。四个量表得分与症状得分及ΔHR相关。结论焦虑、抑郁情绪可能参与了POTS的发病机制。

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Anxiety and depression moods is involved in the pathogenesis of postural tachycardia syndrome

Objective

To explore the significance of anxiety and depression in children with postural tachycardia syndrome (POTS).

Study design

The study enrolled seventy-one children diagnosed as POTS in Beijing Children's Hospital Affiliated to Capital Medical University and Kaifeng Children’s Hospital, aged 13 ± 2 years; The Self-Rating Depression Scale (SDS), the Self-Rating Anxiety Scale (SAS), the Hamilton Depression (HAMD) scale, and the Hamilton Anxiety (HAMA) scale were determined in POTS children. The POTS children were divided into two groups: anxiety/ depression group and non- anxiety / depression group according to the above scales scores. Heart rate (HR), and blood pressure (BP)were monitored by a Dash 2000 Multi-Lead Physiological Monitor.

Results

Twenty POTS children consisted of anxiety / depression group. Twelve were girls and eight were boys, with mean age of 14 ± 2 years. The non- anxiety / depression group included fifty-one POTS children aged 12 ± 2 years. Twenty-six were girls and twenty-five were boys. There were no statically differences in weight, gender, systolic blood pressure (SBP), diastolic blood pressure (DBP), and HR in supine. The age and height of anxiety / depression group were higher than that in non- anxiety / depression group. The maxium HR (HRmax) in ten minutes of upright position or tilt, the change of HR from supine to upright (ΔHR), symptom scores in anxiety / depression group were significantly higher than that in non- anxiety / depression group. Four scale scores were correlated with symptom scores and ΔHR.