术前炎性疼痛加重术后疼痛和神经认知功能障碍

IF 2.9 Q3 NEUROSCIENCES
Hui Yuan , Daofan Sun , Bo Lu , Bo Meng , Rongjun Liu , Ruichun Wang , Xiuzhong Xing , Yiqin Ji , Qianyu Ming , Qiusheng Wang , Junping Chen
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引用次数: 0

摘要

目的许多研究表明,术后疼痛加重围手术期神经认知障碍(PND)。在这项研究中,我们旨在阐明术前炎性疼痛对术后疼痛和认知功能的影响。方法以14月龄C57BL/6小鼠为实验对象,采用注射完全friend佐剂(CFA)建立炎症性疼痛模型和胫骨骨折手术建立PND模型。分别于术前7天和术后3天测定小鼠的足爪戒断阈值和体重。术后第三天,对小鼠进行行为学测试或处死收集脑组织。结果结果显示,CFA加重了小鼠术后疼痛和认知功能障碍,增强了手术诱导的海马小胶质细胞和星形胶质细胞的活化,增加了手术诱导的IL-1β、IL-6和TNF-α的过表达,加重了手术诱导的海马α7nAChR的表达下降和HMGB1的过表达。结论我们的研究表明,术前炎性疼痛进一步加重老龄大鼠术后疼痛和神经认知功能障碍,其机制可能与α 7nachr介导的CAP功能障碍和HMGB1高释放引起的神经炎症有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preoperative inflammatory pain exacerbates postoperative pain and neurocognitive impairment

Aims

Many studies have shown that postoperative pain aggravates perioperative neurocognitive disorder (PND). In this study we aimed to clarify the effect of preoperative inflammatory pain on postoperative pain and cognitive function.

Methods

We established the inflammatory pain model by injected complete freund adjuvant (CFA) and the PND model by tibial fracture surgery in 14- month-old C57BL/6 mice. The paw withdrawal threshold and body weight of the mice were measured 7 days before surgery and 3 days after surgery. On the third postoperative day, mice were subjected to behavioral testing or sacrificed to collect brain tissue.

Results

The result shows that CFA exacerbated postoperative pain and cognitive dysfunction in mice, enhanced surgery-induced activation of microglia and astrocytes in the hippocampus, and increased surgery-induced the overexpression of IL-1β, IL-6, and TNF-α, as well as aggravated the decreased expression of α7nAChR and the overexpression of HMGB1 in the hippocampus induced by surgery.

Conclusion

Our study shows that preoperative inflammatory pain further aggravates postoperative pain and neurocognitive dysfunction in aged rats, and the mechanism may be related to neuroinflammation caused by α7nAChR-mediated CAP dysfunction and high release of HMGB1.
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来源期刊
IBRO Neuroscience Reports
IBRO Neuroscience Reports Neuroscience-Neuroscience (all)
CiteScore
2.80
自引率
0.00%
发文量
99
审稿时长
14 weeks
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