消极情绪调节帕金森病的体位性震颤变异性：针对行为干预的多模态脑电图和运动传感器研究

IF 2.9 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2025-04-11 DOI:10.1016/j.ibneur.2025.04.003

Kang Lin , Pei Li , Pei-zhu Zhang , Ping Jin , Xin-feng Ma , Guang-an Tong , Xiao Wen , Xue Bai , Gong-qiang Wang , Yong-zhu Han

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引用次数: 0

摘要

尽管在帕金森病（PD）中有情绪-震颤相互作用的临床观察，但介导这种关系的神经生理机制仍然不清楚。方法采用多模态方法，结合16通道脑电图（EEG）和惯性运动传感器，研究20例PD患者和20例健康对照者在标准化视频诱导的情绪状态（积极/中性/消极）下情绪调节的体位性震颤动力学。结果主要研究结果表明PD患者的负面情绪处理受损，表现为主观效价（快乐-不快乐评级）的矛盾增加以及生理唤醒的减少。震颤变异性主要与负性情绪状态相关，与效价分数呈负相关，与觉醒水平呈正相关。脑电分析发现，在负性情绪处理过程中，前额叶（Fp1/Fp2）和颞叶（T3/T4）区域的β波段功率调制存在差异。这些结果表明，PD中情绪驱动的震颤波动源于边缘和运动网络的功能失调整合。结论：这些发现表明情绪调节性震颤是一种独特的PD表型，为个性化神经调节的闭环生物反馈系统的发展提供了信息。

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Negative emotion modulates postural tremor variability in Parkinson’s disease: A multimodal EEG and motion sensor study toward behavioral interventions

Background

Despite clinical observations of emotion-tremor interactions in Parkinson’s disease (PD), the neurophysiological mechanisms mediating this relationship remain poorly characterized.

Methods

This study employs a multimodal approach integrating 16-channel electroencephalography (EEG) and inertial motion sensors to investigate emotion-modulated postural tremor dynamics in 20 PD patients and 20 healthy controls (HCs) during standardized video-induced emotional states (positive/neutral/negative).

Results

Key findings demonstrate impaired negative emotional processing in PD, manifested as paradoxical increases in subjective valence (pleasure-displeasure ratings) coupled with reduced physiological arousal. Tremor variability predominantly correlated with negative emotional states, showing a negative association with valence scores and positive correlation with arousal levels. EEG analysis identified differential beta-band power modulation in prefrontal (Fp1/Fp2) and temporal (T3/T4) regions during negative emotion processing. These results suggest that emotion-driven tremor fluctuations in PD originate from dysfunctional integration of limbic and motor networks.

Conclusion

These findings establish emotion-modulated tremor as a distinct PD phenotype, informing the development of closed-loop biofeedback systems for personalized neuromodulation.

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