Health and Quality of Life Outcomes最新文献

{"title":"Measuring health-related quality of life and well-being in adults with fecal incontinence: a comparative psychometric evaluation.","authors":"Sylvester R Groen, Daniel Keszthelyi, Zsa Zsa R M Weerts, Sadé L Assmann, Stéphanie O Breukink, Brigitte A B Essers","doi":"10.1186/s12955-026-02566-0","DOIUrl":"10.1186/s12955-026-02566-0","url":null,"abstract":"<p><strong>Background: </strong>While traditional disease-management regarding fecal incontinence (FI) primarily focuses on symptom-control and health-related quality of life (HrQoL) outcomes, patients often prioritize broader aspects of health, like well-being. This study evaluates the psychometric performance of ICEpop CAPability measure for Adults (ICECAP-A), a capability-based well-being instrument, alongside two established HrQoL-instruments, EQ-5D-5L and the FI quality of life (FIQL) questionnaire, in an outpatient-population with FI.</p><p><strong>Methods: </strong>Data were obtained from patients with FI recruited from a randomized-controlled trial evaluating the efficacy of anal plugs for FI ((The CONFIDEnCE trial, NCT04657588). Psychometric evaluation of ICECAP-A involved the assessment of the convergent validity, known-group validity (examined across predefined subgroups), acceptability, and floor and ceiling effects.</p><p><strong>Results: </strong>Among 72 participants (mean age 67.3years; 83.3% female), the mean ICECAP-A capability score (0.86, scale 0-1) exceeded the mean EQ-5D-5L utility (0.71, scale - 0.446-1) and the FIQL score (2.34, scale 1-5). ICECAP-A showed good convergent validity (76.6% predefined hypotheses confirmed). Known-group validity was comparable across instruments; ICECAP-A demonstrating significant differences by EQ-VAS, anxiety, and education level, but not outperforming EQ-5D-5L or FIQL. EQ-5D-5L showed stronger effect sizes for anxiety (p < 0.001), depression and symptom severity (non-significant), while FIQL was stronger for education level (p = 0.002). Questionnaire completion was 84.7% overall, reflecting trial dropout only (100% among completers) with no substantial floor or ceiling effects.</p><p><strong>Conclusions: </strong>In patients with FI, ICECAP-A showed psychometric performance comparable to EQ-5D-5L and FIQL, despite its broader conceptual scope. Well-being appeared less influenced by symptom severity, possibly reflecting coping or adaptation. Further research is warranted evaluating ICECAP-A's psychometric advantage over traditional HrQoL-instruments in this clinical context.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13520379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How health literacy and eHealth literacy influence quality of life in older adults with chronic diseases: a network and path analysis.","authors":"Hao Zou, Shenglan Zhou, Li Jin, Lijun Xie, Yuchen Wang, Haoyang Shi, Linlin Zhang, Hong Li","doi":"10.1186/s12955-026-02562-4","DOIUrl":"10.1186/s12955-026-02562-4","url":null,"abstract":"<p><strong>Background: </strong>Despite existing research on factors influencing quality of life (QOL) in older adults with chronic diseases, the underlying mechanisms by which health literacy (HL) and e-health literacy (eHL) contribute to QOL improvement remain underexplored. This study aimed to elucidate the complex relationships among HL, eHL, health behaviors, psychosocial factors, and QOL, and to identify the driving pathways of HL and eHL in enhancing QOL.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between March and June 2025 at a tertiary hospital in Xi'an, China. A total of 304 older adults with chronic diseases participated in the study. Participants completed assessments for HL, eHL, cognitive function, frailty, nutrition, physical activity, sleep quality, family function, depression, and QOL (including Physical and Mental Component Summaries, PCS and MCS). Grip strength was also measured. Multiple linear regression, network analysis, and path analysis were employed to determine influencing factors and structural relationships.</p><p><strong>Results: </strong>Higher HL and eHL levels were associated with younger age, higher socioeconomic status, longer daily smartphone usage, and having personal interests; HL was additionally linked to better family function. Network and path analyses revealed that depression, frailty, physical activity, grip strength, and family function were primary direct predictors of QOL, PCS and MCS. Depression and frailty were identified as key risk factors, while sleep quality and nutritional status served as significant mediators. Although HL and eHL did not directly influence QOL, they functioned as upstream variables that indirectly improved QOL by positively influencing these intermediary health behaviors and psychosocial factors.</p><p><strong>Conclusions: </strong>HL and eHL indirectly enhance QOL in older adults with chronic diseases by driving improvements in health behaviors and psychological status. Interventions should target depression, frailty, sleep quality, and nutrition as critical modifiable factors. Future programs aiming to improve HL and eHL should prioritize older individuals with low socioeconomic status and limited digital experience, incorporating age-friendly designs, social interaction, and family involvement.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting poor health-related quality of life among Chinese adolescents using explainable machine learning: the role of school adjustment, family context, and lifestyle factors.","authors":"Liangyu Zhao, Yan Gao, Chenchen Liu, Zeqi Zhang, Yuke Yang, Yining Hu, Wenze Sui, Sen Ma, Shuoqin Zhang, Xinxin Lai, Zhiying Wang, Zhiwen Yang, Xiangren Yi","doi":"10.1186/s12955-026-02568-y","DOIUrl":"10.1186/s12955-026-02568-y","url":null,"abstract":"<p><strong>Background: </strong>Adolescents' health-related quality of life (HRQoL) is influenced by multiple domains, including school, family, and individual lifestyle. However, evidence remains limited on accurately predicting adolescent HRQoL and identifying modifiable determinants. This study aimed to develop a machine-learning prediction model for adolescent HRQoL and to determine key contextual factors associated with low quality of life.</p><p><strong>Methods: </strong>This cross-sectional study included 20,236 adolescents (51.71% female; mean age 15.97 years). HRQoL was assessed using the validated Quality of Life Scale for Children and Adolescents (QLSCA). Twenty predictors covering school adjustment, family characteristics, and health behaviours were entered into 9 machine-learning classifiers and logistic regression. Feature contributions were examined using permutation importance, partial dependence plots (PDPs), and SHapley Additive exPlanations (SHAP). Stratified analyses by sex and school stage were conducted to identify group-specific determinants.</p><p><strong>Results: </strong>School adjustment was the primary predictor of HRQoL, with self-management and peer relations contributing most. Family factors ranked next, particularly more frequent exercise with parents, which was associated with higher HRQoL. Among lifestyle behaviours, higher physical activity and healthier dietary patterns were associated with better HRQoL, whereas excessive screen time was associated with poorer HRQoL. In stratified analyses, peer relations and physical activity were more influential among boys, while self-management, exercising with parents, and adequate sleep contributed more among girls. Middle school students showed more adverse associations with disruptive/antisocial behaviours and screen time, whereas high school students derived greater benefits from family interaction and health behaviours.</p><p><strong>Conclusions: </strong>Explainable machine-learning analyses highlight school adjustment as a central correlate of adolescent HRQoL, alongside family characteristics and health behaviours. These findings provide multidimensional evidence to support targeted interventions in educational, family, and public health settings to improve adolescents' HRQoL.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13479416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring spiritual health among South Korean older adults using the ICECAP-O measure: a cross-sectional study.","authors":"Yifei Chen, Ishtiaq Ahmad, Yoshihisa Shirayama, Miyoko Okamoto, Eun Woo Nam, Motoyuki Yuasa","doi":"10.1186/s12955-026-02557-1","DOIUrl":"10.1186/s12955-026-02557-1","url":null,"abstract":"<p><strong>Background: </strong>Spiritual Health (SH) is regarded as a factor that influences an individual's overall well-being. SH is about finding meaning, having a sense of purpose, and feeling inner peace. At the same time, the holistic health viewpoints stress their proximity to human capability and the entirety of life's quality.</p><p><strong>Objective: </strong>The present study sought to determine the relationship between capabilities and subjective well-being in older adults using the ICECAP-O (ICEpop CAPability measure for older people) instrument and also examined the role of the SH measured by PIL (Purpose in Life) as a moderator of the ICECAP-O capability outcomes.</p><p><strong>Methods: </strong>This cross-sectional study was a paper-based questionnaire survey targeting 300 older adults aged 65 and over from Wonju and Yeoju, South Korea. The demographic characteristics, health perception, ICECAP-O result and PIL score were collected. Exploratory Factor Analysis (EFA) identified latent dimensions such as HP, IL and ELS. OLS and Pearson correlation were performed on the ICECAP-O tariff, EFA factors, and PIL scores. Stata 18 was used, with a significance level set at p < 0.05.</p><p><strong>Results: </strong>The mean PIL score was 98.5 ± 15.6, which represents moderate well-being. Regression analyses revealed significant effects of the 3 from 5 EFA factors, including HP (β = -0.09, p < 0.001), IL (β = 0.03, p < 0.05), and ELS (β = -0.03, p < 0.05) on the ICECAP-O tariff. PIL scores significantly and positively correlated with ICECAP-O tariff (r = 0.44, p < 0.001), with HP showing a noteworthy moderating effect (β = 0.05, p < 0.01).</p><p><strong>Conclusion: </strong>The PIL score is a positive predictor of ICECAP-O among South Korea older adults, suggesting that a better sense of purpose improves capability and quality of life. Further research is needed to examine the applicability of this capability instrument across different countries and cultural contexts for spiritual health.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative assessment of content validity of the modified EQ-HWB-9 by patients, caregivers, and social care users in the United States.","authors":"Jonathan L Nazari, A Simon Pickard, Justin Yu, Maja Kuharic","doi":"10.1186/s12955-026-02561-5","DOIUrl":"10.1186/s12955-026-02561-5","url":null,"abstract":"<p><strong>Background: </strong>The EQ-HWB-9 is a measure designed to capture health, social care, and caregiver-related quality of life across relevant populations. As part of ongoing development, modifications have been made to item wording, response scales, and layout informed by international collaborations. Qualitative evidence to support the content validity of the modified EQ-HWB-9 in the United States (US) is important to support its use in this major market. This study evaluated the comprehensibility, relevance, and comprehensiveness of the modified EQ-HWB-9 in US adults.</p><p><strong>Methods: </strong>US adults with chronic health conditions, serving as unpaid caregivers, and/or social care users were purposively recruited through an online panel. Participants independently completed an online, pre-interview survey including both experimental and modified EQ-HWB-9 versions and a cognitive interview conducted online using a semi-structured interview guide. Participants compared experimental and modified wording, response scales, layout, provided item-level interpretations and examples, and discussed perceived comprehensiveness of the measure. Interviews were conducted until thematic saturation was achieved. Verbatim transcripts were qualitatively coded and analyzed using the framework method.</p><p><strong>Results: </strong>Thirty-four participants (mean age 55; 71% female) completed interviews. Most items demonstrated strong face and content validity; participants readily interpreted daily activities, exhaustion, loneliness, anxiety, sadness/depression, and pain as intended and provided rich, relevant examples. However, the mobility item was identified by several participants as applying only to users of mobility devices. Across modifications, participants preferred \"difficulty\" over \"trouble\" (cognition), \"lack of control\" over \"no control,\" \"a little of the time\" over \"only occasionally,\" and \"moderate difficulty\" over \"some difficulty.\" Most participants found repeated question stems clearer than shared item stems. Half of respondents perceived the EQ-HWB-9 as comprehensive, with suggested additions (e.g., sleep, self-care) largely aligning with domains included in the long-form EQ-HWB.</p><p><strong>Conclusions: </strong>Findings provide qualitative support for the content validity of the modified EQ-HWB-9 in US populations and reinforce several proposed wording and response-scale refinements. Select issues identified with the wording of the mobility and control items can inform revisions in the wording of a finalized version of the EQ-HWB.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13466492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life and its associated factors among patients with neuromyelitis optica spectrum disorder in China: a questionnaire survey analysis.","authors":"Wenxuan Jiang, Shihan Yan, Shitong Xie, Jing Wu","doi":"10.1186/s12955-026-02560-6","DOIUrl":"10.1186/s12955-026-02560-6","url":null,"abstract":"<p><strong>Background: </strong>To assess the health-related quality of life (HRQoL) of Chinese Neuromyelitis optica spectrum disorder (NMOSD) patients, and to explore the influencing factors.</p><p><strong>Methods: </strong>An online survey was conducted among patients with NMOSD in China from May to June 2024. Data on socio-demographic characteristics, clinical characteristics, healthcare resource utilization, and HRQoL measured by EQ-5D-5 L were collected. Multivariable linear regression analysis was performed to identify factors associated with HRQoL.</p><p><strong>Results: </strong>A total of 336 patients with NMOSD (mean age 40.4 years; 89.3% female) were included in the analysis. The EQ-5D-5 L utility value was 0.665 ± 0.335 (mean ± SD). NMOSD patients most frequently reported problems in anxiety/depression whereas self-care was least affected; the proportion reporting no problems was 14.9% and 75.9%, respectively. According to multivariable linear regression analyses, older age, a greater number of comorbidities and chronic diseases, functional impairment (disability, difficulty walking), and higher caregiving needs were independently associated with lower HRQoL, whereas higher treatment satisfaction score and higher income (≥ 5000 CNY) were associated with higher HRQoL. Relapse status was not independently associated with HRQoL after adjustment for disease duration and current functional impairment.</p><p><strong>Conclusions: </strong>Chinese NMOSD patients experience substantially decreased HRQoL. Functional impairment and caregiving dependence are the main determinants of HRQoL, highlighting the need for patient-centered management beyond relapse prevention.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13465230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updated algorithms for direct and indirect mapping of WHOQOL-BREF to EQ-5D-5L utility scores using data from a multi-provincial Thai general population sample.","authors":"Krittaphas Kangwanrattanakul, Yi Jing Tan","doi":"10.1186/s12955-026-02558-0","DOIUrl":"10.1186/s12955-026-02558-0","url":null,"abstract":"<p><strong>Background: </strong>Mapping techniques can estimate EQ-5D-5L utility scores from non-preference-based WHOQOL-BREF responses. A previous Thai study used a reciprocal linear model, but it may not adequately address the left-skewed distribution of utility scores. This study aimed to develop improved mapping algorithms using alternative regression models that better account for the distributional characteristics of utility scores in the Thai general population.</p><p><strong>Methods: </strong>A 2022 national survey dataset of paired WHOQOL-BREF and EQ-5D-5L responses (n = 2,000), representative of the Thai general population, was used. Five predictor sets were fitted using eight regression models, including ordinary least squares, Tobit, censored least absolute deviations, generalized linear model (GLM), two-part models, adjusted limited dependent variable mixture model, and beta regression-based mixture model for the direct mapping approach; and multinomial logistic regression (MLOGIT) for the indirect mapping approach. The best-performing models were identified based on the lowest ten-fold cross-validated mean absolute error (MAE) and root mean square error (RMSE), together with minimal prediction bias from graphical assessment.</p><p><strong>Results: </strong>The GLM-poisson model, fitted using a predictor set comprising age, general WHOQOL-BREF items, and selected Physical Health, Psychological Health and Environment items, emerged as the best-performing model, with predictions closely aligning with observed values. A MLOGIT model performed less well, with overpredictions for utility scores > 0.6.</p><p><strong>Conclusions: </strong>This study advances the literature on mapping WHOQOL-BREF to EQ-5D-5L by providing updated algorithms for estimating EQ-5D-5L utility scores from WHOQOL-BREF responses in the Thai general population. The improved algorithms offer more accurate predictions, supporting their use in health economic analyses in Thailand.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proxy reports on the EQ-5D-5L in residential aged care facilities: a validation study.","authors":"Tiet-Hanh Dao-Tran, Syed Afroz Keramat, Christopher Etherton-Beer, Amy Page, Vasi Naganathan, Dee Mangin, Kathleen Potter, Sarah Hilmer, Tracy Comans","doi":"10.1186/s12955-026-02553-5","DOIUrl":"10.1186/s12955-026-02553-5","url":null,"abstract":"<p><strong>Background: </strong>The EuroQol 5-Dimension 5-Level questionnaire (EQ-5D-5L) is a common scale to measure health-related quality of life in residential aged care facilities. Many residents are unable to answer the scale independently; therefore, a proxy usually responds on the residents' behalf. The quality of data reported by proxy is not well understood. This study examines the psychometric properties, including convergent validity, known-group validity, interrater reliability, and responsiveness of proxy reports on the EQ-5D-5L.</p><p><strong>Methods: </strong>The study used data from 281 residents participating in a 12-month deprescribing randomised control trial in Australia. Interview-administered questionnaires were used for data collection. Convergent validity, known-group validity, and responsiveness were evaluated using a hypothesis-testing approach. Interrater reliability was assessed by calculating the intra-class correlation coefficient, weighted Cohen's kappa coefficient, and generating Bland-Altman plots and bar charts.</p><p><strong>Results: </strong>Proxy (staff) reports on EQ-5D-5L were significantly associated with residents' cognitive functioning, physical functioning, neuropsychiatric behaviours and frailty. Proxy (staff) reports on EQ-5D-5L were significantly different across groups of patients with varying levels of cognitive and physical functioning, frailty and neuropsychiatric behaviours. Changes over 12 months in residents' cognitive and physical functioning, frailty and neuropsychiatric behaviours were associated with changes in proxy reports on EQ-5D-5L. Interrater correlation at the total score measured by the intra-class correlation coefficient was 0.744 at baseline and 0.664 at 12 months (moderate). Interrater correlation at the domain level, measured by weighted Cohen's kappa, ranged from 0.206 to 0.432 (minimal to weak).</p><p><strong>Conclusion: </strong>Proxy reports on the EQ-5D-5L demonstrated satisfactory convergent validity, known-group validity, and responsiveness. Interrater reliability was moderate at the total utility score but poor at the domain level. Proxy reports on the EQ-5D-5L can serve as an alternative method to measure residents' HRQOL. However, data from proxy reports at the domain level is not recommended for future research and practice evaluation.</p><p><strong>Clinical trial registration: </strong>This study is part of a large deprescribing trial known as 'Opti-Med', which has been registered with the Australian New Zealand Clinical Trials Registry (Registry number: ACTRN12613001204730, dated 4 November 2013) and the World Health Organisation Clinical Trials Registry Platform (the universal trial number: U1111-1148-6094).</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between health-related quality of life and medication discrepancies: a cross-sectional study of older Chinese adults with type 2 diabetes mellitus.","authors":"Junming Tan, Meijuan Zhao, Rong Shao, Jianzhou Yan","doi":"10.1186/s12955-026-02556-2","DOIUrl":"10.1186/s12955-026-02556-2","url":null,"abstract":"<p><strong>Background: </strong>Health-related quality of life (HRQoL) is a widely used indicator for assessing individuals' subjective perception of life quality and population health status. It evaluates the multiple dimensions related to health, including physical, psychological, and social aspects, and may be associated with self-management behaviors and treatment adherence in patients with chronic diseases. This study examines the association between HRQoL and medication discrepancies (MDs) among older adults with type 2 diabetes mellitus (T2DM) during the transition from hospital to home care.</p><p><strong>Methods: </strong>The cross-sectional survey was conducted in Baoding City, Hebei Province, China. Data from patients (N = 552) were collected using a questionnaire that included the Chinese version of the MOS 36-Item Short Form Health Survey, a sinicized and modified version of the Medication Discrepancy Tool, and a general information form. Descriptive statistics, logistic regression models, and generalized additive models were employed to examine the associations between the variables.</p><p><strong>Results: </strong>The prevalence of MD in the study population was 55.8%. After adjustment for sociodemographic, clinical, and medication-related characteristics, both the Physical Component Summary and Mental Component Summary scores were significantly associated with MD. In the adjusted analyses, the medium-score group showed the highest odds of MD, followed by the high-score group, whereas the low-score group showed the lowest odds.</p><p><strong>Conclusions: </strong>HRQoL is associated with MD among older adults with T2DM during the post-discharge care transition, with a non-monotonic pattern in which MD prevalence peaks in the moderate HRQoL range. Solely disease severity-based models may overlook the relevance of subjective health perceptions in relation to medication behaviors. These findings suggest that HRQoL warrants consideration in understanding medication safety during care transitions, though the conclusions await confirmation in prospective studies.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13440091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship quality among people living with HIV/AIDS: a systematic review and meta-analysis.","authors":"Marcin Rzeszutek, Ewa Gruszczyńska, Magdalena Grabowska, Paula Malinowska, Barbara Sosińska","doi":"10.1186/s12955-026-02555-3","DOIUrl":"10.1186/s12955-026-02555-3","url":null,"abstract":"<p><strong>Background: </strong>The aim of this systematic review and meta-analysis was to summarize the existing literature on the factors associated with relationship quality among people living with HIV (PLWH).</p><p><strong>Method: </strong>A structured literature search was performed on APA PsycArticles, ProQuest and PubMed for quantitative, peer-reviewed studies published in English between 1994 and March 2025. Fifteen studies (N = 2579; 78% men, predominantly in serodiscordant couples) met the inclusion criteria and contributed 76 effect sizes, which were categorized as either protective or risk factors for relationship quality among PLWH. A three-level meta-analytic model was employed to address the nested data structure.</p><p><strong>Results: </strong>The pooled effect sizes were comparable for protective factors (r = 0.26, 95% CI [0.08, 0.43]) and risk factors (r = 0.24, 95% CI [0.16, 0.31]), reflecting small-to-moderate effects. Significant heterogeneity was observed at the between-study level, whereas within-study variability was negligible. The only significant moderator was relationship length: the association between protective factors and relationship quality was stronger in longer-term PLWH relationships.</p><p><strong>Conclusion: </strong>This review and meta-analysis suggest that, despite the unique context of HIV/AIDS, several correlates of relationship quality may reflect broader patterns observed across populations. The findings improve our understanding of factors associated with psychological well-being among PLWH, particularly given the importance of satisfying romantic relationships for quality of life in this population.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}