Health and Quality of Life Outcomes最新文献

{"title":"The impact of physical symptoms on depression and quality of life in patients with lung cancer: the moderating effects of illness perceptions and gender.","authors":"Jinhuan Yang, Danni Dong, Gan He, Zhenghao Ge, Zhonglin Chen, Chenyan Han, Yi Zhao, Yaping He, Qiao Chu","doi":"10.1186/s12955-025-02395-7","DOIUrl":"https://doi.org/10.1186/s12955-025-02395-7","url":null,"abstract":"<p><strong>Background: </strong>Physical symptoms negatively affect lung cancer patients' emotional well-being and quality of life. It remains understudied about what psychosocial factors may buffer the negative impact of physical symptoms. This study examines how illness perceptions moderate the impact of physical symptoms on depression and quality of life, and further considers gender differences.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 316 lung cancer patients from Shanghai Chest Hospital in Shanghai, China, between July and September 2021. Participants completed questionnaires assessing physical symptoms, depression, quality of life, and illness perceptions.</p><p><strong>Results: </strong>Hierarchical regression analyses revealed significant two-way interactions between physical symptoms and illness timeline perceptions on both depression (β = 0.12, P = 0.028) and quality of life (β = -0.13, P = 0.010). Additionally, significant three-way interactions involving physical symptoms, illness perceptions, and gender were found. Specifically, illness consequences perceptions interacted with physical symptoms and gender to predict depression (β = 0.17, P = 0.012), while personal control (β = 0.14, P = 0.022) and treatment control (β = 0.17, P = 0.017) interacted similarly to predict quality of life. Simple slope analyses indicated that positive illness perceptions alleviated the negative effects of physical symptoms on depression and quality of life, particularly in females.</p><p><strong>Conclusions: </strong>These findings indicate that facilitating positive illness perceptions may buffer the adverse effects of physical symptoms on depression and quality of life. Personalized psychological interventions aimed at enhancing patients' illness beliefs through positive psychological and behavioral strategies may contribute to improved coping and overall well-being.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"64"},"PeriodicalIF":3.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal DCE design for modelling nonlinear time preferences in EQ-5D-5L valuation studies: exploration of data from Denmark and Peru.","authors":"Alice Yu, Deborah Street, Marcel Jonker, Sterre Bour, Brendan Mulhern, Federico Augustovski, Cathrine Jensen, Claire Gudex, Morten Jensen, Romina Tejada, Richard Norman, Rosalie Viney, Elly Stolk","doi":"10.1186/s12955-025-02391-x","DOIUrl":"10.1186/s12955-025-02391-x","url":null,"abstract":"","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"62"},"PeriodicalIF":3.2,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between obstructive sleep apnea and quality of life in Korean middle-aged people: a cross-sectional study.","authors":"Jiwon Kim, Min Jeong Joo, Jae Yong Shin, Chung-Mo Nam, Eun-Cheol Park","doi":"10.1186/s12955-025-02390-y","DOIUrl":"10.1186/s12955-025-02390-y","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA), a serious sleep disorder, can lead to comorbidities and decreased quality of life if untreated. Poor sleep quality from OSA affects concentration, cognitive function, and mental health, contributing to conditions such as depression and anxiety. OSA prevalence increases with age, and middle-aged adults are particularly at risk owing to age-related social and physical changes. Enhancing sleep quality is essential for improving overall quality of life. The aim of this study was to investigate the relationship between OSA risk and quality of life among middle-aged and older adults in South Korea.</p><p><strong>Methods: </strong>This study utilized data from the 8th Korea National Health and Nutrition Examination Survey for 2019 and 2021 to investigate the relationship between OSA and health-related quality of life (HRQoL). After excluding missing values, the analysis included 8,109 adults aged ≥ 40 years. The primary variable of interest was OSA risk, with HRQoL measured using the HINT-8 index. Chi-square tests, binary logistic regression, and multinomial logistic regression analyses were conducted to examine the association between OSA and HRQoL.</p><p><strong>Results: </strong>In this study of 4,831 participants, 59.6% were classified as high-risk for OSA. Low quality of life was significantly associated with high-risk OSA (adjusted odds ratio [aOR], 1.17: 95% confidence interval [CI], 1.03-1.33). Subgroup analyses showed higher odds of low quality of life in high-risk OSA individuals, particularly among those not engaged in economic activity (aOR, 1.39; 95% CI, 1.15-1.67), those who consumed alcohol (aOR, 1.24; 95% CI, 1.03-1.49), and those with limited physical activity (aOR, 1.21; 95% CI, 1.03-1.43). Higher OSA risk correlated with poorer quality of life, especially in the lowest quality of life category (aOR, 2.49; 95% CI 1.18-3.43).</p><p><strong>Conclusions: </strong>The study found that middle-aged and older adults in South Korea at high risk for OSA had a lower quality of life than those at low risk. High-risk individuals who were economically inactive, consumed alcohol, or engaged in low physical activity also showed a lower quality of life. Future research should focus on accurately measuring OSA and further exploring its impact on quality of life in this population.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"63"},"PeriodicalIF":3.2,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convergent validity, reliability and responsiveness of the AP-7D and EQ-5D-5L based on the survey for the general people in five countries: a new cultural-specific preference-based measure developed in east and southeast asia.","authors":"Yuta Suzuki, Takeru Shiroiwa, Tatsunori Murata, Emi Kamono, Yasuhiro Morii, Takashi Fukuda","doi":"10.1186/s12955-025-02393-9","DOIUrl":"10.1186/s12955-025-02393-9","url":null,"abstract":"<p><strong>Background: </strong>The AP-7D is a preference-based measure that was recently developed for use in East and Southeast Asia. This study investigated the reliability and convergent validity of the new instrument.</p><p><strong>Methods: </strong>For this, surveys were conducted in Japan, Korea, China, Thailand, and Singapore. In each country, 500 respondents were selected using quota sampling and were stratified by sex and age. We conducted a face-to-face survey in Japan and a web-based survey in the remaining countries at two time points. The AP-7D and the EQ-5D-5L were collected from all countries, and the SF-6D was only collected in Japan. The instruments' reliabilities were confirmed by comparing the responses using self-report test-retest methods. For convergent validity, we compared responses provided to the AP-7D with those provided to the EQ-5D-5L and the SF-6D based on predetermined hypotheses.</p><p><strong>Results: </strong>The percentage of agreement between the two surveys (in separate categories) was 73.9% (pain/discomfort), 71.2% (mental health), 68.6% (energy), 89.6% (mobility), 82.1% (work/school), 84.3% (social relations), and 86.4% (burden to others) in the five countries. These values demonstrate equivalent performance to those of the EQ-5D-5L. The kappa coefficients for the AP-7D items were similar to those for the EQ-5D-5L. In the correlation matrix between the AP-7D and EQ-5D-5L, correlation exceeded 0.5 in the following items: 0.69 between \"mental health\" (AP-7D) and \"anxiety/depression\" (EQ-5D-5L), 0.54 for \"pain/discomfort\" in both, 0.51 between \"energy\" (AP-7D) and \"anxiety/depression\" (EQ-5D-5L), and 0.50 for \"mobility\" in both.</p><p><strong>Conclusions: </strong>The results of this survey showed the good test-retest reliability and convergent validity of the AP-7D. The basic psychometric properties of the new instrument were confirmed.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"61"},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent profile analysis of health-related quality of life and its associated factors in postoperative aortic dissection patients: a cross-sectional study.","authors":"Wanbing Huang, Qiansheng Wu, Yufen Zhang, Hongmei Zhu","doi":"10.1186/s12955-025-02392-w","DOIUrl":"10.1186/s12955-025-02392-w","url":null,"abstract":"<p><strong>Background: </strong>Aortic dissection (AD) is a rare but dangerous cardiovascular condition, and research on the health-related quality of life (HRQOL) of postoperative patients after discharge is limited. This study aimed to classify patterns of HRQOL among this population, and to examine the psychological and social factors associated with different HRQOL categories based on the common sense model of self-regulation and the social-cognitive processing model.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in two tertiary general hospitals in Wuhan from January 2022 to August 2022. HRQOL was assessed via the validated Patient-Reported Outcomes Measurement Information System 29-item Profile. Characteristic categories of HRQOL were identified through exploratory latent profile analysis. Univariate analysis and multinominal logistic regression were employed to explore the factors associated with HRQOL.</p><p><strong>Results: </strong>Among the 379 patients, the mean health utility was 0.36 ± 0.17. A total of 35.4% and 32.5% of the patients had obvious anxiety and depression, respectively. The patients were divided into three HRQOL subgroups: \"high psychological distress-pain group\" (29.0%), \"mild functional impairment-anxiety group\" (49.3%), and \"mild functional impairment-adaptation group\" (21.6%). Significant factors associated with HRQOL included age, AD type, illness cognitive representation, fear of disease progression, daily life management and exercise (P < 0.05).</p><p><strong>Conclusions: </strong>The self-reported health status of postoperative AD patients is concerning. HRQOL within this population displays significant heterogeneity, and stratified care tailored to each group is recommended. Interventions targeting cognitive representations and fear reduction may enhance HRQOL. Continuous care to facilitate self-management behaviors is essential for improving health outcomes for postoperative AD patients. These findings require further longitudinal and interventional studies to confirm.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"60"},"PeriodicalIF":3.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent validity testing of the patient perspective of arrhythmia questionnaire.","authors":"Kathryn A Wood, Yutong Jin, Robert T Krafty, Jameze H James, Sivaraman K Iyer, Nitish Badhwar","doi":"10.1186/s12955-025-02385-9","DOIUrl":"10.1186/s12955-025-02385-9","url":null,"abstract":"<p><strong>Background: </strong>Disease-specific patient reported outcome measures (PROMs) are widely used to evaluate not only a patient's view of their symptoms, functional status, and health related quality of life, but also clinical benefit of treatments. The Patient Perspective of Arrhythmia Questionnaire (PPAQ) was initially developed as a self-administered, disease-specific PROM for patients with supraventricular tachycardia (SVT) assessing the impact of the arrhythmia and symptoms on patients' daily activities and physical, emotional, and social functioning. Preliminary evidence of content and construct validity has been previously demonstrated, but only in SVT patients in the U.S. and Poland. The aim of this study was to further evaluate the concurrent validity of the PPAQ in patients having a variety of arrhythmias and to explore whether differences in symptoms existed by gender.</p><p><strong>Methodology: </strong>In this cross-sectional study, adult cardiac arrhythmia outpatients from a tertiary care, academic medical center completed the 6-item PPAQ, the SF-12, a Fatigue Visual Analog Scale (VAS), the Brief Symptom Inventory (BSI), and the Patient Health Questionnaire (PHQ-9). Included were patients with atrial fibrillation (82.4%), ventricular tachycardia (15.7%), and atrial tachycardia (2%). Descriptive statistics and independent t-tests, pairwise comparisons with Pearson correlations, Goodman Kruskal gamma statistic for ordinal associations, Cronbach's alpha, and Kuder-Richardson-20 (KR-20) were used to determine concurrent construct validity and internal consistency reliability.</p><p><strong>Results: </strong>Participants (n=51) had a mean age of 59.4 years (± 12.6), were majority male (66.7%) and Caucasian (75%). Preliminary evidence of concurrent construct validity was found based on moderate to strong correlations (range from 0.4 to 0.7) between the PPAQ and other validated measures, as well as strong internal reliability (KR-20 of 0.80 and Cronbach's alpha of 0.91). The most common symptoms reported were fatigue (60.8%) and heart fluttering (52.9%). Blurred vision (p<0.04), dizziness (p<0.01), and fatigue (p<0.04) were seen significantly more frequently in men compared to women.</p><p><strong>Conclusions: </strong>Results present additional evidence of the validity and reliability of the PPAQ. The PPAQ comprehensively measures the burden of the disease from cardiac arrhythmia patients' perspective. Validated, reliable, disease-specific PROMs are needed to direct personalized clinical decision-making.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"59"},"PeriodicalIF":3.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The moderating effect of neuroticism on the relationship of migration status and health-related quality of life in Germany: a population-based study.","authors":"Arieja Farugie, Lisa-Marie Maukel, Ana N Tibubos","doi":"10.1186/s12955-025-02380-0","DOIUrl":"10.1186/s12955-025-02380-0","url":null,"abstract":"<p><strong>Purpose: </strong>Ample research exists on the association of migration status and health-related quality of life (HRQoL). Specific personality traits linked to the Big Five such as neuroticism, have been found to be predictive of migrants' intercultural success. This study aimed to analyze the moderating effect of neuroticism on migration status and HRQoL in a representative German sample.</p><p><strong>Methods: </strong>Data from the German Socioeconomic Panel (GSOEP) (N = 29,968) were analyzed. The sample included Germans without migration background (n = 19,749), immigrants (n = 3,491), foreigners residing in Germany (n = 2,460), and refugees (n = 4,268). Gender-stratified moderation analyses were performed using General Linear Models with HRQoL (SF-12; mental and physical health) as outcome, migration status as predictor, and neuroticism (BFI-S) as moderator.</p><p><strong>Results: </strong>Refugees reported the lowest HRQoL (F(3, 29192) = 27.54, p <.001). Refugees also displayed the lowest neuroticism scores. Significant moderation effects of neuroticism on the relationship between migration status and SF-12 mental HRQoL scores were observed, especially for refugees (β = 0.05, CI [0.01 - 0.10], p =.03) and immigrants (β = 0.04, CI [0.00 - 0.08], p =.03; R² = 0.064). Women had lower SF-12 scores compared to men across all groups. Additionally, there was a significant three-way interaction effect for female refugees with neuroticism on mental HRQoL (β = - 0.24; CI [-0.34 - - 0.14]; p <.001).</p><p><strong>Conclusion: </strong>The results corroborated research pointing out differences in HRQoL depending on migration status and gender. Refugees seem to benefit particularly from low neuroticism, in terms of emotional stability, as a psychological resource.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"58"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, cultural adaptation, and content validation of the Hong Kong Chinese version of Self-completion Adult Social Care Outcomes Toolkit (ASCOT-SCT4) for care service users.","authors":"Siyue Yu, Judy Chu Dik Sze, Annie Wai Ling Cheung, Kailu Wang, Elizabeth Welch, Nick Smith, Richard Huan Xu, Eliza Lai Yi Wong","doi":"10.1186/s12955-025-02389-5","DOIUrl":"10.1186/s12955-025-02389-5","url":null,"abstract":"<p><strong>Background: </strong>In light of the global challenges posed by an ageing population, the evaluation of long-term care (LTC) is of particular importance. The Adult Social Care Outcomes Toolkit Four-Level Self-completion Tool (ASCOT-SCT4) is a preference-based instrument developed to measure long-term care (LTC) related quality of life (QoL). However, it is not yet available in Hong Kong (HK). This study aims to translate and culturally adapt the ASCOT-SCT4 into Chinese and evaluate its content validity in the HK context.</p><p><strong>Methods: </strong>The study adhered to well-established international guidelines for conducting translation, cultural adaptation, and content validation of instruments. The translation process included forward, backward translations, and expert committee review. Subsequently, LTC users aged 60 or above and experts with diverse professional backgrounds in LTC were involved in content validation in terms of comprehensibility, relevance, and comprehensiveness through cognitive interviews and a content validity index (CVI) survey. For clarity and relevance, an item-level CVI (I-CVI) of ≥ 0.78 and a scale-level CVI (S-CVI) of ≥ 0.90 were considered acceptable.</p><p><strong>Results: </strong>In the translation process, concern was raised about the literal translation of 'Control over daily life' item. During the cognitive interviews, 27 LTC users perceived the instrument's length as acceptable, and experienced no sensitive feelings while completing it. However, seven of the nine items were found to have comprehension and interpretation issues, which were mostly resolved through revisions of wordings. For the 'Food and drink' and 'Dignity' items, alternative terms were used and sentence structure was revised to improve its comprehensibility while ensuring equivalence to the original English version. The final translated version demonstrated acceptable clarity (S-CVI: 0.92, I-CVIs: 0.86-1.00) as evaluated by seven experts. Both LTC users and experts found the items relevant (S-CVI: 0.97, I-CVIs: 0.94 to 1.00), and no additional LTC-related QoL domains were identified as missing from the instrument.</p><p><strong>Conclusions: </strong>This study provides evidence that the Chinese version of the ASCOT-SCT4 is comprehensible, relevant, and comprehensive for the HK context, which allows for further testing on psychometric properties in a larger population.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"57"},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Working towards a new normal: a meta-synthesis of patient-reported aspects of a good life with heart disease.","authors":"Lisa Nebel, Timothy R Le Butt, Christoph Herrmann-Lingen, Daniel Broschmann","doi":"10.1186/s12955-025-02388-6","DOIUrl":"10.1186/s12955-025-02388-6","url":null,"abstract":"<p><strong>Aims: </strong>This meta-synthesis challenges the medical notion of health-related quality of life (HRQOL) by identifying aspects of the more holistic philosophical concept of the good life from the perspective of patients with heart disease.</p><p><strong>Design: </strong>Systematic meta-synthesis.</p><p><strong>Methods: </strong>Following preregistration on PROSPERO, a systematic literature search was conducted in PubMed, PsycInfo, PsycArticles, and PSYNDEX from February 2023 to March 2024. Studies focusing on the experiences of adults living with heart disease were included based on predefined criteria. Articles were assessed for methodological quality using a modified CASP tool, and data synthesis followed Interpretative Phenomenological Analysis. Reporting adheres to PRISMA and ENTREQ guidelines.</p><p><strong>Results: </strong>Forty-three articles were included, revealing the overarching theme of \"Working towards a new normal,\" with four sub-themes: (1) Feeling safe in my own body again, (2) Important relationships provide security and meaning, (3) Taking my life into my own hands again and (4) Living more consciously.</p><p><strong>Conclusions: </strong>While HRQOL is a valuable and widely used concept, it primarily captures quality of life from a functional perspective. Qualitative studies on individuals with heart disease reveal the additional aspects of coherence, connectedness, and self-determination that align more closely with the concept of a good life.</p><p><strong>Implications: </strong>To enhance care and counseling for patients with heart disease, the concept of HRQOL should be broadened to incorporate preferences, interests, and needs regarding life planning, aligned with the notion of a good life.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"56"},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current use and application of thresholds for clinical importance of the EORTC QLQ-C30, the EORTC CAT core and the EORTC QLQ-C15-PAL- a systematic scoping review.","authors":"Micha J Pilz, Anna M M Thurner, Lisa M Storz, Daniela Krepper, Johannes M Giesinger","doi":"10.1186/s12955-025-02387-7","DOIUrl":"10.1186/s12955-025-02387-7","url":null,"abstract":"<p><strong>Background: </strong>Thresholds for clinical importance (TCIs) were previously established for the cancer-specific patient reported outcome (PRO) measures EORTC QLQ-C30, EORTC QLQ CAT Core, and EORTC QLQ-C15-PAL. TCIs aim to aid the interpretation of scores for individual patients at a single point in time. They intend to indicate whether a symptom or functional health limitation is of clinical relevance, i.e., requires to be discussed with healthcare professionals. In this systematic scoping review, we aimed to describe the uptake of TCIs by the research community and discuss opportunities and threats in their application to PRO data.</p><p><strong>Methods: </strong>We systematically searched PubMed and Web of Science databases that contained search terms on the respective PRO measures and TCIs. Additionally, we performed a hand search on citations of the original TCI articles on Google Scholar. Articles were included if they applied TCIs in the analysis or the interpretation of PRO data or in clinical practice. Data concerning the study design, the use of TCIs, the terminology, and the application of TCIs were extracted.</p><p><strong>Results: </strong>A total of 512 articles were identified. After title, abstract and full-text screening, data extraction was performed on 117 of these articles. Most articles reported on longitudinal-observational (n = 55) or cross-sectional observational (n = 49) studies, whereby the most frequent cancer populations having mixed diagnoses (n = 25), breast cancer (n = 23), haematological malignancies (n = 18), or colorectal cancer (n = 11). Various terms were used to refer to the concept of TCIs, with \"thresholds for clinical importance\" being the most frequently used term (n = 63; 50.8%). Strikingly, 41 of the 117 articles (35.0%) reported that TCIs were applied to group-level data (e.g. mean scores), which is a clearly unintended application of the TCIs.</p><p><strong>Conclusion: </strong>TCIs are frequently used by the research community and thus enhanced the interpretability of PRO data in oncology. While most studies correctly applied TCIs in their analysis and interpretation, further guidance and clarification on their use are required. This article aims to contribute to this endeavour.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"55"},"PeriodicalIF":3.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}