{"title":"COVID-19患者健康相关生活质量：EQ-5D研究的系统回顾和荟萃分析","authors":"Kidu Gidey, Yirga Legesse Niriayo, Solomon Weldegebreal Asgedom, Erica Lubetkin","doi":"10.1186/s12955-025-02421-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>COVID-19 has affected millions globally, with a significant proportion experiencing long-COVID and impaired health-related quality of life (HRQoL). This systematic review and meta-analysis aimed to synthesize the existing literature on HRQoL in COVID-19 patients.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed, Embase, Web of Science, Scopus, and the Cochrane Library for studies published between December 2019 and March 2025. Eligible studies were peer-reviewed and assessed HRQoL in COVID-19 patients using the EQ-5D instrument. Study quality and risk of bias were evaluated using the Newcastle-Ottawa Scale. Pooled health utility values were estimated using a random-effects model, and heterogeneity was assessed via I<sup>2</sup> statistics. Predictors of poor HRQoL were qualitatively narrated.</p><p><strong>Results: </strong>Out of 3539 references, 187 studies with 116,525 participants were analyzed. The majority (80.2%) used the EQ-5D-5 L version. The pooled mean EQ-5D utility score was 0.76 (95% CI 0.74-0.79, I<sup>2</sup> = 99.9%) while the mean EQ-5D Visual Analogue Scale (VAS) score was 70.76 (95% CI 68.48-73.04; I<sup>2</sup> = 99.7%). Pain/discomfort and anxiety/depression were the most affected domains, reported by 51% and 46% of patients, respectively. Subgroup analysis showed significant differences in HRQoL based on national income status (p = 0.038) and geographic region (p < 0.001). Common predictors of lower HRQoL included older age, female gender, disease severity, comorbidities, and post-COVID-19 symptoms.</p><p><strong>Conclusion: </strong>This systematic review demonstrates a substantial reduction in HRQoL among COVID-19 patients compared to the general population. The pooled utility values of COVID-19 contribute to understanding patients' HRQoL and can assist in calculating Quality-Adjusted Life Years. This provides essential data for future economic evaluations and informs health policy decisions.</p>","PeriodicalId":12980,"journal":{"name":"Health and Quality of Life Outcomes","volume":"23 1","pages":"97"},"PeriodicalIF":3.4000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Health-related quality of life in COVID-19 patients: a systematic review and meta-analysis of EQ-5D studies.\",\"authors\":\"Kidu Gidey, Yirga Legesse Niriayo, Solomon Weldegebreal Asgedom, Erica Lubetkin\",\"doi\":\"10.1186/s12955-025-02421-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>COVID-19 has affected millions globally, with a significant proportion experiencing long-COVID and impaired health-related quality of life (HRQoL). This systematic review and meta-analysis aimed to synthesize the existing literature on HRQoL in COVID-19 patients.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed, Embase, Web of Science, Scopus, and the Cochrane Library for studies published between December 2019 and March 2025. Eligible studies were peer-reviewed and assessed HRQoL in COVID-19 patients using the EQ-5D instrument. Study quality and risk of bias were evaluated using the Newcastle-Ottawa Scale. Pooled health utility values were estimated using a random-effects model, and heterogeneity was assessed via I<sup>2</sup> statistics. Predictors of poor HRQoL were qualitatively narrated.</p><p><strong>Results: </strong>Out of 3539 references, 187 studies with 116,525 participants were analyzed. The majority (80.2%) used the EQ-5D-5 L version. The pooled mean EQ-5D utility score was 0.76 (95% CI 0.74-0.79, I<sup>2</sup> = 99.9%) while the mean EQ-5D Visual Analogue Scale (VAS) score was 70.76 (95% CI 68.48-73.04; I<sup>2</sup> = 99.7%). Pain/discomfort and anxiety/depression were the most affected domains, reported by 51% and 46% of patients, respectively. Subgroup analysis showed significant differences in HRQoL based on national income status (p = 0.038) and geographic region (p < 0.001). Common predictors of lower HRQoL included older age, female gender, disease severity, comorbidities, and post-COVID-19 symptoms.</p><p><strong>Conclusion: </strong>This systematic review demonstrates a substantial reduction in HRQoL among COVID-19 patients compared to the general population. The pooled utility values of COVID-19 contribute to understanding patients' HRQoL and can assist in calculating Quality-Adjusted Life Years. 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引用次数: 0
摘要
背景：COVID-19影响了全球数百万人，其中很大一部分人经历了长时间的covid和健康相关生活质量（HRQoL）受损。本系统综述和荟萃分析旨在综合现有关于COVID-19患者HRQoL的文献。方法：我们对PubMed、Embase、Web of Science、Scopus和Cochrane Library进行了系统检索，检索了2019年12月至2025年3月期间发表的研究。对符合条件的研究进行同行评审，并使用EQ-5D仪器评估COVID-19患者的HRQoL。采用纽卡斯尔-渥太华量表评估研究质量和偏倚风险。使用随机效应模型估计综合健康效用值，并通过I2统计量评估异质性。对不良HRQoL的预测因素进行定性叙述。结果：在3539篇文献中，分析了187项研究，116,525名参与者。大多数（80.2%）使用eq - 5d - 5l型。EQ-5D综合平均效用评分为0.76 (95% CI 0.74-0.79, I2 = 99.9%)，而EQ-5D视觉模拟量表（VAS）平均评分为70.76 （95% CI 68.48-73.04, I2 = 99.7%）。疼痛/不适和焦虑/抑郁是最受影响的领域，分别有51%和46%的患者报告。亚组分析显示，不同国民收入状况和地理区域的HRQoL存在显著差异（p = 0.038）。结论：本系统评价显示，与一般人群相比，COVID-19患者的HRQoL显著降低。COVID-19的综合效用值有助于了解患者的HRQoL，并有助于计算质量调整生命年。这为今后的经济评估和卫生政策决策提供了重要数据。
Health-related quality of life in COVID-19 patients: a systematic review and meta-analysis of EQ-5D studies.
Background: COVID-19 has affected millions globally, with a significant proportion experiencing long-COVID and impaired health-related quality of life (HRQoL). This systematic review and meta-analysis aimed to synthesize the existing literature on HRQoL in COVID-19 patients.
Methods: We conducted a systematic search of PubMed, Embase, Web of Science, Scopus, and the Cochrane Library for studies published between December 2019 and March 2025. Eligible studies were peer-reviewed and assessed HRQoL in COVID-19 patients using the EQ-5D instrument. Study quality and risk of bias were evaluated using the Newcastle-Ottawa Scale. Pooled health utility values were estimated using a random-effects model, and heterogeneity was assessed via I2 statistics. Predictors of poor HRQoL were qualitatively narrated.
Results: Out of 3539 references, 187 studies with 116,525 participants were analyzed. The majority (80.2%) used the EQ-5D-5 L version. The pooled mean EQ-5D utility score was 0.76 (95% CI 0.74-0.79, I2 = 99.9%) while the mean EQ-5D Visual Analogue Scale (VAS) score was 70.76 (95% CI 68.48-73.04; I2 = 99.7%). Pain/discomfort and anxiety/depression were the most affected domains, reported by 51% and 46% of patients, respectively. Subgroup analysis showed significant differences in HRQoL based on national income status (p = 0.038) and geographic region (p < 0.001). Common predictors of lower HRQoL included older age, female gender, disease severity, comorbidities, and post-COVID-19 symptoms.
Conclusion: This systematic review demonstrates a substantial reduction in HRQoL among COVID-19 patients compared to the general population. The pooled utility values of COVID-19 contribute to understanding patients' HRQoL and can assist in calculating Quality-Adjusted Life Years. This provides essential data for future economic evaluations and informs health policy decisions.
期刊介绍：
Health and Quality of Life Outcomes is an open access, peer-reviewed, journal offering high quality articles, rapid publication and wide diffusion in the public domain.
Health and Quality of Life Outcomes considers original manuscripts on the Health-Related Quality of Life (HRQOL) assessment for evaluation of medical and psychosocial interventions. It also considers approaches and studies on psychometric properties of HRQOL and patient reported outcome measures, including cultural validation of instruments if they provide information about the impact of interventions. The journal publishes study protocols and reviews summarising the present state of knowledge concerning a particular aspect of HRQOL and patient reported outcome measures. Reviews should generally follow systematic review methodology. Comments on articles and letters to the editor are welcome.
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