Estimating a preference-based index for patients with myasthenia gravis from the MGQoL-6D measure.

IF 3.2 2区医学 Q1 HEALTH CARE SCIENCES & SERVICES

Health and Quality of Life Outcomes Pub Date : 2025-04-20 DOI:10.1186/s12955-025-02370-2

Richard Huan Xu, Richard Norman, Ji Liu, Dong Dong

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引用次数: 0

Abstract

Objective: Myasthenia gravis is a chronic neuromuscular disease that causes weakness. It's uncertain whether generic health instruments can adequately capture its impact. This study aimed to develop a scoring system to generate utility values for all health states defined by the myasthenia gravis quality of life 6-dimension (MGQoL-6D) classification in Chinese patients with myasthenia gravis (MG).

Methods: The data used in this study were obtained from a web-based cross-sectional study conducted in China. Patients with MG were invited to complete an online discrete choice experiment (DCE) survey. Each participant completed 10 randomly assigned choice pairs from a set of 40 choice pairs, with each pair comprising two health states and a duration attribute. Conditional logistic regression analysis was employed to analyse the data, which included responses from 300 patients.

Results: Utility decrements estimated by conditional logit regression were generally monotonic, with the largest decrements observed for emotion (- 0.419), social activity (- 0.323), and hobbies and fun activities (- 0.323). The MGQoL-6D utility scores ranged between - 0.559 and 1.

Conclusion: This study established utility weights for the MGQoL-6D that can facilitate cost-utility analyses related to MG-related health interventions and technologies.

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从MGQoL-6D测量估计重症肌无力患者的偏好指数。

目的：重症肌无力是一种慢性神经肌肉疾病。目前尚不确定通用卫生工具能否充分反映其影响。本研究旨在建立一个评分系统，对中国重症肌无力（MG）患者的生活质量6维度（MGQoL-6D）分类所定义的所有健康状态产生效用值。方法：本研究使用的数据来自一项在中国进行的基于网络的横断面研究。MG患者被邀请完成一项在线离散选择实验（DCE）调查。每个参与者从一组40对选择对中完成10对随机分配的选择对，每对选择对包括两种健康状态和持续时间属性。采用条件logistic回归分析对数据进行分析，其中包括300例患者的反应。结果：条件logit回归估计的效用下降总体上是单调的，情感（- 0.419），社会活动（- 0.323）和爱好和娱乐活动（- 0.323）的降幅最大。MGQoL-6D效用得分在- 0.559到1之间。结论：本研究建立了MGQoL-6D的效用权重，可以促进与mg相关的健康干预措施和技术相关的成本-效用分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Health and Quality of Life Outcomes 医学-卫生保健

CiteScore

7.30

自引率

2.80%

发文量

154

审稿时长

3-8 weeks

期刊介绍： Health and Quality of Life Outcomes is an open access, peer-reviewed, journal offering high quality articles, rapid publication and wide diffusion in the public domain. Health and Quality of Life Outcomes considers original manuscripts on the Health-Related Quality of Life (HRQOL) assessment for evaluation of medical and psychosocial interventions. It also considers approaches and studies on psychometric properties of HRQOL and patient reported outcome measures, including cultural validation of instruments if they provide information about the impact of interventions. The journal publishes study protocols and reviews summarising the present state of knowledge concerning a particular aspect of HRQOL and patient reported outcome measures. Reviews should generally follow systematic review methodology. Comments on articles and letters to the editor are welcome.