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Evaluation of the Radioactive Material Released in the Harborview Research and Training Building and Some Implications for Emergency Response. 港景研究培训大楼放射性物质泄漏评价及应急响应启示
IF 1 4区 医学
Health physics Pub Date : 2025-04-28 DOI: 10.1097/HP.0000000000001978
Stephen V Musolino, Frederick T Harper, Daniel J Blumenthal, Jon Schwantes, Edgar C Buck, Kevin P Carney, David L Chichester, Thomas V Holschuh, Joshua J Kane, Daniel J Murray
{"title":"Evaluation of the Radioactive Material Released in the Harborview Research and Training Building and Some Implications for Emergency Response.","authors":"Stephen V Musolino, Frederick T Harper, Daniel J Blumenthal, Jon Schwantes, Edgar C Buck, Kevin P Carney, David L Chichester, Thomas V Holschuh, Joshua J Kane, Daniel J Murray","doi":"10.1097/HP.0000000000001978","DOIUrl":"https://doi.org/10.1097/HP.0000000000001978","url":null,"abstract":"<p><strong>Abstract: </strong>On 2 May 2019, during the 137Cs source recovery operation, a source capsule in a research irradiator containing approximately 77.1 TBq was breached. Based on a geometric reconstruction analysis of the damage to the capsule, approximately 46.3 GBq (0.04%) was impacted by the chop saw (grinder) inside a mobile hot cell on the loading dock at the University of Washington Harborview Research and Training (HRT) Building. A very small fraction of the material impacted, less than 1%, was released from the mobile hot cell and then to the rest of the HRT Building. The objectives of this project were to assess the accidental release of 137CsCl and its implications related to emergency response methods and the ramifications of 137CsCl transport. The phenomenology of this event was also compared with past alkali halide dispersal events. The vast number of measurements and samples collected by the remediation contractors, the Department of Energy's Nuclear Emergency Support Team, and the small number of retrospective samples collected by the authors informed the analysis. The techniques included (1) autoradiography and electron microscopy of samples collected from the HRT Building and the irradiator, (2) 3D visualization of deposition on surfaces and within the ventilation system, and (3) a study of the damage to the source capsule to evaluate the Cs particle size and particle composition due to the grinding accident. Subsequently, the cesium contaminant transport through the numerous pathways in the building was reconstructed to assess the deposition on surfaces as a function of particle size. The implications for emergency response are relevant to data quality and management. A Data Quality Objective guides data collection methods so that they have appropriate accuracy and precision for the intended application. Recommendations were made with respect to the sample collection protocols and archiving of samples.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clarification of Johnston Island Nuclear Tests. 澄清约翰斯顿岛核试验。
IF 1 4区 医学
Health physics Pub Date : 2025-04-28 DOI: 10.1097/HP.0000000000001981
Kathleen M Thiessen, Steven L Simon
{"title":"Clarification of Johnston Island Nuclear Tests.","authors":"Kathleen M Thiessen, Steven L Simon","doi":"10.1097/HP.0000000000001981","DOIUrl":"https://doi.org/10.1097/HP.0000000000001981","url":null,"abstract":"<p><strong>Abstract: </strong>US nuclear weapons launched from Johnston Island for testing purposes in 1958 and 1962 resulted in 12 successful launches, from which high-altitude nuclear detonations occurred, and four failed launches, resulting in aborted tests with no nuclear detonations. Lists of US nuclear tests produced by testing organizations include only events in which nuclear detonations occurred. Hence, the four failed launches in which no nuclear detonation occurred were not considered tests and are not in the lists, even though three of the failed launches resulted in significant local contamination of Johnston Island. A few summaries of nuclear testing at Johnston Island have mistakenly assumed that the launches resulting in local contamination were among the 12 nuclear tests listed for Johnston Island. This note explicitly lists the identities of all 16 launches of nuclear devices from Johnston Island for the purpose of correcting this assumption.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Y-90 Treatment Dose Delivery Uncertainty from Measurement Uncertainties. Y-90治疗剂量传递不确定度来自测量不确定度。
IF 1 4区 医学
Health physics Pub Date : 2025-04-03 DOI: 10.1097/HP.0000000000001975
Tianliang Gu
{"title":"Y-90 Treatment Dose Delivery Uncertainty from Measurement Uncertainties.","authors":"Tianliang Gu","doi":"10.1097/HP.0000000000001975","DOIUrl":"https://doi.org/10.1097/HP.0000000000001975","url":null,"abstract":"<p><strong>Abstract: </strong>The objective of this note was to study the measurement uncertainties at each step of Yttrium-90 radioembolization. We studied the measurement uncertainty contribution from the dose calibrator accuracy during the initial dose assay, the survey meter accuracy, and the operator's reading uncertainties during the dose rate measurements. The propagation of these uncertainties was calculated to determine the final dose delivery uncertainty for various prescribed doses. The percentage of final dose delivered could be affected significantly by the uncertainties associated with operation at each step of dose assay and dose rate measurements, especially for low prescribed doses.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electret Production and Applications with Special Regard to Health Physics Dosimetry: A Review. 驻极体的生产和应用,特别是在健康物理剂量测定方面:综述。
IF 1 4区 医学
Health physics Pub Date : 2025-04-01 Epub Date: 2024-11-27 DOI: 10.1097/HP.0000000000001896
Mehdi Sohrabi, Sahel Rabiee
{"title":"Electret Production and Applications with Special Regard to Health Physics Dosimetry: A Review.","authors":"Mehdi Sohrabi, Sahel Rabiee","doi":"10.1097/HP.0000000000001896","DOIUrl":"10.1097/HP.0000000000001896","url":null,"abstract":"<p><strong>Abstract: </strong>An electret detector is a piece of dielectric material film charged or polarized by a specific charging method to induce a quasi-permanent electric field. Electret films perform unique characteristics for production and applications in many areas of science and technology, especially in health physics dosimetry. A charged electret detector, when placed in an ionized environment, collects negative or positive ions depending on its original charging state, which reduces its original charge. The number of charges reduced in the ionized field is usually proportional to the absorbed radiation dose. In this paper, the state-of-the-art information on the type of electrets, production methods, some applications in particular in health physics dosimetry, and relevant concepts are reviewed.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":" ","pages":"320-331"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cosmic Radiation Exposure: A Review of Recent Research on the Incidence and Prevention of Cancer in Aircrews. 宇宙辐射暴露:机组人员癌症发病率及预防研究进展综述。
IF 1 4区 医学
Health physics Pub Date : 2025-04-01 Epub Date: 2024-11-14 DOI: 10.1097/HP.0000000000001894
Lisa D Eckhardt
{"title":"Cosmic Radiation Exposure: A Review of Recent Research on the Incidence and Prevention of Cancer in Aircrews.","authors":"Lisa D Eckhardt","doi":"10.1097/HP.0000000000001894","DOIUrl":"10.1097/HP.0000000000001894","url":null,"abstract":"<p><strong>Abstract: </strong>The author provides a literature review examining the clinical risks of cosmic radiation exposure and incidence of cancer in aircrews including pilots, flight attendants, and flight engineers or navigators. The review focuses on ionizing radiation exposure in aircrews as an occupational working group. The author will discuss the types of cancer associated with cosmic ionizing radiation exposure and the prevalence of certain cancer types noted in this population. Monitoring of ionizing radiation of aircrews in the United States is not required in 2024, which makes assessing exposure a challenge. The author also discusses associated risk factors and prevention strategies in aircrews. United States aircrews are an occupational group with known elevated exposure to ionizing radiation from natural cosmic sources, which has been linked to health risks, particularly for cancer. This occupational group is not monitored in 2024 and would benefit from occupational exams for medical surveillance and hazard awareness.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":"128 4","pages":"291-297"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Waveforms of 4G and 5G Radiofrequency Signals: Are Differences Relevant to Biology or Health? 4G和5G射频信号的波形:差异与生物学或健康有关?
IF 1 4区 医学
Health physics Pub Date : 2025-04-01 Epub Date: 2024-11-20 DOI: 10.1097/HP.0000000000001895
Kenneth R Foster, David Maxson, Peter M Zollman
{"title":"Waveforms of 4G and 5G Radiofrequency Signals: Are Differences Relevant to Biology or Health?","authors":"Kenneth R Foster, David Maxson, Peter M Zollman","doi":"10.1097/HP.0000000000001895","DOIUrl":"10.1097/HP.0000000000001895","url":null,"abstract":"<p><strong>Abstract: </strong>This Note briefly reviews, at a level that is intended to be accessible to non-specialists, the similarities and differences between waveforms of 4G Long-Term Evolution (4G LTE) and 5G New Radio (5G NR) transmitted by cellular base stations, as a resource for health physicists and others who are engaged in public communication about cellular telephone technologies. Despite the difference in levels of controversy presently existing between 4G LTE (introduced in 2008) and 5G NR (introduced in 2019), the differences in waveform as represented by the baseband waveform are minimal, although 5G NR offers system designers a much wider choice of parameters. Transmitted radiofrequency signals in both technologies appear noise-like, in a frequency range that is narrowly contained in the assigned channel. It is concluded that the modulation differences between 4G LTE and 5G NR are unlikely to have any biological relevance, but the greater range of accessible frequencies in 5G NR suggests the need for further health research, particularly in the 5G FR2 millimeter-wave band.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":"128 4","pages":"332-336"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ionizing Radiation Dose to the Skin Assessed after Rapid Detection of 232 Th in Consumer Products. 快速检测消费品中的 232Th 后评估的皮肤电离辐射剂量。
IF 1 4区 医学
Health physics Pub Date : 2025-04-01 Epub Date: 2024-11-08 DOI: 10.1097/HP.0000000000001891
Christine Karbiwnyk, Philip Stafford, Elon Malkin, Kelly Garnick, Thomas A Scott, Cong Wei
{"title":"Ionizing Radiation Dose to the Skin Assessed after Rapid Detection of 232 Th in Consumer Products.","authors":"Christine Karbiwnyk, Philip Stafford, Elon Malkin, Kelly Garnick, Thomas A Scott, Cong Wei","doi":"10.1097/HP.0000000000001891","DOIUrl":"10.1097/HP.0000000000001891","url":null,"abstract":"<p><strong>Abstract: </strong>After some consumer products indicated elevated levels of 232 Th progeny by gamma-ray spectrometry, a microwave digestion and inductively coupled plasma-mass spectrometry (ICP-MS) procedure was implemented for the direct assay of 232 Th content to ensure compliance with Federal regulations and guidelines. Levels of 232 Th were determined by ICP-MS based on standard calibration using a 205 Tl internal standard. The method had a method detection limit (MDL) of 0.15 Bq g -1 and a lower limit of quantification (LLOQ) of 0.65 Bq g -1 for 232 Th, making it a suitable confirmatory method following gamma-ray spectrometry. The 232 Th activity concentration calculated from the ICP-MS results ranged from 2.0-3.4 Bq g -1 for the kinesiology tape samples and 20 Bq g -1 for the silicone ion bracelet. The VARSKIN+1.0 software program was used to calculate the shallow dose equivalent of ionizing radiation from 232 Th and its progeny from the ICP-MS results. The skin dose to the consumer wearing the kinesiology tape ranged from 0.48-1.6 mSv y -1 . The skin dose to the consumer with constant wear of the silicone ion bracelet was estimated to be 17 mSv y -1 . Although 232 Th may be determined indirectly by assay of high abundance gamma rays produced by its progeny, the US Code of Federal Regulations (CFR) requires the direct assay of 232 Th for confirmatory analysis. We found this ICP-MS method to be a rapid 232 Th confirmatory technique compared to a chemical separation followed by alpha spectrometry procedure.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":" ","pages":"279-285"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultra-low to Moderate Radiation Level Neutron Dosimetry Measurements with H*10-TMFD vs. ROSPEC, Eberline, and Ludlum Detector Systems. H*10-TMFD与ROSPEC, Eberline和Ludlum探测器系统的超低至中等辐射水平中子剂量测量。
IF 1 4区 医学
Health physics Pub Date : 2025-04-01 Epub Date: 2025-01-15 DOI: 10.1097/HP.0000000000001907
Stepan Ozerov, Nathan Boyle, Catalin Harabagiu, David DiPrete, Tad Whiteside, Alan Boone, William Noll, Rusi P Taleyarkhan
{"title":"Ultra-low to Moderate Radiation Level Neutron Dosimetry Measurements with H*10-TMFD vs. ROSPEC, Eberline, and Ludlum Detector Systems.","authors":"Stepan Ozerov, Nathan Boyle, Catalin Harabagiu, David DiPrete, Tad Whiteside, Alan Boone, William Noll, Rusi P Taleyarkhan","doi":"10.1097/HP.0000000000001907","DOIUrl":"10.1097/HP.0000000000001907","url":null,"abstract":"<p><strong>Abstract: </strong>H*10 neutron dosimetry (unlike gamma dosimetry), requires consideration of neutron energy spectra due to the 20× variation of the weight factor over the thermal-to-fast energy range, as well as the neutron radiation field dose rates ranging from cosmic, ~.01 μSv h -1 levels to commonly encountered ~10-200 μSv h -1 in nuclear laboratories/processing plants, and upwards of 10 4 Sv h -1 in nuclear reactor environments. This paper discusses the outcome of the comparison of spectrum-weighted neutron dosimetry covering thermal-to-fast energy using the novel H*-TMFD spectroscopy-enabled sensor system in comparison with measurements using state-of-the-art neutron dosimetry systems at SRNS-Rotating Spectrometer (ROSPEC), and non-spectroscopic Eberline ASP2E (\"Eberline\") and Ludlum 42-49B (\"Ludlum\") survey instrumentation. The H*-TMFD was validated for gamma blindness using a 2.48×10 10 Bq 137 Cs source. The background dose rate in Savannah River Nuclear Solutions' (SRNS) low-scatter facility with all neutron sources withdrawn was estimated at 0.005 μSv h -1 . From moderately high radiation field tests conducted with the high intensity (1.4 × 10 9 n s -1 ) 252 Cf source and a total data collection time of ~0.15 h, the predicted dose rates from Eberline (non-spectroscopic), Ludlum (non-spectroscopic), and spectroscopic H*-TMFD instruments were found to be: ~170 μSv h -1 , ~200 μSv h - , and ~ 120 μSv h -1 , respectively. The equivalent spectroscopic (SRNS measured) H*10 dose rate from ROSPEC value is 130 μSv h -1 , within 10% of H*10-TMFD measurement. Tests conducted for ultra-low intensity radiation field used a ~ 1.6 × 10 3 n s -1 252 Cf bare neutron source for which over a collection time of ~18 h, the Eberline meter measured an instantaneous dose/count rate of 0 μSv h -1 and a pulse-integrated dose rate of 0.034 μSv h -1 at ~1 m. In contrast, the H*-TMFD panel located 0.22 m in direct line of sight of the 252 Cf source spectroscopically measured ~0.4 μSv h -1 (within +/- 5%) over 1.8 h collection live time-with which spectrum matched perfectly to that of a bare 252 Cf source. The H*TMFD predicted value of ~0.4 μSv h -1 was cross-checked and found to be within 10% of LLNL's published value of ~0.37 μSv h -1 (intensity/distance corrected via 1/r 2 law of 25.5 μSv h -1 at 1 m for a 1 μg 252 Cf source); as well as from use of ICRP 74 conversion coefficients and MCNP code simulations. As expected, for a bare 252 Cf source, H*TMFD measured epithermal neutron energy-related dose rates are well below 1% of the total dose rates. For ~0.01 μSv h -1 neutron radiation fields, ROSPEC measurements for H*10 dose rates are estimated to take 7+ d, vs. under 2 h with the H*TMFD. The feasibility of using a single CTMFD in survey mode for H*10 dose rate (nSv h - to μSv h -1 ) measurements within 2-3 min is demonstrated.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":" ","pages":"298-319"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dosimetry Testing for a New In Vivo X-ray Fluorescence Measurement System. 一种新型体内x射线荧光测量系统的剂量学测试。
IF 1 4区 医学
Health physics Pub Date : 2025-04-01 Epub Date: 2024-05-27 DOI: 10.1097/HP.0000000000001839
Chandler J Burgos, Daniel E Read, Thomas R Grier, Maruf Khan, Marc G Weisskopf, Kathryn M Taylor, Aaron J Specht
{"title":"Dosimetry Testing for a New In Vivo X-ray Fluorescence Measurement System.","authors":"Chandler J Burgos, Daniel E Read, Thomas R Grier, Maruf Khan, Marc G Weisskopf, Kathryn M Taylor, Aaron J Specht","doi":"10.1097/HP.0000000000001839","DOIUrl":"10.1097/HP.0000000000001839","url":null,"abstract":"<p><strong>Abstract: </strong>Lead exposure poses severe health risks to individuals, impacting cognitive function, growth, learning, and behavior. Current lead detection methods, primarily blood testing and x-ray fluorescence (XRF) of bone, have limitations. This study introduces a novel in vivo XRF measurement system using K-shell energies of lead, addressing limitations of previous methods. The study aimed to characterize beam directionality, subject radiation dose, and operator occupational exposure. Using a high-energy x-ray tube and room-temperature detectors, various parameters were assessed with bone and tissue phantoms. Dose measurements were taken by altering voltage, current, and shielding. Scatter and spatial measurements highlighted increased scatter with bone and tissue presence, emphasizing the safest positions for bystanders and operators. Results exhibited expected dose rate changes with varying parameters, showcasing the impact of bone and tissue on scatter radiation. The system's total body effective dose (with an 8-mm molybdenum shielding indicating minimal risk compared to established public dose limits) for an adult was 1.94 μSv; for a child aged 10 y, it was 3.28 μSv. This system demonstrates promising capabilities for lead exposure monitoring, offering negligible occupational exposure and minimal risk to individuals being scanned. Its safety and efficacy position it as a valuable tool in assessing lead exposure, potentially improving preventive measures.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":"128 4","pages":"273-278"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lutetium-177 Therapy in Italy: Environmental Impact Assessment in Anticipation of Its Widespread Use in Prostate Cancer Treatment. 意大利的镥 177 治疗:前列腺癌治疗广泛使用前的环境影响评估。
IF 1 4区 医学
Health physics Pub Date : 2025-04-01 Epub Date: 2024-09-27 DOI: 10.1097/HP.0000000000001893
Anna Brusa, Fabrizio Campi, Claudia Cavatorta, Alessandro Antonio Porta, Sofia Viganò
{"title":"Lutetium-177 Therapy in Italy: Environmental Impact Assessment in Anticipation of Its Widespread Use in Prostate Cancer Treatment.","authors":"Anna Brusa, Fabrizio Campi, Claudia Cavatorta, Alessandro Antonio Porta, Sofia Viganò","doi":"10.1097/HP.0000000000001893","DOIUrl":"10.1097/HP.0000000000001893","url":null,"abstract":"<p><strong>Abstract: </strong>This article addresses the evolving state of lutetium-177 radiopharmaceutical therapies in Italy, focusing on the importance of the definition of patient management practices regarding the approved treatments based on [ 177 Lu]Lu-DOTATATE for neuroendocrine tumors and [ 177 Lu]Lu-PSMA-617 for metastatic castration-resistant prostate cancer. Italian medical facilities are facing new challenges with the increase in the demand for such therapies while transitioning from restrictive hospitalization requirements to more flexible outpatient options. Therefore, four management strategies are described here, varying from immediate discharge after the administration to 24-h hospitalization, and their environmental and radiation safety implications are evaluated through simple models aimed at assessing the effective doses on the local population and wastewater purification plant workers. Results show that, while higher effective doses may be caused by an immediate discharge-based modality, they remain within acceptable limits, particularly when dealing with a smaller number of patients. Prolonged hospitalizations guarantee superior radiation safety levels but might not be sustainable with the expected increase in patient volumes in the future.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":" ","pages":"286-290"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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