Health physics最新文献_第10页

4区医学

Health physics Pub Date : 2023-10-01 DOI: 10.1097/01.hp.0000978224.90319.54

引用次数: 0

Local Dose Coefficients for Radionuclide Contamination in Wounds. 伤口放射性核素污染的局部剂量系数。

IF 2.2 4区医学

Health physics Pub Date : 2023-09-01 DOI: 10.1097/HP.0000000000001704

Natasha Galipeau, Stephen L Sugarman, Edward Waller

{"title":"Local Dose Coefficients for Radionuclide Contamination in Wounds.","authors":"Natasha Galipeau, Stephen L Sugarman, Edward Waller","doi":"10.1097/HP.0000000000001704","DOIUrl":"https://doi.org/10.1097/HP.0000000000001704","url":null,"abstract":"Abstract: When a radiation accident has occurred that leads to radioactive material being imparted to a wound, this is treated as an internal contamination scenario. It is common for the material to transport throughout the body based upon biokinetics of the material in the body. While standard internal dosimetry approaches can be used to estimate committed effective dose from the insult, some material may get fixed for longer periods of time at the wound location, even after medical procedures such as decontamination and debridement have been applied. In this case, the radioactive material becomes a local dose contributor. This research was to generate local dose coefficients for radionuclide-contaminated wounds to supplement committed effective dose coefficients. These dose coefficients can be used to calculate activity limits at the wound site that could lead to a clinically significant dose. This is useful for emergency response to assist in decisions on medical treatment, including decorporation therapy. Wound models were created for injections, lacerations, abrasions, and burns, and the MCNP radiation transport code was used to simulate the dose to tissue considering 38 radionuclides. Biokinetic models accounted for biological removal of the radionuclides from the wound site. It was found that radionuclides that are not retained well at the wound site are likely of little concern locally, but for highly retained radionuclides, estimated local doses may require further investigation by medical and health physics personnel.","PeriodicalId":12976,"journal":{"name":"Health physics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9853046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Thermoluminescent Dosimetry Systems According to the IEC 62387:2020 Standard. 根据IEC 62387:2020标准的热发光剂量测定系统的特性。

IF 2.2 4区医学

Health physics Pub Date : 2023-09-01 Epub Date: 2023-06-23 DOI: 10.1097/HP.0000000000001711

Nikola Kržanović, Jelena Stanković Petrović, Miloš Živanović, Marko Krajinović, Predrag Božović, Andrea Kojić, Dušan Topalović

{"title":"Characterization of Thermoluminescent Dosimetry Systems According to the IEC 62387:2020 Standard.","authors":"Nikola Kržanović, Jelena Stanković Petrović, Miloš Živanović, Marko Krajinović, Predrag Božović, Andrea Kojić, Dušan Topalović","doi":"10.1097/HP.0000000000001711","DOIUrl":"10.1097/HP.0000000000001711","url":null,"abstract":"Abstract: A need for detailed testing of individual monitoring systems used in accredited service at the Vinca Institute of Nuclear Sciences was recognized following changes in individual, workplace, and environmental monitoring passive dosimetry systems acceptability criteria stated in IEC 62387:2020 and changes related to reference fields used in radiation protection defined in ISO 4037:2019. Reliability and accuracy of dosimetry data acquired by passive dosimetry systems used for individual monitoring is assured by carrying out type tests. In this manner, the effects of different radiation influence quantities are examined. Passive dosimetry systems comprised of an LiF:Mg,Ti (TLD-100) detector card placed in two different holder models (8814 and 8850) and the Harshaw TLD Model 6600 Plus Automated Reader were tested. Type tests were done in an extended range of photon energies from 40 keV up to 1.25 MeV, angle of incidence values of ±45° and ± 60° for both vertical and horizontal dosimeter orientation, and in the dose range from 0.05 mSv to 1 Sv. Both dosimetry system configurations perform in line with IEC 62387:2020 within mandatory range for tested influence quantities. Dosimeters that use the 8850 holder type showed less pronounced energy and angular dependence of the response in the low-energy range.","PeriodicalId":12976,"journal":{"name":"Health physics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9850020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE HEALTH PHYSICS SOCIETY 健康物理学会

4区医学

Health physics Pub Date : 2023-09-01 DOI: 10.1097/01.hp.0000947344.60748.f6

引用次数: 0

Pacemakers, Implantable Defibrillators, and 5G Technology: What We Need to Know. 起搏器、植入式除颤器和5G技术:我们需要知道的。

IF 2.2 4区医学

Health physics Pub Date : 2023-09-01 DOI: 10.1097/HP.0000000000001699

Eugenio Mattei, Cecilia Vivarelli, Daniele Franci, Settimio Pavoncello, Tommaso Aureli, Giovanni Calcagnini, Federica Censi

引用次数: 0

Evaluation of Low-dose Radiation-induced DNA Damage and Repair in 3D Printed Human Cellular Constructs. 低剂量辐射诱导的DNA损伤和3D打印人体细胞结构修复的评估。

IF 2.2 4区医学

Health physics Pub Date : 2023-09-01 DOI: 10.1097/HP.0000000000001709

Wenxuan Chai, Yunfan Kong, Maria B Escalona, Chunshan Hu, Adayabalam S Balajee, Yong Huang

{"title":"Evaluation of Low-dose Radiation-induced DNA Damage and Repair in 3D Printed Human Cellular Constructs.","authors":"Wenxuan Chai, Yunfan Kong, Maria B Escalona, Chunshan Hu, Adayabalam S Balajee, Yong Huang","doi":"10.1097/HP.0000000000001709","DOIUrl":"https://doi.org/10.1097/HP.0000000000001709","url":null,"abstract":"Abstract: DNA double-strand breaks (DSBs) induced by ionizing radiation (IR) are considered to be the most critical lesion that when unrepaired or misrepaired leads to genomic instability or cell death depending on the radiation exposure dose. The potential health risks associated with exposures of low-dose radiation are of concern since they are being increasingly used in diverse medical and non-medical applications. Here, we have used a novel human tissue-like 3-dimensional bioprint to evaluate low-dose radiation-induced DNA damage response. For the generation of 3-dimensional tissue-like constructs, human hTERT immortalized foreskin fibroblast BJ1 cells were extrusion printed and further enzymatically gelled in a gellan microgel-based support bath. Low-dose radiation-induced DSBs and repair were analyzed in the tissue-like bioprints by indirect immunofluorescence using a well-known DSB surrogate marker, 53BP1, at different post-irradiation times (0.5 h, 6 h, and 24 h) after treatment with various doses of γ rays (50 mGy, 100 mGy, and 200 mGy). The 53BP1 foci showed a dose dependent induction in the tissue bioprints after 30 min of radiation exposure and subsequently declined at 6 h and 24 h in a dose-dependent manner. The residual 53BP1 foci number observed at 24 h post-irradiation time for the γ-ray doses of 50 mGy, 100 mGy, and 200 mGy was not statistically different from mock treated bioprints illustrative of an efficient DNA repair response at these low-dose exposures. Similar results were obtained for yet another DSB surrogate marker, γ-H2AX (phosphorylated form of histone H2A variant) in the human tissue-like constructs. Although we have primarily used foreskin fibroblasts, our bioprinting approach-mimicking a human tissue-like microenvironment-can be extended to different organ-specific cell types for evaluating the radio-response at low-dose and dose-rates of IR.","PeriodicalId":12976,"journal":{"name":"Health physics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9853048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Erratum. 勘误表。

IF 2.2 4区医学

Health physics Pub Date : 2023-09-01 DOI: 10.1097/HP.0000000000001717

引用次数: 0

177 Lu-DOTATATE Therapy: Effects of Water Intake and Drinking Duration on Patient Peripheral Dose Equivalent Rates. ludotatate治疗:饮水量和饮水时间对患者外周剂量当量率的影响。

IF 2.2 4区医学

Health physics Pub Date : 2023-09-01 DOI: 10.1097/HP.0000000000001700

Yudan Ni, Qing Ye, Xiangnan Liu, Ke Wang, Fei Yu, Jingjing Fu, Feng Wang, Lin Li

{"title":"177 Lu-DOTATATE Therapy: Effects of Water Intake and Drinking Duration on Patient Peripheral Dose Equivalent Rates.","authors":"Yudan Ni, Qing Ye, Xiangnan Liu, Ke Wang, Fei Yu, Jingjing Fu, Feng Wang, Lin Li","doi":"10.1097/HP.0000000000001700","DOIUrl":"https://doi.org/10.1097/HP.0000000000001700","url":null,"abstract":"Abstract: This study investigated the amount and duration of water consumption in neuroendocrine tumor patients after receiving 177 Lu-DOTATATE radionuclide therapy. We recruited 39 patients with neuroendocrine tumors, all of whom were treated with 177 Lu-DOTATATE radionuclide while in the nuclear medicine ward of a tertiary hospital in Nanjing from January 2021 to April 2022. We conducted a cross-sectional survey to investigate their drinking times, water consumption, and urine volumes at 0 min, 30 min, 60 min, 2 h, 24 h, and 48 h after radionuclide treatment. At each timepoint, their radiation dose equivalent rates were monitored at 0 m, 1 m, and 2 m from the middle abdomen. f at 24 h were significantly lower than those at 0 min, 30 min, 60 min, and 2 h (all p < 0.05). The dose equivalent rates at 48 h were significantly lower than those at 24 h (all p < 0.05). At 1 m or 2 m from the patient, the dose equivalent rate gradually decreased at all six timepoints and was significantly different between groups ( P < 0.05). To achieve lower radiation doses, there was a correlation with 24 h water consumption (P < 0.05) but no correlation with 48 h water consumption (P > 0.05); there were lower peripheral dose equivalents for patients when 24 h water consumption was no less than 2,750 mL. Patients with neuroendocrine tumors should drink at least 2,750 mL of water 24 h after treatment with 177 Lu-DOTATATE radionuclides. Drinking water in the first 24 h after treatment is more critical to reduce the peripheral dose equivalent, which can accelerate the reduction of peripheral radiation dose equivalent in early patients.","PeriodicalId":12976,"journal":{"name":"Health physics","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9855743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radon Flux Measurement System. 氡通量测量系统。

IF 2.2 4区医学

Health physics Pub Date : 2023-09-01 DOI: 10.1097/HP.0000000000001708

Emily A Caffrey, Colby D Mangini, Arthur S Rood, Helen A Grogan, John E Till

引用次数: 0

HEALTH PHYSICS SOCIETY . 2023 AFFILIATE MEMBERS. 健康物理学会。2023个附属会员。

IF 2.2 4区医学

Health physics Pub Date : 2023-09-01 DOI: 10.1097/01.HP.0000947348.96332.0c

引用次数: 0