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Establishment and validation of a nomogram for predicting overall survival in patients with vulvar carcinoma based on the SEER database 基于SEER数据库的外阴癌患者总生存预测图的建立和验证
Frontiers in Medical Science Research Pub Date : 2021-05-12 DOI: 10.25236/FMSR.2021.030209
Min Liu, Li Li, Juan Du, Jun Lyu, Zuhui Chen
{"title":"Establishment and validation of a nomogram for predicting overall survival in patients with vulvar carcinoma based on the SEER database","authors":"Min Liu, Li Li, Juan Du, Jun Lyu, Zuhui Chen","doi":"10.25236/FMSR.2021.030209","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030209","url":null,"abstract":"Background: Vulvar carcinoma (VC) is a rare female gynecological malignancy, and optimizing prognostic factors for VC requires large-scale research containing various clinical indicators of patients. Our study attempted to develop and validate a detailed survival nomogram for predicting the overall survival (OS) probability in patients diagnosed with VC. Methods: Patients diagnosed with VC between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox regression analyses were performed followed by the construction of the nomogram for OS. The performance of this model was evaluated using the concordance index (C-index), area under the time-dependent receiver operating characteristics curve (AUC), net reclassification improvement (NRI), integrated discrimination improvement (IDI), calibration plots and decision curve analysis (DCA). In addition, the C-index, AUC and DCA of the model and the 2009 International Federation of Gynecology and Obstetrics (FIGO) staging system were compared. Results: A total of 6275 patients were randomly assigned to the training cohort (n=4392) and the validation cohort (n=1883). Multivariate analysis identified independent prognostic factors (p","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"7 16 Suppl 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126958141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the key miRNAs and target genes in basal cell carcinoma by bioinformatics analysis 生物信息学分析鉴定基底细胞癌的关键mirna和靶基因
Frontiers in Medical Science Research Pub Date : 2021-05-07 DOI: 10.21203/RS.3.RS-455253/V1
H. Liu, L. Chen
{"title":"Identification of the key miRNAs and target genes in basal cell carcinoma by bioinformatics analysis","authors":"H. Liu, L. Chen","doi":"10.21203/RS.3.RS-455253/V1","DOIUrl":"https://doi.org/10.21203/RS.3.RS-455253/V1","url":null,"abstract":": The highly tissue-destructive and localized accumulation of basal cell carcinoma(BCC) makes it one of the most important cancers affecting people's lives. Existing therapeutic approaches, including surgical treatment, chemotherapy, and Hedgehog pathway inhibitors, have failed to achieve broad therapeutic effects for various reasons. This study aims to explore additional potential therapeutic targets and possible diagnostic and prognostic biomarkers using bioinformatics analysis. The Gene Expression Omnibus (GEO) database identified the microarray dataset GSE34535. The GEO2R tool was used to screen out differentially expressed genes (DEGs) between BCC and non-lesional skin. Potential target genes of DE-miRNA were screened using the miRWalk, mirDIP and miRTarBase databases. Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for target genes were established using the DAVID database. Protein–protein interaction network and miRNA-hub gene network were analyzed based on the STRING database and visualized by Cytoscape software. 51 up-regulated DE-miRNAs and 38 down-regulated DE-miRNAs were identified from the BCC samples. miR-455-5p was mainly up-regulated and miR-139-5p was mainly down-regulated. Two key bub genes MAPK1 and EGFR were identified in the PPI network. Four out of the ten hub genes were regulated by up-regulated miR-18a and four by down-regulated miR-133b. Viral infections were also identified in the study. Bioinformatics identified four miRNAs and two important hub genes that may be associated with BCC, and it was suggested that viruses may play a role in BCC. Cytoscape determine","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"263 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116077217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Competing Endogenous RNA (ceRNA) Network in Ischemic Cardiomyopathy by Bioinformatic Analysis 生物信息学分析竞争内源性RNA (ceRNA)网络在缺血性心肌病中的作用
Frontiers in Medical Science Research Pub Date : 2021-04-24 DOI: 10.25236/FMSR.2021.030208
Yajie Fan, Z. Yao, Tuo Han, Lixia Wang, Yiwen Wang, Congxia Wang
{"title":"The Role of Competing Endogenous RNA (ceRNA) Network in Ischemic Cardiomyopathy by Bioinformatic Analysis","authors":"Yajie Fan, Z. Yao, Tuo Han, Lixia Wang, Yiwen Wang, Congxia Wang","doi":"10.25236/FMSR.2021.030208","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030208","url":null,"abstract":"Background: Ischemic cardiomyopathy (ISCM) following myocardial infarction is closely related with a poor prognosis in patients with coronary heart disease. Several researches have showed that noncoding RNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are involved in the progression of ISCM. The aim of the present study was to explore the potential biomarkers and competing endogenous RNA (ceRNA) machenism in ISCM. Methods: Based on the open-source database, we identified differentially expressed genes (DEGs) and differentially expressed lncRNAs (DELs) between samples from ISCM patients and controls using affy and limma package in R (absolute log2 fold change ≥1 and p","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127875803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mini review: the relationship between inflammasome and colon cancer 小综述:炎性体与结肠癌的关系
Frontiers in Medical Science Research Pub Date : 2021-04-12 DOI: 10.25236/FMSR.2021.030206
Haonan Chen, Yuehang Zhang, S. Deng, Xu Deng
{"title":"Mini review: the relationship between inflammasome and colon cancer","authors":"Haonan Chen, Yuehang Zhang, S. Deng, Xu Deng","doi":"10.25236/FMSR.2021.030206","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030206","url":null,"abstract":"Colon cancer is a common malignant tumor of the digestive system. In the world, the incidence and mortality of colorectal cancer rank the third among malignant tumors. Although there have been great advances in the technical means of this treatment in recent years, the mortality rate continues to rise. Studies have shown that inflammasomes are an important type of polyprotein complex in the innate immune system, which play an important role in identifying and eliminating intestinal pathogens and maintaining intestinal homeostasis. Their abnormal functions are involved in inflammatory bowel disease. And its carcinogenesis. The inflammasome is the central link of the inflammatory response, which is of great significance in the study of many functions and related mechanisms in colon cancer.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129449385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress of HIF- 1α and its Intervention Factors in Osteogenic Synthesis of Blood Vessels in Bone Marrow Mesenchymal Stem Cells HIF- 1α及其干预因子在骨髓间充质干细胞血管成骨合成中的研究进展
Frontiers in Medical Science Research Pub Date : 2021-04-12 DOI: 10.25236/FMSR.2021.030207
Y. Pu, Hao Sun, Quan Yang, Yu Su, Shangyi Lv, B. Zheng, Xiangzhen Han, Hui-xia He
{"title":"Research Progress of HIF- 1α and its Intervention Factors in Osteogenic Synthesis of Blood Vessels in Bone Marrow Mesenchymal Stem Cells","authors":"Y. Pu, Hao Sun, Quan Yang, Yu Su, Shangyi Lv, B. Zheng, Xiangzhen Han, Hui-xia He","doi":"10.25236/FMSR.2021.030207","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030207","url":null,"abstract":"Objective to review the development and applications and intervention factors of hypoxia-inducible factor 1α (HIF-1α) in the strategy of tissue engineered angiogenesis and osteogenesis. Methods the literature about HIF-1α in tissue engineering technology was reviewed, analyzed, and summarized. Results HIF-1α and its intervention factors plays a key role in angiogenicosteogenic coupling, and as an upstream regulator.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128920186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Study on the Relationship between UGT2B7 Gene Polymorphism and Clinical Prognosis UGT2B7基因多态性与临床预后关系的研究
Frontiers in Medical Science Research Pub Date : 2021-04-09 DOI: 10.25236/FMSR.2021.030205
Yang Xiao, M. Ma, Yichen Li
{"title":"A Study on the Relationship between UGT2B7 Gene Polymorphism and Clinical Prognosis","authors":"Yang Xiao, M. Ma, Yichen Li","doi":"10.25236/FMSR.2021.030205","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030205","url":null,"abstract":"Breast cancer (BC) is the most common cancer diagnosis in women, often referred to as the \"pink killer\" [1], and its incidence ranks first among female malignancies, accounting for 25% of all cancer cases and 15% of all cancer deaths in the world [2]. With the improvement of medical level, the treatment methods of breast cancer have become relatively mature, including chemical therapy, adjuvant chemotherapy, neoadjuvant chemotherapy (mainly anthracycline and zisanchun drugs), endocrine therapy (tamoxifen, etc.), anti-estrogen drugs, aromatase inhibitors, etc. [3].In recent years, the role of UGT2B7 in drug metabolism and prognosis has been gradually discovered. To summarize the important role of UGT2B7 in prognosis diagnosis in recent years. In this paper, we search for qualified research by searching Pubmed, Uniprot and Chinese knowledge network. The data analysis and conclusion are helpful to the glucuronidation of many therapeutic drugs, including opioid drugs (such as codeine, morphine, naloxone), anticancer drugs (such as antitumor drugs: epirubicin, diclofenac, naproxen, etc.). In each treatment, the prognostic effect of UGT2B7 is gradually reflected, which is expected to be an important prognostic index.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128439643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical Research Progress of NRF2 Activators in the Treatment of Age-related Diseases NRF2激活剂治疗老年性疾病的临床研究进展
Frontiers in Medical Science Research Pub Date : 2021-03-30 DOI: 10.25236/FMSR.2021.030204
Man Xu
{"title":"Clinical Research Progress of NRF2 Activators in the Treatment of Age-related Diseases","authors":"Man Xu","doi":"10.25236/FMSR.2021.030204","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030204","url":null,"abstract":"Oxidation is closely related to the occurrence and development of aging and age-related diseases. NRF2 (Nuclear factor erythroid 2 related factor 2) is a key regulator of oxidative stress, which regulates the expression of antioxidant proteins, detoxification enzymes and various cytoprotective proteins. NRF2 maintains organism redox balance and genome stability, delaying the aging process and the occurrence and development of aging-related diseases. Pharmacological activators of NRF2 has been widely reported in basic research, and has performed well in clinical application research. In this article, we will focus on the latest news in basic and clinical research of NRF2 activators in age related diseases.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134558807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Post Pregnancy Complications of Polycystic Ovary Syndrome Patients with Hyperandrogenemia 多囊卵巢综合征伴高雄激素血症患者妊娠后并发症的研究
Frontiers in Medical Science Research Pub Date : 2021-03-25 DOI: 10.25236/FMSR.2021.030203
Yuhua Yin, Chaoyang Lv
{"title":"Study on Post Pregnancy Complications of Polycystic Ovary Syndrome Patients with Hyperandrogenemia","authors":"Yuhua Yin, Chaoyang Lv","doi":"10.25236/FMSR.2021.030203","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030203","url":null,"abstract":"Objective: to analyze the complications of pregnant women with polycystic ovary syndrome and hyperandrogenemia. Methods: To observe the clinical reaction of pregnant women with polycystic ovary syndrome and hyperandrogenemia in different age groups. Results: through clinical observation, different stages of maternal pregnancy complications, including postpartum hypertension, uterine fibroids and dyslipidemia. Conclusion: there are more complications after pregnancy in elderly women with hyperandrogenemia, and the incidence of complications after pregnancy in elderly women and young women is relatively high, which should be found and treated early.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"440 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121462547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Effect of Medical Cosmetic Suture on Patients with Complicated Eyelid Laceration 医学美容缝合治疗复杂性眼睑撕裂伤的临床效果
Frontiers in Medical Science Research Pub Date : 2021-03-25 DOI: 10.25236/FMSR.2021.030202
Q. Deng, Bo Chen, Fuguo Cao
{"title":"Clinical Effect of Medical Cosmetic Suture on Patients with Complicated Eyelid Laceration","authors":"Q. Deng, Bo Chen, Fuguo Cao","doi":"10.25236/FMSR.2021.030202","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030202","url":null,"abstract":"Objective: To investigate the clinical effect of medical cosmetic suture on patients with complicated eyelid laceration. Methods: Objective: To investigate the clinical effect of medical cosmetic suture on patients with complicated eyelid laceration. Methods: medical cosmetic suture. Results: the postoperative recovery effect reduced the anxiety and depression evaluation index of patients. From the third group, the sixth group and the eighth group, it can be seen that the anxiety and depression evaluation of patients has shown a downward trend. Conclusion: through the medical cosmetic suture eyelid laceration patients, reduce the possibility of patients with scar, for patients with postoperative rehabilitation to a positive role in promoting, from the postoperative anxiety and depression index of patients can be seen, medical cosmetic suture complex eyelid laceration patients effect is very good.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128327263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the Influence of Intelligent Pre Triage System on Emergency Quality 智能预分诊系统对急救质量影响的研究
Frontiers in Medical Science Research Pub Date : 2021-03-25 DOI: 10.25236/FMSR.2021.030201
Fuguo Cao, Bo Chen, Liman Yang
{"title":"Study on the Influence of Intelligent Pre Triage System on Emergency Quality","authors":"Fuguo Cao, Bo Chen, Liman Yang","doi":"10.25236/FMSR.2021.030201","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030201","url":null,"abstract":"In order to improve the emergency quality of domestic hospitals and promote the rapid development of medical and health system, the impact of intelligent pre triage system on emergency quality is studied. Through the analysis of the feedback from the pilot hospitals, it is found that the system has an important impact on the collection and transmission of patients' information, early warning of patients' condition, grading of patients' condition and arrangement of triage order, promotion of flexible scheduling system, and improvement of rescue effectiveness. This study affirms the practicability and advanced nature of the intelligent system of preview triage, so as to promote the system in all hospitals in China and improve the quality of emergency.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130073308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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