Y. Pu, Hao Sun, Quan Yang, Yu Su, Shangyi Lv, B. Zheng, Xiangzhen Han, Hui-xia He
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Research Progress of HIF- 1α and its Intervention Factors in Osteogenic Synthesis of Blood Vessels in Bone Marrow Mesenchymal Stem Cells
Objective to review the development and applications and intervention factors of hypoxia-inducible factor 1α (HIF-1α) in the strategy of tissue engineered angiogenesis and osteogenesis. Methods the literature about HIF-1α in tissue engineering technology was reviewed, analyzed, and summarized. Results HIF-1α and its intervention factors plays a key role in angiogenicosteogenic coupling, and as an upstream regulator.
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