Clinical Research Progress of NRF2 Activators in the Treatment of Age-related Diseases

Abstract

Oxidation is closely related to the occurrence and development of aging and age-related diseases. NRF2 (Nuclear factor erythroid 2 related factor 2) is a key regulator of oxidative stress, which regulates the expression of antioxidant proteins, detoxification enzymes and various cytoprotective proteins. NRF2 maintains organism redox balance and genome stability, delaying the aging process and the occurrence and development of aging-related diseases. Pharmacological activators of NRF2 has been widely reported in basic research, and has performed well in clinical application research. In this article, we will focus on the latest news in basic and clinical research of NRF2 activators in age related diseases.