Frontiers in Medical Science Research最新文献

{"title":"Differential gene expression in B lymphocyte immune process induced by COVID-19 infection","authors":"Kehan Lin, Hengxi Liu, Junying Li, Chenhao Shou, Yi-Feng Xia, M. Chu, Xi Chen","doi":"10.25236/FMSR.2021.030601","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030601","url":null,"abstract":"The Sequencing reads of this study are derived from research shared by Aaron J. Wilk. We conducted a deep analysis of B lymphocyte data. A total of 2126 differentially expressed genes were listed out. Through GO enrichment analysis, 24 clusters related to B lymphocyte functioning were screened out, and genes with significant differential expression were mainly enriched in 10 KEGG signaling pathways related to immune regulatory functions. This suggests that there are differences in the expression of immune regulatory genes in the immune process of B lymphocytes during the Sars-Cov2 infection.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"133 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130960662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between gut microbiota and Parkinson's disease","authors":"Ziyun Zhang","doi":"10.25236/FMSR.2021.030510","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030510","url":null,"abstract":"The unique environment in the gut and its astounding microbiota creates an ecosystem that is unique to every individual living on this earth. There are more than enough studies done which proofs that the strong neuro-connection between the brain and the gut impact greatly to the daily decisions and motor functions of its host. Previous research has shown a bacterial tyrosine decarboxylase which converts levodopa(used to treat Parkinson’s patients) to dopamine can have great impacts on the hosts body. There are also researches that shows that in a germ-free gut microbiota, the model object is less likely to perform symptoms of Parkinson’s disease. The question waiting to be solved is: How can we isolate and cultivate healthy gut microbiota to find the key micro-organism that cures Parkinson’s disease. By filling in this gap using this research, scientists will be able to advance their way to finding cures for other untreatable disease. Not only will Parkinson’s patients benefit from this, many others who might have a critical condition could utilize this new method of medicine.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126115913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of Shengyang Yiwei Decoction as The Main Intervention in The Treatment of Diarrhea-Predominant Irritable Bowel Syndrome","authors":"T. Zhu, Hui Ding, Leilei Zheng","doi":"10.25236/FMSR.2021.030506","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030506","url":null,"abstract":"OBJECTIVE: To investigate the efficacy and safety of Shengyang Yiwei Decoction as the main intervention in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D), and to provide evidence for its clinical application. METHODS: Randomized controlled trials (RCTs) of Shengyang Yiwei Decoction in The treatment of IBS-D were searched from CNKI, Wanfang database, PubMed, The Cochrane Library and VIP database from the establishment of these databases to June 10, 2020. The Cochrane risk bias tool in the Cochrane manual was used to evaluate the literature quality. Meta-analysis was performed using RevMan5.3 software. Results: A total of 16 RCTs were included, involving 1244 patients. Meta-analysis results showed that: Total effective rate (N =1204, OR=3.38, 95%CI [2.43, 4.71], P","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128379713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of left hand back burn scar complicated with squamous cell carcinoma","authors":"H. Guo, Lixue Yang, Chunzhi Liu, M. Gao","doi":"10.25236/FMSR.2021.030508","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030508","url":null,"abstract":"A case of a burn scar on the back of the left hand complicated by squamous cell carcinoma admitted to our hospital is presented. [Methods] The patient was treated with an enlarged excision of the tumour tissue and a right anterolateral femoral flap graft. [Results] The patient's wound healed well without infection, oozing or dehiscence. At six months follow-up, there was no local recurrence or distant metastasis of scar carcinoma. [Conclusion] Scar carcinoma is mostly a chronic refractory ulcer that is easily overlooked by clinicians, so early detection, early diagnosis and early surgery are needed.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122881573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation of modified greater trochanteric osteotomy for the treatment of hip dysplasia in adults with high dislocation","authors":"Peng-fei Han, Weiwei Pei, Su Yang, Xi-yao Li, Chang-tai Sun, J. Niu","doi":"10.25236/FMSR.2021.030509","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030509","url":null,"abstract":"Objective: To investigate the feasibility, perioperative complications and early follow-up effect of modified greater trochanteric osteotomy for the treatment of severe hip dysplasia in adults with high dislocation. Methods: a retrospective analysis in January 2017 - June 2020, the modified sliding femoral greater trochanter osteotomy combined proximal femoral prosthesis handle fixed type of bone cement type and biological acetabulum prosthesis for 14 cases of 15 adult hip dysplasia hips high dislocation severe deformity of patients with primary total hip replacement, 1 case of bilateral, an average follow-up of 18.267±8.876 months. Preoperative X-ray films showed that all patients had unequal length of both lower limbs, small and shallow acetabular development, obvious anterior wall defect, small amount of bone in the acetabular wall, increased femoral neck dry angle and anterior inclination angle, and small and irregular medullary cavity, etc. Clinical and imaging evaluations were conducted for hip joint function, unequal length of both lower limbs, postoperative complications and prosthesis survival rate after surgery. Results: As of the last follow-up, all the patients showed significant improvement in walking ability and pain symptoms after surgery. All the 14 patients with Trendelenburg sign were positive before surgery and all the 15 hips were negative after surgery. All Ⅰ healing of incision, cut extremities were osseous healing. Before surgery, Harris score was (43.47±7.10) points, and 3 months after surgery, Harris score improved to (87.73±4.23) points, with statistically significant difference (t =-24.16, P","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127304452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of angelica Sini Decoction in the treatment of diabetic peripheral neuropathy","authors":"Ying Wei, Lu Shen, Jiajia Zhan","doi":"10.25236/FMSR.2021.030505","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030505","url":null,"abstract":"[Objective] To systematically evaluate the effectiveness of Angelica Sini Decoction in the treatment of DPN.[Method] Randomized controlled trials of Angelica Sini Decoction in the treatment of DPN as of December 2020 were searched using RevMan 5.4.[Result] A total of 12 literatures and 936 patients were included. The total effective rate of experimental group was higher than that of control group [I2=0%, RR=1.38,95%CI(1.28,1.48), P","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115151327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professor Ren Xiaofang's Clinical Experience in Treating Essential Hypertension","authors":"Meng-fan Peng, Borui Liu, Xiaofang Ren","doi":"10.25236/FMSR.2021.030507","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030507","url":null,"abstract":"This paper introduces professor Ren Xiaofang's clinical experience in treating essential hypertension.Professor Ren Xiaofang believes that regulation of qi can relieve the clinical symptoms of patients and effectively regulate blood pressure.This paper discusses professor Ren Xiaofang's experience in treating essential hypertension from the aspects of the association between essential hypertension and qi activity, clinical prescription selection and mechanism of action, and medical records.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130755608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Ganoderma lucidum fermentation on the main chemical components in mulberry leaves and the inhibition of α-glucosidase","authors":"Ruiqi Wan, Tianyi Wu, Yuzhuo Zhang","doi":"10.25236/FMSR.2021.030503","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030503","url":null,"abstract":"Mulberry leaves have been used in the clinical treatment of diabetes since ancient times. A variety of bioactive components in mulberry leaf extract are effective α-glucosidase inhibitors. Though much research has been done on dry mulberry leaves, few have been done on the fresh mulberry leaves. In this study, Ganoderma lucidum was used to ferment fresh mulberry leaves, the effects of microbial fermentation on the content of active components and α-glucosidase inhibitory activity in dry and fresh mulberry leaves were measured. The results showed that, compared with dry mulberry leaves, fresh mulberry leaves were more suitable for the growth of Ganoderma lucidum. The nutrition needed for the growth of Ganoderma lucidum was mainly from the degradation of polysaccharides in fresh mulberry leaves. After fermentation, the polysaccharides content of fresh mulberry leaves decreased from 224.18 mg/g to 22.08 mg/g. The enrichment of bioactive components in fresh mulberry leaves was higher than that in dry mulberry leaves. The contents of flavonoids and alkaloids in fresh mulberry leaves were increased by 34% and 35% respectively compared with nonfermented mulberry leaves. The inhibitory effect of flavonoids and alkaloids on α-glucosidase of fresh mulberry leaves was significantly enhanced by fermentation. In conclusion, the fermentation of fresh mulberry leaves by Ganoderma lucidum fungus can not only enrich the content of α-glucosidase inhibitors in mulberry leaves, but also significantly improve their inhibitory activity.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130658737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The involvement of mitochondrial proteins in tumorigenesis","authors":"Mengyun Li","doi":"10.25236/FMSR.2021.030502","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030502","url":null,"abstract":"Mitochondria are the key organelles for life. Mitochondria are important mediators of tumorigenesis. Mitochondria are key participants in tumorigenesis and development. In-depth study on the role of mitochondria in the survival and growth of tumor cells is not only conducive to our understanding of tumor genesis and development, including oncogene activation, tumor suppressor gene inactivation and other aspects, but also of far-reaching significance in the diagnosis and treatment of tumors.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126515383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta analysis of treatment efficacy for posterior circulation ischemic vertigo using therapy for elevating Yang","authors":"Xin Dang, Zucheng Han, Y. Jie, Yu Lv, Ruolan Wang","doi":"10.25236/FMSR.2021.030501","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030501","url":null,"abstract":"Objective: To evaluate the clinical efficacy of TCM therapy for elevating Yang in the treatment of posterior circulation ischemic vertigo. Methods: all clinical randomized controlled trials of therapy for elevating Yang's posterior circulation ischemic vertigo were screened by computer searching Chinese databases such as CNKI, Wanfang database, VIP Chinese science and technology and the Cochrane Library, PubMed, EMBASE and other English databases from the time the library was built to October 2020, and relevant references were manually reviewed. Patients in the control group were treated with western medicine, while those in the experimental group were treated with either Elevating Yang recipe (decoction) or Elevating Yang recipe (decoction) combined with western medicine. The Review Manager 5.3 software was used to conduct a meta-analysis on the clinical effective rate, TCM syndrome scores, vertebrobasilar blood flow velocity, and adverse reactions. Results: Eleven articles were finally included, covering a total of 1049 patients, including 522 cases in the observation group and 527 cases in the control group. The clinical effective rate of patients in the experimental group is higher than that in the control group [RR=1.22(1.16,1.28)], the vertebral-basilar artery blood flow velocity in the experimental group includes left vertebral artery (LVA) [MD = 4.88, 95%CI(3.30, 6.46)], right vertebral artery (RVA) [MD = 4.87, 95%CI(2.85, 6.88)], and basilar artery (BA) [MD = 5.17. 95%CI(4.55, 5.78)], TCM symptom scores significantly improved in the experimental group [MD = -4.17, 95%CI(-4.66, -3.67)], the difference was statistically significant. Conclusion: The results of this meta-analysis indicated that Therapy for Raising Yang had good therapeutic effects on CI after treatment, in that it could effectively improve the clinical efficiency, promote the blood flow velocity of vertebrobasilar artery, and reduce TCM symptom scores. However, it still needs to be further confirmed by large sample size and high quality RCTs.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132048185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}