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The Role of IL-6 in Macrophage-Mediated Fibrosis in Alcoholic Chronic Pancreatitis IL-6在酒精性慢性胰腺炎巨噬细胞介导纤维化中的作用
Frontiers in Medical Science Research Pub Date : 2021-08-31 DOI: 10.25236/FMSR.2021.030410
Baofeng Chen, Huan Zhang, Yun Liu
{"title":"The Role of IL-6 in Macrophage-Mediated Fibrosis in Alcoholic Chronic Pancreatitis","authors":"Baofeng Chen, Huan Zhang, Yun Liu","doi":"10.25236/FMSR.2021.030410","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030410","url":null,"abstract":"Alcoholic chronic pancreatitis has become one of the important factors that threaten the safety of human life and endanger human tissue cells for the occurrence and spread of metabolic syndrome diseases. Therefore, this article is studying the role of IL-6 in the disease, with the purpose of improving the level of medical treatment through the study of interleukins. This article mainly adopted the experimental method and the control method to test and analyze the signal pathway of IL-6 in stimulating the differentiation of macrophages, and then draw relevant conclusions, and found that it has a catalytic effect in macrophage-mediated fibrosis. Experiments show that the STAT3 in the experiment is greater than 0.5, and the STAT3 signal pathway is positively correlated with the IL-6 concentration.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126261343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress of Oral Chinese Medicine in Treating Ulcerative Colitis and Its Pathogenesis 中药口服治疗溃疡性结肠炎及其发病机制的研究进展
Frontiers in Medical Science Research Pub Date : 2021-08-22 DOI: 10.25236/FMSR.2021.030408
Dai Rui, Xiaoquan Du
{"title":"Research Progress of Oral Chinese Medicine in Treating Ulcerative Colitis and Its Pathogenesis","authors":"Dai Rui, Xiaoquan Du","doi":"10.25236/FMSR.2021.030408","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030408","url":null,"abstract":"Ulcerative colitis is a common and difficult disease of the digestive system, which has the characteristics of long course of disease and easy to repeat the condition. Studies have shown that with the extension of the course of the disease, patients with ulcerative colitis also have an increased chance of colon cancer. Western medicine still lacks specific and effective treatments for this disease, but traditional Chinese medicine in the treatment of ulcerative colitis in continuous in-depth research and testing, has made a series of progress, and traditional Chinese medicine in the treatment of this disease has the characteristics of high cost performance, fewer adverse reactions, so it is gradually accepted by patients in the clinical treatment. This article intends to summarize the research on oral treatment of ulcerative colitis with traditional Chinese medicine in recent years, and systematically elaborate its related mechanism of action, in order to provide new ideas for the clinical research and diagnosis and treatment of ulcerative colitis in the future.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129150558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Application of SQL in hospital statistics SQL在医院统计中的应用
Frontiers in Medical Science Research Pub Date : 2021-08-20 DOI: 10.25236/FMSR.2021.030406
Xue Lixiang
{"title":"Application of SQL in hospital statistics","authors":"Xue Lixiang","doi":"10.25236/FMSR.2021.030406","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030406","url":null,"abstract":"In hospital statistics, due to the difference of data query language, the hospital statistical results are often quite different from the actual data. Therefore, the application of SQL in hospital statistics is proposed. Use java + spark SQL to read the data information to be counted in the hospital, and have an in-depth understanding of common basic tables and fields, so as to facilitate the smooth completion of subsequent statistical work. Using structured query language, the statistical indicators such as postoperative complications, disease ranking and workload of the surgeon are written into SQL statements, and finally the SQL statement integration results are presented in the form of tables. The experimental results show that compared with the two statistical methods proposed in the literature, the statistical error is reduced by 30.25% and 35.61%.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116881381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on multidrug resistance mechanism and reversal strategy of hepatocellular carcinoma based on exosome 基于外泌体的肝癌多药耐药机制及逆转策略研究
Frontiers in Medical Science Research Pub Date : 2021-08-20 DOI: 10.25236/FMSR.2021.030405
Zhigang Zhang, L. Fang
{"title":"Study on multidrug resistance mechanism and reversal strategy of hepatocellular carcinoma based on exosome","authors":"Zhigang Zhang, L. Fang","doi":"10.25236/FMSR.2021.030405","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030405","url":null,"abstract":"MDR (multidrug resistance) refers to the phenomenon that after tumor cells develop resistance to a chemotherapeutic drug, they also develop cross-resistance to other chemotherapeutic drugs with different chemical structures and mechanisms. HCC (Hepatocellular carcinoma) is the fourth most common cause of cancer-related deaths in the world. Exosomes, produced by polyhedra, are extracellular lipid nano-vesicles with various bioactive substances, which contain lipid RNA, DNA and protein. Exosomes produced by tumor cells carry important information about tumor cells. Studies have found that non-coding RNAs, as an important part of exosomes, are involved in the regulation of the tumor microenvironment of HCC, including tumorigenesis, tumor metastasis, angiogenesis, immune regulation and other processes, and play an important role in the diagnosis, treatment and prognosis of tumors. Therefore, studying the molecular mechanism of MDR and exploring the reversal strategy is a hot topic in tumor research at present. This paper reviews the research progress in this field.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126338263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A network meta-analysis of the effectiveness and safety of different doses of ertugliflozin in the treatment of type 2 diabetes 不同剂量厄图列净治疗2型糖尿病的有效性和安全性的网络meta分析
Frontiers in Medical Science Research Pub Date : 2021-08-20 DOI: 10.25236/FMSR.2021.030407
Z. Qian, Sang Yafei, Lijing Shang, Ma Yujin
{"title":"A network meta-analysis of the effectiveness and safety of different doses of ertugliflozin in the treatment of type 2 diabetes","authors":"Z. Qian, Sang Yafei, Lijing Shang, Ma Yujin","doi":"10.25236/FMSR.2021.030407","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030407","url":null,"abstract":"Objective: To conduct a network meta-analysis to systematically evaluate the efficacy and safety of different doses of ertugliflozin in the treatment of Type 2 diabetes. Methods: The Pubmed, Embase, Cochrane library, CNKI, Wanfang, Weipu, CBM, Web of science and other daTableases were searched by computer from the beginning of the daTablease to 2021. To search for randomized controlled trial of different doses of ertugliflozin in the treatment of type 2 diabetes, to screen the literature according to inclusion and exclusion criteria, to extract data, and to evaluate the quality of the included studies by Cochrane systematic evaluation methods,using RevMan5.3 software and Stata 16.0 versions for analysis. RESULTS: A total of 11 randomized controlled trials (RCTs) were enrolled, including 5713 patients, The results of network meta-analysis showed that ertugliflozin 5,10,15,25 mg were superior to placebo in reducing glycosylated hemoglobin, Only 15 mg was statistically significant(p","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"423 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126713958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of blood cell morphology test in the diagnosis of pediatric diseases 血细胞形态学检查在儿科疾病诊断中的价值
Frontiers in Medical Science Research Pub Date : 2021-08-10 DOI: 10.25236/FMSR.2021.030403
Xin Gong
{"title":"The value of blood cell morphology test in the diagnosis of pediatric diseases","authors":"Xin Gong","doi":"10.25236/FMSR.2021.030403","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030403","url":null,"abstract":"In order to improve the accuracy of pediatric disease diagnosis, the value of blood cell morphology test in the diagnosis of pediatric diseases is studied. Through the analysis of blood cell morphology test methods, it is proposed that the value of blood cell morphology test can screen the types of pediatric diseases. Blood cells can be divided into red blood cells, platelets and white blood cells according to their morphology In a normal operation state, the appearance of blood cells is round and smooth without significant change. However, once it is found that the morphology of blood cells or their peripheral fibrous tissue changes, it can be considered that there is a certain degree of body disease in the human body. At the same time, the analysis of blood cell content can provide the basis for disease diagnosis. After the classification of blood cell morphological changes, the number or content of deformed blood cells can be screened. According to the proportion of blood cell morphological changes, the final diagnosis decision of pediatric diseases can be provided.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130576912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phantom Limbs and Mirror Therapy: Brain Plasticity and Future Treatment for Brain Disorders and Injuries 幻肢和镜像疗法:脑可塑性和脑疾病和损伤的未来治疗
Frontiers in Medical Science Research Pub Date : 2021-08-10 DOI: 10.25236/FMSR.2021.030404
Junyi Wang
{"title":"Phantom Limbs and Mirror Therapy: Brain Plasticity and Future Treatment for Brain Disorders and Injuries","authors":"Junyi Wang","doi":"10.25236/FMSR.2021.030404","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030404","url":null,"abstract":"Every thirty seconds globally, a person loses his or her arm or leg due to amputation. Annually, more than one million people around the world undergo amputation surgery. In the United States alone, 185,000 people lose their limbs due to this type of surgery each year. Amputation may cause many problems in patients' daily lives since they have lost one or more of their limbs, which means that their motor ability will be significantly reduced. Interestingly, after the amputation, many patients report that they can still feel their amputated limb, which, of course, does not exist physically.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"359 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131762383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of 5:2 Intermittent Fasting Diet for Weight Loss among Overweight and obese College Students 5:2间歇性禁食对超重和肥胖大学生减肥的影响
Frontiers in Medical Science Research Pub Date : 2021-08-03 DOI: 10.25236/FMSR.2021.030402
Lishan Li
{"title":"Effect of 5:2 Intermittent Fasting Diet for Weight Loss among Overweight and obese College Students","authors":"Lishan Li","doi":"10.25236/FMSR.2021.030402","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030402","url":null,"abstract":"Objective: A study was designed to determine whether 5:2 intermittent fating diet intervention (IF 5:2 diet) benefits the weight loss among overweight and obese college students. Methods: Nine subjects with BMI>24 were maintained for 4-week IF 5:2 diet in which they ate restrictedly twice a week, while women or men consuming respectively less than 500 or 700 calories on the fasting days from September 2020 to January 2021. The first four weeks were the control phase, while the last four weeks were the intervention phase, with IF 5:2 diet. Results: All indexes measured were no significant difference during the control phase (P>0.05). In the intervention phase, reductions in body weight (2.678±2.230kg) waist circumference (3.389±2.868cm), hip circumference (2.733±2.560cm), BMI (0.875±0.667) and waist-to-height ratio (0.019±0.015) were observed (P 0.05). Change of the average number of exercise steps, heart rate and sleep scores were not significant (P>0.05). The fullness on the light fasting day increased significantly (P 0.05). Conclusions: These findings demonstrate that a 4-week IF 5:2 diet has a significant weight loss effect for overweight and obese college students, which effectively improves their body shape, without suffering from hunger for a long time. This diet pattern, with high safety and value, suggests a novel approach for weight loss among overweight and obese college students.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124539373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on the Model of Fungus Decomposition Rate of Wood Fiber Based on Principal Component Analysis Algorithm 基于主成分分析算法的木质纤维真菌分解率模型研究
Frontiers in Medical Science Research Pub Date : 2021-07-15 DOI: 10.25236/FMSR.2021.030401
Ziqian Yang, W. Xie, Shibao Chen
{"title":"Research on the Model of Fungus Decomposition Rate of Wood Fiber Based on Principal Component Analysis Algorithm","authors":"Ziqian Yang, W. Xie, Shibao Chen","doi":"10.25236/FMSR.2021.030401","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030401","url":null,"abstract":"Regarding the lignin fiber decomposition rate under the interaction of multiple fungi in the short term, was simplified as the interaction of two bacteria without the influence of external regulation, based on the two shapes of growth rate and moisture tolerance. Based on the growth rate data of fungal pair interaction, the decomposition rate model of lignin fiber based on principal component analysis was established, and the contribution ranking of fungi to decomposition rate was obtained. Then the moisture tolerance data were fitted to find the difference between the water niche width and the competition ranking of fungi. Based on the ranking of the two traits, a linear weighting equation was established, and the cumulative decomposition rate of the interaction between various bacteria was finally obtained to be1298.7.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125382491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis on the Characteristics of Callers of Psychological Aid Hotline in Suzhou City 苏州市心理援助热线呼叫者特征分析
Frontiers in Medical Science Research Pub Date : 2021-06-30 DOI: 10.25236/FMSR.2021.030310
Zhengyan Wu, Zhuoheng Li, Xiaobin Zhang, Lin Luo, Xiangdong Du
{"title":"Analysis on the Characteristics of Callers of Psychological Aid Hotline in Suzhou City","authors":"Zhengyan Wu, Zhuoheng Li, Xiaobin Zhang, Lin Luo, Xiangdong Du","doi":"10.25236/FMSR.2021.030310","DOIUrl":"https://doi.org/10.25236/FMSR.2021.030310","url":null,"abstract":"Objective: To study the relationship between caller characteristics and counseling content of Suzhou psychological aid hotline through the analysis of caller data and content during the ten years. Methods: 13685 incoming calls with complete information in Suzhou psychological assistance hotline from January 2010 to November 2020 were selected as the research objects. After basic information screening and data analysis, chi-square test and Phi related data analysis were performed. Results: 1. Psychological hotline calls mainly focus on marriage and family (30%), love emotion (28%), mental psychology (22%), while work and interpersonal relationship (10%) and study and education (10%) call less. There is a significant correlation between call types and gender, educational background and marital status (P","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"2008 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125585285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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