{"title":"A network meta-analysis of the effectiveness and safety of different doses of ertugliflozin in the treatment of type 2 diabetes","authors":"Z. Qian, Sang Yafei, Lijing Shang, Ma Yujin","doi":"10.25236/FMSR.2021.030407","DOIUrl":null,"url":null,"abstract":"Objective: To conduct a network meta-analysis to systematically evaluate the efficacy and safety of different doses of ertugliflozin in the treatment of Type 2 diabetes. Methods: The Pubmed, Embase, Cochrane library, CNKI, Wanfang, Weipu, CBM, Web of science and other daTableases were searched by computer from the beginning of the daTablease to 2021. To search for randomized controlled trial of different doses of ertugliflozin in the treatment of type 2 diabetes, to screen the literature according to inclusion and exclusion criteria, to extract data, and to evaluate the quality of the included studies by Cochrane systematic evaluation methods,using RevMan5.3 software and Stata 16.0 versions for analysis. RESULTS: A total of 11 randomized controlled trials (RCTs) were enrolled, including 5713 patients, The results of network meta-analysis showed that ertugliflozin 5,10,15,25 mg were superior to placebo in reducing glycosylated hemoglobin, Only 15 mg was statistically significant(p","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"423 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medical Science Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25236/FMSR.2021.030407","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To conduct a network meta-analysis to systematically evaluate the efficacy and safety of different doses of ertugliflozin in the treatment of Type 2 diabetes. Methods: The Pubmed, Embase, Cochrane library, CNKI, Wanfang, Weipu, CBM, Web of science and other daTableases were searched by computer from the beginning of the daTablease to 2021. To search for randomized controlled trial of different doses of ertugliflozin in the treatment of type 2 diabetes, to screen the literature according to inclusion and exclusion criteria, to extract data, and to evaluate the quality of the included studies by Cochrane systematic evaluation methods,using RevMan5.3 software and Stata 16.0 versions for analysis. RESULTS: A total of 11 randomized controlled trials (RCTs) were enrolled, including 5713 patients, The results of network meta-analysis showed that ertugliflozin 5,10,15,25 mg were superior to placebo in reducing glycosylated hemoglobin, Only 15 mg was statistically significant(p
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