{"title":"The Role of IL-6 in Macrophage-Mediated Fibrosis in Alcoholic Chronic Pancreatitis","authors":"Baofeng Chen, Huan Zhang, Yun Liu","doi":"10.25236/FMSR.2021.030410","DOIUrl":null,"url":null,"abstract":"Alcoholic chronic pancreatitis has become one of the important factors that threaten the safety of human life and endanger human tissue cells for the occurrence and spread of metabolic syndrome diseases. Therefore, this article is studying the role of IL-6 in the disease, with the purpose of improving the level of medical treatment through the study of interleukins. This article mainly adopted the experimental method and the control method to test and analyze the signal pathway of IL-6 in stimulating the differentiation of macrophages, and then draw relevant conclusions, and found that it has a catalytic effect in macrophage-mediated fibrosis. Experiments show that the STAT3 in the experiment is greater than 0.5, and the STAT3 signal pathway is positively correlated with the IL-6 concentration.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"58 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medical Science Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25236/FMSR.2021.030410","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Alcoholic chronic pancreatitis has become one of the important factors that threaten the safety of human life and endanger human tissue cells for the occurrence and spread of metabolic syndrome diseases. Therefore, this article is studying the role of IL-6 in the disease, with the purpose of improving the level of medical treatment through the study of interleukins. This article mainly adopted the experimental method and the control method to test and analyze the signal pathway of IL-6 in stimulating the differentiation of macrophages, and then draw relevant conclusions, and found that it has a catalytic effect in macrophage-mediated fibrosis. Experiments show that the STAT3 in the experiment is greater than 0.5, and the STAT3 signal pathway is positively correlated with the IL-6 concentration.