Frontiers in Medical Science Research最新文献

{"title":"Upstream Process Design of Antibody-drug Conjugates for the Treatment of Colorectal Cancer","authors":"Xiaomu Wang, Ioscani Jimenez del Val","doi":"10.25236/fmsr.2022.040303","DOIUrl":"https://doi.org/10.25236/fmsr.2022.040303","url":null,"abstract":": Colorectal cancer is a common tumor in the digestive tract with high morbidity and mortality. The products will continue the design of the previous group, PatritumabVedotion. The main treatment target population is HER3-positive colorectal cancer patients who are in stage 3 and stage 4. The antibody selected by our drug is patritumab, which is linked to the cytotoxic drug MMAE through a coupling reaction with MC-Val-Cit-PAB, and the average DAR of this product is expected to be 4. The target market is Europe, and combined with the actual production capacity of the factory, the annual target output is 529.7KG. In addition, two different production modes: fed-batch and Continuous is compared,and the technical and economic is analyzed.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128599372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Developments in the Study of Surface Coatings for Titanium Implants","authors":"","doi":"10.25236/fmsr.2022.041505","DOIUrl":"https://doi.org/10.25236/fmsr.2022.041505","url":null,"abstract":"","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127277481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Meta-Analysis of the Effects of Otago Exercise in Patients after Hip and Knee Replacement","authors":"Jiayang Zhang, Yin Yang, Xinyu Zhang, X. Ai","doi":"10.25236/fmsr.2023.050703","DOIUrl":"https://doi.org/10.25236/fmsr.2023.050703","url":null,"abstract":": Hip and knee osteoarthritis is common in the elderly, and its prevalence is increasing, which is one of the important causes of physical disability. At present, hip and knee replacement is one of the important means of treatment, and it is of great significance to promote the recovery of limb function as soon as possible. In order to evaluate the effect of Otago exercise on hip and knee replacement after hip and knee replacement, this study conducted a meta-analysis of relevant clinical studies to provide a theoretical basis for clinical care. Meta results showed that Otago exercise had a good effect after hip/knee replacement, which could reduce the level of phobia, improve fall efficiency and balance ability, promote the recovery of hip/knee function, reduce joint swelling, and further improve patients' daily living ability.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131024997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical basis and clinical application of tumors due to spleen deficiency and dampness","authors":"","doi":"10.25236/fmsr.2022.041409","DOIUrl":"https://doi.org/10.25236/fmsr.2022.041409","url":null,"abstract":"","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131088548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of the Clinical Efficacy of Manipulation and Acupuncture in the Treatment of Knee Osteoarthritis","authors":"Zhang Da-f","doi":"10.25236/fmsr.2023.050608","DOIUrl":"https://doi.org/10.25236/fmsr.2023.050608","url":null,"abstract":"Objective To compare the clinical efficacy of manipulation and acupuncture therapy in the treatment of knee osteoarthritis, and to provide reference for the optimization of the non-drug treatment scheme of the disease. Methods One hundred and twenty patients with knee osteoarthritis were selected and randomly divided into acupuncture group and manipulation group, with 60 cases in each group. The acupuncture group was treated by acupuncture therapy, and the manipulation group was treated by manipulation. WOMAC scale was used to evaluate the clinical efficacy of the two groups before treatment, 2 weeks and 4 weeks after treatment. Results After 2 weeks' treatment, in the acupuncture group, the pain score was(71.52±36.81), the stiff score was(32.94±31.06), and the joint function score was(286.33±208.92). In the manipulation group, the pain score was(83.39±42.73), the stiff score was(21.17±36.54), and the joint function score was(292.46±213.48). The pain score and joint function score of the two groups were significantly lower than those before treatment(P0.05). The difference of the stiff score in the acupuncture group before and after treatment was not statistically significant(P0.05). The stiff score of the manipulation group was significantly lower than that before treatment(P0.05). Two weeks after treatment, the pain score and joint function score showed no statistically significant difference between the two groups(P0.05), but the stiff score of the manipulation group was significantly lower than the acupuncture group(P0.05). Four weeks after treatment, the pain score, stiff score, the joint function score were(43.86 ± 35.31),(13.69 ± 12.32),(179.41 ± 165.18) in the acupuncture group, and(51.79±42.68),(11.52±10.74),(195.39±158.92) in the manipulation group, respectively, which were significantly less than the scores 2 weeks after treatment(P0.05). But the differences between the two groups 4 weeks after treatment were not statistically significant(P0.05). Conclusion Compared with the therapy of acupuncture, manipulation treatment for joint stiffness results in faster onset. Two kinds of therapies are all effective for patients with knee osteoarthritis, which are ideal non-drug therapies for the disease.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130638258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of Comprehensive Care Interventions Received by Patients with T2DM to Improve Compliance and Satisfaction Rates","authors":"W. Rong","doi":"10.25236/fmsr.2023.050716","DOIUrl":"https://doi.org/10.25236/fmsr.2023.050716","url":null,"abstract":": Type 2 diabetes mellitus (T2DM) is a kind of chronic metabolic disease, which is caused by insufficient insulin secretion or cell resistance to insulin, but more and more young people are being diagnosed. Type 2 diabetes can be managed by controlling diet, exercise, medication, and monitoring blood glucose levels, and timely adjustment of treatment and management can help prevent complications, and improve the quality of life of patients. Comprehensive Nursing is a coordinated, comprehensive, systematic and continuous nursing mode with patients as the center. The service includes many aspects, such as body, psychology and society, etc., it involves the application of comprehensive nursing care in type 2 diabetes mellitus patients from the aspects of disease prevention, disease evaluation, nursing intervention, rehabilitation and disease management, etc., it can also prevent complications and promote rehabilitation. This article studies the effect of comprehensive nursing on the compliance and satisfaction rate of patients with type 2 diabetes mellitus.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129034739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on the Combination of Acupuncture and Medicine in the Treatment of Premature Ovarian Failure","authors":"Nana Xue, Mei Chen","doi":"10.25236/fmsr.2023.050302","DOIUrl":"https://doi.org/10.25236/fmsr.2023.050302","url":null,"abstract":": Premature ovarian failure (POF) is a condition in which the ovarian reserve function decreases due to a variety of factors, resulting in menstrual irregularities, amenorrhea, and decreased fertility before the age of 40. POF is a common reproductive endocrine disorder in gynecology that seriously affects the physical and mental health of women of appropriate age. Western medicine mostly uses hormone replacement and assisted reproduction techniques in clinical treatment, but in the long run, the side effects are large. With the development of Chinese medicine in recent years, the efficacy of Chinese medicine in the treatment of POF has been recognized. A large number of studies have shown that the combined effect of Chinese and Western medicine in the treatment of POF is better than that of Chinese medicine alone. The treatment methods mainly include Chinese medicine combined with Western medicine therapy, Chinese medicine combined with acupuncture therapy, Western medicine combined with acupuncture therapy treatment and Chinese medicine - Western medicine - acupuncture triple therapy. It is found that the combined effect of Chinese and Western medicine is better than the treatment of Chinese medicine or Western medicine alone, with significant clinical effect, which can effectively improve the endocrine level of the body, restore normal menstruation and improve fertility.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128797586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Stratified Strain Technique on Left Ventricular Systolic Function in Essential Hypertension","authors":"","doi":"10.25236/fmsr.2022.040505","DOIUrl":"https://doi.org/10.25236/fmsr.2022.040505","url":null,"abstract":"","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125419430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Comorbid Mechanism and Treatment of Coronary Heart Disease and Depression under the Framework of Bicardiac Medicine","authors":"Xiaolong Gao, Junru Zhang","doi":"10.25236/fmsr.2022.040409","DOIUrl":"https://doi.org/10.25236/fmsr.2022.040409","url":null,"abstract":": In recent years, coronary heart disease and depression are gradually becoming two diseases that endanger human health and impose a huge burden on medical care in various countries. At present, depression has become one of the risk factors of coronary heart disease, and coronary heart disease can increase the incidence of depression, both of which can be seen in the same patient. With the society entering a new era, the traditional medical model has gradually changed to the bio-psycho-social medical model, and it is particularly important to explore the co-disease mechanism of coronary heart disease and depression based on the framework of bicardiac medicine. it has important clinical significance for disease prevention, early intervention and late treatment.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126928376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature Visual Analysis of the Theoretical Research of \"Yin Fire Theory\" Based on Citespace","authors":"Wang Jiancheng, Qiao Hongjun","doi":"10.25236/fmsr.2023.050611","DOIUrl":"https://doi.org/10.25236/fmsr.2023.050611","url":null,"abstract":": Objective Based on Citespace software, to visually analyze the literature related to yin fire theory. Methods Citespace 6.1R3 software was used to carry out data visualization analysis on the research institutions, authors and keywords of the literature on the theory of yin and fire published from the establishment of the database to November 2022. Results 532 Chinese literatures were included, and the overall annual volume of papers was on the rise. The main institutions and authors were obtained through visual analysis. The results of key words showed that the main research direction and trend was clinical experience. Conclusion. This study directly shows the research status in this field, shows the research institutions and authors, analyzes the research hotspots and trends, and points out the direction for the further development of the theory of \"Yin Fire\" in the future.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123148433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}