Study on multidrug resistance mechanism and reversal strategy of hepatocellular carcinoma based on exosome

Abstract

MDR (multidrug resistance) refers to the phenomenon that after tumor cells develop resistance to a chemotherapeutic drug, they also develop cross-resistance to other chemotherapeutic drugs with different chemical structures and mechanisms. HCC (Hepatocellular carcinoma) is the fourth most common cause of cancer-related deaths in the world. Exosomes, produced by polyhedra, are extracellular lipid nano-vesicles with various bioactive substances, which contain lipid RNA, DNA and protein. Exosomes produced by tumor cells carry important information about tumor cells. Studies have found that non-coding RNAs, as an important part of exosomes, are involved in the regulation of the tumor microenvironment of HCC, including tumorigenesis, tumor metastasis, angiogenesis, immune regulation and other processes, and play an important role in the diagnosis, treatment and prognosis of tumors. Therefore, studying the molecular mechanism of MDR and exploring the reversal strategy is a hot topic in tumor research at present. This paper reviews the research progress in this field.