The relationship between gut microbiota and Parkinson's disease

Ziyun Zhang
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Abstract

The unique environment in the gut and its astounding microbiota creates an ecosystem that is unique to every individual living on this earth. There are more than enough studies done which proofs that the strong neuro-connection between the brain and the gut impact greatly to the daily decisions and motor functions of its host. Previous research has shown a bacterial tyrosine decarboxylase which converts levodopa(used to treat Parkinson’s patients) to dopamine can have great impacts on the hosts body. There are also researches that shows that in a germ-free gut microbiota, the model object is less likely to perform symptoms of Parkinson’s disease. The question waiting to be solved is: How can we isolate and cultivate healthy gut microbiota to find the key micro-organism that cures Parkinson’s disease. By filling in this gap using this research, scientists will be able to advance their way to finding cures for other untreatable disease. Not only will Parkinson’s patients benefit from this, many others who might have a critical condition could utilize this new method of medicine.
肠道微生物群与帕金森病之间的关系
肠道内独特的环境及其惊人的微生物群创造了一个生态系统,对地球上的每个人来说都是独一无二的。有足够多的研究证明,大脑和肠道之间强大的神经联系对宿主的日常决策和运动功能有很大的影响。先前的研究表明,一种细菌酪氨酸脱羧酶可以将左旋多巴(用于治疗帕金森患者)转化为多巴胺,对宿主身体有很大的影响。也有研究表明,在无菌的肠道微生物群中,模型对象不太可能表现出帕金森病的症状。等待解决的问题是:我们如何分离和培养健康的肠道微生物群,以找到治疗帕金森病的关键微生物。通过利用这项研究填补这一空白,科学家们将能够在寻找其他无法治愈的疾病的治疗方法方面取得进展。不仅帕金森患者会从中受益,许多其他可能有危急情况的人也可以利用这种新的药物方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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