Meta analysis of treatment efficacy for posterior circulation ischemic vertigo using therapy for elevating Yang

Objective: To evaluate the clinical efficacy of TCM therapy for elevating Yang in the treatment of posterior circulation ischemic vertigo. Methods: all clinical randomized controlled trials of therapy for elevating Yang's posterior circulation ischemic vertigo were screened by computer searching Chinese databases such as CNKI, Wanfang database, VIP Chinese science and technology and the Cochrane Library, PubMed, EMBASE and other English databases from the time the library was built to October 2020, and relevant references were manually reviewed. Patients in the control group were treated with western medicine, while those in the experimental group were treated with either Elevating Yang recipe (decoction) or Elevating Yang recipe (decoction) combined with western medicine. The Review Manager 5.3 software was used to conduct a meta-analysis on the clinical effective rate, TCM syndrome scores, vertebrobasilar blood flow velocity, and adverse reactions. Results: Eleven articles were finally included, covering a total of 1049 patients, including 522 cases in the observation group and 527 cases in the control group. The clinical effective rate of patients in the experimental group is higher than that in the control group [RR=1.22(1.16,1.28)], the vertebral-basilar artery blood flow velocity in the experimental group includes left vertebral artery (LVA) [MD = 4.88, 95%CI(3.30, 6.46)], right vertebral artery (RVA) [MD = 4.87, 95%CI(2.85, 6.88)], and basilar artery (BA) [MD = 5.17. 95%CI(4.55, 5.78)], TCM symptom scores significantly improved in the experimental group [MD = -4.17, 95%CI(-4.66, -3.67)], the difference was statistically significant. Conclusion: The results of this meta-analysis indicated that Therapy for Raising Yang had good therapeutic effects on CI after treatment, in that it could effectively improve the clinical efficiency, promote the blood flow velocity of vertebrobasilar artery, and reduce TCM symptom scores. However, it still needs to be further confirmed by large sample size and high quality RCTs.