Research Progress of HIF- 1α and its Intervention Factors in Osteogenic Synthesis of Blood Vessels in Bone Marrow Mesenchymal Stem Cells

Abstract

Objective to review the development and applications and intervention factors of hypoxia-inducible factor 1α (HIF-1α) in the strategy of tissue engineered angiogenesis and osteogenesis. Methods the literature about HIF-1α in tissue engineering technology was reviewed, analyzed, and summarized. Results HIF-1α and its intervention factors plays a key role in angiogenicosteogenic coupling, and as an upstream regulator.