{"title":"NRF2激活剂治疗老年性疾病的临床研究进展","authors":"Man Xu","doi":"10.25236/FMSR.2021.030204","DOIUrl":null,"url":null,"abstract":"Oxidation is closely related to the occurrence and development of aging and age-related diseases. NRF2 (Nuclear factor erythroid 2 related factor 2) is a key regulator of oxidative stress, which regulates the expression of antioxidant proteins, detoxification enzymes and various cytoprotective proteins. NRF2 maintains organism redox balance and genome stability, delaying the aging process and the occurrence and development of aging-related diseases. Pharmacological activators of NRF2 has been widely reported in basic research, and has performed well in clinical application research. In this article, we will focus on the latest news in basic and clinical research of NRF2 activators in age related diseases.","PeriodicalId":129141,"journal":{"name":"Frontiers in Medical Science Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Research Progress of NRF2 Activators in the Treatment of Age-related Diseases\",\"authors\":\"Man Xu\",\"doi\":\"10.25236/FMSR.2021.030204\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Oxidation is closely related to the occurrence and development of aging and age-related diseases. NRF2 (Nuclear factor erythroid 2 related factor 2) is a key regulator of oxidative stress, which regulates the expression of antioxidant proteins, detoxification enzymes and various cytoprotective proteins. NRF2 maintains organism redox balance and genome stability, delaying the aging process and the occurrence and development of aging-related diseases. Pharmacological activators of NRF2 has been widely reported in basic research, and has performed well in clinical application research. In this article, we will focus on the latest news in basic and clinical research of NRF2 activators in age related diseases.\",\"PeriodicalId\":129141,\"journal\":{\"name\":\"Frontiers in Medical Science Research\",\"volume\":\"11 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Medical Science Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.25236/FMSR.2021.030204\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medical Science Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25236/FMSR.2021.030204","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
氧化与衰老和衰老相关疾病的发生发展密切相关。NRF2 (Nuclear factor erythroid 2 related factor 2)是氧化应激的关键调控因子，调控抗氧化蛋白、解毒酶和多种细胞保护蛋白的表达。NRF2维持生物体氧化还原平衡和基因组稳定，延缓衰老过程和衰老相关疾病的发生和发展。NRF2的药理激活剂在基础研究中被广泛报道，并在临床应用研究中表现良好。在本文中，我们将重点介绍NRF2激活剂在年龄相关疾病中的基础和临床研究的最新进展。
Clinical Research Progress of NRF2 Activators in the Treatment of Age-related Diseases
Oxidation is closely related to the occurrence and development of aging and age-related diseases. NRF2 (Nuclear factor erythroid 2 related factor 2) is a key regulator of oxidative stress, which regulates the expression of antioxidant proteins, detoxification enzymes and various cytoprotective proteins. NRF2 maintains organism redox balance and genome stability, delaying the aging process and the occurrence and development of aging-related diseases. Pharmacological activators of NRF2 has been widely reported in basic research, and has performed well in clinical application research. In this article, we will focus on the latest news in basic and clinical research of NRF2 activators in age related diseases.
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