Gut Microbes最新文献_第8页

The contribution of age-related changes in the gut-brain axis to neurological disorders 与年龄有关的肠脑轴变化对神经系统疾病的影响

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-18 DOI: 10.1080/19490976.2024.2302801

Romeesa Khan, Claudia M. Di Gesù, Juneyoung Lee, Louise D. McCullough

引用次数: 0

Influence of age, socioeconomic status, and location on the infant gut resistome across populations 不同人群的年龄、社会经济地位和地点对婴儿肠道抗性组的影响

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-13 DOI: 10.1080/19490976.2023.2297837

Dhrati V. Patangia, Ghjuvan Grimaud, Shaopu Wang, R. Paul Ross, Catherine Stanton

引用次数: 0

The influence of the gut microbiome on ovarian aging 肠道微生物群对卵巢衰老的影响

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-03 DOI: 10.1080/19490976.2023.2295394

Feiling Huang, Ying Cao, Jinghui Liang, Ruiyi Tang, Si Wu, Peng Zhang, Rong Chen

引用次数: 0

Human breastmilk-derived Bifidobacterium longum subsp. infantis CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway. 人母乳来源的长双歧杆菌亚种 CCFM1269 通过 PI3K/AKT 通路调节 GH/IGF 轴的骨形成。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-01 Epub Date: 2023-12-20 DOI: 10.1080/19490976.2023.2290344

Mengfan Ding, Bowen Li, Haiqin Chen, Dong Liang, R Paul Ross, Catherine Stanton, Jianxin Zhao, Wei Chen, Bo Yang

{"title":"Human breastmilk-derived Bifidobacterium longum subsp. infantis CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway.","authors":"Mengfan Ding, Bowen Li, Haiqin Chen, Dong Liang, R Paul Ross, Catherine Stanton, Jianxin Zhao, Wei Chen, Bo Yang","doi":"10.1080/19490976.2023.2290344","DOIUrl":"10.1080/19490976.2023.2290344","url":null,"abstract":"Bifidobacterium longum subsp. infantis is a prevalent member of the gut microbiota of breastfed infants. In this study, the effects of human breastmilk-derived B.longum subsp. infantis CCFM1269 on bone formation in developing BALB/c mice were investigated. Newborn female and male mice were assigned to control group (administered saline), CCFM11269 group (administered B. longum subsp. infantis CCFM1269, 1 × 109 CFU/mouse/day) and I5TI group (administered B. longum subsp. infantis I5TI, 1 × 109 CFU/mouse/day) from 1-week-old to 3-, 4- and 5-week old. B. longum subsp. infantis I5TI served as a negative control in this study. The results demonstrated that B. longum subsp. infantis CCFM1269 promoted bone formation in growing mice by modulating the composition of the gut microbiota and metabolites. The expression of genes and proteins in the PI3K/AKT pathway was stimulated by B. longum subsp. infantis CCFM1269 through the GH/IGF-1 axis in growing mice. This finding suggests B. longum subsp. infantis CCFM1269 may be useful for modulating bone metabolism during growth.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"16 1","pages":"2290344"},"PeriodicalIF":12.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation. 核酸镰刀菌通过 ADP-庚糖释放和 ALPK1/TIFA 轴激活促进结直肠癌细胞的炎症和抗凋亡反应。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-01 Epub Date: 2023-12-21 DOI: 10.1080/19490976.2023.2295384

Camille Martin-Gallausiaux, Laurène Salesse, Diego Garcia-Weber, Ludovica Marinelli, Fabienne Beguet-Crespel, Vincent Brochard, Camille Le Gléau, Alexandre Jamet, Joël Doré, Hervé M Blottière, Cécile Arrieumerlou, Nicolas Lapaque

{"title":"Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation.","authors":"Camille Martin-Gallausiaux, Laurène Salesse, Diego Garcia-Weber, Ludovica Marinelli, Fabienne Beguet-Crespel, Vincent Brochard, Camille Le Gléau, Alexandre Jamet, Joël Doré, Hervé M Blottière, Cécile Arrieumerlou, Nicolas Lapaque","doi":"10.1080/19490976.2023.2295384","DOIUrl":"10.1080/19490976.2023.2295384","url":null,"abstract":"The anaerobic bacterium Fusobacterium nucleatum is significantly associated with human colorectal cancer (CRC) and is considered a significant contributor to the disease. The mechanisms underlying the promotion of intestinal tumor formation by F. nucleatum have only been partially uncovered. Here, we showed that F. nucleatum releases a metabolite into the microenvironment that strongly activates NF-κB in intestinal epithelial cells via the ALPK1/TIFA/TRAF6 pathway. Furthermore, we showed that the released molecule had the biological characteristics of ADP-heptose. We observed that F. nucleatum induction of this pathway increased the expression of the inflammatory cytokine IL-8 and two anti-apoptotic genes known to be implicated in CRC, BIRC3 and TNFAIP3. Finally, it promoted the survival of CRC cells and reduced 5-fluorouracil chemosensitivity in vitro. Taken together, our results emphasize the importance of the ALPK1/TIFA pathway in Fusobacterium induced-CRC pathogenesis, and identify the role of ADP-H in this process.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"16 1","pages":"2295384"},"PeriodicalIF":12.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From a hunger-regulating hormone to an antimicrobial peptide: gastrointestinal derived circulating endocrine hormone-peptide YY exerts exocrine antimicrobial effects against selective gut microbiota. 从饥饿调节激素到抗菌肽：源自胃肠道的循环内分泌激素-肽 YY 对选择性肠道微生物群具有外分泌抗菌作用。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-02-14 DOI: 10.1080/19490976.2024.2316927

Yuchen Xiao, Lingjing Jin, Chao Zhang

引用次数: 0

Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons. 益生菌乳酸杆菌通过提高大脑蘑菇体神经元的乳酸脱氢酶水平改善果蝇的记忆。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-02-19 DOI: 10.1080/19490976.2024.2316533

Shuk-Man Ho, Wan-Hua Tsai, Chih-Ho Lai, Meng-Hsuan Chiang, Wang-Po Lee, Hui-Yu Wu, Pei-Yi Bai, Tony Wu, Chia-Lin Wu

{"title":"Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons.","authors":"Shuk-Man Ho, Wan-Hua Tsai, Chih-Ho Lai, Meng-Hsuan Chiang, Wang-Po Lee, Hui-Yu Wu, Pei-Yi Bai, Tony Wu, Chia-Lin Wu","doi":"10.1080/19490976.2024.2316533","DOIUrl":"10.1080/19490976.2024.2316533","url":null,"abstract":"Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying biogenic effects remain unclear. Lactic acid bacteria, specifically Lactobacillus spp. are known probiotics. Drosophila melanogaster, commonly known as the fruit fly, is a well-established model organism for investigating the interaction between the host and gut microbiota in translational research. Herein, we showed that 5-day administration of Lactobacillus acidophilus (termed GMNL-185) or Lacticaseibacillus rhamnosus (termed GMNL-680) enhances olfactory-associative memory in Drosophila. Moreover, a combined diet of GMNL-185 and GMNL-680 demonstrated synergistic effects on memory functions. Live brain imaging revealed a significant increase in calcium responses to the training odor in the mushroom body β and γ lobes of flies that underwent mixed feeding with GMNL-185 and GMNL-680. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and whole-mount brain immunohistochemistry revealed significant upregulation of lactate dehydrogenase (LDH) expression in the fly brain following the mixed feeding. Notably, the genetic knockdown of Ldh in neurons, specifically in mushroom body, ameliorated the beneficial effects of mixed feeding with GMNL-185 and GMNL-680 on memory improvement. Altogether, our results demonstrate that supplementation with L. acidophilus and L. rhamnosus enhances memory functions in flies by increasing brain LDH levels.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"16 1","pages":"2316533"},"PeriodicalIF":12.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10877976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B. longum CKD1 enhances the efficacy of anti-diabetic medicines through upregulation of IL- 22 response in type 2 diabetic mice. B. longum CKD1 通过上调 2 型糖尿病小鼠对 IL- 22 的反应增强了抗糖尿病药物的疗效。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-02-23 DOI: 10.1080/19490976.2024.2319889

Won Jun Kim, Bum Ju Kil, Chaewon Lee, Tae Young Kim, Goeun Han, Yukyung Choi, Kyunghwan Kim, Chang Hun Shin, Seung-Young Park, Heebal Kim, Myunghoo Kim, Chul Sung Huh

{"title":"B. longum CKD1 enhances the efficacy of anti-diabetic medicines through upregulation of IL- 22 response in type 2 diabetic mice.","authors":"Won Jun Kim, Bum Ju Kil, Chaewon Lee, Tae Young Kim, Goeun Han, Yukyung Choi, Kyunghwan Kim, Chang Hun Shin, Seung-Young Park, Heebal Kim, Myunghoo Kim, Chul Sung Huh","doi":"10.1080/19490976.2024.2319889","DOIUrl":"10.1080/19490976.2024.2319889","url":null,"abstract":"The gut microbiota plays a pivotal role in metabolic disorders, notably type 2 diabetes mellitus (T2DM). In this study, we investigated the synergistic potential of combining the effects of Bifidobacterium longum NBM7-1 (CKD1) with anti-diabetic medicines, LobeglitazoneⓇ (LO), SitagliptinⓇ (SI), and MetforminⓇ (Met), to alleviate hyperglycemia in a diabetic mouse model. CKD1 effectively mitigated insulin resistance, hepatic steatosis, and enhanced pancreatic β-cell function, as well as fortifying gut-tight junction integrity. In the same way, SI-CKD1 and Met- CKD1 synergistically improved insulin sensitivity and prevented hepatic steatosis, as evidenced by the modulation of key genes associated with insulin signaling, β-oxidation, gluconeogenesis, adipogenesis, and inflammation by qRT-PCR. The comprehensive impact on modulating gut microbiota composition was observed, particularly when combined with MetforminⓇ. This combination induced an increase in the abundance of Rikenellaceae and Alistipes related negatively to the T2DM incidence while reducing the causative species of Cryptosporangium, Staphylococcaceae, and Muribaculaceae. These alterations intervene in gut microbiota metabolites to modulate the level of butyrate, indole-3-acetic acid, propionate, and inflammatory cytokines and to activate the IL-22 pathway. However, it is meaningful that the combination of B. longum NBM7-1(CKD1) reduced the medicines' dose to the level of the maximal inhibitory concentrations (IC50). This study advances our understanding of the intricate relationship between gut microbiota and metabolic disorders. We expect this study to contribute to developing a prospective therapeutic strategy modulating the gut microbiota.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"16 1","pages":"2319889"},"PeriodicalIF":12.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10896159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk. 幽门螺杆菌 cag 致病岛是胃癌风险的决定因素。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-02-23 DOI: 10.1080/19490976.2024.2314201

Sirena C Tran, Kaeli N Bryant, Timothy L Cover

引用次数: 0

Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity. 母亲在怀孕期间吸烟会增加与肠道微生物相关的儿童超重和肥胖的风险。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-03-04 DOI: 10.1080/19490976.2024.2323234

Ye Peng, Hein M Tun, Siew C Ng, Hogan Kok-Fung Wai, Xi Zhang, Jaclyn Parks, Catherine J Field, Piush Mandhane, Theo J Moraes, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, Jeffrey R Brook, Tim K Takaro, James A Scott, Francis Kl Chan, Anita L Kozyrskyj

{"title":"Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity.","authors":"Ye Peng, Hein M Tun, Siew C Ng, Hogan Kok-Fung Wai, Xi Zhang, Jaclyn Parks, Catherine J Field, Piush Mandhane, Theo J Moraes, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, Jeffrey R Brook, Tim K Takaro, James A Scott, Francis Kl Chan, Anita L Kozyrskyj","doi":"10.1080/19490976.2024.2323234","DOIUrl":"10.1080/19490976.2024.2323234","url":null,"abstract":"Childhood obesity is linked to maternal smoking during pregnancy. Gut microbiota may partially mediate this association and could be potential targets for intervention; however, its role is understudied. We included 1,592 infants from the Canadian Healthy Infants Longitudinal Development Cohort. Data on environmental exposure and lifestyle factors were collected prenatally and throughout the first three years. Weight outcomes were measured at one and three years of age. Stool samples collected at 3 and 12 months were analyzed by sequencing the V4 region of 16S rRNA to profile microbial compositions and magnetic resonance spectroscopy to quantify the metabolites. We showed that quitting smoking during pregnancy did not lower the risk of offspring being overweight. However, exclusive breastfeeding until the third month of age may alleviate these risks. We also reported that maternal smoking during pregnancy significantly increased Firmicutes abundance and diversity. We further revealed that Firmicutes diversity mediates the elevated risk of childhood overweight and obesity linked to maternal prenatal smoking. This effect possibly occurs through excessive microbial butyrate production. These findings add to the evidence that women should quit smoking before their pregnancies to prevent microbiome-mediated childhood overweight and obesity risk, and indicate the potential obesogenic role of excessive butyrate production in early life.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"16 1","pages":"2323234"},"PeriodicalIF":12.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10913716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0