Gut Microbes最新文献

Candida tropicalis-derived vitamin B3 exerts protective effects against intestinal inflammation by promoting IL-17A/IL-22-dependent epithelial barrier function 热带念珠菌衍生的维生素 B3 通过促进 IL-17A/IL-22 依赖性上皮屏障功能对肠道炎症产生保护作用

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-27 DOI: 10.1080/19490976.2024.2416922

Ha T Doan, Li-Chieh Cheng, Yi-Ling Chiu, Yuan-Kai Cheng, Cheng-Chih Hsu, Yee-Chun Chen, Hsiu-Jung Lo, Hao-Sen Chiang

引用次数: 0

The role and mechanism of gut-lung axis mediated bidirectional communication in the occurrence and development of chronic obstructive pulmonary disease. 肠肺轴介导的双向交流在慢性阻塞性肺病的发生和发展中的作用和机制。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-24 DOI: 10.1080/19490976.2024.2414805

Xiaofan Song,Xina Dou,Jiajing Chang,Xiaonan Zeng,Qinhong Xu,Chunlan Xu

{"title":"The role and mechanism of gut-lung axis mediated bidirectional communication in the occurrence and development of chronic obstructive pulmonary disease.","authors":"Xiaofan Song,Xina Dou,Jiajing Chang,Xiaonan Zeng,Qinhong Xu,Chunlan Xu","doi":"10.1080/19490976.2024.2414805","DOIUrl":"https://doi.org/10.1080/19490976.2024.2414805","url":null,"abstract":"The current studies have shown that the occurrence and development of chronic obstructive pulmonary disease (COPD) are closely related to the changes in gut health and its microenvironment, and even some gut diseases have significant clinical correlation with COPD. The dysbiosis of gut microbiota observed in COPD patients also suggests a potential bidirectional interaction between the gut and lung. Communication between the gut and lung may occur through circulating inflammatory cells, gut microbial metabolites, and circulating inflammatory mediators, but the mechanism of bidirectional communication between the gut and lung in COPD is still under study. Therefore, more research is still needed in this area. In this review, we summarize recent clinical studies and animal models on the role of the gut-lung axis in the occurrence and development of COPD and its mechanisms, so as to provide ideas for further research in this field. In addition, we also summarized the negative effects of COPD medication on gut microbiota and the gut microbiota risk factors for COPD and proposed the potential prevention and treatment strategies.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"97 1","pages":"2414805"},"PeriodicalIF":12.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphine-induced intestinal microbial dysbiosis drives TLR-dependent IgA targeting of gram-positive bacteria and upregulation of CD11b and TLR2 on a sub-population of IgA+ B cells. 吗啡诱导的肠道微生物菌群失调促使 TLR 依赖性 IgA 靶向革兰氏阳性细菌，并上调 IgA+ B 细胞亚群的 CD11b 和 TLR2。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-23 DOI: 10.1080/19490976.2024.2417729

Nicolas Vitari,Salma Singh,Junyi Tao,Bridget Truitt,Udhghatri Kolli,Richa Jalodia,Kathryn M LaPorte,Yaa Abu,Danielle Antoine,Umakant Sharma,Sabita Roy

{"title":"Morphine-induced intestinal microbial dysbiosis drives TLR-dependent IgA targeting of gram-positive bacteria and upregulation of CD11b and TLR2 on a sub-population of IgA+ B cells.","authors":"Nicolas Vitari,Salma Singh,Junyi Tao,Bridget Truitt,Udhghatri Kolli,Richa Jalodia,Kathryn M LaPorte,Yaa Abu,Danielle Antoine,Umakant Sharma,Sabita Roy","doi":"10.1080/19490976.2024.2417729","DOIUrl":"https://doi.org/10.1080/19490976.2024.2417729","url":null,"abstract":"IgA binding dictates the composition of the intestinal microbiome and reflects dysbiotic states during chronic disease. Both pathogenic and commensal bacteria differentially bind to IgA with varying outcomes. Little is known regarding IgA dynamics immediately following microbial dysbiosis. Recent work shows that morphine treatment rapidly induces microbial dysbiosis within hours of administration. This microbial shift is characterized by the expansion of pathogenic bacteria with a concurrent decrease in commensal bacteria. Because of this rapid microbial shift, a murine model of chronic morphine treatment was used to gain insight on the host IgA response during early microbial disruption. Within 24 h, morphine treatment induces microbial dysbiosis which disrupts IgA-bacterial homeostasis, resulting in an increased concentration of unbound IgA with a corresponding decrease in the frequency of IgA-bound bacteria. Additionally, the increased concentration of unbound IgA is dependent on the microbiome, as microbial depletion abolishes the increase. At 48 h of morphine treatment, the frequency of IgA-bound bacteria increases and IgA-seq reveals increased IgA targeting of gram-positive bacteria. Both a whole-body TLR2 KO and treatment with the TLR inhibitor OxPAPC resulted in abrogation of IgA binding to bacteria, implicating modulation of IgA binding through TLR signaling. Finally, we identify that a sub-population of IgA+ B cells in the intestinal lamina propria has increased CD11b and TLR2 expression at 24 h of morphine treatment which could be a potential source of the observed IgA that targets gram-positive bacteria. Together, we demonstrate for the first time the role of TLR2 in IgA targeting of intestinal bacteria, and this study sheds light on the IgA dynamics during the initial hours of microbial dysbiosis.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"235 1","pages":"2417729"},"PeriodicalIF":12.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fecal samples and rectal swabs adequately reflect the human colonic luminal microbiota. 粪便样本和直肠拭子能充分反映人体结肠腔微生物群。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-22 DOI: 10.1080/19490976.2024.2416912

Julia Rode,Linnea Brengesjö Johnson,Julia König,Ignacio Rangel,Lars Engstrand,Dirk Repsilber,Robert J Brummer

引用次数: 0

Muropeptides and muropeptide transporters impact on host immune response. 肽和肽转运体对宿主免疫反应的影响

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-22 DOI: 10.1080/19490976.2024.2418412

Maria Lucia Orsini Delgado,Joao Gamelas Magalhaes,Rachel Morra,Antonietta Cultrone

引用次数: 0

Inflammasome activation links enteric Salmonella Typhimurium infection to a rapid, cytokine-dependent increase in intestinal mucin release 炎症小体激活将肠道鼠伤寒沙门氏菌感染与细胞因子依赖性肠粘蛋白释放的快速增加联系起来

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-20 DOI: 10.1080/19490976.2024.2413372

Xiao Han, Joannie M. Allaire, Shauna M. Crowley, Jocelyn J. Chan, Kelly Lau, Conghao Zhang, Simon A. Hirota, Kirk Bergstrom, Leigh A. Knodler, Bruce A. Vallance

引用次数: 0

Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications. 糖尿病的肠道微生物代谢特征及潜在的预防和治疗应用。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-18 DOI: 10.1080/19490976.2024.2401654

Enriqueta Garcia-Gutierrez,A Kate O'Mahony,Reinaldo Sousa Dos Santos,Laura Marroquí,Paul D Cotter

{"title":"Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications.","authors":"Enriqueta Garcia-Gutierrez,A Kate O'Mahony,Reinaldo Sousa Dos Santos,Laura Marroquí,Paul D Cotter","doi":"10.1080/19490976.2024.2401654","DOIUrl":"https://doi.org/10.1080/19490976.2024.2401654","url":null,"abstract":"Diabetes mellitus can be subdivided into several categories based on origin and clinical characteristics. The most common forms of diabetes are type 1 (T1D), type 2 diabetes (T2D) and gestational diabetes mellitus (GDM). T1D and T2D are chronic diseases affecting around 537 million adults worldwide and it is projected that these numbers will increase by 12% over the next two decades, while GDM affects up to 30% of women during pregnancy, depending on diagnosis methods. These forms of diabetes have varied origins: T1D is an autoimmune disease, while T2D is commonly associated with, but not limited to, certain lifestyle patterns and GDM can result of a combination of genetic predisposition and pregnancy factors. Despite some pathogenic differences among these forms of diabetes, there are some common markers associated with their development. For instance, gut barrier impairment and inflammation associated with an unbalanced gut microbiota and their metabolites may be common factors in diabetes development and progression. Here, we summarize the microbial signatures that have been linked to diabetes, how they are connected to diet and, ultimately, the impact on metabolite profiles resulting from host-gut microbiota-diet interactions. Additionally, we summarize recent advances relating to promising preventive and therapeutic interventions focusing on the targeted modulation of the gut microbiota to alleviate T1D, T2D and GDM.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"77 1","pages":"2401654"},"PeriodicalIF":12.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota determines the fate of dietary fiber-targeted interventions in host health. 肠道微生物群决定了以膳食纤维为目标的干预措施在宿主健康中的命运。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-17 DOI: 10.1080/19490976.2024.2416915

Wenjing Wang,Zhexin Fan,Qingqing Yan,Tong Pan,Jing Luo,Yijiang Wei,Baokun Li,Zhifeng Fang,Wenwei Lu

{"title":"Gut microbiota determines the fate of dietary fiber-targeted interventions in host health.","authors":"Wenjing Wang,Zhexin Fan,Qingqing Yan,Tong Pan,Jing Luo,Yijiang Wei,Baokun Li,Zhifeng Fang,Wenwei Lu","doi":"10.1080/19490976.2024.2416915","DOIUrl":"https://doi.org/10.1080/19490976.2024.2416915","url":null,"abstract":"Epidemiological investigation confirmed that the intake of dietary fiber (DF) is closely related to human health, and the most important factor affecting the physiological function of DF, besides its physicochemical properties, is the gut microbiota. This paper mainly summarizes the interaction between DF and gut microbiota, including the influence of DF on the colonization of gut microbiota based on its different physicochemical properties, and the physiological role of gut microbiota in destroying the complex molecular structure of DF by encoding carbohydrate-active enzymes, thus producing small molecular products that affect the metabolism of the host. Taking cardiovascular disease (Atherosclerosis and hypertension), liver disease, and immune diseases as examples, it is confirmed that some DF, such as fructo-oligosaccharide, galactooligosaccharide, xylo-oligosaccharide, and inulin, have prebiotic-like physiological effects. These effects are dependent on the metabolites produced by the gut microbiota. Therefore, this paper further explores how DF affects the gut microbiota's production of substances such as short-chain fatty acids, bile acids, and tryptophan metabolites, and provides a preliminary explanation of the mechanisms associated with their impact on host health. Finally, based on the structural properties of DF and the large heterogeneity in the composition of the population gut microbiota, it may be a future trend to utilize DF and the gut microbiota to correlate host health for precision nutrition by combining the information from population disease databases.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"12 1","pages":"2416915"},"PeriodicalIF":12.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled infection with cryopreserved human hookworm induces CTLA-4 expression on Tregs and upregulates tryptophan metabolism 冷冻保存的人钩虫控制感染可诱导 Tregs 上 CTLA-4 的表达并上调色氨酸代谢

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-16 DOI: 10.1080/19490976.2024.2416517

Francesco Vacca, Thomas C. Mules, Mali Camberis, Brittany Lavender, Sophia-Louise Noble, Alissa Cait, Kate Maclean, John Mamum, Bibek Yumnam, Tama Te Kawa, Laura Ferrer-Font, Jeffry S. Tang, Olivier Gasser, Graham Le Gros, Stephen Inns

引用次数: 0

Giardia spp.-induced microbiota dysbiosis disrupts intestinal mucin glycosylation. 贾第虫引起的微生物群失调会破坏肠道粘蛋白糖基化。

IF 12.2 1区医学

Gut Microbes Pub Date : 2024-10-16 DOI: 10.1080/19490976.2024.2412676

Elena Fekete,Thibault Allain,Olivia Sosnowski,Stephanie Anderson,Ian A Lewis,Andre G Buret

{"title":"Giardia spp.-induced microbiota dysbiosis disrupts intestinal mucin glycosylation.","authors":"Elena Fekete,Thibault Allain,Olivia Sosnowski,Stephanie Anderson,Ian A Lewis,Andre G Buret","doi":"10.1080/19490976.2024.2412676","DOIUrl":"https://doi.org/10.1080/19490976.2024.2412676","url":null,"abstract":"Infection with the protozoan parasite Giardia duodenalis (syn. intestinalis, lamblia) has been associated with intestinal mucus disruptions and microbiota dysbiosis. The mechanisms remain incompletely understood. Mucus consists primarily of densely glycosylated mucin glycoproteins. Mucin O-glycans influence mucus barrier properties and mucin-microbe interactions and are frequently altered during disease. In this study, we observed time-dependent and regiospecific alterations to intestinal mucin glycosylation patterns and the expression of mucin-associated glycosyltransferase genes during Giardia infection. Glycosylation alterations were observed in Giardia-infected mice in the upper small intestine, the site of parasite colonization, and in the distal colon, where active trophozoites were absent. Alterations occurred as early as day 2 post-infection and persisted in mice after parasite clearance. We also observed small intestinal goblet cell hyperplasia and thinning of the distal colon mucus barrier during early infection, and microbiota alterations and altered production of cecal SCFAs. Giardia-induced alterations to mucin glycosylation were at least in part dependent on microbiota dysbiosis, as transplantation of a dysbiotic mucosal microbiota collected from Giardia-infected mice recapitulated some alterations. This study describes a novel mechanism by which Giardia alters intestinal mucin glycosylation, and implicates the small intestinal microbiota in regulation of mucin glycosylation patterns throughout the gastrointestinal tract.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"24 1","pages":"2412676"},"PeriodicalIF":12.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0